{"id":"https://openalex.org/W2773380604","doi":"https://doi.org/10.1128/jvi.01883-17","title":"Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells","display_name":"Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells","publication_year":2017,"publication_date":"2017-12-13","ids":{"openalex":"https://openalex.org/W2773380604","doi":"https://doi.org/10.1128/jvi.01883-17","mag":"2773380604","pmid":"https://pubmed.ncbi.nlm.nih.gov/29237833","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5809738"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01883-17","doi":"https://doi.org/10.1128/jvi.01883-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01883-17","pdf_url":"https://jvi.asm.org/content/jvi/92/5/e01883-17.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jvi.asm.org/content/jvi/92/5/e01883-17.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058708609","display_name":"Yehuda Z. Cohen","orcid":"https://orcid.org/0000-0001-6987-1478","observed_orcids":["https://orcid.org/0000-0001-6987-1478","https://orcid.org/0000-0001-9279-0887"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yehuda Z. Cohen","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-6987-1478","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086462012","display_name":"Julio C. C. Lorenzi","orcid":"https://orcid.org/0000-0003-2492-3961","observed_orcids":["https://orcid.org/0000-0003-2492-3961"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio C. C. Lorenzi","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080175927","display_name":"Michael S. Seaman","orcid":"https://orcid.org/0000-0001-6444-3562","observed_orcids":["https://orcid.org/0000-0001-6444-3562"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Seaman","raw_affiliation_strings":["Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040045885","display_name":"Lilian Nogueira","orcid":"https://orcid.org/0000-0001-8168-2629","observed_orcids":["https://orcid.org/0000-0001-8168-2629"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lilian Nogueira","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076385528","display_name":"Till Schoofs","orcid":"https://orcid.org/0000-0002-3584-8736","observed_orcids":["https://orcid.org/0000-0002-3584-8736"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Till Schoofs","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012728238","display_name":"Lisa Krassnig","orcid":"https://orcid.org/0000-0002-8722-4618","observed_orcids":["https://orcid.org/0000-0002-8722-4618"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Krassnig","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035687358","display_name":"Allison L. Butler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Butler","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088304264","display_name":"Katrina G. Millard","orcid":"https://orcid.org/0000-0003-2247-3178","observed_orcids":["https://orcid.org/0000-0003-2247-3178"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina Millard","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031570865","display_name":"Tomas Fitzsimons","orcid":"https://orcid.org/0000-0002-2623-330X","observed_orcids":["https://orcid.org/0000-0002-2623-330X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomas Fitzsimons","raw_affiliation_strings":["Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042394698","display_name":"Xiaoju G. Daniell","orcid":"https://orcid.org/0000-0002-3706-9816","observed_orcids":["https://orcid.org/0000-0002-3706-9816"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoju Daniell","raw_affiliation_strings":["Duke University Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082201074","display_name":"Juan P. Dizon","orcid":"https://orcid.org/0000-0003-1956-1169","observed_orcids":["https://orcid.org/0000-0003-1956-1169"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan P. Dizon","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007760651","display_name":"Irina Shimeliovich","orcid":"https://orcid.org/0000-0002-7030-294X","observed_orcids":["https://orcid.org/0000-0002-7030-294X"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina Shimeliovich","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004036928","display_name":"David C. Montefiori","orcid":"https://orcid.org/0000-0003-0856-6319","observed_orcids":["https://orcid.org/0000-0003-0856-6319"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Montefiori","raw_affiliation_strings":["Duke University Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025789964","display_name":"Marina F. Caskey","orcid":"https://orcid.org/0000-0003-1727-8693","observed_orcids":["https://orcid.org/0000-0003-1727-8693"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Caskey","raw_affiliation_strings":["Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003699560","display_name":"Michel C. Nussenzweig","orcid":"https://orcid.org/0000-0003-0592-8564","observed_orcids":["https://orcid.org/0000-0003-0592-8564"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michel C. Nussenzweig","raw_affiliation_strings":["Howard Hughes Medical Institute, Chevy Chase, Maryland, USA","Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, Maryland, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003699560"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":3.2479,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.93164557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"92","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/broadly-neutralizing-antibodies","display_name":"broadly