{"id":"https://openalex.org/W2771323587","doi":"https://doi.org/10.1158/1557-3265.aacrahns17-62","title":"Abstract 62: Loss of PERP p53/p63 target gene may indicate tumorigenesis at the margin and local recurrence","display_name":"Abstract 62: Loss of PERP p53/p63 target gene may indicate tumorigenesis at the margin and local recurrence","publication_year":2017,"publication_date":"2017-11-30","ids":{"openalex":"https://openalex.org/W2771323587","doi":"https://doi.org/10.1158/1557-3265.aacrahns17-62","mag":"2771323587"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3265.aacrahns17-62","doi":"https://doi.org/10.1158/1557-3265.aacrahns17-62","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.aacrahns17-62","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112391474","display_name":"Amanda L. Simmons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Simmons","raw_affiliation_strings":["1Stanford University, Stanford, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stanford University, Stanford, CA,","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067230315","display_name":"Christina S. Kong","orcid":"https://orcid.org/0000-0003-2098-6842","observed_orcids":["https://orcid.org/0000-0003-2098-6842"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Kong","raw_affiliation_strings":["1Stanford University, Stanford, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stanford University, Stanford, CA,","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042159358","display_name":"Rie von Eyben","orcid":"https://orcid.org/0000-0003-2355-8667","observed_orcids":["https://orcid.org/0000-0003-2355-8667"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rie von Eyben","raw_affiliation_strings":["1Stanford University, Stanford, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stanford University, Stanford, CA,","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019574388","display_name":"Laura Donatella Attardi","orcid":"https://orcid.org/0000-0003-1782-9045","observed_orcids":["https://orcid.org/0000-0003-1782-9045"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Attardi","raw_affiliation_strings":["1Stanford University, Stanford, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stanford University, Stanford, CA,","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101105161","display_name":"Xiaohui Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohui Ma","raw_affiliation_strings":["2Louisiana State University Health Science Ctr., Shreveport, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Louisiana State University Health Science Ctr., Shreveport, LA","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013860869","display_name":"Quynh\u2010Thu Le","orcid":"https://orcid.org/0000-0002-3682-1439","observed_orcids":["https://orcid.org/0000-0002-3682-1439"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quynh-Thu Le","raw_affiliation_strings":["1Stanford University, Stanford, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stanford University, Stanford, CA,","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076122892","display_name":"Cherie\u2010Ann O. Nathan","orcid":"https://orcid.org/0000-0001-7386-318X","observed_orcids":["https://orcid.org/0000-0001-7386-318X"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cherie-Ann Nathan","raw_affiliation_strings":["2Louisiana State University Health Science Ctr., Shreveport, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Louisiana State University Health Science Ctr., Shreveport, LA","institution_ids":["https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"23_Supplement","first_page":"62","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perp","display_name":"PERP","score":0.9789999723434448},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8240000009536743},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.8199999928474426},{"id":"https://openalex.org/keywords/p53-target-genes","display_name":"p53 target genes","score":0.6669999957084656},{"id":"https://openalex.org/keywords/desmosomes","display_name":"desmosomes","score":0.5960000157356262},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6570000052452087},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7889999747276306},{"id":"https://openalex.org/keywords/competing-risk-analysis","display_name":"competing risk analysis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.640999972820282},{"id":"https://openalex.org/keywords/hypopharyngeal-cancer","display_name":"hypopharyngeal