{"id":"https://openalex.org/W2774152107","doi":null,"title":"Development of stainless cardiac histology of clinical biopsy samples with infrared spectroscopy","display_name":"Development of stainless cardiac histology of clinical biopsy samples with infrared spectroscopy","publication_year":2016,"publication_date":"2016-12-20","ids":{"openalex":"https://openalex.org/W2774152107","mag":"2774152107"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/97236","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/97236","pdf_url":"https://www.ideals.illinois.edu/items/102289/bitstreams/325881/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/102289/bitstreams/325881/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020820383","display_name":"Saumya Tiwari","orcid":"https://orcid.org/0000-0001-5148-6539","observed_orcids":["https://orcid.org/0000-0001-5148-6539"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Saumya Tiwari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5148-6539","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020820383"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infrared-spectroscopy","display_name":"infrared spectroscopy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cardiac-histology","display_name":"cardiac histology","score":0.753000020980835},{"id":"https://openalex.org/keywords/endomyocardial-biopsy","display_name":"endomyocardial biopsy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cardiac-allograft-rejection","display_name":"cardiac allograft rejection","score":0.703000009059906},{"id":"https://openalex.org/keywords/lymphocytic-infiltration","display_name":"lymphocyte infiltration","score":0.9909999966621399},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/quantum-cascade-laser","display_name":"quantum cascade lasers","score":0.8339999914169312},{"id":"https://openalex.org/keywords/fourier-transform-infrared-imaging","display_name":"Fourier transform infrared imaging","score":0.7940000295639038},{"id":"https://openalex.org/keywords/bayesian-classification","display_name":"Bayesian classification","score":0.6620000004768372},{"id":"https://openalex.org/keywords/unsupervised-clustering","display_name":"unsupervised clustering","score":0.7229999899864197},{"id":"https://openalex.org/keywords/h-e-staining","display_name":"H&E staining","score":0.734000027179718},{"id":"https://openalex.org/keywords/interobserver-variability","display_name":"interobserver variability","score":0.7120000123977661},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.4480000138282776},{"id":"https://openalex.org/keywords/alcoholic-cardiomyopathy","display_name":"alcoholic cardiomyopathy","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.7839957475662231},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5298497676849365},{"id":"https://openalex.org/C158355884","wikidata":"https://www.wikidata.org/wiki/Q11388","display_name":"Infrared","level":2,"score":0.4597715139389038},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4232303500175476},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4082389771938324},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3351789116859436},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15234169363975525},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.12726399302482605}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/97236","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/97236","pdf_url":"https://www.ideals.illinois.edu/items/102289/bitstreams/325881/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2774152107","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/97236","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/97236","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/97236","pdf_url":"https://www.ideals.illinois.edu/items/102289/bitstreams/325881/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