neutralizing antibodies","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neutralizing-activity","display_name":"neutralizing activity","score":0.5410000085830688},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/primary-hiv-1-isolates","display_name":"primary HIV-1 isolates","score":0.8740000128746033},{"id":"https://openalex.org/keywords/membrane-proximal-external-region","display_name":"membrane-proximal external region","score":0.9610000252723694},{"id":"https://openalex.org/keywords/antibody-epitopes","display_name":"antibody epitopes","score":0.5609999895095825},{"id":"https://openalex.org/keywords/neutralization-sensitivity","display_name":"neutralization sensitivity","score":0.621999979019165},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8000152111053467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.787493109703064},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.7809742093086243},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7786831855773926},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7510523796081543},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6382656097412109},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.596937358379364},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5726473927497864},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.53586345911026},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4254187345504761},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31403905153274536},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.29881858825683594},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2568243443965912},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06613847613334656}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009518","descriptor_name":"New York","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054299","descriptor_name":"env Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054299","descriptor_name":"env Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.01883-17","doi":"https://doi.org/10.1128/jvi.01883-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01883-17","pdf_url":"https://jvi.asm.org/content/jvi/92/5/e01883-17.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:29237833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29237833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5809738","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5809738/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/35014376","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:35014376","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.01883-17","doi":"https://doi.org/10.1128/jvi.01883-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01883-17","pdf_url":"https://jvi.asm.org/content/jvi/92/5/e01883-17.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1840298301","display_name":"Transforming Translational Science and Education to Benefit Human Health","funder_award_id":"UL1TR000043","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2705185627","display_name":"BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy","funder_award_id":"UM1AI126620","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G629634775","display_name":null,"funder_award_id":"OPP1124068","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G6919142390","display_name":"Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery","funder_award_id":"UM1AI100663","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7381980221","display_name":null,"funder_award_id":"OPP1092074","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G7807330887","display_name":"Duke University - to facilitate the discovery of a safe, effective and practical HIV-1 vaccine by using valid laboratory criteria and Good Clinical Laboratory Practi...","funder_award_id":"OPP1032144","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G8988186284","display_name":"3BNC117 mAb in HIV-infected subjects on combination ART","funder_award_id":"U01AI118536","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000867978","display_name":"Institutional Career Development Core","funder_award_id":"KL2TR001865","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000873372","display_name":"ERC Einstein-Rockefeller-CUNY Center for AIDS research","funder_award_id":"P30AI124414","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320314691","display_name":"Robertson Foundation","ror":"https://ror.org/04h2x1077"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2773380604.pdf","grobid_xml":"https://content.openalex.org/works/W2773380604.