{"id":"https://openalex.org/W2771420153","doi":"https://doi.org/10.1158/1557-3265.aacrahns17-60","title":"Abstract 60: Characterization of papillary thyroid carcinoma primary cell culture derived cancer stem-like cells","display_name":"Abstract 60: Characterization of papillary thyroid carcinoma primary cell culture derived cancer stem-like cells","publication_year":2017,"publication_date":"2017-11-30","ids":{"openalex":"https://openalex.org/W2771420153","doi":"https://doi.org/10.1158/1557-3265.aacrahns17-60","mag":"2771420153"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3265.aacrahns17-60","doi":"https://doi.org/10.1158/1557-3265.aacrahns17-60","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.aacrahns17-60","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000720953","display_name":"Alfred Simental","orcid":"https://orcid.org/0000-0003-2549-306X","observed_orcids":["https://orcid.org/0000-0003-2549-306X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred Simental","raw_affiliation_strings":["Loma Linda Unversity, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda Unversity, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650756","display_name":"Steve C. Lee","orcid":"https://orcid.org/0000-0002-4460-4303","observed_orcids":["https://orcid.org/0000-0002-4460-4303"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Lee","raw_affiliation_strings":["Loma Linda Unversity, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda Unversity, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040602779","display_name":"Pedro Andrade Filho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro A. De Andrade Filho","raw_affiliation_strings":["Loma Linda Unversity, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda Unversity, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013497697","display_name":"Nathaniel R. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel R. Peterson","raw_affiliation_strings":["Loma Linda Unversity, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda Unversity, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007644298","display_name":"Saied Mirshahidi","orcid":"https://orcid.org/0000-0003-1747-8070","observed_orcids":["https://orcid.org/0000-0003-1747-8070"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saied Mirshahidi","raw_affiliation_strings":["Loma Linda Unversity, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda Unversity, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042664406","display_name":"Penelope J. Duerksen-Hughes","orcid":"https://orcid.org/0000-0002-0998-2157","observed_orcids":["https://orcid.org/0000-0002-0998-2157"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Penelope Duerksen-Hughes","raw_affiliation_strings":["Loma Linda Unversity, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda Unversity, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111517803","display_name":"Xiangpeng Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangpeng Yuan","raw_affiliation_strings":["Loma Linda Unversity, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda Unversity, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26347476"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"23_Supplement","first_page":"60","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.08320000022649765,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":1.0},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-sphere-formation","display_name":"tumor sphere formation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.5600000023841858},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6489999890327454},{"id":"https://openalex.org/keywords/primary-culture","display_name":"primary cell culture","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cell-sorting","display_name":"cell sorting","score":0.3610000014305115},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.621999979019165},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.41100001335144043},{"id":"https://openalex.org/keywords/thyroid-cancer-biomarkers","display_name":"thyroid cancer biomarkers","score":0.5410000085830688},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.3610000014305115},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.3009999990463257},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.7176198363304138},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7128351926803589},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5971959233283997},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5545823574066162},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.5510051846504211},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5340344905853271},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4994776248931885},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4953533411026001},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.4725379943847656},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4569573402404785},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.4393928349018097},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.43763408064842224},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4230734407901764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3930296003818512},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3573395013809204},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.34873634576797485