2774152107.pdf","grobid_xml":"https://content.openalex.org/works/W2774152107.grobid-xml"},"referenced_works_count":162,"referenced_works":["https://openalex.org/W1503033818","https://openalex.org/W1547842005","https://openalex.org/W1577665082","https://openalex.org/W1580904219","https://openalex.org/W1580995169","https://openalex.org/W1683474607","https://openalex.org/W1888522739","https://openalex.org/W1944363068","https://openalex.org/W1957880470","https://openalex.org/W1963508535","https://openalex.org/W1964436833","https://openalex.org/W1965195010","https://openalex.org/W1965576493","https://openalex.org/W1969043349","https://openalex.org/W1970541658","https://openalex.org/W1971054665","https://openalex.org/W1971918133","https://openalex.org/W1972124734","https://openalex.org/W1972511344","https://openalex.org/W1973586733","https://openalex.org/W1974000725","https://openalex.org/W1974390406","https://openalex.org/W1974398392","https://openalex.org/W1974889478","https://openalex.org/W1976345209","https://openalex.org/W1977420938","https://openalex.org/W1977699193","https://openalex.org/W1980877019","https://openalex.org/W1981955132","https://openalex.org/W1982401067","https://openalex.org/W1983549854","https://openalex.org/W1984538686","https://openalex.org/W1984640808","https://openalex.org/W1986042279","https://openalex.org/W1987389391","https://openalex.org/W1987648423","https://openalex.org/W1987955706","https://openalex.org/W1988146527","https://openalex.org/W1989360915","https://openalex.org/W1989581551","https://openalex.org/W1989773587","https://openalex.org/W1989931540","https://openalex.org/W1989987625","https://openalex.org/W1990612198","https://openalex.org/W1991354544","https://openalex.org/W1995206944","https://openalex.org/W1997190463","https://openalex.org/W2000034029","https://openalex.org/W2001120773","https://openalex.org/W2002333711","https://openalex.org/W2003760854","https://openalex.org/W2004599468","https://openalex.org/W2006697052","https://openalex.org/W2007249865","https://openalex.org/W2007435139","https://openalex.org/W2009181584","https://openalex.org/W2010331750","https://openalex.org/W2011055829","https://openalex.org/W2012183591","https://openalex.org/W2014959995","https://openalex.org/W2015195838","https://openalex.org/W2017148126","https://openalex.org/W2017203317","https://openalex.org/W2019358153","https://openalex.org/W2019440201","https://openalex.org/W2020079801","https://openalex.org/W2020832531","https://openalex.org/W2021270211","https://openalex.org/W2022153546","https://openalex.org/W2022797435","https://openalex.org/W2024021832","https://openalex.org/W2024737114","https://openalex.org/W2024971501","https://openalex.org/W2028612481","https://openalex.org/W2033083554","https://openalex.org/W2033165016","https://openalex.org/W2033970221","https://openalex.org/W2038641524","https://openalex.org/W2038871162","https://openalex.org/W2038878430","https://openalex.org/W2041551651","https://openalex.org/W2043935688","https://openalex.org/W2047284613","https://openalex.org/W2048547563","https://openalex.org/W2050031215","https://openalex.org/W2050544896","https://openalex.org/W2052238709","https://openalex.org/W2055644700","https://openalex.org/W2057890883","https://openalex.org/W2058610272","https://openalex.org/W2060719207","https://openalex.org/W2062482916","https://openalex.org/W2062662703","https://openalex.org/W2063477565","https://openalex.org/W2064095640","https://openalex.org/W2065110720","https://openalex.org/W2065592018","https://openalex.org/W2068081034","https://openalex.org/W2075440794","https://openalex.org/W2076366036","https://openalex.org/W2077100815","https://openalex.org/W2078665885","https://openalex.org/W2079720345","https://openalex.org/W2080422716","https://openalex.org/W2086950984","https://openalex.org/W2088990891","https://openalex.org/W2090086153