{"id":"https://openalex.org/W2771990929","doi":"https://doi.org/10.2174/1573406413666171129224424","title":"Prodrugs for Nitroreductase Based Cancer Therapy- 1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB","display_name":"Prodrugs for Nitroreductase Based Cancer Therapy- 1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB","publication_year":2018,"publication_date":"2018-01-15","ids":{"openalex":"https://openalex.org/W2771990929","doi":"https://doi.org/10.2174/1573406413666171129224424","mag":"2771990929","pmid":"https://pubmed.ncbi.nlm.nih.gov/29189173"},"language":"en","primary_location":{"id":"doi:10.2174/1573406413666171129224424","doi":"https://doi.org/10.2174/1573406413666171129224424","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573406413666171129224424","pdf_url":null,"source":{"id":"https://openalex.org/S155723790","display_name":"Medicinal Chemistry","issn_l":"1573-4064","issn":["1573-4064","1875-6638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039260116","display_name":"Tu\u011fba G\u00fcng\u00f6r","orcid":"https://orcid.org/0000-0001-5261-1856","observed_orcids":["https://orcid.org/0000-0001-5261-1856"]},"institutions":[{"id":"https://openalex.org/I115953327","display_name":"\u00c7anakkale Onsekiz Mart \u00dcniversitesi","ror":"https://ror.org/05rsv8p09","country_code":"TR","type":"education","lineage":["https://openalex.org/I115953327"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tugba Gungor","raw_affiliation_strings":["Department of Chemistry,  Faculty of Sciences and Arts, \u00c7anakkale Onsekiz Mart University, \u00c7anakkale, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry,  Faculty of Sciences and Arts, \u00c7anakkale Onsekiz Mart University, \u00c7anakkale, Turkey","institution_ids":["https://openalex.org/I115953327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127175315","display_name":"G\u00fclden A\u015fc\u0131 Yeti\u015f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gulden Yetis","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze-Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze-Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039693391","display_name":"Ferah C\u00f6mert \u00d6nder","orcid":"https://orcid.org/0000-0002-4037-1979","observed_orcids":["https://orcid.org/0000-0002-4037-1979"]},"institutions":[{"id":"https://openalex.org/I115953327","display_name":"\u00c7anakkale Onsekiz Mart \u00dcniversitesi","ror":"https://ror.org/05rsv8p09","country_code":"TR","type":"education","lineage":["https://openalex.org/I115953327"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ferah C. Onder","raw_affiliation_strings":["Department of Chemistry,  Faculty of Sciences and Arts, \u00c7anakkale Onsekiz Mart University, \u00c7anakkale, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry,  Faculty of Sciences and Arts, \u00c7anakkale Onsekiz Mart University, \u00c7anakkale, Turkey","institution_ids":["https://openalex.org/I115953327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127180267","display_name":"Esra TOKAY","orcid":"https://orcid.org/0000-0001-9993-2753","observed_orcids":["https://orcid.org/0000-0001-9993-2753"]},"institutions":[{"id":"https://openalex.org/I115600380","display_name":"Bal\u0131kesir University","ror":"https://ror.org/02tv7db43","country_code":"TR","type":"education","lineage":["https://openalex.org/I115600380"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esra Tokay","raw_affiliation_strings":["Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Bal\u0131kesir University, Bal\u0131kesir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Bal\u0131kesir University, Bal\u0131kesir, Turkey","institution_ids":["https://openalex.org/I115600380"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091044841","display_name":"Tu\u011fba Ta\u015fk\u0131n\u2010Tok","orcid":"https://orcid.org/0000-0002-0064-8400","observed_orcids":["https://orcid.org/0000-0002-0064-8400"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tugba T. Tok","raw_affiliation_strings":["Department of Chemistry, Faculty of Sciences and Arts, Gaziantep University, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Sciences and Arts, Gaziantep University, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090440647","display_name":"Ayhan \u00c7elik","orcid":"https://orcid.org/0000-0003-1355-9252","observed_orcids":["https://orcid.org/0000-0003-1355-9252"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ayhan Celik","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze-Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze-Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029816308","display_name":"Mehmet