{"id":"https://openalex.org/W2772280433","doi":"https://doi.org/10.1089/jmf.2017.0062","title":"Metabolomics Approach in the Study of the Well-Defined Polyherbal Preparation Zyflamend","display_name":"Metabolomics Approach in the Study of the Well-Defined Polyherbal Preparation Zyflamend","publication_year":2017,"publication_date":"2017-12-11","ids":{"openalex":"https://openalex.org/W2772280433","doi":"https://doi.org/10.1089/jmf.2017.0062","mag":"2772280433","pmid":"https://pubmed.ncbi.nlm.nih.gov/29227176"},"language":"en","primary_location":{"id":"doi:10.1089/jmf.2017.0062","doi":"https://doi.org/10.1089/jmf.2017.0062","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2017.0062","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019972430","display_name":"Eric D. Tague","orcid":"https://orcid.org/0000-0001-8031-4816","observed_orcids":["https://orcid.org/0000-0001-8031-4816"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. Tague","raw_affiliation_strings":["Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091510554","display_name":"Allen K. Bourdon","orcid":"https://orcid.org/0000-0002-9373-1130","observed_orcids":["https://orcid.org/0000-0002-9373-1130"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen K. Bourdon","raw_affiliation_strings":["Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034214826","display_name":"Amber MacDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber MacDonald","raw_affiliation_strings":["Department of Nutrition, University of Tennessee Knoxville, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, University of Tennessee Knoxville, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049835005","display_name":"Maggie S. Lookadoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maggie S. Lookadoo","raw_affiliation_strings":["Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110423661","display_name":"Edward D. Kim","orcid":"https://orcid.org/0009-0006-1144-6130","observed_orcids":["https://orcid.org/0009-0006-1144-6130"]},"institutions":[{"id":"https://openalex.org/I2802076678","display_name":"University of Tennessee Medical Center","ror":"https://ror.org/0277n1841","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802076678"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward D. Kim","raw_affiliation_strings":["Department of Surgery, University of Tennessee Medical Center, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Tennessee Medical Center, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I2802076678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109236661","display_name":"Wesley M. White","orcid":"https://orcid.org/0000-0002-0257-1806","observed_orcids":["https://orcid.org/0000-0002-0257-1806"]},"institutions":[{"id":"https://openalex.org/I2802076678","display_name":"University of Tennessee Medical Center","ror":"https://ror.org/0277n1841","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802076678"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley M. White","raw_affiliation_strings":["Department of Surgery, University of Tennessee Medical Center, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Tennessee Medical Center, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I2802076678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077676753","display_name":"Paul Terry","orcid":"https://orcid.org/0000-0002-0353-9197","observed_orcids":["https://orcid.org/0000-0002-0353-9197"]},"institutions":[{"id":"https://openalex.org/I2802076678","display_name":"University of Tennessee Medical Center","ror":"https://ror.org/0277n1841","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802076678"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Terry","raw_affiliation_strings":["Department of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I2802076678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025355779","display_name":"Shawn Robert Campagna","orcid":"https://orcid.org/0000-0001-6809-3862","observed_orcids":["https://orcid.org/0000-0001-6809-3862","https://orcid.org/0009-0008-5687-5507"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn R. Campagna","raw_affiliation_strings":["Biological Small Molecule Mass Spectrometry Core, University of Tennessee, Knoxville, Tennessee, USA","Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Small Molecule Mass Spectrometry Core, University of Tennessee, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"Department of Chemistry, University of Tennessee Knoxville, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007918640","display_name":"Brynn H. Voy","orcid":"https://orcid.org/0000-0003-1923-9110","observed_orcids":["https://orcid.org/0000-0003-1923-9110"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brynn H. Voy","raw_affiliation_strings":["Department of Animal Science, University of Tennessee Knoxville, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, University of Tennessee Knoxville, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102859048","display_name":"Jay N. Whelan","orcid":"https://orcid.org/0000-0001-7804-9144","observed_orcids":["https://orcid.org/0000-0001-7804-9144"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jay Whelan","raw_affiliation_strings":["Department of Nutrition, University of Tennessee Knoxville, Knoxville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, University of Tennessee Knoxville, Knoxville, Tennessee, USA","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102859048"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":null,"apc_paid":null,"fwci":0.595,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63422407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"21","issue":"3","first_page":"306","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.4332999885082245,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.4332999885082245,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyherbal-formulation","display_name":"polyherbal formulation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ampk-activation","display_name":"AMPK activation","score":0.871999979019165},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase","display_name":"acetyl-CoA