","https://openalex.org/W2096576324","https://openalex.org/W2101199164","https://openalex.org/W2102248106","https://openalex.org/W2104483699","https://openalex.org/W2106242560","https://openalex.org/W2106473563","https://openalex.org/W2107134698","https://openalex.org/W2108369743","https://openalex.org/W2108712876","https://openalex.org/W2108842111","https://openalex.org/W2109248096","https://openalex.org/W2110909984","https://openalex.org/W2113155690","https://openalex.org/W2116062769","https://openalex.org/W2118644955","https://openalex.org/W2119106121","https://openalex.org/W2122829469","https://openalex.org/W2123913716","https://openalex.org/W2125422089","https://openalex.org/W2125893301","https://openalex.org/W2128722360","https://openalex.org/W2129285756","https://openalex.org/W2130379367","https://openalex.org/W2132294579","https://openalex.org/W2134130921","https://openalex.org/W2138131118","https://openalex.org/W2139790640","https://openalex.org/W2140949288","https://openalex.org/W2142773345","https://openalex.org/W2143629680","https://openalex.org/W2144563885","https://openalex.org/W2145270758","https://openalex.org/W2148096101","https://openalex.org/W2153632464","https://openalex.org/W2157070021","https://openalex.org/W2161789671","https://openalex.org/W2163092745","https://openalex.org/W2163455805","https://openalex.org/W2168667907","https://openalex.org/W2169509672","https://openalex.org/W2169702966","https://openalex.org/W2172422019","https://openalex.org/W2222744863","https://openalex.org/W2226954115","https://openalex.org/W2227496933","https://openalex.org/W2281888594","https://openalex.org/W2293200316","https://openalex.org/W2325938367","https://openalex.org/W2397741949","https://openalex.org/W2409545802","https://openalex.org/W2470545058","https://openalex.org/W2548352112","https://openalex.org/W4250483374","https://openalex.org/W4250555131","https://openalex.org/W4293084779"],"related_works":["https://openalex.org/W2078665885","https://openalex.org/W7095969027","https://openalex.org/W3136562086","https://openalex.org/W7100576612","https://openalex.org/W2894705094","https://openalex.org/W1536739746","https://openalex.org/W2467240019","https://openalex.org/W206512267","https://openalex.org/W2029068410","https://openalex.org/W4392982610"],"abstract_inverted_index":{"Cardiac":[0,179],"diseases":[1,26],"are":[2,20],"the":[3,9,45,56,120,128,137,140,177,211,233,252,282,286,294,306,337,365,410,420,446,457],"leading":[4],"cause":[5,278],"of":[6,24,59,122,127,155,163,214,293,339,348,368,405,430,438,456,514,525],"mortality":[7],"in":[8,16,44,94,109,119,132,176,232,235,251,259,263,268,321,402,413,427,474,496,517,527],"United":[10],"States,":[11],"accounting":[12],"for":[13,33,115,316,468,522],"every":[14],"one":[15],"seven":[17],"deaths.":[18],"There":[19],"a":[21,34],"large":[22],"proportion":[23],"cardiac":[25,123,497],"that":[27,136,186,409,441,463,485],"need":[28,464],"histopathological":[29],"examination":[30],"by":[31,61,89,100,145,302,336,353,394],"pathologists":[32,101,205],"conclusive":[35],"diagnosis,":[36],"but":[37,332],"this":[38,49,215,369,431,515],"technique":[39],"hasn\u2019t":[40],"been":[41],"improved":[42],"upon":[43],"past":[46],"decade.":[47],"In":[48,210,364,478],"work,":[50,216,370],"we":[51,217,371,433,480],"have":[52,434],"attempted":[53],"to":[54,73,134,204,206,226,248,255,281,310,328,384,398,423,445,454,465,489,512],"advance":[55],"current":[57,70,197],"state":[58],"histology":[60,304],"developing":[62,113],"stainless":[63],"staining":[64],"protocols":[65],"using":[66,341,354,504],"infrared":[67,219,319,344,360],"spectroscopy.":[68],"The":[69,153,346],"gold":[71],"standard":[72],"identify":[74,188,227,249],"cardiovascular":[75],"complications":[76],"such":[77],"as":[78],"ischemia,":[79],"fibrosis,":[80],"alcoholic":[81],"cardiomyopathy":[82],"and":[83,106,112,158,191,200,230,243,254,270,284