{"id":"https://openalex.org/W2771849404","doi":"https://doi.org/10.1002/jlb.3mr0717-307r","title":"Interferons and beyond: Induction of antiretroviral restriction factors","display_name":"Interferons and beyond: Induction of antiretroviral restriction factors","publication_year":2017,"publication_date":"2017-12-15","ids":{"openalex":"https://openalex.org/W2771849404","doi":"https://doi.org/10.1002/jlb.3mr0717-307r","mag":"2771849404","pmid":"https://pubmed.ncbi.nlm.nih.gov/29345347"},"language":"en","primary_location":{"id":"doi:10.1002/jlb.3mr0717-307r","doi":"https://doi.org/10.1002/jlb.3mr0717-307r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlb.3mr0717-307r","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064903981","display_name":"Dominik Hotter","orcid":"https://orcid.org/0000-0002-9359-9985","observed_orcids":["https://orcid.org/0000-0002-9359-9985"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Hotter","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center , Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center , Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075006919","display_name":"Frank Kirchhoff","orcid":"https://orcid.org/0000-0002-7052-2360","observed_orcids":["https://orcid.org/0000-0002-7052-2360"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank Kirchhoff","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center , Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center , Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075006919"],"corresponding_institution_ids":["https://openalex.org/I196349391"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.4775,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.41885766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"103","issue":"3","first_page":"465","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.07729999721050262,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiretroviral-restriction-factors","display_name":"antiretroviral restriction factors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.8230000138282776},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9269999861717224},{"id":"https://openalex.org/keywords/il-27","display_name":"IL-27","score":0.7409999966621399},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.578000009059906},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8968554735183716},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.4523792862892151},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4504214823246002},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4411095976829529},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43178868293762207},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2941906452178955}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jlb.3mr0717-307r","doi":"https://doi.org/10.1002/jlb.3mr0717-307r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlb.3mr0717-307r","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:29345347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29345347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W15054139","https://openalex.org/W38393735","https://openalex.org/W74613182","https://openalex.org/W1146193992","https://openalex.org/W1530235393","https://openalex.org/W1544174173","https://openalex.org/W1547593654","https://openalex.org/W1842979957","https://openalex.org/W1906529308","https://openalex.org/W1930098850","https://openalex.org/W1931451499","https://openalex.org/W1933898011","https://openalex.org/W1953974801","https://openalex.org/W1964761653","https://openalex.org/W1966060871","https://openalex.org/W1966343819","https://openalex.org/W1967475015","https://openalex.org/W1968073284","https://openalex.org/W1970051039","https://openalex.org/W1974786493","https://openalex.org/W1980192086","https://openalex.org/W1982194661","https://openalex.org/W1982280354","https://openalex.org/W1982424156","https://openalex.org/W1983150631","https://openalex.org/W1986829091","https://openalex.org/W1987009823","https://openalex.org/W1988429158","https://openalex.org/W1996463917","https://openalex.org/W1996788258","https://openalex.org/W1997345818","https://openalex.org/W1998016101","https://openalex.org/W1998646075","https://openalex.org/W1999295228","https://openalex.org/W2000177767","https://openalex.org/W2001375348","https://openalex.org/W2003823192","https://openalex.org/W2004891682","https://openalex.org/W2009047406","https://openalex.org/W2009378735","https://openalex.org/W2010458160","https://openalex.org/W2016160459","https://openalex.org/W2021736427","https://openalex.org/W2023882799","https://openalex.org/W2024380558","https://openalex.org/W2024769122","https://openalex.org/W2027844128","https://openalex.org/W2029930485","https://openalex.org/W2031013309","https://openalex.org/W2032075422","https://openalex.org/W2032523448","https://openalex.org/W2033218403","https://openalex.org/W2033464993","https://openalex.org/W2034275921","https://openalex.org/W2035509260","https://openalex.org/W2035813371","https://openalex.org/W2037105562","https://openalex.org/W2043726848","https://openalex.org/W2045958044","https://openalex.org/W2053633009","https://openalex.org/W2057023184","https://openalex.org/W2057040546","https://openalex.org/W2057592601","https://openalex.org/W2061546617","https://openalex.org/W2063763622","https://openalex.org/W2065714540","https://openalex.org/W2065958240","https://openalex.org/W2066106215","https://openalex.org/W2066829584","https://openalex.org/W2069