{"id":"https://openalex.org/W2772058283","doi":"https://doi.org/10.5301/tj.5000696","title":"EURO-B.O.S.S.: A European study on chemotherapy in bone-sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma","display_name":"EURO-B.O.S.S.: A European study on chemotherapy in bone-sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma","publication_year":2017,"publication_date":"2017-12-08","ids":{"openalex":"https://openalex.org/W2772058283","doi":"https://doi.org/10.5301/tj.5000696","mag":"2772058283","pmid":"https://pubmed.ncbi.nlm.nih.gov/29218692"},"language":"en","primary_location":{"id":"doi:10.5301/tj.5000696","doi":"https://doi.org/10.5301/tj.5000696","is_oa":false,"landing_page_url":"https://doi.org/10.5301/tj.5000696","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101746409","display_name":"Stefano Ferrari","orcid":"https://orcid.org/0000-0001-6462-6000","observed_orcids":["https://orcid.org/0000-0001-6462-6000"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Stefano Ferrari","raw_affiliation_strings":["Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027746254","display_name":"Stefan Bielack","orcid":"https://orcid.org/0000-0003-2144-3153","observed_orcids":["https://orcid.org/0000-0003-2144-3153"]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan S. Bielack","raw_affiliation_strings":["Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082008325","display_name":"Sigbj\u00f8rn Smeland","orcid":"https://orcid.org/0000-0002-5743-8244","observed_orcids":["https://orcid.org/0000-0002-5743-8244"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Sigbj\u00f8rn Smeland","raw_affiliation_strings":["Division of Cancer Medicine, Oslo University Hospital and Institute of Clinical Medicine, Oslo - Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Medicine, Oslo University Hospital and Institute of Clinical Medicine, Oslo - Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047205597","display_name":"Alessandra Longhi","orcid":"https://orcid.org/0000-0001-6708-3777","observed_orcids":["https://orcid.org/0000-0001-6708-3777"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Longhi","raw_affiliation_strings":["Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084241424","display_name":"Gerlinde Egerer","orcid":"https://orcid.org/0009-0005-0462-4165","observed_orcids":["https://orcid.org/0009-0005-0462-4165"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerlinde Egerer","raw_affiliation_strings":["Department of Hematology, Oncology, and Rheumatology, Heidelberg University Hospital, Heidelberg - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology, and Rheumatology, Heidelberg University Hospital, Heidelberg - Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090145105","display_name":"Kirsten Sundby Hall","orcid":"https://orcid.org/0000-0002-2126-8255","observed_orcids":["https://orcid.org/0000-0002-2126-8255"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kirsten Sundby Hall","raw_affiliation_strings":["Division of Cancer Medicine, Oslo University Hospital and Institute of Clinical Medicine, Oslo - Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Medicine, Oslo University Hospital and Institute of Clinical Medicine, Oslo - Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086814670","display_name":"Davide Mar\u00eda Donati","orcid":"https://orcid.org/0000-0002-9170-0576","observed_orcids":["https://orcid.org/0000-0002-9170-0576"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Donati","raw_affiliation_strings":["Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113711184","display_name":"Matthias Kevric","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Kevric","raw_affiliation_strings":["Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109965105","display_name":"Otte Brosj\u00f6","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Otte Brosj\u00f6","raw_affiliation_strings":["Department of Orthopedics, Karolinska University Hospital, Stockholm - Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Karolinska University Hospital, Stockholm - Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033483931","display_name":"Alessandro Comandone","orcid":"https://orcid.org/0000-0003-4677-1807","observed_orcids":["https://orcid.org/0000-0003-4677-1807"]},"institutions":[{"id":"https://openalex.org/I4210109509","display_name":"Ospedale Humanitas Gradenigo","ror":"https://ror.org/017j6af40","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109509"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Comandone","raw_affiliation_strings":["Oncology Department, Ospedale Humanitas-Gradenigo, Turin - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Ospedale Humanitas-Gradenigo, Turin - Italy","institution_ids":["https://openalex.org/I4210109509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048655803","display_name":"Mathias Werner","orcid":"https://orcid.org/0000-0002-7138-9055","observed_orcids":["https://orcid.org/0000-0002-7138-9055"]},"institutions":[{"id":"https://openalex.org/I4210098899","display_name":"Helios Klinikum Emil von Behring","ror":"https://ror.org/00td6v066","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210098899","https://openalex.org/I4210138940"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Werner","raw_affiliation_strings":["Department of Orthopedic Pathology, HELIOS Klinikum Emil von Behring GmbH, Berlin - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Pathology, HELIOS Klinikum Emil von Behring GmbH, Berlin - Germany","institution_ids":["https://openalex.org/I4210098899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000823999","display_name":"Odd