{"id":"https://openalex.org/W2774097016","doi":"https://doi.org/10.1097/00007890-201407151-00957","title":"A Mathematical Model for Predicting In Vitro Stem Cell Proliferation Kinetics.","display_name":"A Mathematical Model for Predicting In Vitro Stem Cell Proliferation Kinetics.","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W2774097016","doi":"https://doi.org/10.1097/00007890-201407151-00957","mag":"2774097016"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-201407151-00957","doi":"https://doi.org/10.1097/00007890-201407151-00957","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-201407151-00957","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114069267","display_name":"E. Szilagyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Szilagyi","raw_affiliation_strings":["\"; University of Illinois at Chicago\""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"; University of Illinois at Chicago\"","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058043574","display_name":"Arif Masud","orcid":"https://orcid.org/0000-0002-4708-4251","observed_orcids":["https://orcid.org/0000-0002-4708-4251"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Masud","raw_affiliation_strings":["\"; University of Illinois at Urbana-Champaign\""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"; University of Illinois at Urbana-Champaign\"","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005944710","display_name":"JaeHyuk Kwack","orcid":"https://orcid.org/0000-0002-8272-1201","observed_orcids":["https://orcid.org/0000-0002-8272-1201"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Kwack","raw_affiliation_strings":["\"; University of Illinois at Urbana-Champaign\""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"; University of Illinois at Urbana-Champaign\"","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053684076","display_name":"Eduardo Reina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Reina","raw_affiliation_strings":["\"; University of Illinois at Chicago\""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"; University of Illinois at Chicago\"","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072811993","display_name":"Melissa A. Willman","orcid":"https://orcid.org/0000-0002-0688-5490","observed_orcids":["https://orcid.org/0000-0002-0688-5490"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Willman","raw_affiliation_strings":["University of Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038917516","display_name":"Norma Sue Kenyon","orcid":"https://orcid.org/0000-0003-3157-339X","observed_orcids":["https://orcid.org/0000-0003-3157-339X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Kenyon","raw_affiliation_strings":["University of Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112803953","display_name":"Amelia M. Bartholomew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Bartholomew","raw_affiliation_strings":["\"; University of Illinois at Chicago\""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"; University of Illinois at Chicago\"","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33296345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":null,"first_page":"303","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ex-vivo-expansion","display_name":"ex vivo expansion","score":0.6930000185966492},{"id":"https://openalex.org/keywords/power-law-model","display_name":"power law model","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.6019999980926514},{"id":"https://openalex.org/keywords/autologous-stem-cell-therapy","display_name":"autologous stem cell therapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/irradiation","display_name":"irradiation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.781000018119812},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cynomolgus-macaques","display_name":"cynomolgus macaques","score":0.9990000128746033},{"id":"https://openalex.org/keywords/allosensitization","display_name":"allosensitization","score":0.6740000247955322},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7498282194137573},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6857998371124268},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5897616147994995},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5586115121841431},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5196982026100159},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.510123074054718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4459001421928406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42415109276771545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38856661319732666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32526493072509766},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32058531045913696},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21