{"id":"https://openalex.org/W2773229331","doi":"https://doi.org/10.1111/cts.12525","title":"Pharmacogenetic Analysis of the Model\u2010Based Pharmacokinetics of Five Anti\u2010HIV Drugs: How Does This Influence the Effect of Aging?","display_name":"Pharmacogenetic Analysis of the Model\u2010Based Pharmacokinetics of Five Anti\u2010HIV Drugs: How Does This Influence the Effect of Aging?","publication_year":2017,"publication_date":"2017-12-03","ids":{"openalex":"https://openalex.org/W2773229331","doi":"https://doi.org/10.1111/cts.12525","mag":"2773229331","pmid":"https://pubmed.ncbi.nlm.nih.gov/29205871","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5866997"},"language":"en","primary_location":{"id":"doi:10.1111/cts.12525","doi":"https://doi.org/10.1111/cts.12525","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.12525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cts.12525","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cts.12525","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087089583","display_name":"Jingxian Chen","orcid":"https://orcid.org/0000-0002-3493-5491","observed_orcids":["https://orcid.org/0000-0002-3493-5491"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingxian Chen","raw_affiliation_strings":["University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057937361","display_name":"Farida S. Akhtari","orcid":"https://orcid.org/0000-0002-1089-4488","observed_orcids":["https://orcid.org/0000-0002-1089-4488"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farida S. Akhtari","raw_affiliation_strings":["Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA","Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101503471","display_name":"Michael J. Wagner","orcid":"https://orcid.org/0000-0001-8664-4998","observed_orcids":["https://orcid.org/0000-0001-8664-4998"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Wagner","raw_affiliation_strings":["University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040069705","display_name":"Oscar Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar Suzuki","raw_affiliation_strings":["University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042956546","display_name":"Tim Wiltshire","orcid":"https://orcid.org/0000-0001-5960-4034","observed_orcids":["https://orcid.org/0000-0001-5960-4034"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim Wiltshire","raw_affiliation_strings":["University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055785853","display_name":"Alison A. Motsinger\u2010Reif","orcid":"https://orcid.org/0000-0003-1346-2493","observed_orcids":["https://orcid.org/0000-0003-1346-2493"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison A. Motsinger\u2010Reif","raw_affiliation_strings":["Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA","Department of Statistics, North Carolina State University, Raleigh, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Statistics, North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021388560","display_name":"Julie B. Dumond","orcid":"https://orcid.org/0000-0002-3500-5819","observed_orcids":["https://orcid.org/0000-0002-3500-5819"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julie B. Dumond","raw_affiliation_strings":["University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021388560"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":0.5813,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70564257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"2","first_page":"226","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.1662999987602234,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.9279999732971191},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.699999988079071},{"id":"https://openalex.org/keywords/antiretroviral-drugs","display_name":"antiretroviral drugs","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7860000133514404},{"id":"https://openalex.org/keywords/atazanavir-ritonavir","display_name":"atazanavir/ritonavir","score":0.9490000009536743},{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.9990000128746033},{"id":"https://openalex.org/keywords/emtricitabine-tenofovir","display_name":"tenofovir/emtricitabine","score":0.9330000281333923},{"id":"https://openalex.org/keywords/multidrug-resistance-protein-4","display_name":"multidrug resistance protein 4","score":0.7960000038146973},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.968999981880188},{"id":"https://openalex.org/keywords/cyp2b6","display_name":"CYP2B6","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.8650000095367432},{"id":"https://openalex.org/keywords/organic-cation-transporters","display_name":"organic cation transporters","score":0.859000027179718},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.8610000014305115},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.5149999856948853},{"id":"https://openalex.org/keywords/precision-dosing","display_name":"precision dosing","score":0.7059999704360962},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.7304457426071167},{"id":"https://openalex.org/C2781432083","wikidata":"https://www.wikidata.org/wiki/Q422645","display_name":"Efavirenz","level":5,"score":0.7169530391693115},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6471693515777588},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6405899524688721},{"id":"https://openalex.org/C2779778239","wikidata":"https://www.wikidata.org/wiki/Q422604","display_name":"Emtricitabine","level":5,"score":0.6037507057189941},{"id":"https://openalex.org/C2778414717","wikidata":"https://www.wikidata.org/wiki/Q423467","display_name":"Atazanavir","level":5,"score":0.6032102704048157},{"id":"https://openalex.org/C36201501","wikidata":"https://www.wikidata.org/wiki/Q17907816","display_name":"Multidrug resistance-associated protein 