{"id":"https://openalex.org/W2773960118","doi":null,"title":"Cocaine residue in plasma, cardiac and tracheal tissues of chronic cocaine-treated guinea-pigs","display_name":"Cocaine residue in plasma, cardiac and tracheal tissues of chronic cocaine-treated guinea-pigs","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2773960118","mag":"2773960118"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:d53ae598dd3e4c35ab94f7d7a63795e6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d53ae598dd3e4c35ab94f7d7a63795e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Songklanakarin Journal of Science and Technology (SJST), Vol 32, Iss 1, Pp 43-49 (2010)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038830877","display_name":"Sawpheeyah Nima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sawpheeyah Nima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045754506","display_name":"Peerarat Thaina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peerarat Thaina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019557586","display_name":"Methi Sunbhanich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Methi Sunbhanich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.3073999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.3073999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.20479999482631683,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.09830000251531601,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.47600001096725464},{"id":"https://openalex.org/keywords/tracheal-smooth-muscle","display_name":"tracheal smooth muscle","score":0.8989999890327454},{"id":"https://openalex.org/keywords/atrium","display_name":"atrium","score":0.6930000185966492},{"id":"https://openalex.org/keywords/ventricles","display_name":"ventricles","score":0.7590000033378601},{"id":"https://openalex.org/keywords/postsynaptic-mechanisms","display_name":"postsynaptic mechanisms","score":0.7639999985694885},{"id":"https://openalex.org/keywords/chronic-cocaine-use","display_name":"chronic cocaine use","score":0.5709999799728394},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.6422274112701416},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.5655434131622314},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4701195955276489},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46807536482810974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38942134380340576},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38187330961227417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28334975242614746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13967576622962952}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:d53ae598dd3e4c35ab94f7d7a63795e6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d53ae598dd3e4c35ab94f7d7a63795e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Songklanakarin Journal of Science and Technology (SJST), Vol 32, Iss 1, Pp 43-49 (2010)","raw_type":"article"},{"id":"mag:2773960118","doi":null,"is_oa":false,"landing_page_url":"https://agris.fao.org/agris-search/search.do?recordID=TH2010000551","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1423439514","https://openalex.org/W1855961190","https://openalex.org/W1963113608","https://openalex.org/W2000663842","https://openalex.org/W2001617119","https://openalex.org/W2004857398","https://openalex.org/W2005452669","https://openalex.org/W2014360159","https://openalex.org/W2024197486","https://openalex.org/W2029782637","https://openalex.org/W2030220857","https://openalex.org/W2030229741","https://openalex.org/W2030461741","https://openalex.org/W2031287529","https://openalex.org/W2043079603","https://openalex.org/W2057969597","https://openalex.org/W2062847384","https://openalex.org/W2079331340","https://openalex.org/W2092446113","https://openalex.org/W2118141474","https://openalex.org/W2118473782","https://openalex.org/W2140638813","https://openalex.org/W2338565293"],"related_works":["https://openalex.org/W1423439514","https://openalex.org/W2048940563","https://openalex.org/W2029782637","https://openalex.org/W2405004060","https://openalex.org/W1987349805","https://openalex.org/W3201901475","https://openalex.org/W1896454513","https://openalex.org/W1986691227","https://openalex.org/W1976432794","https://openalex.org/W2809002496"],"abstract_inverted_index":{"Supersensitivity":[0],"of":[1,7,10,17,21,27,34,57,80,204,217],"adrenoceptors":[2,22],"to":[3,44,50,145,170],"catecholamines":[4],"is":[5,23,183],"one":[6],"the":[8,32,47,83,103,139,161,165,189,202,214],"mechanisms":[9],"cocaine-related":[11],"cardiac":[12,38,88,226],"complication.":[13],"The":[14,25,99],"precise":[15],"mechanism":[16,216],"cocaine":[18,35,66,81,84,104,218,230],"enhancing":[19,219],"supersensitivity":[20,48,169,220],"unconcluded.":[24],"aim":[26],"this":[28,53],"study":[29,167],"was":[30],"todetermine":[31],"levels":[33,85,105,135],"in":[36,42,86,106,121,160,174,180,228],"plasma,":[37,87],"and":[39,89,108,115,123,130,172,197],"tracheal":[40,90,109],"tissues":[41,91],"order":[43],"correlate":[45],"with":[46,63,225],"ofadrenoceptors":[49],"catecholamines.":[51],"In":[52,192],"study,":[54],"two":[55],"groups":[56],"ten":[58],"guinea-pigs":[59],"each":[60],"were":[61,92,112,125,136,207],"injected":[62],"2.5":[64],"mg/kg":[65],"or":[67],"normal":[68],"saline":[69],"solution":[70],"intraperitoneally":[71],"twice":[72],"daily":[73],"for":[74],"14":[75],"days.":[76],"After":[77],"24":[78],"hours":[79],"cessation,":[82],"determined":[93],"using":[94],"high":[95],"performance":[96],"liquid":[97],"chromatography.":[98],"results":[100],"showed":[101],"that":[102,141,158],"plasma":[107],"smooth":[110],"muscle":[111],"5.08\u00b10.63":[113],"ng/ml":[114],"2.8\u00b10.41":[116],"ng/mg,":[117],"respectively,":[118],"while":[119],"those":[120],"atria":[122,176],"ventricle":[124],"lower":[126],"than":[127,138,150],"17.5":[128],"ng/g":[129],"3.8":[131],"ng/g,":[132],"respectively.":[133],"These":[134],"less":[137],"level":[140],"had":[142,155],"been":[143,156],"reported":[144],"block":[146],"norepinephrine":[147,171],"uptake":[148],"(more":[149],"30.34":[151],"ng/ml).":[152],"Moreover,":[153],"it":[154],"demonstrated":[157],"cocainetreatment":[159],"same":[162],"condition":[163],"as":[164,177,179],"present":[166],"produced":[168],"epinephrine":[173],"isolatedguinea-pig":[175],"well":[178],"trachea":[181],"which":[182,199,221],"almost":[184],"entirely":[185],"not":[186,201],"innervated":[187],"by":[188],"adrenergic":[190],"nerves.":[191],"addition,":[193],"supersensitivityto":[194],"oxymetazoline,":[195],"isoproterenol":[196],"salbutamol":[198],"are":[200],"substrates":[203],"neuronal":[205],"reuptake":[206],"also":[208],"demonstrated.":[209],"All":[210],"these":[211],"data":[212],"support":[213],"postsynaptic":[215],"might":[222],"be":[223],"correlated":[224],"complication":[227],"chronic":[229],"use.":[231]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2017-12-22T00:00:00"}