603904","https://openalex.org/W2070661904","https://openalex.org/W2071509584","https://openalex.org/W2072517432","https://openalex.org/W2075394423","https://openalex.org/W2075426476","https://openalex.org/W2075527727","https://openalex.org/W2075699964","https://openalex.org/W2077620427","https://openalex.org/W2078646756","https://openalex.org/W2078844752","https://openalex.org/W2079671323","https://openalex.org/W2082314789","https://openalex.org/W2082510200","https://openalex.org/W2083973986","https://openalex.org/W2085237060","https://openalex.org/W2086876304","https://openalex.org/W2089307417","https://openalex.org/W2089852194","https://openalex.org/W2090001019","https://openalex.org/W2090154299","https://openalex.org/W2090822316","https://openalex.org/W2091129202","https://openalex.org/W2092397134","https://openalex.org/W2094109087","https://openalex.org/W2104816728","https://openalex.org/W2105896882","https://openalex.org/W2108256128","https://openalex.org/W2109857863","https://openalex.org/W2110382067","https://openalex.org/W2119870029","https://openalex.org/W2119951120","https://openalex.org/W2121632263","https://openalex.org/W2124058652","https://openalex.org/W2125524975","https://openalex.org/W2127862779","https://openalex.org/W2129977988","https://openalex.org/W2130320029","https://openalex.org/W2134559961","https://openalex.org/W2137051059","https://openalex.org/W2138739411","https://openalex.org/W2141199943","https://openalex.org/W2141271993","https://openalex.org/W2141819122","https://openalex.org/W2143875917","https://openalex.org/W2145848202","https://openalex.org/W2152074759","https://openalex.org/W2152327707","https://openalex.org/W2157135427","https://openalex.org/W2157911948","https://openalex.org/W2157914777","https://openalex.org/W2158029765","https://openalex.org/W2159911919","https://openalex.org/W2161190844","https://openalex.org/W2161871072","https://openalex.org/W2165042671","https://openalex.org/W2168326171","https://openalex.org/W2202193919","https://openalex.org/W2219893450","https://openalex.org/W2262818350","https://openalex.org/W2272141132","https://openalex.org/W2274212151","https://openalex.org/W2301676073","https://openalex.org/W2324845132","https://openalex.org/W2326617441","https://openalex.org/W2333588857","https://openalex.org/W2339763143","https://openalex.org/W2357078125","https://openalex.org/W2418857738","https://openalex.org/W2464834014","https://openalex.org/W2470691583","https://openalex.org/W2474576471","https://openalex.org/W2516743428","https://openalex.org/W2519084386","https://openalex.org/W2520119998","https://openalex.org/W2520600517","https://openalex.org/W2530840652","https://openalex.org/W2558825847","https://openalex.org/W2560960192","https://openalex.org/W2565680402","https://openalex.org/W2568629935","https://openalex.org/W2571660330","https://openalex.org/W2581151188","https://openalex.org/W2589048181","https://openalex.org/W2604891032","https://openalex.org/W2615346513","https://openalex.org/W2616387156","https://openalex.org/W2624493522","https://openalex.org/W2630192492","https://openalex.org/W2734545793","https://openalex.org/W2736796793","https://openalex.org/W6675725686","https://openalex.org/W6683688055"],"related_works":["https://openalex.org/W1973877707","https://openalex.org/W2041769542","https://openalex.org/W2065714540","https://openalex.org/W2967288843","https://openalex.org/W2023664577","https://openalex.org/W1981647545","https://openalex.org/W2160102865","https://openalex.org/W3082349677","https://openalex.org/W1577415107","https://openalex.org/W7098629228"],"abstract_inverted_index":{"Antiviral":[0],"restriction":[1,30,67,99,113,158],"factors":[2,31,100,159],"are":[3,91],"structurally":[4],"and":[5,42,50,85,101,129,160],"functionally":[6],"diverse":[7],"cellular":[8,107],"proteins":[9],"that":[10,60,72,110],"play":[11],"a":[12],"key":[13],"role":[14],"in":[15,37],"the":[16,53,89,96,143,150,154],"first":[17],"line":[18],"of":[19,52,75,88,94,98,149,156],"defense":[20],"against":[21,122],"viral":[22,40,123],"pathogens.":[23,55],"Although":[24],"many":[25],"cell":[26,90],"types":[27,74],"constitutively":[28],"express":[29],"at":[32],"low":[33],"levels,":[34],"their":[35,116],"induction":[36,155],"response":[38],"to":[39,103],"exposure":[41],"replication":[43],"is":[44,57],"often":[45],"required":[46],"for":[47,136,162],"potent":[48],"control":[49],"repulse":[51],"invading":[54],"It":[56],"well":[58,78],"established":[59],"type":[61],"I":[62],"IFNs":[63],"efficiently":[64,111],"induce":[65,112],"antiviral":[66,106],"factors.":[68],"Accumulating":[69],"evidence":[70],"suggests":[71],"other":[73,86],"IFN,":[76],"as":[77,79,83],"specific":[80],"cytokines,":[81],"such":[82],"IL-27,":[84],"activators":[87],"also":[92],"capable":[93],"enhancing":[95],"expression":[97],"hence":[102],"establish":[104],"an":[105],"state.":[108],"Agents":[109],"factors,":[114],"increase":[115],"activity,":[117],"and/or":[118],"render":[119],"them":[120],"resistant":[121],"antagonists":[124],"without":[125],"causing":[126],"general":[127],"inflammation":[128],"significant":[130],"side":[131],"effects":[132],"hold":[133],"some":[134,148],"promise":[135],"novel":[137],"therapeutic":[138,163],"or":[139],"preventive":[140],"strategies.":[141],"In":[142],"present":[144],"review,":[145],"we":[146],"summarize":[147],"current":[151],"knowledge":[152],"on":[153],"antiretroviral":[157],"perspectives":[161],"application.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-22T00:00:00"}