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1587830797","https://openalex.org/W1974431423","https://openalex.org/W1989174077","https://openalex.org/W1993052631","https://openalex.org/W2000475809","https://openalex.org/W2014071844","https://openalex.org/W2020100193","https://openalex.org/W2021085054","https://openalex.org/W2023989211","https://openalex.org/W2038110764","https://openalex.org/W2041584347","https://openalex.org/W2066082644","https://openalex.org/W2070086938","https://openalex.org/W2071164066","https://openalex.org/W2076198413","https://openalex.org/W2078437475","https://openalex.org/W2081313987","https://openalex.org/W2113236498","https://openalex.org/W2118274231","https://openalex.org/W2119779320","https://openalex.org/W2133367683","https://openalex.org/W2135151522","https://openalex.org/W2135847964","https://openalex.org/W2146704167","https://openalex.org/W2147947123","https://openalex.org/W2157210912","https://openalex.org/W2166378435","https://openalex.org/W2167867167","https://openalex.org/W2171478268","https://openalex.org/W2200798239","https://openalex.org/W2343862396","https://openalex.org/W2346116821","https://openalex.org/W2347047438","https://openalex.org/W2473595575","https://openalex.org/W2488909960","https://openalex.org/W2549615728","https://openalex.org/W2551273870","https://openalex.org/W2557191642","https://openalex.org/W2572760626","https://openalex.org/W2597074085","https://openalex.org/W2743105554","https://openalex.org/W4245781185","https://openalex.org/W4293279301"],"related_works":["https://openalex.org/W3113130098","https://openalex.org/W2009151161","https://openalex.org/W4392294189","https://openalex.org/W2023989211","https://openalex.org/W2801119994","https://openalex.org/W2158417216","https://openalex.org/W7207781614","https://openalex.org/W2520177145","https://openalex.org/W4281755578","https://openalex.org/W2743105554"],"abstract_inverted_index":{"ABSTRACT":[0],"Recently":[1],"discovered":[2],"broadly":[3],"neutralizing":[4,125,276],"antibodies":[5,37,134,304,340,352,370,391],"(bNAbs)":[6],"against":[7,14,109,116,278,337,353,361],"HIV-1":[8,16,29,46,75,271,279,312],"demonstrate":[9],"extensive":[10],"breadth":[11,32,106],"and":[12,18,26,33,84,107,163,172,263,297,379],"potency":[13,34,108],"diverse":[15],"strains":[17],"represent":[19],"a":[20,152,293,329],"promising":[21],"approach":[22],"for":[23],"the":[24,62,86,92,98,130,147,178,187,233,245,270,348,369,387,400,411],"treatment":[25],"prevention":[27],"of":[28,35,45,64,121,137,236,247,249,302,350,389,402],"infection.":[30],"The":[31,100,119,300],"these":[36,250,303,351,390],"have":[38],"primarily":[39],"been":[40,306],"evaluated":[41],"by":[42,193,310,324],"using":[43],"panels":[44,94,162],"Env-pseudotyped":[47,117,160,195,219,313,363],"viruses":[48,205,217,220,314,318,336],"produced":[49,112,206,221,320],"in":[50,68,113,124,156,181,207,222,251,256,308,321,342,377,404,410],"293T":[51,208,223,322,362],"cells":[52,82,209,224,323],"expressing":[53],"molecularly":[54,203],"cloned":[55,204],"Env":[56,326],"proteins.":[57],"Here":[58],"we":[59,175],"report":[60],"on":[61,129],"ability":[63],"five":[65,101,338],"bNAbs":[66,102,237],"currently":[67,341],"clinical":[69,110,234,343],"development":[70,235,388],"to":[71,88,96,140,186,190,213,230,243,255,268,284,397,408],"neutralize":[72],"circulating":[73,317,335],"primary":[74,165,170],"isolates":[76,111,171,355],"derived":[77,315],"from":[78,316],"peripheral":[79],"blood":[80],"mononuclear":[81],"(PBMCs)":[83],"compare":[85],"results":[87,401],"those":[89],"obtained":[90],"with":[91,274,328,372],"pseudovirus":[93],"used":[95],"characterize":[97],"bNAbs.":[99],"demonstrated":[103],"significantly":[104,357],"less":[105,358],"PBMCs":[114],"than":[115,215,359],"viruses.":[118,196,364],"magnitude":[120],"this":[122],"difference":[123],"activity":[126,157,277,301,349,378],"varied,":[127],"depending":[128],"antibody":[131,143,258],"epitope.":[132],"Glycan-targeting":[133],"showed":[135,151],"differences":[136],"only":[138],"3-":[139],"4-fold,":[141],"while":[142,201],"10E8,":[144],"which":[145],"targets":[146],"membrane-proximal":[148],"external":[149],"region,":[150],"nearly":[153],"100-fold":[154,384],"decrease":[155],"between":[158],"published":[159],"virus":[161],"PBMC-derived":[164,169,216],"isolates.":[166],"Utilizing":[167],"clonal":[168],"molecular":[173],"clones,":[174],"determined":[176],"that":[177,200,347,360],"observed":[179],"discrepancy":[180],"bNAb":[182],"performance":[183,409],"is":[184,356],"due":[185],"increased":[188],"sensitivity":[189,212,229],"neutralization":[191,214,253],"exhibited":[192],"293T-produced":[194],"We":[197,332,345],"also":[198],"found":[199,346],"full-length":[202],"exhibit":[210,226],"greater":[211,228],"do,":[218],"generally":[225],"even":[227],"neutralization.":[231],"As":[232,386],"progresses,":[238,392],"it":[239,393],"will":[240,394],"be":[241,395],"critical":[242,396],"determine":[244,398],"relevance":[246],"each":[248],"vitro":[252,309,405],"assays":[254],"vivo":[257],"performance.":[259],"IMPORTANCE":[260],"Novel":[261],"therapeutic":[262],"preventive":[264],"strategies":[265],"are":[266],"needed":[267],"contain":[269],"epidemic.":[272],"Antibodies":[273],"exceptional":[275],"may":[280],"provide":[281],"several":[282],"advantages":[283],"traditional":[285],"HIV":[286],"drugs,":[287],"including":[288],"an":[289,382],"improved":[290],"side-effect":[291],"profile,":[292],"reduced":[294],"dosing":[295],"frequency,":[296],"immune":[298],"enhancement.":[299],"has":[305],"established":[307],"utilizing":[311],"but":[319],"pairing":[325],"proteins":[327],"backbone":[330],"vector.":[331],"tested":[333],"PBMC-produced":[334],"anti-HIV-1":[339],"development.":[344],"PBMC":[354],"This":[365],"decline":[366],"varied":[367],"among":[368],"tested,":[371],"some":[373],"demonstrating":[374],"moderate":[375],"reductions":[376],"others":[380],"showing":[381],"almost":[383],"reduction.":[385],"how":[399],"different":[403],"tests":[406],"correspond":[407],"clinic.":[412]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-12-22T00:00:00"}