R. Monge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Odd Monge","raw_affiliation_strings":["Department of Oncology and Radiotherapy, Haukeland University Hospital, Bergen - Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Radiotherapy, Haukeland University Hospital, Bergen - Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080548972","display_name":"Emanuela Palmerini","orcid":"https://orcid.org/0000-0003-3406-6705","observed_orcids":["https://orcid.org/0000-0003-3406-6705"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuela Palmerini","raw_affiliation_strings":["Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025105470","display_name":"Wolfgang E. Berdel","orcid":"https://orcid.org/0000-0002-3030-6567","observed_orcids":["https://orcid.org/0000-0002-3030-6567"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang E. Berdel","raw_affiliation_strings":["Department of Medicine A, University Hospital of Muenster, Muenster - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine A, University Hospital of Muenster, Muenster - Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036087034","display_name":"Bodil Bjerkehagen","orcid":"https://orcid.org/0000-0003-4572-9279","observed_orcids":["https://orcid.org/0000-0003-4572-9279"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Bodil Bjerkehagen","raw_affiliation_strings":["Division of Cancer Medicine, Oslo University Hospital and Institute of Clinical Medicine, Oslo - Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Medicine, Oslo University Hospital and Institute of Clinical Medicine, Oslo - Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006719017","display_name":"Anna Paioli","orcid":"https://orcid.org/0000-0002-8587-7893","observed_orcids":["https://orcid.org/0000-0002-8587-7893"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Paioli","raw_affiliation_strings":["Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000610387","display_name":"Sylvie Lorenzen","orcid":"https://orcid.org/0000-0001-7933-2507","observed_orcids":["https://orcid.org/0000-0001-7933-2507"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sylvie Lorenzen","raw_affiliation_strings":["Department of Hematology and Oncology, Klinikum rechts der Isar der TU Muenchen, Muenchen - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Klinikum rechts der Isar der TU Muenchen, Muenchen - Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mikael Eriksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mikael Eriksson","raw_affiliation_strings":["Department of Oncology, Skane University Hospital and Lund University, Lund - Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Skane University Hospital and Lund University, Lund - Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079825894","display_name":"Marco Gambarotti","orcid":"https://orcid.org/0000-0002-8080-4484","observed_orcids":["https://orcid.org/0000-0002-8080-4484"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Gambarotti","raw_affiliation_strings":["Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016409767","display_name":"Per\u2010Ulf Tunn","orcid":"https://orcid.org/0000-0003-4837-5525","observed_orcids":["https://orcid.org/0000-0003-4837-5525"]},"institutions":[{"id":"https://openalex.org/I4210156283","display_name":"Helios Hospital Berlin-Buch","ror":"https://ror.org/05hgh1g19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940","https://openalex.org/I4210156283"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Per-Ulf Tunn","raw_affiliation_strings":["Department of Tumor Orthopedics, HELIOS Klinikum Berlin-Buch, Berlin - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Orthopedics, HELIOS Klinikum Berlin-Buch, Berlin - Germany","institution_ids":["https://openalex.org/I4210156283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010518603","display_name":"Nina Louise Jebsen","orcid":"https://orcid.org/0000-0003-3776-6774","observed_orcids":["https://orcid.org/0000-0003-3776-6774"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Nina L. Jebsen","raw_affiliation_strings":["Department of Clinical Science, Haukeland University Hospital and Center for Cancer Biomarkers CCBIO, University of Bergen, Bergen - Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Science, Haukeland University Hospital and Center for Cancer Biomarkers CCBIO, University of Bergen, Bergen - Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030668768","display_name":"Marilena Cesari","orcid":"https://orcid.org/0000-0003-1505-758X","observed_orcids":["https://orcid.org/0000-0003-1505-758X"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marilena Cesari","raw_affiliation_strings":["Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011059803","display_name":"Thekla v. Kalle","orcid":"https://orcid.org/0000-0001-8851-5014","observed_orcids":["https://orcid.org/0000-0001-8851-5014"]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thekla von Kalle","raw_affiliation_strings":["Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033258883","display_name":"Virginia Ferraresi","orcid":"https://orcid.org/0000-0001-6419-1668","observed_orcids":["https://orcid.org/0000-0001-6419-1668"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Virginia Ferraresi","raw_affiliation_strings":["Oncology Department, Istituto Regina Elena, Rome - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Regina Elena, Rome - Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112551354","display_name":"Rudolf Schwarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rudolf Schwarz","raw_affiliation_strings":["Department of Radiation Oncology, Medical Center Hamburg-Eppendorf, Hamburg - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Medical Center Hamburg-Eppendorf, Hamburg - Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044256192","display_name":"Rossella Bertulli","orcid":"https://orcid.org/0000-0002-7237-7515","observed_orcids":["https://orcid.org/0000-0002-7237-7515"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Bertulli","raw_affiliation_strings":["Oncology Department, Istituto Nazionale Tumori, Milan - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Nazionale Tumori, Milan - Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111573783","display_name":"Anne-Katrin Kasparek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anne-Katrin Kasparek","raw_affiliation_strings":["Department of Internal Medicine, Division of Oncology, Medical University of Graz, Graz - Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Oncology, Medical University of Graz, Graz - Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050031420","display_name":"Giovanni Grignani","orcid":"https://orcid.org/0000-0001-5515-569X","observed_orcids":["https://orcid.org/0000-0001-5515-569X"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Grignani","raw_affiliation_strings":["Oncology Department, Istituto di Candiolo IRCCS, Turin - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto di Candiolo IRCCS, Turin - Italy","institution_ids":["https://openalex.org/I4210151091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041567047","display_name":"Fatime Krasniqi","orcid":"https://orcid.org/0000-0003-3742-4248","observed_orcids":["https://orcid.org/0000-0003-3742-4248"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fatime Krasniqi","raw_affiliation_strings":["Oncology Deparment, University Hospital of Basel, Basel - Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Deparment, University Hospital of Basel, Basel - Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064757626","display_name":"Benjamin Sorg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benjamin Sorg","raw_affiliation_strings":["Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066172709","display_name":"Stefanie Hecker\u2010Nolting","orcid":"https://orcid.org/0000-0002-1815-138X","observed_orcids":["https://orcid.org/0000-0002-1815-138X"]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Hecker-Nolting","raw_affiliation_strings":["Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stuttgart Cancer Center, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart Olgahospital, Stuttgart - Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083948167","display_name":"Piero Picci","orcid":"https://orcid.org/0000-0002-8519-4101","observed_orcids":["https://orcid.org/0000-0002-8519-4101"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Picci","raw_affiliation_strings":["Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Istituto Ortopedico Rizzoli, Bologna - Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048170384","display_name":"Peter Reichardt","orcid":"https://orcid.org/0009-0008-1410-3111","observed_orcids":["https://orcid.org/0009-0008-1410-3111"]},"institutions":[{"id":"https://openalex.org/I4210098899","display_name":"Helios Klinikum Emil von Behring","ror":"https://ror.org/00td6v066","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210098899","https://openalex.org/I4210138940"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Reichardt","raw_affiliation_strings":["Department of Orthopedic Pathology, HELIOS Klinikum Emil von Behring GmbH, Berlin - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Pathology, HELIOS Klinikum Emil von Behring GmbH, Berlin - Germany","institution_ids":["https://openalex.org/I4210098899"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":22,"corresponding_author_ids":["https://openalex.org/A5101746409"],"corresponding_institution_ids":["https://openalex.org/I4210121742"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":3.5342,"has_fulltext":false,"cited_by_count":125,"citation_normalized_percentile":{"value":0.94804258,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"104","issue":"1","first_page":"30","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-osteosarcoma","display_name":"high-grade osteosarcoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/primary-osteosarcoma","display_name":"primary osteosarcoma","score":0.7229999899864197},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ifosfamide","display_name":"ifosfamide","score":1.0},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intensive-chemotherapy","display_name":"intensive chemotherapy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9369999766349792},{"id":"https://openalex.org/keywords/synchronous-metastasis","display_name":"synchronous metastases","score":0.800000011920929},{"id":"https://openalex.org/keywords/pelvic-tumors","display_name":"pelvic tumors","score":0.6480000019073486},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8483626842498779},{"id":"https://openalex.org/C2909636867","wikidata":"https://www.wikidata.org/wiki/Q56014469","display_name":"Bone Sarcoma","level":3,"score":0.6962729692459106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6175655722618103},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6014321446418762},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5441833138465881},{"id":"https://openalex.org/C2779561271","wikidata":"https://www.wikidata.org/wiki/Q7243102","display_name":"Primary