{"id":"https://openalex.org/W2773077993","doi":"https://doi.org/10.1212/nxi.0000000000000417","title":"Anti-LINGO-1 has no detectable immunomodulatory effects in preclinical and phase 1 studies","display_name":"Anti-LINGO-1 has no detectable immunomodulatory effects in preclinical and phase 1 studies","publication_year":2017,"publication_date":"2017-12-16","ids":{"openalex":"https://openalex.org/W2773077993","doi":"https://doi.org/10.1212/nxi.0000000000000417","mag":"2773077993","pmid":"https://pubmed.ncbi.nlm.nih.gov/29259995","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5732005"},"language":"en","primary_location":{"id":"doi:10.1212/nxi.0000000000000417","doi":"https://doi.org/10.1212/nxi.0000000000000417","is_oa":true,"landing_page_url":"https://doi.org/10.1212/nxi.0000000000000417","pdf_url":"https://www.neurology.org/doi/pdfdirect/10.1212/nxi.0000000000000417","source":{"id":"https://openalex.org/S2764892302","display_name":"Neurology Neuroimmunology & Neuroinflammation","issn_l":"2332-7812","issn":["2332-7812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology Neuroimmunology & Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.neurology.org/doi/pdfdirect/10.1212/nxi.0000000000000417","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027421276","display_name":"Ann M. 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Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","institution_ids":[]},{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","institution_ids":["https://openalex.org/I1297540436"]},{"raw_affiliation_string":"MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial","institution_ids":["https://openalex.org/I4210109909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014834868","display_name":"Soma S. 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Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","institution_ids":[]},{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","institution_ids":["https://openalex.org/I1297540436"]},{"raw_affiliation_string":"MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial","institution_ids":["https://openalex.org/I4210109909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010626323","display_name":"Suzanne T. 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Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. 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Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","institution_ids":[]},{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","institution_ids":["https://openalex.org/I1297540436"]},{"raw_affiliation_string":"MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial","institution_ids":["https://openalex.org/I4210109909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006344036","display_name":"Norm Allaire","orcid":"https://orcid.org/0000-0002-3497-8459","observed_orcids":["https://orcid.org/0000-0002-3497-8459"]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]},{"id":"https://openalex.org/I4210109909","display_name":"IMMUNOe Research Center","ror":"https://ror.org/01xepk867","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210109909"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norm Allaire","raw_affiliation_strings":["From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. 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Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","institution_ids":[]},{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","institution_ids":["https://openalex.org/I1297540436"]},{"raw_affiliation_string":"MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial","institution_ids":["https://openalex.org/I4210109909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103223187","display_name":"Rebecca Gardner","orcid":"https://orcid.org/0000-0003-1532-3200","observed_orcids":["https://orcid.org/0000-0003-1532-3200","https://orcid.org/0000-0001-6393-3834"]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]},{"id":"https://openalex.org/I4210109909","display_name":"IMMUNOe Research Center","ror":"https://ror.org/01xepk867","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210109909"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Gardner","raw_affiliation_strings":["From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","institution_ids":[]},{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","institution_ids":["https://openalex.org/I1297540436"]},{"raw_affiliation_string":"MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial","institution_ids":["https://openalex.org/I4210109909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088163706","display_name":"Diego Cadavid","orcid":"https://orcid.org/0000-0002-5361-3834","observed_orcids":["https://orcid.org/0000-0002-5361-3834"]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]},{"id":"https://openalex.org/I4210109909","display_name":"IMMUNOe Research Center","ror":"https://ror.org/01xepk867","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210109909"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego Cadavid","raw_affiliation_strings":["From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. 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Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company","From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA","MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Biogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. 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