Ay","orcid":"https://orcid.org/0000-0002-1095-1614","observed_orcids":["https://orcid.org/0000-0002-1095-1614"]},"institutions":[{"id":"https://openalex.org/I115953327","display_name":"\u00c7anakkale Onsekiz Mart \u00dcniversitesi","ror":"https://ror.org/05rsv8p09","country_code":"TR","type":"education","lineage":["https://openalex.org/I115953327"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mehmet Ay","raw_affiliation_strings":["Department of Chemistry,  Faculty of Sciences and Arts, \u00c7anakkale Onsekiz Mart University, \u00c7anakkale, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry,  Faculty of Sciences and Arts, \u00c7anakkale Onsekiz Mart University, \u00c7anakkale, Turkey","institution_ids":["https://openalex.org/I115953327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071435180","display_name":"FERAY TURA KOCKAR","orcid":"https://orcid.org/0000-0003-2572-8391","observed_orcids":["https://orcid.org/0000-0003-2572-8391"]},"institutions":[{"id":"https://openalex.org/I115600380","display_name":"Bal\u0131kesir University","ror":"https://ror.org/02tv7db43","country_code":"TR","type":"education","lineage":["https://openalex.org/I115600380"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Feray Kockar","raw_affiliation_strings":["Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Bal\u0131kesir University, Bal\u0131kesir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetic, Faculty of Sciences and Arts, Bal\u0131kesir University, Bal\u0131kesir, Turkey","institution_ids":["https://openalex.org/I115600380"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029816308"],"corresponding_institution_ids":["https://openalex.org/I115953327"],"apc_list":null,"apc_paid":null,"fwci":1.8762,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81096582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"5","first_page":"495","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.066600002348423,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitroreductase","display_name":"nitroreductase","score":0.9020000100135803},{"id":"https://openalex.org/keywords/nitrobenzamide","display_name":"nitrobenzamide","score":0.8709999918937683},{"id":"https://openalex.org/keywords/enzymatic-reduction","display_name":"enzymatic reduction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/metabolomic-profiles","display_name":"metabolite profiles","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.734000027179718},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cb1954","display_name":"CB1954","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hep3b-cells","display_name":"Hep3B cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.941646933555603},{"id":"https://openalex.org/C2781326480","wikidata":"https://www.wikidata.org/wiki/Q7041501","display_name":"Nitroreductase","level":3,"score":0.8772722482681274},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6505160331726074},{"id":"https://openalex.org/C2780231548","wikidata":"https://www.wikidata.org/wiki/Q417731","display_name":"Benzamide","level":2,"score":0.64849853515625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6283466219902039},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5922014713287354},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5648684501647949},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49945902824401855},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4264361262321472},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4099878668785095},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31672704219818115},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2839386463165283},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20107898116111755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19525954127311707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1306934654712677},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10313093662261963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08341348171234131}],"mesh":[{"descriptor_ui":"D000816","descriptor_name":"Aniline Mustard","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000816","descriptor_name":"Aniline Mustard","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001388","descriptor_name":"Aziridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009601","descriptor_name":"Nitroreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009601","descriptor_name":"Nitroreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057790","descriptor_name":"Staphylococcus saprophyticus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/1573406413666171129224424","doi":"https://doi.org/10.2174/1573406413666171129224424","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573406413666171129224424","pdf_url":null,"source":{"id":"https://openalex.org/S155723790","display_name":"Medicinal