{"id":"https://openalex.org/W2772355432","doi":"https://doi.org/10.18632/oncotarget.22806","title":"GATA3-induced vWF upregulation in the lung adenocarcinoma vasculature","display_name":"GATA3-induced vWF upregulation in the lung adenocarcinoma vasculature","publication_year":2017,"publication_date":"2017-11-30","ids":{"openalex":"https://openalex.org/W2772355432","doi":"https://doi.org/10.18632/oncotarget.22806","mag":"2772355432","pmid":"https://pubmed.ncbi.nlm.nih.gov/29299165","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5746400"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.22806","doi":"https://doi.org/10.18632/oncotarget.22806","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.22806","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22806&path%5B%5D=71998","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22806&path%5B%5D=71998","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101523905","display_name":"Yinghua Xu","orcid":"https://orcid.org/0000-0003-2245-3249","observed_orcids":["https://orcid.org/0000-0003-2245-3249"]},"institutions":[{"id":"https://openalex.org/I4210149885","display_name":"Taishan Medical University","ror":"https://ror.org/04983z422","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210149885"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yinghua Xu","raw_affiliation_strings":["Taishan Medical College, Tai\u2019an, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taishan Medical College, Tai\u2019an, Shandong, China","institution_ids":["https://openalex.org/I4210149885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112128464","display_name":"Silin Pan","orcid":"https://orcid.org/0000-0001-9831-4961","observed_orcids":["https://orcid.org/0000-0001-9831-4961"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210167271","display_name":"Qingdao Women and Children's Hospital","ror":"https://ror.org/05pwzcb81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167271"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Silin Pan","raw_affiliation_strings":["Heart Center, Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center, Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210167271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375110","display_name":"Jing Liu","orcid":"https://orcid.org/0000-0003-2302-5289","observed_orcids":["https://orcid.org/0000-0003-2302-5289"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101053784","display_name":"Fengyun Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyun Dong","raw_affiliation_strings":["Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089381351","display_name":"Zuowang Cheng","orcid":"https://orcid.org/0000-0002-6707-6304","observed_orcids":["https://orcid.org/0000-0002-6707-6304"]},"institutions":[{"id":"https://openalex.org/I4210149885","display_name":"Taishan Medical University","ror":"https://ror.org/04983z422","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210149885"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zuowang Cheng","raw_affiliation_strings":["Taishan Medical College, Tai\u2019an, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taishan Medical College, Tai\u2019an, Shandong, China","institution_ids":["https://openalex.org/I4210149885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628654","display_name":"Jinjin Zhang","orcid":"https://orcid.org/0000-0002-4414-866X","observed_orcids":["https://orcid.org/0000-0002-4414-866X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinjin Zhang","raw_affiliation_strings":["Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]},{"raw_affiliation_string":"Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072623456","display_name":"Ruixia Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149885","display_name":"Taishan Medical University","ror":"https://ror.org/04983z422","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210149885"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruixia Qi","raw_affiliation_strings":["Taishan Medical College, Tai\u2019an, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taishan Medical College, Tai\u2019an, Shandong, China","institution_ids":["https://openalex.org/I4210149885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091036195","display_name":"Qi Zang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zang","raw_affiliation_strings":["Department of Thoracic Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057583869","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0001-9004-1161","observed_orcids":["https://orcid.org/0000-0001-9004-1161"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiqing Zhang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397911","display_name":"Xia Wang","orcid":"https://orcid.org/0000-0002-4294-8022","observed_orcids":["https://orcid.org/0000-0002-4294-8022"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Wang","raw_affiliation_strings":["Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366278","display_name":"Jiandong Zhang","orcid":"https://orcid.org/0000-0002-0635-3419","observed_orcids":["https://orcid.org/0000-0002-0635-3419"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiandong Zhang","raw_affiliation_strings":["Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]},{"raw_affiliation_string":"Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051382127","display_name":"Fufang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fufang