{"id":"https://openalex.org/W2773894666","doi":"https://doi.org/10.1007/978-1-4614-7322-0_22-1","title":"Side Effects of Systemic Therapy and Their Clinical Management","display_name":"Side Effects of Systemic Therapy and Their Clinical Management","publication_year":2017,"publication_date":"2017-10-12","ids":{"openalex":"https://openalex.org/W2773894666","doi":"https://doi.org/10.1007/978-1-4614-7322-0_22-1","mag":"2773894666"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4614-7322-0_22-1","doi":"https://doi.org/10.1007/978-1-4614-7322-0_22-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-7322-0_22-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Melanoma","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4255778772","display_name":"Melanoma"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042621368","display_name":"Suthee Rapisuwon","orcid":"https://orcid.org/0000-0002-1389-925X","observed_orcids":["https://orcid.org/0000-0002-1389-925X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suthee Rapisuwon","raw_affiliation_strings":["Department of Oncology, Georgetown University, Washington, USA","Georgetown-Lombardi Comprehensive Cancer Center, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University, Washington, USA","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Georgetown-Lombardi Comprehensive Cancer Center, Washington, USA","institution_ids":["https://openalex.org/I4390039356"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026672076","display_name":"Geoffrey Thomas Gibney","orcid":"https://orcid.org/0000-0002-5401-8498","observed_orcids":["https://orcid.org/0000-0002-5401-8498"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Geoffrey T. Gibney","raw_affiliation_strings":["Division of Hematology/Oncology, Medstar-Georgetown University Hospital, Washington, USA","Georgetown-Lombardi Comprehensive Cancer Center, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Medstar-Georgetown University Hospital, Washington, USA","institution_ids":["https://openalex.org/I2802534011"]},{"raw_affiliation_string":"Georgetown-Lombardi Comprehensive Cancer Center, Washington, USA","institution_ids":["https://openalex.org/I4390039356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026672076"],"corresponding_institution_ids":["https://openalex.org/I2802534011","https://openalex.org/I4390039356"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22169266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.4668000042438507,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-melanoma","display_name":"advanced melanoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8519999980926514},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":1.0},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.6940000057220459},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.5429999828338623},{"id":"https://openalex.org/keywords/toxicity-management","display_name":"toxicity management","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.8115335702896118},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.806144654750824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8015259504318237},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.7088783979415894},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.5420026183128357},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4929830729961395},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44247063994407654},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.42834970355033875},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4037218391895294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33277377486228943},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.30050480365753174},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23532918095588684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11162462830543518},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.09047150611877441},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4614-7322-0_22-1","doi":"https://doi.org/10.1007/978-1-4614-7322-0_22-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-7322-0_22-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Melanoma","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1568317937","https://openalex.org/W1612479149","https://openalex.org/W1769186443","https://openalex.org/W1833228626","https://openalex.org/W1842966157","https://openalex.org/W1923122596","https://openalex.org/W1950572133","https://openalex.org/W1965370740","https://openalex.org/W1969965329","https://openalex.org/W1971989824","https://openalex.org/W1974451438","https://openalex.org/W1991301773","https://openalex.org/W1992987036","https://openalex.org/W1997904458","https://openalex.org/W2001710734","https://openalex.org/W2002673340","https://openalex.org/W2015085911","https://openalex.org/W2018383416","https://openalex.org/W2030858378","https://openalex.org/W2031529458","https://openalex.org/W2046737793","https://openalex.org/W2050660950","https://openalex.org/W2051093099","https://openalex.org/W2056535502","https://openalex.org/W2070645893","https://openalex.org/W2070753851","https://openalex.org/W2073713419","https://openalex.org/W2082150850","https://openalex.org/W2093550507","https://openalex.org/W2095312392","https://openalex.org/W2096511276","https://openalex.org/W2097995306","https://openalex.org/W2098515117","https://openalex.org/W2098853737","https://openalex.org/W2100738068","https://openalex.org/W2102095362","https://openalex.org/W2105057287","https://openalex.org/W2107752337","https://openalex.org/W2108155957","https://openalex.org/W2109274792","https://openalex.org/W2109465910","https://openalex.org/W2109653150","https://openalex.org/W2116548718","https://openalex.org/W2119198740","https://openalex.org/W2121545342","https://openalex.org/W2128035403","https://openalex.org/W2128542677","https://openalex.org/W2128758225","https://openalex.org/W2136474966","https://openalex.org/W2137649087","https://openalex.org/W2152897456","https://openalex.org/W2160766792","https://openalex.org/W2162519330","https://openalex.org/W2165320653","https://openalex.org/W2166262263","https://openalex.org/W2166662937","https://openalex.org/W2274895737","https://openalex.org/W2288531107","https://openalex.org/W2291247846","https://openalex.org/W2301706587","https://openalex.org/W2313175236","https://openalex.org/W2320537501","https://openalex.org/W2338423971","https://openalex.org/W2338994579","https://openalex.org/W2339081870","https://openalex.org/W2341408002","https://openalex.org/W2344221521","https://openalex.org/W2463257517","https://openalex.org/W2474527756","https://openalex.org/W2475052247","https://openalex.org/W2478478625","https://openalex.org/W2518470597","https://openalex.org/W2591388111","https://openalex.org/W2600933018"],"related_works":["https://openalex.org/W4408015415","https://openalex.org/W2617848088","https://openalex.org/W4400613132","https://openalex.org/W4211142919","https://openalex.org/W7167715492","https://openalex.org/W2416504125","https://openalex.org/W2995040934","https://openalex.org/W2186710172","https://openalex.org/W3199488631","https://openalex.org/W1825818314"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-12-22T00:00:00"}