{"id":"https://openalex.org/W2773990701","doi":null,"title":"\u00c9tude de CLEC-1, un r\u00e9cepteur lectin-like de type C dans la fonction des cellules dendritiques et la tol\u00e9rance immune","display_name":"\u00c9tude de CLEC-1, un r\u00e9cepteur lectin-like de type C dans la fonction des cellules dendritiques et la tol\u00e9rance immune","publication_year":2017,"publication_date":"2017-09-29","ids":{"openalex":"https://openalex.org/W2773990701","mag":"2773990701"},"language":"fr","primary_location":{"id":"pmh:2017NANT1025","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2017NANT1025","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009786728","display_name":"Luis O. Burciaga-Robles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. O. Burciaga Robles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108111664","display_name":"Mar\u00eda Dolores","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Dolores","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.777999997138977},{"id":"https://openalex.org/keywords/th17-response","display_name":"Th17 response","score":0.8730000257492065},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.9200000166893005},{"id":"https://openalex.org/keywords/il-12p40","display_name":"IL-12p40","score":0.8799999952316284},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.6890000104904175},{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.7570000290870667},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7091289162635803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5277486443519592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2451533079147339}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:2017NANT1025","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2017NANT1025","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:2773990701","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2017NANT1025","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7134706021","https://openalex.org/W2603212780","https://openalex.org/W2961082226","https://openalex.org/W2799824981","https://openalex.org/W1484912852","https://openalex.org/W2996419469","https://openalex.org/W7150942635","https://openalex.org/W1598618419","https://openalex.org/W7148938426","https://openalex.org/W6980547797"],"abstract_inverted_index":{"Les":[0,17],"cellules":[1],"dendritiques":[2],"(DCs)":[3],"sont":[4,25],"essentielles":[5],"pourconnecter":[6],"l'immunit\u00e9":[7],"inn\u00e9e":[8],"et":[9,11,81,89,106,124,142,197,204,208,224],"adaptative":[10],"orienter":[12],"lesr\u00e9ponses":[13,237],"des":[14,28,111,200],"lymphocytes":[15],"T.":[16],"r\u00e9cepteurs":[18],"Lectin":[19],"de":[20,42,54,68,84,98,101,114,182,185,190,216],"type-Cpr\u00e9sents":[21],"dans":[22,56,194,218,240],"les":[23,57,86,108,117,139,195,219],"DCs":[24,58,87,102,109],"activ\u00e9s":[26],"par":[27,121,126],"ligands":[29],"exog\u00e8nes":[30],"etendog\u00e8nes,":[31],"ce":[32],"qui":[33],"dicte":[34],"la":[35,43,69,82,99,148,158,183,191,225],"r\u00e9ponse":[36,44,70,226],"aux":[37],"agents":[38],"pathog\u00e8nes":[39],"parla":[40],"modulation":[41],"T":[45,71,239],"immunitaire.":[46],"Nous":[47],"avons":[48,60,78,91,131,178],"d\u00e9j\u00e0d\u00e9crit":[49],"chez":[50],"le":[51,127,214],"rat,":[52],"l'expression":[53,80],"CLEC-1":[55,115,134,186,217,229],"etnous":[59],"d\u00e9montr\u00e9":[61,132],"in":[62,206],"vitro":[63,207],"son":[64,93],"r\u00f4le":[65],"inhibiteur":[66],"dansl'activation":[67],"helper":[72],"(Th17)":[73],").":[74],"Dans":[75],"cette":[76],"\u00e9tude,nous":[77],"examin\u00e9":[79],"fonction":[83],"CLEC-1dans":[85],"humaines":[88],"nous":[90,177],"montr\u00e9":[92,179],"expression":[94],"\u00e0la":[95],"surface":[96],"cellulaire":[97],"sous-population":[100],"CD16-":[103],"dansle":[104],"sang":[105],"sur":[107,116,138],"d\u00e9riv\u00e9es":[110],"monocytes":[112],"(moDCs).L'expression":[113],"moDCs":[118,140],"est":[119,135],"diminu\u00e9e":[120],"desstimuli":[122],"inflammatoires":[123],"renforc\u00e9e":[125],"TGF-\u03b2.":[128],"De":[129,167],"plus,nous":[130],"que":[133,180],"un":[136,241],"r\u00e9cepteurfonctionnel":[137],"humains":[141],"que,":[143],"bien":[144],"qu'il":[145],"nemodule":[146],"pas":[147],"voie":[149],"classique":[150],"d\u2019activation":[151],"du":[152],"facteur":[153],"detranscription":[154],"NF\u043aB":[155],"li\u00e9":[156],"\u00e0":[157,188,198],"prot\u00e9ine":[159],"kinase":[160],"Syk,":[161],"il":[162],"r\u00e9prime":[163],"lar\u00e9ponse":[164],"ult\u00e9rieure":[165,227],"Th17.":[166,228],"fa\u00e7on":[168],"tr\u00e8s":[169],"importante,":[170],"en":[171],"utilisantdes":[172],"rats":[173],"d\u00e9ficients":[174],"pour":[175,235],"CLEC-1,":[176],"laperturbation":[181],"signalisation":[184],"conduit":[187],"unesurexpression":[189],"sous-unit\u00e9":[192],"Il-12p40":[193],"DCs,":[196,220],"uneexacerbation":[199],"r\u00e9ponses":[201],"CD4+":[202],"Th1":[203],"Th17":[205],"invivo.":[209],"Collectivement,":[210],"nos":[211],"r\u00e9sultats":[212],"\u00e9tablissent":[213],"r\u00f4leinhibiteur":[215],"capable":[221],"d'amortir":[222],"leuractivation":[223],"peutrepr\u00e9senter":[230],"une":[231],"cible":[232],"th\u00e9rapeutique":[233],"utile":[234],"moduler":[236],"immunitaires":[238],"contexte":[242],"clinique.":[243]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-12-22T00:00:00"}
