{"id":"https://openalex.org/W2773524083","doi":null,"title":"Pathogenesis of ovarian cancer: current perspectives","display_name":"Pathogenesis of ovarian cancer: current perspectives","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2773524083","mag":"2773524083"},"language":"en","primary_location":{"id":"mag:2773524083","doi":null,"is_oa":true,"landing_page_url":"https://africaneditors.org/journal/EAMJ/full-text-pdf/91458-58833","pdf_url":null,"source":{"id":"https://openalex.org/S4140075","display_name":"East African Medical Journal","issn_l":"0012-835X","issn":["0012-835X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"East African Medical Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://africaneditors.org/journal/EAMJ/full-text-pdf/91458-58833","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068758891","display_name":"Jacqueline Chesang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jacqueline Chesang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068758891"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"94","issue":"7","first_page":"561","last_page":"574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ovarian-surface-epithelium","display_name":"ovarian surface epithelium","score":0.871999979019165},{"id":"https://openalex.org/keywords/gonadotropin-stimulation","display_name":"gonadotropin stimulation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hormone-stimulation","display_name":"hormonal stimulation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ovarian-cancer-prevention","display_name":"ovarian cancer prevention","score":0.578000009059906},{"id":"https://openalex.org/keywords/ovarian-cancer-screening","display_name":"ovarian cancer screening","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.8097178936004639},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6984909176826477},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.5700781941413879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5316869020462036},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.49167901277542114},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.4712396562099457},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38931047916412354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.380873441696167},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3793357312679291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3384853005409241},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32687002420425415},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29684436321258545},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.27536696195602417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27512994408607483}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2773524083","doi":null,"is_oa":true,"landing_page_url":"https://africaneditors.org/journal/EAMJ/full-text-pdf/91458-58833","pdf_url":null,"source":{"id":"https://openalex.org/S4140075","display_name":"East African Medical Journal","issn_l":"0012-835X","issn":["0012-835X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"East African Medical Journal","raw_type":null}],"best_oa_location":{"id":"mag:2773524083","doi":null,"is_oa":true,"landing_page_url":"https://africaneditors.org/journal/EAMJ/full-text-pdf/91458-58833","pdf_url":null,"source":{"id":"https://openalex.org/S4140075","display_name":"East African Medical Journal","issn_l":"0012-835X","issn":["0012-835X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"East African Medical Journal","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W71961220","https://openalex.org/W1608888283","https://openalex.org/W1754419963","https://openalex.org/W1966199527","https://openalex.org/W1966932597","https://openalex.org/W1972383287","https://openalex.org/W1974756790","https://openalex.org/W1981229689","https://openalex.org/W1987220103","https://openalex.org/W1995165487","https://openalex.org/W1997273613","https://openalex.org/W2005071828","https://openalex.org/W2005598650","https://openalex.org/W2017482101","https://openalex.org/W2019279964","https://openalex.org/W2020374144","https://openalex.org/W2020658557","https://openalex.org/W2022183953","https://openalex.org/W2025344263","https://openalex.org/W2029678906","https://openalex.org/W2030214755","https://openalex.org/W2032236898","https://openalex.org/W2046218692","https://openalex.org/W2047701458","https://openalex.org/W2050505846","https://openalex.org/W2056068434","https://openalex.org/W2059143304","https://openalex.org/W2070369494","https://openalex.org/W2073965709","https://openalex.org/W2085881076","https://openalex.org/W2091128933","https://openalex.org/W2096501083","https://openalex.org/W2097938363","https://openalex.org/W2098050793","https://openalex.org/W2103660633","https://openalex.org/W2106787323","https://openalex.org/W2107100377","https://openalex.org/W2108394200","https://openalex.org/W2109853661","https://openalex.org/W2121172394","https://openalex.org/W2123489261","https://openalex.org/W2125222593","https://openalex.org/W2125681453","https://openalex.org/W2126945850","https://openalex.org/W2127706095","https://openalex.org/W2130344626","https://openalex.org/W2133955927","https://openalex.org/W2137849078","https://openalex.org/W2154850696","https://openalex.org/W2155222298","https://openalex.org/W2155921775","https://openalex.org/W2160830598","https://openalex.org/W2163503517","https://openalex.org/W2166973467"],"related_works":["https://openalex.org/W2967529884","https://openalex.org/W2164916859","https://openalex.org/W2398330439","https://openalex.org/W1973422778","https://openalex.org/W1974756790","https://openalex.org/W2070369494","https://openalex.org/W2556773157","https://openalex.org/W2121334345","https://openalex.org/W4253754900","https://openalex.org/W2130648158"],"abstract_inverted_index":{"Objective":[0],":":[1,54,70,185,220],"To":[2],"present":[3],"a":[4],"review":[5],"of":[6,9,12,46,73,78,86,92,141,154,176,188,196,199,210],"current":[7],"knowledge":[8],"the":[10,38,65,108,142,144,174],"pathogenesis":[11,45,187],"ovarian":[13,47,79,87,101,109,116,131,189,211,229],"cancer":[14,48,88,158,190],"and":[15,75,84,123,147,165,171,181,208],"its":[16],"clinical":[17],"implications.":[18],"Data":[20,52,68],"Source:":[21],"Extensive":[23],"literature":[24],"search":[25],"was":[26],"conducted":[27],"to":[28,44,105],"identify":[29],"relevant":[30],"studies.":[31,66],"Study":[33],"Selection:":[34],"Studies":[36],"in":[37,64],"English":[39],"language":[40],"about":[41],"or":[42,167],"related":[43],"were":[49,60],"selected.":[50],"Extraction":[53],"Applicable":[55],"findings":[56],"from":[57,107,135],"selected":[58],"studies":[59],"extracted":[61],"as":[62,162],"reported":[63],"Synthesis":[69],"Proposed":[71,112],"theories":[72],"pathogenesis,":[74,223],"source":[76],"population":[77],"tumour":[80,132,200],"cells":[81,133,201],"are":[82,96,103],"discussed,":[83],"classification":[85],"presented.":[89,98],"Clinical":[90],"implications":[91,204],"these":[93],"new":[94],"insights":[95],"also":[97],"Traditionally,":[99],"epithelial":[100],"tumours":[102],"thought":[104],"arise":[106,134],"surface":[110,230],"epithelium.":[111],"factors":[113],"that":[114,130],"drive":[115],"tumourigenesis":[117],"include":[118],"incessant-ovulation,":[119,228],"gonadotropin":[120],"stimulation,":[121],"inflammation,":[122],"hormonal":[124],"stimulation.":[125],"There":[126],"is":[127,159],"evidence":[128],"suggesting":[129],"extra-ovarian":[136,197],"sites":[137],"with":[138],"secondary":[139],"involvement":[140],"ovary;":[143],"most":[145],"prevalent":[146],"aggressive":[148],"histological":[149],"type":[150,163,168],"(serous":[151],"tumours)":[152],"being":[153],"tubal":[155],"origin.":[156],"Ovarian":[157,221],"now":[160],"classified":[161],"I":[164],"II":[166,170],"I,":[169],"III":[172],"on":[173],"basis":[175],"shared":[177],"mutations,":[178],"histogenetic":[179],"pathways,":[180],"behaviour.":[182],"Conclusion":[184],"The":[186],"has":[191],"not":[192],"been":[193],"established.":[194],"Adoption":[195],"origin":[198],"may":[202],"have":[203],"for":[205],"prevention,":[206],"screening,":[207],"treatment":[209],"cancer.":[212],"Key":[218],"Words":[219],"cancer,":[222],"Mullerian,":[224,226],"extra-":[225],"extra-ovarian,":[227],"epithelium,":[231],"hormonal.":[232]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-12-22T00:00:00"}