{"id":"https://openalex.org/W2773429520","doi":"https://doi.org/10.1039/c7sc04749e","title":"Designing interactions by control of protein\u2013ligand complex conformation: tuning arginine\u2013arene interaction geometry for enhanced electrostatic protein\u2013ligand interactions","display_name":"Designing interactions by control of protein\u2013ligand complex conformation: tuning arginine\u2013arene interaction geometry for enhanced electrostatic protein\u2013ligand interactions","publication_year":2017,"publication_date":"2017-12-04","ids":{"openalex":"https://openalex.org/W2773429520","doi":"https://doi.org/10.1039/c7sc04749e","mag":"2773429520","pmid":"https://pubmed.ncbi.nlm.nih.gov/29675148","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5883865"},"language":"en","primary_location":{"id":"doi:10.1039/c7sc04749e","doi":"https://doi.org/10.1039/c7sc04749e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c7sc04749e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2018/sc/c7sc04749e","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2018/sc/c7sc04749e","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005016040","display_name":"Ann\u2010Louise Noresson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A.-L. Noresson","raw_affiliation_strings":["Centre for Analysis and Synthesis","Department of Chemistry","Lund University","SE-221 00 Lund","Sweden","Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Analysis and Synthesis","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Sweden","institution_ids":[]},{"raw_affiliation_string":"Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012833249","display_name":"Oskar Aurelius","orcid":"https://orcid.org/0000-0002-9268-351X","observed_orcids":["https://orcid.org/0000-0002-9268-351X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"O. Aurelius","raw_affiliation_strings":["Center for Molecular Protein Science","Department of Chemistry","Lund University","SE-221 00 Lund","Section for Biochemistry and Structural Biology","Section for Biochemistry and Structural Biology, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Protein Science","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Section for Biochemistry and Structural Biology","institution_ids":[]},{"raw_affiliation_string":"Section for Biochemistry and Structural Biology, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037576236","display_name":"Christopher T. \u00d6berg","orcid":"https://orcid.org/0000-0002-8804-829X","observed_orcids":["https://orcid.org/0000-0002-8804-829X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"C. T. \u00d6berg","raw_affiliation_strings":["Centre for Analysis and Synthesis","Department of Chemistry","Lund University","SE-221 00 Lund","Sweden","Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Analysis and Synthesis","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Sweden","institution_ids":[]},{"raw_affiliation_string":"Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"O. Engstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"O. Engstr\u00f6m","raw_affiliation_strings":["Centre for Analysis and Synthesis","Department of Chemistry","Lund University","SE-221 00 Lund","Sweden","Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Analysis and Synthesis","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Sweden","institution_ids":[]},{"raw_affiliation_string":"Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087600237","display_name":"Anders Sundin","orcid":"https://orcid.org/0000-0001-6615-2419","observed_orcids":["https://orcid.org/0000-0001-6615-2419"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. P. Sundin","raw_affiliation_strings":["Centre for Analysis and Synthesis","Department of Chemistry","Lund University","SE-221 00 Lund","Sweden","Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Analysis and Synthesis","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Sweden","institution_ids":[]},{"raw_affiliation_string":"Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009481643","display_name":"M. H\u00e5kansson","orcid":"https://orcid.org/0000-0002-7264-6316","observed_orcids":["https://orcid.org/0000-0002-7264-6316"]},"institutions":[{"id":"https://openalex.org/I4210088933","display_name":"Medicon Village","ror":"https://ror.org/00a1grh69","country_code":"SE","type":"other","lineage":["https://openalex.org/I4210088933"]},{"id":"https://openalex.org/I4210092524","display_name":"SARomics Biostructures (Sweden)","ror":"https://ror.org/00md1r011","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210092524"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. H\u00e5kansson","raw_affiliation_strings":["SARomics Biostructures AB","SE-223 81 Lund","Sweden","SARomics Biostructures AB, Medicon Village, SE-223 81 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SARomics Biostructures AB","institution_ids":["https://openalex.org/I4210092524"]},{"raw_affiliation_string":"SE-223 81 Lund","institution_ids":[]},{"raw_affiliation_string":"Sweden","institution_ids":[]},{"raw_affiliation_string":"SARomics Biostructures AB, Medicon Village, SE-223 81 Lund, Sweden","institution_ids":["https://openalex.org/I4210088933","https://openalex.org/I4210092524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060930607","display_name":"Olof Stenstr\u00f6m","orcid":"https://orcid.org/0000-0002-0308-7311","observed_orcids":["https://orcid.org/0000-0002-0308-7311"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"O. Stenstr\u00f6m","raw_affiliation_strings":["Biophysical