cancer","score":0.9549999833106995},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6302856206893921},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6196744441986084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.581878125667572},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.5670197010040283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5150958895683289},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5090000629425049},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.49808454513549805},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.4877982437610626},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.44625645875930786},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3443233370780945},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30113059282302856},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22092676162719727},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3265.aacrahns17-62","doi":"https://doi.org/10.1158/1557-3265.aacrahns17-62","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.aacrahns17-62","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3042154842","https://openalex.org/W2148591855","https://openalex.org/W2472579680","https://openalex.org/W2139599388","https://openalex.org/W2350065012","https://openalex.org/W2740640198","https://openalex.org/W2363387910","https://openalex.org/W1995268052","https://openalex.org/W4410051661","https://openalex.org/W3021684136"],"abstract_inverted_index":{"Abstract":[0],"Objectives:":[1],"PERP":[2,27,54,72,112,141,189,225,234,256,265,289,322,331,360,410],"(p53":[3],"apoptosis":[4],"effector":[5],"related":[6],"to":[7,10,30,163,228,259,325,367,383],"PMP22)":[8],"localizes":[9],"the":[11,69,99,111,119,149,158,209,212,223,232,240,243,254,263,271,305,309,320,329,355,363,418,427],"desmosomal":[12],"adhesion":[13],"complexes":[14],"and":[15,40,46,81,96,106,188,298,348,420,430,436,443],"is":[16],"involved":[17],"in":[18,36,44,59,91,118,148,196,293,296,301,377,386],"suppressing":[19],"squamous":[20],"cell":[21],"carcinoma":[22],"(SCC)":[23],"development.":[24],"Loss":[25,408],"of":[26,32,63,71,83,102,123,131,152,160,217,248,314,357,374,409,426,438],"expression":[28,114,142,190,290],"leads":[29],"destabilization":[31],"desmosome":[33],"complexes,":[34],"resulting":[35],"enhanced":[37],"tumor":[38,80],"aggressiveness":[39],"worse":[41,342],"local":[42,84,186,218,249,315,375,421],"control":[43],"head":[45],"neck":[47],"SCC":[48],"(HNSCC).":[49],"We":[50,108],"had":[51],"previously":[52,109],"examined":[53,110],"loss":[55,70,356,361],"at":[56,362,417],"surgical":[57,120,150,364],"margins":[58,122,151,365],"a":[60,76,197,204,229,260,326,339,371,387],"small":[61],"cohort":[62,95,129],"HNSCC":[64,125,168],"patients.":[65,126,154,303],"Results":[66],"suggested":[67],"that":[68],"may":[73,414],"serve":[74],"as":[75,203],"marker":[77],"for":[78,179,222,231,253,262,282,319,328,341],"persistent":[79],"predictive":[82],"relapse.":[85],"Here":[86],"we":[87,156,278],"validate":[88],"these":[89,153],"findings":[90],"an":[92],"independent":[93],"patient":[94],"report":[97],"on":[98],"combined":[100,157,279,287],"results":[101,159,272,381],"both":[103,161],"groups.":[104],"Materials":[105],"Methods:":[107],"protein":[113],"by":[115,146],"immunohistochemistry":[116],"(IHC)":[117],"mucosal":[121],"17":[124],"The":[127,183],"validation":[128,241],"consists":[130],"31":[132],"patients":[133,166],"(15":[134],"oral":[135,170,175],"cavity,":[136,171],"11":[137],"hypopharynx,":[138,173],"5":[139],"larynx).":[140],"was":[143,194,220,251,291,317,337],"similarly":[144],"assessed":[145],"IHC":[147],"Finally,":[155],"groups":[162],"yield":[164],"48":[165],"with":[167,201,354,370],"(18":[169],"12":[172],"4":[174],"pharynx,":[176],"14":[177],"larynx)":[178],"competing":[180,198,205],"risk":[181,199,373],"analysis.":[182],"relationship":[184],"between":[185,275],"relapse":[187,219,250,316],"(positive":[191],"or":[192],"negative)":[193],"analyzed":[195],"model":[200],"death":[202],"risk.":[206],"Results:":[207],"In":[208,239,285],"initial":[210],"cohort,":[211,242],"2-year":[213,244,310],"cumulative":[214,245,311],"incidence":[215,246,312],"rate":[216,247,313],"37.5%":[221],"negative":[224,255,292,321],"group":[226,235,257,266,323,332],"compared":[227,258,324],"20%":[230],"positive":[233,264,295,330],"(p":[236,267,333,345,351],"=":[237,268,334,346,352],"0.177).":[238],"50%":[252],"15%":[261],"0.063).":[269],"Since":[270],"were":[273],"similar":[274],"two":[276],"groups,":[277],"them":[280],"together":[281],"additional":[283],"analyses.":[284],"this":[286],"dataset,":[288],"18,":[294],"26,":[297],"not":[299],"assessable":[300],"three":[302],"Of":[304],"45":[306],"analyzable":[307],"patients,":[308],"44.4%":[318],"16.4%":[327],"0.010).":[335],"There":[336],"also":[338],"trend":[340],"progression-free":[343],"survival":[344,350],"0.059)":[347],"overall":[349],"0.085)":[353],"PERP.":[358],"Conclusions:":[359],"appears":[366],"be":[368,384],"associated":[369],"higher":[372],"recurrence":[376,422],"HNSCC.":[378],"These":[379],"promising":[380],"need":[382],"tested":[385],"larger":[388],"prospective":[389],"study.":[390],"Citation":[391],"Format:":[392],"Amanda":[393],"Simmons,":[394],"Christina":[395],"Kong,":[396],"Rie":[397],"von":[398],"Eyben,":[399],"Laura":[400],"Attardi,":[401],"Xiaohui":[402],"Ma,":[403],"Quynh-Thu":[404],"Le,":[405],"Cherie-Ann":[406],"Nathan.":[407],"p53/p63":[411],"target":[412],"gene":[413],"indicate":[415],"tumorigenesis":[416],"margin":[419],"[abstract].":[423],"In:":[424],"Proceedings":[425],"AACR-AHNS":[428],"Head":[429],"Neck":[431],"Cancer":[432,456],"Conference:":[433],"Optimizing":[434],"Survival":[435],"Quality":[437],"Life":[439],"through":[440],"Basic,":[441],"Clinical,":[442],"Translational":[444],"Research;":[445],"April":[446],"23-25,":[447],"2017;":[448],"San":[449],"Diego,":[450],"CA.":[451],"Philadelphia":[452],"(PA):":[453],"AACR;":[454],"Clin":[455],"Res":[457],"2017;23(23_Suppl):Abstract":[458],"nr":[459],"62.":[460]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-12-22T00:00:00"}
