{"id":"https://openalex.org/W2773300655","doi":"https://doi.org/10.1371/journal.pone.0189494","title":"Biological characterization of a novel in vitro cell irradiator","display_name":"Biological characterization of a novel in vitro cell irradiator","publication_year":2017,"publication_date":"2017-12-12","ids":{"openalex":"https://openalex.org/W2773300655","doi":"https://doi.org/10.1371/journal.pone.0189494","mag":"2773300655","pmid":"https://pubmed.ncbi.nlm.nih.gov/29232400","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5726654"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0189494","doi":"https://doi.org/10.1371/journal.pone.0189494","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0189494","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0189494&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0189494&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041416079","display_name":"Tyler L. Fowler","orcid":"https://orcid.org/0000-0002-1623-638X","observed_orcids":["https://orcid.org/0000-0002-1623-638X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler L. Fowler","raw_affiliation_strings":["Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103898051","display_name":"Michael M. Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Fisher","raw_affiliation_strings":["Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alison M. Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison M. Bailey","raw_affiliation_strings":["Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079824614","display_name":"Bryan P. Bednarz","orcid":"https://orcid.org/0000-0002-7467-9816","observed_orcids":["https://orcid.org/0000-0002-7467-9816"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan P. Bednarz","raw_affiliation_strings":["Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073175528","display_name":"Randall J. Kimple","orcid":"https://orcid.org/0000-0001-8336-8000","observed_orcids":["https://orcid.org/0000-0001-8336-8000"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall J. Kimple","raw_affiliation_strings":["Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8336-8000","affiliations":[{"raw_affiliation_string":"Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073175528"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.8388,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72679557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"12","issue":"12","first_page":"e0189494","last_page":"e0189494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.22859999537467957,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-characterization","display_name":"biological characterization","score":0.4490000009536743},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7049999833106995},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6179999709129333},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.8640000224113464},{"id":"https://openalex.org/keywords/absorbed-dose","display_name":"absorbed dose","score":0.4690000116825104},{"id":"https://openalex.org/keywords/137cs-source","display_name":"137Cs source","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6613675355911255},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.6604333519935608},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.5062848329544067},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4963741898536682},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4632716178894043},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4575861692428589},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.448916494846344},{"id":"https://openalex.org/C105636585","wikidata":"https://www.wikidata.org/wiki/Q303665","display_name":"Dosimeter","level":3,"score":0.4332621991634369},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4211093485355377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34964072704315186},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.34184467792510986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3224855661392212},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32059213519096375},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.3081929087638855},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2248581349849701},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18833619356155396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16389241814613342},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12737667560577393},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002588","descriptor_name":"Cesium Radioisotopes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0189494","doi":"https://doi.org/10.1371/journal.pone.0189494","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0189494","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0189494&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5726654","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5726654","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:29232400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29232400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pone00:0189494","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189494","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4743b5a833e248dcb677c6ebb436ef0c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4743b5a833e248dcb677c6ebb436ef0c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 