,314,381,493],"transplant":[84,129,164,180],"rejection":[85,173],"is":[86,130,143,161,170,174],"biopsy":[87,237,275,498],"followed":[88],"histology.":[90],"This":[91,142,239,298,391,449,508],"approach":[92],"lacks":[93],"many":[95,455],"aspects.":[96],"Major":[97],"challenges":[98],"faced":[99],"are:":[102],"addressing":[103],"inter-observer":[104],"variability":[105],"experimental":[107],"variations":[108],"stain":[110,272],"development,":[111],"approaches":[114,440],"in-situ":[116,331],"histopathology.":[117],"Specifically,":[118],"case":[121],"transplants,":[124],"regular":[125],"monitoring":[126],"required":[131,171],"order":[133],"ensure":[135],"body":[138],"accepts":[139],"transplant.":[141],"done":[144,393,435],"collecting":[146],"tissue":[147,253,295,307,495],"biopsies":[148],"at":[149,501],"specific":[150,482],"time":[151,290],"intervals.":[152],"presence":[154],"lymphocytic":[156,189,228],"infiltration":[157,190,229],"accompanying":[159],"fibrosis":[160,192,231,258,262,492,526],"indicative":[162],"rejection.":[165],"A":[166],"prompt":[167],"clinical":[168],"action":[169],"if":[172],"identified":[175,481],"biopsy.":[178],"patients":[181],"can":[182,187,277,325,350,442,509],"benefit":[183],"from":[184],"techniques":[185],"with":[193,222,261],"high":[194,502],"accuracy,":[195],"complementing":[196],"pathology":[198],"practice":[199],"giving":[201],"greater":[202],"opportunity":[203],"study":[207,450],"complex":[208],"cases.":[209],"first":[212],"part":[213,367,428],"used":[218,488],"spectroscopy":[220,320],"coupled":[221],"supervised":[223],"Bayesian":[224,460],"classification":[225,439,461],"myocardium":[234,264],"endomyocardial":[236],"samples.":[238],"classifier":[240],"was":[241,392],"robust":[242],"could":[244,486],"be":[245,300,311,326,351,443,452,466,487],"easily":[246],"applied":[247,444],"lymphocytes":[250],"differentiate":[256,490],"between":[257,419,491],"endocardium":[260],"which":[265],"stains":[266],"similarly":[267],"hematoxylin":[269],"eosin":[271],"(H&E).":[273],"Repeated":[274],"procedures":[276],"significant":[279],"trauma":[280],"patient,":[283],"often":[285],"surgeons":[287],"require":[288],"real":[289],"histopathology":[291],"information":[292],"during":[296],"surgeries.":[297],"cannot":[299],"accomplished":[301],"traditional":[303],"where":[305],"sample":[308],"needs":[309],"excised,":[312],"sectioned":[313],"stained":[315],"analysis.":[317],"Since":[318],"stainless,":[322],"probe-based":[323,520],"instruments":[324,380],"developed":[327,377],"provide":[329],"detection":[330,524],"were":[333],"earlier":[334],"limited":[335],"speed":[338,349,503],"imaging":[340,362,389],"Fourier":[342],"Transform":[343],"spectrometers.":[345],"problem":[347],"overcome":[352],"quantum":[355],"cascade":[356],"laser-based":[357],"discrete":[358,378,475,505],"frequency":[359,379,476,506],"(DFIR)":[361],"instruments.":[363,390],"second":[366],"analyzed":[372],"data":[373,385,396,411,472],"collected":[374,386,412,473],"on":[375,387,471],"recently":[376],"compared":[382],"it":[383],"FT-IR":[388],"unsupervised":[395],"clustering":[397],"observe":[399],"histological":[400,421],"classes":[401,422],"both":[403],"types":[404],"data.":[406,448],"After":[407],"establishing":[408],"DFIR":[414,447],"mode":[415],"retained":[416],"spectral":[417,483],"differences":[418],"enable":[424],"their":[425,469],"differentiation,":[426],"three":[429],"work":[432],"extensive":[436],"analysis":[437],"will":[451],"relevant":[453],"previously":[458],"built":[459],"models":[462],"evaluated":[467],"applicability":[470],"mode.":[477],"addition,":[479],"features":[484],"normal":[494],"samples":[499],"computationally":[500],"approach.":[507],"give":[510],"way":[511],"utilization":[513],"model":[516],"fiber":[518],"optic":[519],"technology":[521],"on-site":[523],"patients.":[528]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-12-22T00:00:00"}