Chemistry","issn_l":"1573-4064","issn":["1573-4064","1875-6638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:29189173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29189173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal chemistry (Shariqah (United Arab Emirates))","raw_type":"Journal Article"},{"id":"pmh:6663e383-ca43-4940-82cd-345a1c501f2d","doi":null,"is_oa":false,"landing_page_url":"https://avesis.comu.edu.tr/publication/details/6663e383-ca43-4940-82cd-345a1c501f2d/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055198","display_name":"\u00c7anakkale Onsekiz Mart University AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:acikerisim.comu.edu.tr:20.500.12428/22869","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573406413666171129224424","pdf_url":null,"source":{"id":"https://openalex.org/S7407064138","display_name":"\u00c7anakkale Onsekiz Mart University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115953327","host_organization_name":"\u00c7anakkale Onsekiz Mart \u00dcniversitesi","host_organization_lineage":["https://openalex.org/I115953327"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2992904134","https://openalex.org/W2926519584","https://openalex.org/W3097045885","https://openalex.org/W282953606","https://openalex.org/W3183729373","https://openalex.org/W2081968568","https://openalex.org/W2086407096","https://openalex.org/W2175546597","https://openalex.org/W2016386575","https://openalex.org/W2002353412"],"abstract_inverted_index":{"BACKGROUND:":[0],"Directed":[1],"Enzyme":[2],"Prodrugs":[3],"Therapy":[4],"(DEPT)":[5],"as":[6,257,259],"an":[7,27,295],"alternative":[8],"method":[9],"against":[10],"conventional":[11],"cancer":[12,34,122,130,284,301],"treatments,":[13],"in":[14,30,57,150,178,254],"which":[15],"the":[16,97,101,112,144,165,193,208],"non-toxic":[17],"prodrugs":[18,66,141,180,213,243,285],"is":[19,273,294],"converted":[20],"to":[21],"highly":[22,233],"cytotoxic":[23,188,219],"derivative,":[24],"has":[25],"attracted":[26],"ample":[28],"attention":[29],"recent":[31],"years":[32],"for":[33,224,229,235,275,298],"therapy":[35],"studies.":[36],"OBJECTIVE:":[37],"The":[38,203],"metabolite":[39],"profile,":[40],"cell":[41,123,134,152],"cytotoxicity":[42,198],"and":[43,70,109,127,132,158,161,183,201,252,265,280,288],"molecular":[44,113,263],"modeling":[45],"interactions":[46],"of":[47,50,63,99,139,210,242,286],"a":[48,151],"series":[49,62],"nitro":[51,104,211],"benzamides":[52],"with":[53,96,164,199,221],"Ssap-NtrB":[54,77,110,245,276],"were":[55,68,87,94,148,162],"investigated":[56,72],"this":[58],"study.":[59],"METHOD:":[60],"A":[61],"nitro-substituted":[64],"benzamide":[65,105,140,212],"(1-4)":[67,214],"synthesized":[69],"firstly":[71],"their":[73],"enzymatic":[74],"reduction":[75,138,209],"by":[76,89,142,215],"(S.":[78],"saprophyticus":[79],"Nitroreductase":[80],"B)":[81],"using":[82],"HPLC":[83,266],"analysis.":[84],"Resulting":[85],"metabolites":[86,204,241],"analyzed":[88],"LC-MS/MS.":[90],"Molecular":[91],"docking":[92,264],"studies":[93],"performed":[95],"aim":[98],"investigating":[100],"relationship":[102],"between":[103],"structures":[106],"(prodrugs":[107],"1-4)":[108],"at":[111],"level.":[114],"Cell":[115,174],"viability":[116,175],"assay":[117,176],"was":[118,250],"conducted":[119],"on":[120],"two":[121],"lines,":[124],"hepatoma":[125],"(Hep3B)":[126],"colon":[128],"(HT-29)":[129],"models":[131],"healthy":[133],"model":[135],"HUVEC.":[136,202],"Upon":[137],"Ssap-NtrB,":[143,216],"corresponding":[145],"amine":[146],"effectors":[147],"tested":[149],"line":[153],"panel":[154],"comprising":[155],"PC-3,":[156],"Hep3B":[157,200,230],"HUVEC":[159,225],"cells":[160,256],"compared":[163],"established":[166],"NTR":[167,299],"substrates,":[168],"CB1954":[169,287],"(an":[170],"aziridinyl":[171],"dinitrobenzamide).":[172],"RESULTS:":[173],"resulted":[177],"while":[179],"1,":[181,278],"2":[182,279],"3":[184,272,293],"had":[185],"no":[186],"remarkable":[187],"effects,":[189,220],"prodrug":[190,271,292],"4":[191,281],"showed":[192,217],"differential":[194,218],"effect,":[195],"showing":[196],"moderate":[197,227],"that":[205,270,291],"obtained":[206],"from":[207],"none":[222],"toxic":[223,228,234,253],"cells,":[226,231],"but":[232],"PC3":[236,255],"cells.":[237],"CONCLUSION:":[238],"Amongst":[239],"all":[240],"after":[244],"reduction,":[246],"N-(2,4-":[247],"dinitrophenyl)-4-nitrobenzamide":[248],"(3)":[249],"efficient":[251,296],"comparable":[258],"CB1954.":[260],"Kinetic":[261],"parameters,":[262],"results":[267],"also":[268],"confirm":[269],"better":[274],"than":[277],"or":[282],"known":[283],"SN23862,":[289],"demonstrating":[290],"candidate":[297],"based":[300],"therapy.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-22T00:00:00"}