Wang","raw_affiliation_strings":["Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong, China","Key Laboratory of Cardiovascular Proteomics of Shandong Province, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Key Laboratory of Cardiovascular Proteomics of Shandong Province, Jinan, Shandong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thaddeus D. Allen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thaddeus D. Allen","raw_affiliation_strings":["Tradewind BioScience, Daly City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tradewind BioScience, Daly City, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100763003","display_name":"Ju Liu","orcid":"https://orcid.org/0000-0001-9932-2613","observed_orcids":["https://orcid.org/0000-0001-9932-2613"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ju Liu","raw_affiliation_strings":["Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101523905","https://openalex.org/A5112128464"],"corresponding_institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210149885","https://openalex.org/I4210167271"],"apc_list":null,"apc_paid":null,"fwci":1.071,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.73485876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"66","first_page":"110517","last_page":"110529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gata3","display_name":"GATA3","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.503000020980835},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.49300000071525574},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.4180000126361847},{"id":"https://openalex.org/keywords/tumor-associated-neutrophils","display_name":"tumor-associated neutrophils","score":0.5609999895095825},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.5239999890327454},{"id":"https://openalex.org/keywords/tumor-associated-t-cells","display_name":"tumor-associated T cells","score":0.32600000500679016},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.4790000021457672},{"id":"https://openalex.org/keywords/tumor-associated-b-cells","display_name":"tumor-associated B cells","score":0.3230000138282776},{"id":"https://openalex.org/keywords/tumor-associated-dendritic-cells","display_name":"tumor-associated dendritic cells","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7229564189910889},{"id":"https://openalex.org/C191935318","wikidata":"https://www.wikidata.org/wiki/Q148","display_name":"China","level":2,"score":0.6921032667160034},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.45116639137268066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43383437395095825},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.10270416736602783},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18632/oncotarget.22806","doi":"https://doi.org/10.18632/oncotarget.22806","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.22806","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22806&path%5B%5D=71998","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4665518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5746400","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29299165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29299165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5746400","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5746400/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.22806","doi":"https://doi.org/10.18632/oncotarget.22806","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.22806","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22806&path%5B%5D=71998","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1407206113","display_name":"\u8840\u7ba1\u6027\u8840\u53cb\u75c5\u56e0\u5b50(vWF) \u5728\u5fc3\u808c\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e2d\u8f6c\u5f55\u8c03\u63a7\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"81370269","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5888942099","display_name":null,"funder_award_id":"ZR2015PH041","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320334012","display_name":"Science and Technology Development Plan of Shandong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2772355432.pdf","grobid_xml":"https://content.openalex.org/works/W2772355432.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W59941185","https://openalex.org/W1492513032","https://openalex.org/W1526670106","https://openalex.org/W1534975974","https://openalex.org/W1753603995","https://openalex.org/W1807684861","https://openalex.org/W1809398380","https://openalex.org/W1964734406","https://openalex.org/W1974969632","https://openalex.org/W1978139448","https://openalex.org/W1983649604","https://openalex.org/W1987451500","https://openalex.org/W1990144639","https://openalex.org/W1996077481","https://openalex.org/W2013410789","https://openalex.org/W2017165199","https://openalex.org/W2029255178","https://openalex.org/W2046650653","https://openalex.org/W2049098554","https://openalex.org/W2053134592","https://openalex.org/W2061001430","https://openalex.org/W2066589515","https://openalex.org/W2067794358","https://openalex.org/W2071584103","https://openalex.org/W2099436620","https://openalex.org/W2103476295","https://openalex.org/W2115351274","https://openalex.org/W2119308535","https://openalex.org/W2124732705","https://openalex.org/W2127610641","https://openalex.org/W2130765810","https://openalex.org/W2139271293","https://openalex.org/W2141563055","https://openalex.org