655917167663574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1869453489780426},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.1053357720375061},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-201407151-00957","doi":"https://doi.org/10.1097/00007890-201407151-00957","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-201407151-00957","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.49000000953674316,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2045229788","https://openalex.org/W2004095991","https://openalex.org/W2279073976","https://openalex.org/W3002715866","https://openalex.org/W2061227838","https://openalex.org/W7139625855","https://openalex.org/W2544868549","https://openalex.org/W2511177151","https://openalex.org/W2409534159","https://openalex.org/W4234077394"],"abstract_inverted_index":{"Over":[0],"150":[1],"active":[2],"clinical":[3,70],"trials":[4],"of":[5,41,53,85,103,145,152,184,187,193,235,298,304,320,357],"mesenchymal":[6,127,358],"stem":[7,23,36,71,128,161,240,321,332,359],"cell":[8,24,72,129,162,241,333],"therapies":[9,343],"are":[10],"underway,":[11],"testing":[12],"the":[13,45,63,68,75,83,101,142,149,156,160,175,182,194,259,295,314,318,338,355],"efficacy":[14],"in":[15,27,44,148,159,174,264,307,326],"enhancing":[16],"solid":[17],"organ":[18],"and":[19,124,204,227,268,310],"islet":[20],"transplant,":[21],"hematopoetic":[22],"transplants":[25],"or":[26],"tissue":[28],"regenerative":[29],"strategies":[30],"with":[31,96,206,254,280],"a":[32,39,92,165,185,233,250,302],"majority":[33],"utilizing":[34],"autologous":[35,331,342],"cells.":[37],"With":[38,285,313],"number":[40,102,297],"co-morbidities":[42],"present":[43],"targeted":[46],"host,":[47],"reports":[48],"have":[49],"identified":[50],"adverse":[51],"effects":[52],"these":[54],"comorbidities":[55],"such":[56],"as":[57,213,272,274,351],"diabetes,":[58],"prior":[59],"radiation,":[60],"to":[61,65,77,94,141,154,316,328,340],"reduce":[62],"ability":[64,315],"sufficiently":[66],"expand":[67],"desired":[69],"dose,":[73],"forcing":[74],"recipient":[76],"utilize":[78],"third":[79],"party":[80],"donors,":[81],"carrying":[82],"risk":[84,356],"allosensitization.":[86],"Using":[87,249],"mathematical":[88,137],"modeling,":[89],"we":[90],"developed":[91],"method":[93],"predict":[95,155,317],"greater":[97],"than":[98],"90%":[99],"certainty,":[100],"cells":[104,322],"which":[105,346],"would":[106],"be":[107],"obtained":[108,300,323],"after":[109],"full":[110],"6-passage":[111],"ex":[112,132],"vivo":[113,133],"expansion.":[114],"Methods:":[115],"42":[116],"healthy":[117,207,275,309],"juvenile":[118],"rhesus":[119],"macaques,":[120],"13":[121],"cynomolgus":[122],"macaques":[123,271],"three":[125],"human":[126,276],"preparations":[130],"were":[131,179,212,347],"expanded.":[134],"A":[135],"power-law":[136],"model":[138,178,196,260,292],"was":[139,197,261],"applied":[140],"proliferation":[143],"data":[144,252],"na\u00efve":[146],"MSCs":[147],"early":[150,286],"days":[151],"expansion":[153,247,289],"fold":[157],"increase":[158],"population":[163],"at":[164,199,215,219,223,228],"future":[166],"time":[167,325],"point.":[168],"Based":[169],"on":[170],"normal":[171],"distribution,":[172],"coefficients":[173],"power":[176],"law":[177],"determined":[180],"via":[181],"solution":[183],"system":[186],"coupled":[188],"equations.":[189],"Results:":[190],"Prospective":[191],"validation":[192],"predictive":[195],"verified":[198,263],"two":[200],"different":[201],"laboratories,":[202],"(n=7)":[203],"(n=6)":[205,267],"macaques.":[208],"The":[209],"under-predicting":[210],"ratios":[211],"follows:":[214],"day":[216,220,224,229,245,287],"20,":[217],"8\u00b10.04%,":[218],"30,":[221],"15\u00b10.06%,":[222],"60,":[225],"23\u00b10.13%":[226],"90,":[230],"39\u00b10.16%,":[231],"demonstrating":[232],"lack":[234],"underprediction":[236],"for":[237,344],"determining":[238],"expanded":[239],"doses":[242],"when":[243],"inputting":[244],"10":[246,288],"data.":[248],"confounded":[251],"set":[253],"nonhuman":[255],"primates":[256],"showing":[257],"comorbidities,":[258],"also":[262],"streptozocin-induced":[265],"diabetic":[266],"irradiated":[269],"(n=24)":[270],"well":[273],"MSC":[277,299],"populations":[278],"(n=3)":[279],"similar":[281],"predicting":[282],"power.":[283],"Conclusion:":[284],"data,":[290],"this":[291,335],"consistently":[293],"predicts":[294],"minimum":[296],"over":[301,324],"period":[303],"3-12":[305],"weeks":[306],"both":[308],"diseased":[311],"hosts.":[312],"numbers":[319],"order":[327],"cryopreserve":[329],"adequate":[330],"doses,":[334],"method,":[336],"has":[337],"potential":[339],"enable":[341],"subjects":[345],"previously":[348],"not":[349],"considered":[350],"viable":[352],"candidates":[353],"minimizing":[354],"cell-based":[360],"therapies.":[361]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-12-22T00:00:00"}