Chemistry","Center for Molecular Protein Science","Department of Chemistry","Lund University","SE-221 00 Lund","Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-0308-7311","affiliations":[{"raw_affiliation_string":"Biophysical Chemistry","institution_ids":[]},{"raw_affiliation_string":"Center for Molecular Protein Science","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063659458","display_name":"Mikael Akke","orcid":"https://orcid.org/0000-0002-2395-825X","observed_orcids":["https://orcid.org/0000-0002-2395-825X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. Akke","raw_affiliation_strings":["Biophysical Chemistry","Center for Molecular Protein Science","Department of Chemistry","Lund University","SE-221 00 Lund","Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysical Chemistry","institution_ids":[]},{"raw_affiliation_string":"Center for Molecular Protein Science","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023580049","display_name":"Derek T. Logan","orcid":"https://orcid.org/0000-0002-0098-8560","observed_orcids":["https://orcid.org/0000-0002-0098-8560"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210088933","display_name":"Medicon Village","ror":"https://ror.org/00a1grh69","country_code":"SE","type":"other","lineage":["https://openalex.org/I4210088933"]},{"id":"https://openalex.org/I4210092524","display_name":"SARomics Biostructures (Sweden)","ror":"https://ror.org/00md1r011","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210092524"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"D. T. Logan","raw_affiliation_strings":["Center for Molecular Protein Science","Department of Chemistry","Lund University","SE-221 00 Lund","Section for Biochemistry and Structural Biology","SARomics Biostructures AB, Medicon Village, SE-223 81 Lund, Sweden","Section for Biochemistry and Structural Biology, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-0098-8560","affiliations":[{"raw_affiliation_string":"Center for Molecular Protein Science","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Section for Biochemistry and Structural Biology","institution_ids":[]},{"raw_affiliation_string":"SARomics Biostructures AB, Medicon Village, SE-223 81 Lund, Sweden","institution_ids":["https://openalex.org/I4210088933","https://openalex.org/I4210092524"]},{"raw_affiliation_string":"Section for Biochemistry and Structural Biology, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083922144","display_name":"Hakon Leffler","orcid":"https://orcid.org/0000-0003-4482-8945","observed_orcids":["https://orcid.org/0000-0003-4482-8945"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"H. Leffler","raw_affiliation_strings":["Department of Laboratory Medicine","Lund","Lund University","Section MIG","Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4482-8945","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine","institution_ids":[]},{"raw_affiliation_string":"Lund","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Section MIG","institution_ids":[]},{"raw_affiliation_string":"Sweden","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061685613","display_name":"Ulf J. Nilsson","orcid":"https://orcid.org/0000-0001-5815-9522","observed_orcids":["https://orcid.org/0000-0001-5815-9522"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"U. J. Nilsson","raw_affiliation_strings":["Centre for Analysis and Synthesis","Department of Chemistry","Lund University","SE-221 00 Lund","Sweden","Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-5815-9522","affiliations":[{"raw_affiliation_string":"Centre for Analysis and Synthesis","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lund University","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"SE-221 00 Lund","institution_ids":[]},{"raw_affiliation_string":"Sweden","institution_ids":[]},{"raw_affiliation_string":"Centre for Analysis and Synthesis, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061685613"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":null,"apc_paid":null,"fwci":0.4868,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.57128132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"1014","last_page":"1021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.1581999957561493,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.147599995136261,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-ligand-interactions","display_name":"protein-ligand interactions","score":0.8040000200271606},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.6859999895095825},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.7839999794960022},{"id":"https://openalex.org/keywords/ligand-design","display_name":"ligand design","score":0.6570000052452087},{"id":"https://openalex.org/keywords/interaction-geometry","display_name":"interaction