bone","level":2,"score":0.4944765567779541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4795265197753906},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.4587888717651367},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4400286078453064},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19953259825706482},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1739485263824463},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10930746793746948},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007391","descriptor_name":"International Cooperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064147","descriptor_name":"Febrile Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.5301/tj.5000696","doi":"https://doi.org/10.5301/tj.5000696","is_oa":false,"landing_page_url":"https://doi.org/10.5301/tj.5000696","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},{"id":"pmid:29218692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29218692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori","raw_type":"Clinical Trial"},{"id":"pmh:oai:cris.unibo.it:11585/623419","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/623419","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lup.lub.lu.se:d36a79e0-6ca9-4cd2-a167-fc7a2bd1fef6","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/d36a79e0-6ca9-4cd2-a167-fc7a2bd1fef6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0300-8916","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1586474","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1586474","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W184140439","https://openalex.org/W1777244202","https://openalex.org/W1966288993","https://openalex.org/W1981956631","https://openalex.org/W2003319880","https://openalex.org/W2035317421","https://openalex.org/W2048628494","https://openalex.org/W2052299135","https://openalex.org/W2060688081","https://openalex.org/W2073784198","https://openalex.org/W2095599995","https://openalex.org/W2104608305","https://openalex.org/W2121769039","https://openalex.org/W2127235751","https://openalex.org/W2127748864","https://openalex.org/W2145188374","https://openalex.org/W2148077417","https://openalex.org/W2165678358","https://openalex.org/W2431282426","https://openalex.org/W2513951655","https://openalex.org/W2588196946","https://openalex.org/W2591526702","https://openalex.org/W2613929012"],"related_works":["https://openalex.org/W1777344752","https://openalex.org/W2521274522","https://openalex.org/W2977856567","https://openalex.org/W2606006935","https://openalex.org/W4385476503","https://openalex.org/W2531624866","https://openalex.org/W2588196946","https://openalex.org/W4200247196","https://openalex.org/W2052299135","https://openalex.org/W2479130258"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,68,110,168],"EUROpean":[2],"Bone":[3],"Over":[4],"40":[5,198],"Sarcoma":[6],"Study":[7],"(EURO-B.O.S.S.)":[8],"was":[9,49,96,118,139,154,176],"the":[10,58,65,73,89,144,215],"first":[11],"prospective":[12],"international":[13],"study":[14],"for":[15,33,64,127],"patients":[16,35,52,77,99,114,159,185,196,241],"41-65":[17],"years":[18,199],"old":[19],"with":[20,25,36,54,78,100,115,156,192,202,209,243],"high-grade":[21,37,80,204],"bone":[22],"sarcoma":[23],"treated":[24,53,242],"an":[26,206],"intensive":[27,245],"chemotherapy":[28,210],"regimen":[29],"derived":[30],"from":[31],"protocols":[32],"younger":[34,224,237],"skeletal":[38],"osteosarcoma.":[39,81],"METHODS:":[40],"Chemotherapy":[41],"based":[42],"on":[43,72],"doxorubicin,":[44],"cisplatin,":[45],"ifosfamide,":[46],"and":[47,103,123,125,172,178,211,230],"methotrexate":[48],"suggested,":[50],"but":[51],"other":[55],"regimens":[56],"at":[57],"investigators'":[59],"choice":[60],"were":[61,147],"also":[62],"eligible":[63],"study.":[66],"RESULTS:":[67],"present":[69],"report":[70],"focuses":[71],"subgroup":[74],"of":[75,86,92,107,143,158,165,170,184,200,217,239],"218":[76],"primary":[79,134,203],"With":[82],"a":[83],"median":[84],"follow-up":[85],"47":[87],"months,":[88],"5-year":[90,111],"probability":[91,216],"overall":[93],"survival":[94,218],"(OS)":[95],"66%":[97],"in":[98,105,113,120,141,189,223,236],"localized":[101,116],"disease":[102,117],"22%":[104],"case":[106],"synchronous":[108],"metastases.":[109],"OS":[112],"29%":[119],"pelvic":[121],"tumors,":[122],"70%":[124],"73%":[126],"extremity":[128],"or":[129,162],"craniofacial":[130],"locations,":[131],"respectively.":[132,180],"In":[133,195],"chemotherapy,":[135],"tumor":[136],"necrosis":[137],"\u226590%":[138],"reported":[140,235],"21%":[142],"patients.":[145,225],"There":[146],"no":[148],"toxic":[149],"deaths;":[150],"however,":[151],"hematological":[152],"toxicity":[153,227],"considerable":[155],"32%":[157],"experiencing":[160],"1":[161],"more":[163,244],"episodes":[164],"neutropenic":[166],"fever.":[167],"incidence":[169],"nephrotoxicity":[171],"neurotoxicity":[173],"(mainly":[174],"peripheral)":[175],"28%":[177],"24%,":[179],"After":[181],"methotrexate,":[182],"23%":[183],"experienced":[186],"delayed":[187],"excretion,":[188],"4":[190],"cases":[191],"nephrotoxicity.":[193],"CONCLUSIONS:":[194],"over":[197],"age":[201],"osteosarcoma,":[205],"aggressive":[207],"approach":[208],"surgery":[212],"can":[213],"offer":[214],"similar":[219],"to":[220],"that":[221,234],"achieved":[222],"Chemotherapy-related":[226],"is":[228],"significant":[229],"generally":[231],"higher":[232],"than":[233],"cohorts":[238],"osteosarcoma":[240],"regimens.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-12-22T00:00:00"}