12, Iss 12, p e0189494 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5694310","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Biological_characterization_of_a_novel_in_vitro_cell_irradiator/5694310","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0189494","doi":"https://doi.org/10.1371/journal.pone.0189494","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0189494","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0189494&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1332332826","display_name":null,"funder_award_id":"CA 014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1423601303","display_name":null,"funder_award_id":"CA160639","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1986077458","display_name":"Head and Neck squamous cell carcinoma radiation response modulation by HPV","funder_award_id":"R00CA160639","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5699023890","display_name":null,"funder_award_id":"NIH/NCI P30 CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6403035411","display_name":null,"funder_award_id":"NCI P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7712482860","display_name":"Head and Neck squamous cell carcinoma radiation response modulation by HPV","funder_award_id":"K99CA160639","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000179532","display_name":null,"funder_award_id":"NCI P30 CA014520","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000302559","display_name":null,"funder_award_id":"NIH/NCI P30 CA014520-UW Comprehensive Cancer Center","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000352744","display_name":null,"funder_award_id":"CA014520","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000870050","display_name":"UW Comprehensive Cancer Center Support","funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2773300655.pdf","grobid_xml":"https://content.openalex.org/works/W2773300655.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W110155556","https://openalex.org/W200408074","https://openalex.org/W1855629639","https://openalex.org/W1975762710","https://openalex.org/W1981989316","https://openalex.org/W2006117464","https://openalex.org/W2063139951","https://openalex.org/W2070201618","https://openalex.org/W2093618731","https://openalex.org/W2114119309","https://openalex.org/W2165144107","https://openalex.org/W2170008898","https://openalex.org/W2199347336","https://openalex.org/W2567598337","https://openalex.org/W2621592249","https://openalex.org/W3126096896","https://openalex.org/W4243574300","https://openalex.org/W6684715665","https://openalex.org/W7005515419"],"related_works":["https://openalex.org/W2064468718","https://openalex.org/W2562603154","https://openalex.org/W2591659466","https://openalex.org/W4409627100","https://openalex.org/W2938519420","https://openalex.org/W355677085","https://openalex.org/W2277155337","https://openalex.org/W2896097853","https://openalex.org/W2809413045","https://openalex.org/W2313504006"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,20,54,62,66,91,106,164,178,182,185],"overall":[3],"robustness":[4],"of":[5,14,22,45,56,68,93,105,135,172,181],"a":[6,12,27,34,40,119,129,159],"novel":[7,30,136,160],"cellular":[8,107],"irradiator":[9,161],"we":[10],"performed":[11],"series":[13],"well-characterized,":[15],"dose-responsive":[16],"assays":[17],"to":[18,38,116,156],"assess":[19],"consequences":[21],"DNA":[23,57,69,99],"damage.":[24],"We":[25],"used":[26],"previously":[28],"described":[29,127],"irradiation":[31,117,186],"system":[32],"and":[33,65,85,103,152],"traditional":[35,120],"137Cs":[36,121],"source":[37],"irradiate":[39],"cell":[41],"line.":[42],"The":[43,112,123],"generation":[44],"reactive":[46,95],"oxygen":[47,96],"species":[48],"was":[49,59,72,88],"assessed":[50,73],"using":[51,61],"chloromethyl-H2DCFDA":[52],"dye,":[53],"induction":[55],"DSBs":[58],"observed":[60],"comet":[63],"assay,":[64],"initiation":[67],"break":[70,110],"repair":[71],"through":[74],"\u03b3H2AX":[75],"image":[76],"cytometry.":[77],"A":[78],"high":[79],"correlation":[80],"between":[81],"physical":[82,98,179],"absorbed":[83],"dose":[84,87,166],"biologic":[86,133,190],"seen":[89],"for":[90,132],"production":[92],"intracellular":[94],"species,":[97],"double":[100,108],"strand":[101],"breaks,":[102],"modulation":[104],"stand":[109],"pathway.":[111],"results":[113,188],"compared":[114],"favorably":[115],"with":[118,195],"source.":[122],"rapid,":[124],"straightforward":[125],"tests":[126],"form":[128],"reasonable":[130],"approach":[131],"characterization":[134],"irradiators.":[137],"These":[138],"additional":[139],"testing":[140,146],"metrics":[141,175],"go":[142],"beyond":[143],"standard":[144],"physics":[145],"such":[147],"as":[148],"Monte":[149],"Carlo":[150],"simulation":[151],"thermo-luminescent":[153],"dosimeter":[154],"evaluation":[155],"confirm":[157],"that":[158,177,192],"can":[162],"produce":[163],"desired":[165],"effects":[167,191],"in":[168,189],"vitro.":[169],"Further,":[170],"assessment":[171],"these":[173],"biological":[174],"confirms":[176],"handling":[180],"cells":[183],"during":[184],"process":[187],"scale":[193],"appropriately":[194],"dose.":[196]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-22T00:00:00"}