2","level":5,"score":0.5934654474258423},{"id":"https://openalex.org/C2776598434","wikidata":"https://www.wikidata.org/wiki/Q18035517","display_name":"SLCO1B1","level":5,"score":0.5700242519378662},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.5505988597869873},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.45549213886260986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4288226366043091},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.4147217869758606},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4020302891731262},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.3578762412071228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2853422164916992},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.23337826132774353},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.20153716206550598},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18175867199897766},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.15954884886741638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.130168616771698},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.11521172523498535},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065702","descriptor_name":"Cytochrome P-450 CYP2B6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/cts.12525","doi":"https://doi.org/10.1111/cts.12525","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.12525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cts.12525","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5866997","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5866997","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Sci","raw_type":"Text"},{"id":"pmid:29205871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29205871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational science","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1111/cts.12525","doi":"https://doi.org/10.1111/cts.12525","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.12525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cts.12525","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2759846388","display_name":null,"funder_award_id":"UL1RR02574","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G34429661","display_name":"Optimizing Antiretroviral Use in Aging: Pharmacokinetics, Response, and Toxicity","funder_award_id":"K23AI093156","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3969538665","display_name":"North Carolina Translational & Clinical Sciences Institute (NC TraCS)","funder_award_id":"UL1TR001111","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6816900987","display_name":null,"funder_award_id":"UL1RR02574","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000894295","display_name":"The University of North Carolina Center for AIDS Research","funder_award_id":"P30AI050410","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2773229331.pdf","grobid_xml":"https://content.openalex.org/works/W2773229331.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1812712408","https://openalex.org/W1968328048","https://openalex.org/W1986762731","https://openalex.org/W1992436001","https://openalex.org/W2003529614","https://openalex.org/W2010002499","https://openalex.org/W2010124885","https://openalex.org/W2023418826","https://openalex.org/W2026884584","https://openalex.org/W2027360047","https://openalex.org/W2029773175","https://openalex.org/W2046234948","https://openalex.org/W2050781209","https://openalex.org/W2089348163","https://openalex.org/W2091984641","https://openalex.org/W2091985583","https://openalex.org/W2102046578","https://openalex.org/W2102150960","https://openalex.org/W2102758806","https://openalex.org/W2103115327","https://openalex.org/W2120187456","https://openalex.org/W2123411711","https://openalex.org/W2125487751","https://openalex.org/W2128228188","https://openalex.org/W2140132485","https://openalex.org/W2145580268","https://openalex.org/W2145936062","https://openalex.org/W2146916411","https://openalex.org/W2161633633","https://openalex.org/W2162612111","https://openalex.org/W2164059021","https://openalex.org/W2253998502","https://openalex.org/W2256104905","https://openalex.org/W2412343056","https://openalex.org/W2418793062","https://openalex.org/W2518959531","https://openalex.org/W2564410170","https://openalex.org/W2582743722","https://openalex.org/W2603350119"],"related_works":["https://openalex.org/W2564410170","https://openalex.org/W7208740412","https://openalex.org/W2603350119","https://openalex.org/W3030888331","https://openalex.org/W4404349681","https://openalex.org/W1602572527","https://openalex.org/W2116321559","https://openalex.org/W2045950929","https://openalex.org/W3093952412","https://openalex.org/W2027360047"],"abstract_inverted_index":{"Abstract":[0],"Analysis":[1],"of":[2,47,88],"aging":[3,119,150],"and":[4,34,39,53,73,79,85,95,100,110,123,133,141],"pharmacogenetics":[5],"(PGx)":[6],"on":[7,139,149,153],"antiretroviral":[8],"pharmacokinetics":[9],"(PKs)":[10],"could":[11],"inform":[12],"precision":[13],"dosing":[14],"for":[15],"older":[16],"human":[17],"HIV\u2010infected":[18],"patients.":[19],"Seventy\u2010four":[20],"participants":[21],"receiving":[22],"either":[23],"atazanavir/ritonavir":[24],"(ATV/RTV)":[25],"or":[26],"efavirenz":[27],"(EFV)":[28],"with":[29,64,70,75,92,105,137],"tenofovir/emtricitabine":[30],"(TFV/FTC)":[31],"provided":[32],"PK":[33,125],"PGx":[35,138],"information.":[36],"Aging\u2010PGx\u2010PK":[37],"association":[38],"interaction":[40],"analyses":[41,59],"were":[42,90,103,129],"conducted":[43],"using":[44],"one\u2010way":[45],"analysis":[46],"variance":[48],"(ANOVA),":[49],"multiple":[50],"linear":[51],"regression,":[52],"Random":[54],"Forest":[55],"ensemble":[56],"methods.":[57],"Our":[58],"associated":[60,91,104],"unbound":[61],"ATV":[62,140],"disposition":[63],"multidrug":[65],"resistance":[66],"protein":[67],"(MRP)4,":[68],"RTV":[69],"P\u2010glycoprotein":[71],"(P\u2010gp),":[72],"EFV":[74,122],"cytochrome":[76],"P450":[77],"(CYP)2B6":[78],"MRP4":[80],"genetic":[81,112,127,154],"variants.":[82,113],"The":[83],"clearance":[84],"cellular":[86,118],"distribution":[87],"TFV":[89,142],"P\u2010gp,":[93],"MRP2,":[94],"concentrative":[96],"nucleoside":[97],"transporters":[98,108],"(CNTs),":[99],"FTC":[101,124],"parameters":[102],"organic":[106],"cation":[107],"(OCTs)":[109],"MRP2":[111],"Notably,":[114],"p16INK4a":[115,134],"expression,":[116],"a":[117],"marker,":[120],"predicted":[121],"when":[126],"factors":[128],"adjusted.":[130],"Both":[131],"age":[132],"expression":[135],"interacted":[136],"disposition,":[143],"implying":[144],"potential":[145],"dose":[146],"adjustment":[147],"based":[148],"may":[151],"depend":[152],"background.":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-22T00:00:00"}
