{"id":"https://openalex.org/W2772575461","doi":"https://doi.org/10.4049/jimmunol.1700713","title":"Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines","display_name":"Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2772575461","doi":"https://doi.org/10.4049/jimmunol.1700713","mag":"2772575461","pmid":"https://pubmed.ncbi.nlm.nih.gov/29196459","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760314"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1700713","doi":"https://doi.org/10.4049/jimmunol.1700713","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1700713","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038754317","display_name":"Marwa M. Qadri","orcid":"https://orcid.org/0000-0002-6548-411X","observed_orcids":["https://orcid.org/0000-0002-6548-411X"]},"institutions":[{"id":"https://openalex.org/I185071736","display_name":"Chapman University","ror":"https://ror.org/0452jzg20","country_code":"US","type":"education","lineage":["https://openalex.org/I185071736"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marwa Qadri","raw_affiliation_strings":["Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University , Irvine, CA 92618"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University , Irvine, CA 92618","institution_ids":["https://openalex.org/I185071736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092626087","display_name":"Sara A. Almadani","orcid":"https://orcid.org/0000-0003-1791-6480","observed_orcids":["https://orcid.org/0000-0003-1791-6480"]},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Almadani","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences , Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences , Boston, MA 02115","institution_ids":["https://openalex.org/I165817395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078086926","display_name":"Gregory D. Jay","orcid":"https://orcid.org/0000-0003-1517-8488","observed_orcids":["https://orcid.org/0000-0003-1517-8488"]},"institutions":[{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D Jay","raw_affiliation_strings":["Department of Emergency Medicine, Rhode Island Hospital , Providence, RI 02903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Rhode Island Hospital , Providence, RI 02903","institution_ids":["https://openalex.org/I2800446032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086816730","display_name":"Khaled A. Elsaid","orcid":"https://orcid.org/0000-0002-8925-4255","observed_orcids":["https://orcid.org/0000-0002-8925-4255"]},"institutions":[{"id":"https://openalex.org/I185071736","display_name":"Chapman University","ror":"https://ror.org/0452jzg20","country_code":"US","type":"education","lineage":["https://openalex.org/I185071736"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khaled A Elsaid","raw_affiliation_strings":["Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University , Irvine, CA 92618"],"raw_orcid":"https://orcid.org/0000-0002-8925-4255","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University , Irvine, CA 92618","institution_ids":["https://openalex.org/I185071736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038754317"],"corresponding_institution_ids":["https://openalex.org/I185071736"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.3554,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.92851048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"200","issue":"2","first_page":"758","last_page":"767"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.04259999841451645,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":1.0},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9390000104904175},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8960000276565552},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.8880000114440918},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9520000219345093},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7409999966621399},{"id":"https://openalex.org/keywords/anti-cd44-antibody","display_name":"anti-CD44 antibody","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.8495694398880005},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8148882389068604},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5808160305023193},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.509369969367981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5033394694328308},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4676947593688965},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.4601393938064575},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.42762988805770874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3992733061313629},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36665108799934387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3529835343360901},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34890657663345337},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25210148096084595},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24899742007255554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16047212481498718},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.1700713","doi":"https://doi.org/10.4049/jimmunol.1700713","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1700713","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:29196459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29196459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5304424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760314","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5760314","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760314","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5304424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760314","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G700247910","display_name":"Non-tribologic