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21318241953849792},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.20285341143608093},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07233566045761108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05135369300842285},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05085766315460205},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3265.aacrahns17-60","doi":"https://doi.org/10.1158/1557-3265.aacrahns17-60","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.aacrahns17-60","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2776158501","https://openalex.org/W3040404241","https://openalex.org/W7135047826","https://openalex.org/W144094014","https://openalex.org/W1696605442","https://openalex.org/W6987794511","https://openalex.org/W7038812599","https://openalex.org/W2773815771","https://openalex.org/W2023445598","https://openalex.org/W2214549030"],"abstract_inverted_index":{"Abstract":[0],"Papillary":[1],"thyroid":[2,10,72,350],"carcinoma":[3,351],"is":[4,68,89,102],"the":[5,47,65,76,97,127,138,143,163,171,198,213,220,233,248,252,262,270,298,307,363],"most":[6,13],"frequent":[7],"type":[8],"of":[9,26,46,85,100,132,162,185,206,223,235,243,264,281,303,310,319,348,362,374],"cancer.":[11],"Although":[12],"PTC":[14,51,101,114,267],"patients":[15,27],"can":[16],"be":[17],"treated":[18],"successfully":[19],"and":[20,54,94,178,190,208,227,237,251,286,294,301,366,372,379],"have":[21],"an":[22],"excellent":[23],"prognosis,":[24],"10-20%":[25],"with":[28,197],"stage":[29],"I/II":[30],"disease":[31],"experience":[32],"recurrence,":[33],"developing":[34,59],"invasive":[35],"tumors":[36,73,135,194,245],"and/or":[37],"distant":[38],"metastases.":[39],"For":[40],"these":[41],"patients,":[42],"a":[43,83,151,202,278,288],"greater":[44],"understanding":[45],"mechanisms":[48],"that":[49,71,126,136,159,260],"govern":[50],"tumor":[52,92,140,230,299],"initiation":[53,93,300],"progression":[55,231,302],"would":[56],"aid":[57],"in":[58,155,188,195,297],"effective":[60],"therapeutic":[61,321],"strategies":[62],"to":[63,317,323],"target":[64],"disease.":[66],"It":[67],"becoming":[69],"evident":[70],"may":[74,315],"follow":[75],"cancer":[77,86,283,312,356],"stem":[78,87],"cell":[79,215,225,353],"model":[80],"(CSC),":[81],"where":[82],"population":[84,216,250],"cells":[88,112,117,129,145,165,173,200,272,285,296,314,358],"responsible":[90],"for":[91,146],"progression.":[95],"Currently,":[96],"CSC":[98,156],"biology":[99],"still":[103],"poorly":[104],"understood.":[105],"In":[106,121],"this":[107],"study,":[108,157],"we":[109],"isolated":[110],"sphere-growing":[111],"from":[113,268],"specimen-derived":[115],"primary":[116,352],"using":[118],"serum-free":[119],"culture.":[120],"vivo":[122,196],"transplantation":[123],"analysis":[124],"revealed":[125,158,256,287],"sphere":[128,144,164,172,214,249,271],"were":[130,174,273],"capable":[131],"generating":[133,191],"xenograft":[134,193,229,244],"recapitulated":[137,261],"original":[139,265],"phenotypes.":[141],"Analyzing":[142],"aldehyde":[147],"dehydrogenase":[148],"(ALDH)":[149],"expression,":[150],"marker":[152],"commonly":[153],"used":[154],"around":[160],"half":[161],"did":[166],"not":[167],"express":[168],"ALDH.":[169],"When":[170],"sorted":[175],"into":[176],"ALDH-":[177,236,282,293,311],"ALDH+":[179,199,238,295],"subpopulations,":[180,254],"both":[181],"subpopulations":[182,234],"demonstrated":[183,219],"capabilities":[184],"re-initiating":[186],"subspheres":[187],"vitro":[189],"serial":[192],"exhibiting":[201],"slightly":[203],"higher":[204,221],"efficiency":[205],"sphere-formation":[207],"cancer-initiation.":[209],"Of":[210],"major":[211],"importance,":[212],"without":[217],"sorting":[218],"levels":[222],"cancer-initiating":[224],"frequency,":[226],"quicker":[228],"than":[232],"cells.":[239],"Furthermore,":[240],"histologic":[241],"investigation":[242],"generated":[246],"by":[247],"sphere-sorted":[253],"respectively,":[255],"similar":[257],"morphological":[258],"features":[259],"characteristics":[263],"human":[266],"which":[269],"isolated.":[274],"Our":[275],"data":[276],"established":[277],"vital":[279],"role":[280],"stem-like":[284,313,357],"potential":[289],"synergistic":[290],"activity":[291],"between":[292],"PTC.":[304,326],"Further":[305],"exploring":[306],"biological":[308],"property":[309],"lead":[316],"development":[318],"novel":[320],"solutions":[322],"treating":[324],"aggressive":[325],"Citation":[327],"Format:":[328],"Alfred":[329],"Simental,":[330],"Steve":[331],"Lee,":[332],"Pedro":[333],"A.":[334],"De":[335],"Andrade":[336],"Filho,":[337],"Nathaniel":[338],"R.":[339],"Peterson,":[340],"Saied":[341],"Mirshahidi,":[342],"Penelope":[343],"Duerksen-Hughes,":[344],"Xiangpeng":[345],"Yuan.":[346],"Characterization":[347],"papillary":[349],"culture":[354],"derived":[355],"[abstract].":[359],"In:":[360],"Proceedings":[361],"AACR-AHNS":[364],"Head":[365],"Neck":[367],"Cancer":[368,392],"Conference:":[369],"Optimizing":[370],"Survival":[371],"Quality":[373],"Life":[375],"through":[376],"Basic,":[377],"Clinical,":[378],"Translational":[380],"Research;":[381],"April":[382],"23-25,":[383],"2017;":[384],"San":[385],"Diego,":[386],"CA.":[387],"Philadelphia":[388],"(PA):":[389],"AACR;":[390],"Clin":[391],"Res":[393],"2017;23(23_Suppl):Abstract":[394],"nr":[395],"60.":[396]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-12-22T00:00:00"}