/W2144026946","https://openalex.org/W2171798664","https://openalex.org/W2171973865","https://openalex.org/W2265755372","https://openalex.org/W2314872616","https://openalex.org/W2321926716","https://openalex.org/W2532322090","https://openalex.org/W2591710757","https://openalex.org/W2595560643","https://openalex.org/W2603411876"],"related_works":["https://openalex.org/W4229074709","https://openalex.org/W3158830170","https://openalex.org/W2354758776","https://openalex.org/W2097298892","https://openalex.org/W2003589574","https://openalex.org/W4365814805","https://openalex.org/W2595560643","https://openalex.org/W2361880402","https://openalex.org/W2738855973","https://openalex.org/W2048418340"],"abstract_inverted_index":{"//":[0],"Yinghua":[1],"Xu":[2],"1,":[3],"*":[4,9,173],",":[5,10,14,18,22,26,30,34,38,42,46,51],"Silin":[6],"Pan":[7],"2,":[8],"Jing":[11],"Liu":[12,58],"3":[13,17,25,41,59,80],"Fengyun":[15],"Dong":[16],"Zuowang":[19],"Cheng":[20],"1":[21,29,60],"Jinjin":[23],"Zhang":[24,36,44],"Ruixia":[27],"Qi":[28,31],"Zang":[32],"4":[33,97],"Caiqing":[35],"5":[37,111],"Xia":[39],"Wang":[40,48],"Jiandong":[43],"6":[45,128],"Fufang":[47],"7,":[49],"8":[50,154],"Thaddeus":[52],"D.":[53],"Allen":[54],"9":[55,166],"and":[56,72,115,237,320,413],"Ju":[57,184],"Taishan":[61],"Medical":[62,85],"College,":[63],"Tai\u2019an,":[64],"Shandong,":[65,78,95,109,126,140,152,164],"China":[66,79,96,110,127,141,153,165],"2":[67],"Heart":[68],"Center,":[69,87],"Qingdao":[70,75],"Women":[71],"Children\u2019s":[73],"Hospital,":[74,91,105,122,136],"University,":[76,93,107,124,138,150],"Qingdao,":[77],"Laboratory":[81,156],"of":[82,99,113,130,144,148,157,160,217,223,265,274,281,297,315,383,421,432],"Microvascular":[83],"Medicine,":[84,118],"Research":[86],"Shandong":[88,92,102,106,119,123,133,137,149,161],"Provincial":[89,103,120,134],"Qianfoshan":[90,104,121,135],"Jinan,":[94,108,125,139,151,163],"Department":[98,112,129,143],"Thoracic":[100],"Surgery,":[101],"Respiratory":[114],"Critical":[116],"Care":[117],"Radiation":[131],"Oncology,":[132],"7":[142],"Geriatrics,":[145],"Qilu":[146],"Hospital":[147],"Key":[155],"Cardiovascular":[158],"Proteomics":[159],"Province,":[162],"Tradewind":[167],"BioScience,":[168],"Daly":[169],"City,":[170],"CA,":[171],"USA":[172],"These":[174],"authors":[175],"have":[176],"contributed":[177],"equally":[178],"to":[179,259,402],"this":[180,341],"work":[181],"Correspondence":[182],"to:":[183],"Liu,":[185],"email:":[186],"ju.liu@sdu.edu.cn":[187],"Keywords:":[188],"lung":[189,229],"adenocarcinoma;":[190],"von":[191],"Willebrand":[192,240],"factor":[193,241,375],"(vWF);":[194],"vasculature;":[195],"GATA3":[196,399],"Received:":[197],"September":[198],"14,":[199],"2017":[200,204,208],"Accepted:":[201],"November":[202,206],"13,":[203],"Published:":[205],"30,":[207],"ABSTRACT":[209],"Lung":[210],"adenocarcinoma":[211],"(LAC)":[212],"is":[213,243,363,434],"the":[214,228,272,294,301,327,366,373,390,403,409,419,437],"leading":[215],"cause":[216],"cancer-related":[218],"death":[219],"worldwide.":[220],"Aberrant":[221],"expression":[222,273,308,352,362,429],"genes":[224],"expressed":[225],"preferentially":[226,292],"in":[227,252,268,276,293,311,332,353,386,430],"tumor":[230,282,295],"vasculature":[231,296],"may":[232],"yield":[233],"clues":[234],"for":[235],"prognosis":[236],"treatment.":[238],"Von":[239],"(vWF)":[242],"a":[244,249,337,380],"large":[245],"multifunctional":[246],"glycoprotein":[247],"with":[248,300],"well-known":[250],"function":[251],"hemostasis.":[253,269],"However,":[254],"vWF":[255,275,289,307,330,351,384,391,411,428],"has":[256],"been":[257],"reported":[258],"exert":[260],"an":[261],"anti-tumor":[262],"effect,":[263],"independent":[264],"its":[266],"role":[267],"We":[270,286],"investigated":[271],"LAC":[277,298,318,323,333,367,433],"through":[278,441],"immunohistochemical":[279],"staining":[280],"tissue":[283,303],"microarrays":[284],"(TMAs).":[285],"found":[287,310],"that":[288,372,398,427],"was":[290,309],"overexpressed":[291],"compared":[299],"adjacent":[302],"vasculature.":[304],"Consistently,":[305],"elevated":[306,435],"endothelial":[312,357],"cells":[313,349,358],"(ECs)":[314],"fresh":[316],"human":[317,354,410],"tissues":[319],"transplanted":[321],"mouse":[322],"tissues.":[324],"To":[325],"understand":[326],"mechanism":[328],"underlying":[329],"up-regulation":[331],"vessels,":[334],"we":[335,425],"established":[336],"co-culture":[338],"system.":[339],"In":[340],"system,":[342],"conditioned":[343,415],"media":[344,416],"(CM)":[345],"collected":[346],"from":[347],"A549":[348,414],"increased":[350],"umbilical":[355],"vein":[356],"(HUVECs),":[359],"suggesting":[360],"enhanced":[361,442],"regulated":[364],"by":[365,436],"secretome.":[368],"Subsequent":[369],"studies":[370],"revealed":[371],"transcription":[374,385],"GATA3,":[376],"but":[377],"not":[378],"ERG,":[379],"known":[381],"regulator":[382],"vascular":[387],"cells,":[388],"mediated":[389],"elevation.":[392],"Chromatin":[393],"immunoprecipitation":[394],"(ChIP)":[395],"assays":[396],"validated":[397],"binds":[400],"directly":[401],"+220":[404],"GATA":[405],"binding":[406,420],"motif":[407],"on":[408],"promoter":[412],"significantly":[417],"increases":[418],"GATA3.":[422],"Taken":[423],"together,":[424],"demonstrate":[426],"ECs":[431],"cancer":[438],"cell-derived":[439],"secretome":[440],"GATA3-mediated":[443],"transcription.":[444]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-12-22T00:00:00"}