Bioactivity of Lubricin","funder_award_id":"R01AR067748","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1596483316","https://openalex.org/W1597606892","https://openalex.org/W1670148594","https://openalex.org/W1679604700","https://openalex.org/W1804408139","https://openalex.org/W1964184380","https://openalex.org/W1964189028","https://openalex.org/W1965398132","https://openalex.org/W1965665343","https://openalex.org/W1968652079","https://openalex.org/W1969307566","https://openalex.org/W1975566660","https://openalex.org/W1981937063","https://openalex.org/W1994496279","https://openalex.org/W2004213014","https://openalex.org/W2006315282","https://openalex.org/W2010993726","https://openalex.org/W2013352191","https://openalex.org/W2014415867","https://openalex.org/W2026172623","https://openalex.org/W2034201007","https://openalex.org/W2035242925","https://openalex.org/W2037632318","https://openalex.org/W2070609275","https://openalex.org/W2082954333","https://openalex.org/W2085788584","https://openalex.org/W2086276639","https://openalex.org/W2089293788","https://openalex.org/W2097250275","https://openalex.org/W2101516467","https://openalex.org/W2102181510","https://openalex.org/W2103907900","https://openalex.org/W2107277218","https://openalex.org/W2109228592","https://openalex.org/W2116748379","https://openalex.org/W2119974097","https://openalex.org/W2128616956","https://openalex.org/W2128995450","https://openalex.org/W2131626977","https://openalex.org/W2134945818","https://openalex.org/W2136722399","https://openalex.org/W2137143284","https://openalex.org/W2144995521","https://openalex.org/W2153192975","https://openalex.org/W2167969842","https://openalex.org/W2176725352","https://openalex.org/W2190830971","https://openalex.org/W2288267488","https://openalex.org/W2316985689","https://openalex.org/W2507683743","https://openalex.org/W2549418369","https://openalex.org/W2574647359","https://openalex.org/W2584503597","https://openalex.org/W2613643891","https://openalex.org/W6649844300"],"related_works":["https://openalex.org/W1974276156","https://openalex.org/W25354680","https://openalex.org/W2766287142","https://openalex.org/W4399437372","https://openalex.org/W2996947141","https://openalex.org/W3131543391","https://openalex.org/W4392827801","https://openalex.org/W2154519842","https://openalex.org/W3166391203","https://openalex.org/W3126635837"],"abstract_inverted_index":{"Abstract":[0],"Osteoarthritis":[1],"(OA)":[2],"is":[3,241],"a":[4,30,56,205,219,242],"low-grade":[5],"chronic":[6],"inflammatory":[7],"joint":[8],"disease.":[9],"Innate":[10],"immunity":[11],"contributes":[12],"to":[13],"OA":[14,168,192,237,247],"progression,":[15],"mediated":[16,102,108],"by":[17,99,103,114,160,191,214,236],"TLR2":[18,42,130,149,173,199],"and":[19,38,67,71,78,85,88,122,125,174,177,225,239],"TLR4.":[20],"We":[21],"evaluated":[22],"the":[23,51,109],"role":[24],"of":[25,55,94,212],"cluster":[26],"determinant":[27],"44":[28],"(CD44),":[29],"transmembrane":[31],"glycoprotein,":[32],"in":[33,50,97,111,181,201,207,246],"regulating":[34],"TLR2-linked":[35],"macrophage":[36,189,234],"activation":[37,190,235],"resultant":[39],"proinflammatory":[40,95,227],"responses.":[41],"stimulation":[43,132,150],"was":[44,101],"performed":[45],"on":[46],"differentiated":[47],"THP-1":[48,182],"macrophages":[49,98,140,147,164],"presence":[52],"or":[53,59,210,218],"absence":[54],"CD44-specific":[57,220,231],"Ab":[58,77,185,221,232],"hyaluronan":[60],"(HA).":[61],"NF-\u03baB":[62,82,112,119,179,223],"nuclear":[63,120],"translocation,":[64,83],"IL-1":[65],"\u03b2":[66],"TNF-\u03b1":[68,86,126,143,158],"gene":[69],"expression,":[70,87],"protein":[72,127],"concentrations":[73],"were":[74],"determined.":[75],"Anti-CD44":[76,184],"HA":[79,100,154],"treatments":[80],"reduced":[81,118,188,222,233],"IL-1\u03b2":[84,124],"production":[89,128,159],"(p":[90,133,151,165,194],"<":[91,134,152,166,195],"0.001).":[92,135,167],"Inhibition":[93],"response":[96],"CD44.":[104],"Protein":[105],"phosphatase":[106],"2A":[107],"reduction":[110,206],"translocation":[113,121,180,224],"HA.":[115],"CD44":[116,197,208,213,240],"knockdown":[117],"downstream":[123,226],"following":[129,148],"receptor":[131],"CD44+/+":[136],"murine":[137,161],"bone":[138,162],"marrow\u2013derived":[139,163],"produced":[141],"higher":[142],"compared":[144],"with":[145],"CD44\u2212/\u2212":[146],"0.01).":[153,196],"dose-dependently":[155],"inhibited":[156],"TLR2-induced":[157],"synovial":[169],"fluids":[170],"(SF)":[171],"stimulated":[172],"TLR4":[175],"receptors":[176],"induced":[178],"macrophages.":[183],"treatment":[186],"significantly":[187],"SF":[193],"regulated":[198],"responses":[200],"human":[202],"macrophages,":[203],"whereby":[204],"levels":[209],"engagement":[211],"its":[215],"ligand":[216],"(HA)":[217],"cytokine":[228],"production.":[229],"A":[230],"SF,":[238],"potentially":[243],"novel":[244],"target":[245],"treatment.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-22T00:00:00"}