geometry","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.745518684387207},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6055166125297546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.599463164806366},{"id":"https://openalex.org/C117626034","wikidata":"https://www.wikidata.org/wiki/Q26336","display_name":"Electrostatics","level":2,"score":0.4947749972343445},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3992188572883606},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3483465611934662},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.21196970343589783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1615590751171112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1017182469367981},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08953478932380676},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1039/c7sc04749e","doi":"https://doi.org/10.1039/c7sc04749e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c7sc04749e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2018/sc/c7sc04749e","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4832816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5883865","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29675148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29675148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5883865","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5883865/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chem Sci","raw_type":"Text"},{"id":"pmh:oai:lup.lub.lu.se:057402fb-c650-47c3-806f-fee5d3d2ca13","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/057402fb-c650-47c3-806f-fee5d3d2ca13","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2041-6520","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3188302907","doi":null,"is_oa":true,"landing_page_url":"https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201802246346136426","pdf_url":null,"source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chemical Science (Web)","raw_type":null}],"best_oa_location":{"id":"doi:10.1039/c7sc04749e","doi":"https://doi.org/10.1039/c7sc04749e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c7sc04749e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2018/sc/c7sc04749e","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2427004467","display_name":null,"funder_award_id":"KAW 2013.0022","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G3573747795","display_name":null,"funder_award_id":"621-2009-5326","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7002432341","display_name":null,"funder_award_id":"2013.0022","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G742131306","display_name":"Integrating chemical approaches to treat pancreatic cancer: making new leads for a cure","funder_award_id":"256986","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8676456822","display_name":null,"funder_award_id":"621-2012-2978","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321806","display_name":"Lunds Universitet","ror":"https://ror.org/012a77v79"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322444","display_name":"Stiftelsen Olle Engkvist Byggm\u00e4stare","ror":"https://ror.org/05apbp152"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323415","display_name":"Kungliga Fysiografiska S\u00e4llskapet i Lund","ror":"https://ror.org/05rnj0j91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2773429520.pdf","grobid_xml":"https://content.openalex.org/works/W2773429520.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1269235038","https://openalex.org/W1721114131","https://openalex.org/W1966077354","https://openalex.org/W1967989660","https://openalex.org/W1980337077","https://openalex.org/W2004976660","https://openalex.org/W2005087735","https://openalex.org/W2013578231","https://openalex.org/W2013870127","https://openalex.org/W2018543114","https://openalex.org/W2027811332","https://openalex.org/W2052330241","https://openalex.org/W2058181174","https://openalex.org/W2059971190","https://openalex.org/W2083953784","https://openalex.org/W2085040223","https://openalex.org/W2090602226","https://openalex.org/W2096578270","https://openalex.org/W2098587560","https://openalex.org/W2106694412","https://openalex.org/W2108157089","https://openalex.org/W2126578659","https://openalex.org/W2128441998","https://openalex.org/W2133831816","https://openalex.org/W2135735638","https://openalex.org/W2158947267","https://openalex.org/W2159065552","https://openalex.org/W2307398552","https://openalex.org/W2337489981"],"related_works":["https://openalex.org/W2785884569","https://openalex.org/W2045671029","https://openalex.org/W3044461674","https://openalex.org/W3188302907","https://openalex.org/W2103956185","https://openalex.org/W2463096022","https://openalex.org/W1968664832","https://openalex.org/W1968415710","https://openalex.org/W3040574446","https://openalex.org/W2768036718"],"abstract_inverted_index":{"-sulfate":[0],"of":[1,7,18,31,55],"the":[2,29,52],"ligand.":[3],"By":[4],"contrast,":[5],"binding":[6],"ligands":[8],"with":[9],"non-fluorinated":[10],"substituents":[11],"did":[12],"not":[13],"trigger":[14],"a":[15,21],"conformational":[16],"change":[17],"R144.":[19],"Hence,":[20],"sulfate-arginine":[22],"electrostatic":[23],"interaction":[24,38],"can":[25],"be":[26,69],"tuned":[27],"by":[28],"choice":[30,54],"ligand":[32,49,73],"C3-benzamido":[33],"structures":[34],"to":[35],"favor":[36],"specific":[37],"modes":[39],"and":[40],"geometries.":[41],"These":[42],"results":[43],"have":[44],"important":[45],"general":[46],"implications":[47],"for":[48,61],"design,":[50],"as":[51],"proper":[53],"arginine-aromatic":[56],"interacting":[57],"partners":[58],"opens":[59],"up":[60],"ligand-controlled":[62],"protein":[63],"conformation":[64],"that":[65],"in":[66,72],"turn":[67],"may":[68],"systematically":[70],"exploited":[71],"design.":[74]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-12-22T00:00:00"}