carboxylase","score":0.875},{"id":"https://openalex.org/keywords/purine-and-pyrimidine-metabolism","display_name":"purine and pyrimidine metabolism","score":0.9599999785423279},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.4970000088214874},{"id":"https://openalex.org/keywords/anticancer-effects","display_name":"anticancer effects","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7199123501777649},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5096871852874756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4670770466327667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32567405700683594},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20047035813331604}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050153","descriptor_name":"Abdominal Fat","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D050153","descriptor_name":"Abdominal Fat","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/jmf.2017.0062","doi":"https://doi.org/10.1089/jmf.2017.0062","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2017.0062","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},{"id":"pmid:29227176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29227176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal food","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W110003791","https://openalex.org/W954574116","https://openalex.org/W1520440032","https://openalex.org/W1540977269","https://openalex.org/W1565773531","https://openalex.org/W1914472038","https://openalex.org/W1931079797","https://openalex.org/W1968707800","https://openalex.org/W1971414838","https://openalex.org/W1991736265","https://openalex.org/W1994124478","https://openalex.org/W2002960428","https://openalex.org/W2004306793","https://openalex.org/W2017043004","https://openalex.org/W2023440163","https://openalex.org/W2023657887","https://openalex.org/W2023948074","https://openalex.org/W2028205542","https://openalex.org/W2031716577","https://openalex.org/W2033732701","https://openalex.org/W2035437946","https://openalex.org/W2038227076","https://openalex.org/W2039334336","https://openalex.org/W2043451976","https://openalex.org/W2045259351","https://openalex.org/W2065705538","https://openalex.org/W2070323923","https://openalex.org/W2075199222","https://openalex.org/W2101002427","https://openalex.org/W2107432274","https://openalex.org/W2116172687","https://openalex.org/W2117680364","https://openalex.org/W2124644591","https://openalex.org/W2135607659","https://openalex.org/W2139829500","https://openalex.org/W2148621802","https://openalex.org/W2148828072","https://openalex.org/W2149494499","https://openalex.org/W2149845330","https://openalex.org/W2153721752","https://openalex.org/W2154883306","https://openalex.org/W2313303543","https://openalex.org/W2397396704","https://openalex.org/W2416347552","https://openalex.org/W2559844097"],"related_works":["https://openalex.org/W3174645649","https://openalex.org/W3048464108","https://openalex.org/W954574116","https://openalex.org/W3032868473","https://openalex.org/W3167159532","https://openalex.org/W1029657062","https://openalex.org/W3122947180","https://openalex.org/W2891979214","https://openalex.org/W2901265279","https://openalex.org/W2807842437"],"abstract_inverted_index":{"Zyflamend":[0,73,92,110,139,159,167,209,222,236],"is":[1],"a":[2,77,243],"highly":[3],"controlled":[4],"blend":[5],"of":[6,36,42,58,72,79,102,109,132,203,234,250],"10":[7],"herbal":[8],"extracts":[9],"that":[10,125,245],"synergistically":[11],"impact":[12],"multiple":[13],"cell":[14],"signaling":[15],"pathways":[16],"with":[17,76,89,136,166,183,218],"anticancer":[18],"and":[19,40,129,137,154,160,198,225],"anti-inflammatory":[20],"properties.":[21],"More":[22],"recently,":[23],"its":[24,45],"effects":[25,48,108],"were":[26,113,122,205],"shown":[27,95],"to":[28,53,62,70,96,208],"also":[29,114],"modify":[30],"cellular":[31],"energetics,":[32],"for":[33],"example,":[34],"activation":[35,249],"fatty":[37],"acid":[38],"oxidation":[39],"inhibition":[41],"lipogenesis.":[43,235],"However,":[44],"general":[46],"metabolic":[47],"in":[49,68,74,84,105,116,149,161,173,178,215,229,240],"vivo":[50],"have":[51],"yet":[52],"be":[54],"explored.":[55],"The":[56],"objective":[57],"this":[59],"study":[60],"was":[61,147,175],"characterize":[63],"the":[64,99,103,107,117,127,133,179,219,248],"tissue":[65,239],"specific":[66],"metabolomes":[67],"response":[69],"supplementation":[71,140],"mice,":[75],"comparison":[78],"equivalent":[80,143,170],"metabolomics":[81,146,220],"data":[82],"generated":[83],"plasma":[85,155,162],"from":[86,156,163],"humans":[87,164],"supplemented":[88,165],"Zyflamend.":[90],"Because":[91],"has":[93],"been":[94],"activate":[97],"AMPK,":[98],"\"energy":[100],"sensor\"":[101],"cell,":[104],"vitro,":[106],"on":[111,193],"adiposity":[112],"tested":[115],"murine":[118],"model.":[119],"C57BL/6":[120],"mice":[121,157,174,241],"fed":[123],"diets":[124],"mimicked":[126],"macro-":[128],"micronutrient":[130],"composition":[131],"U.S.":[134],"diet":[135],"without":[138,185],"at":[141,168],"human":[142],"doses.":[144],"Untargeted":[145],"performed":[148],"liver,":[150],"skeletal":[151],"muscle,":[152],"adipose,":[153],"consuming":[158],"an":[169],"dose.":[171],"Adiposity":[172],"significantly":[176],"reduced":[177],"Zyflamend-treated":[180],"animals":[181],"(compared":[182],"controls)":[184],"affecting":[186],"body":[187],"weight":[188,190],"or":[189],"gain.":[191],"Based":[192],"KEGG":[194],"pathway":[195],"enrichment,":[196],"purine":[197],"pyrimidine":[199],"metabolism":[200],"(potential":[201],"regulators":[202,233],"AMPK)":[204],"particularly":[206],"responsive":[207],"across":[210],"all":[211],"tissues,":[212],"but":[213],"only":[214],"mice.":[216],"Consistent":[217],"data,":[221],"activated":[223],"AMPK":[224],"inhibited":[226],"acetyl":[227],"CoA-carboxylase":[228],"adipose":[230,238],"tissue,":[231],"key":[232],"reduces":[237],"through":[242],"mechanism":[244],"likely":[246],"involves":[247],"AMPK.":[251]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-12-22T00:00:00"}
