{"id":"https://openalex.org/W2771320528","doi":"https://doi.org/10.4049/jimmunol.196.supp.63.8","title":"Identification of an amphipathic helix within IFITM3 that promotes inhibition of influenza virus","display_name":"Identification of an amphipathic helix within IFITM3 that promotes inhibition of influenza virus","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2771320528","doi":"https://doi.org/10.4049/jimmunol.196.supp.63.8","mag":"2771320528"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.196.supp.63.8","doi":"https://doi.org/10.4049/jimmunol.196.supp.63.8","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.196.supp.63.8","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086228051","display_name":"Nicholas M. Chesarino","orcid":"https://orcid.org/0000-0002-3582-8508","observed_orcids":["https://orcid.org/0000-0002-3582-8508"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas M Chesarino","raw_affiliation_strings":["Ohio State Univ. Col. of Med","1Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State Univ. Col. of Med","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021110733","display_name":"Temet M. McMichael","orcid":"https://orcid.org/0000-0002-5062-8125","observed_orcids":["https://orcid.org/0000-0002-5062-8125"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Temet M McMichael","raw_affiliation_strings":["Ohio State Univ. Col. of Med","1Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State Univ. Col. of Med","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120017417","display_name":"Lizhi Zhang","orcid":"https://orcid.org/0000-0002-6842-9167","observed_orcids":["https://orcid.org/0000-0002-6842-9167"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lizhi Zhang","raw_affiliation_strings":["Ohio State Univ. Col. of Med","1Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State Univ. Col. of Med","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082084895","display_name":"Matthew J. Davis","orcid":"https://orcid.org/0000-0002-3410-7100","observed_orcids":["https://orcid.org/0000-0002-3410-7100"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J Davis","raw_affiliation_strings":["Ohio State Univ. Col. of Med","1Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State Univ. Col. of Med","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091742838","display_name":"Victoria Soewarna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Soewarna","raw_affiliation_strings":["Ohio State Univ. Col. of Med","1Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State Univ. Col. of Med","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067564248","display_name":"Rachel F Doering","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel F Doering","raw_affiliation_strings":["Ohio State Univ. Col. of Med","1Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State Univ. Col. of Med","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042366783","display_name":"Jacob S. Yount","orcid":"https://orcid.org/0000-0002-6128-4575","observed_orcids":["https://orcid.org/0000-0002-6128-4575"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob S Yount","raw_affiliation_strings":["Ohio State Univ. Col. of Med","1Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State Univ. Col. of Med","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"196","issue":"1_Supplement","first_page":"63.8","last_page":"63.8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ifitm3","display_name":"IFITM3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amphipathic-helix","display_name":"amphipathic helix","score":0.9419999718666077},{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.9150000214576721},{"id":"https://openalex.org/keywords/viral-fusion-inhibition","display_name":"viral fusion inhibition","score":0.5619999766349792},{"id":"https://openalex.org/keywords/endosomal-membrane","display_name":"endosomal membrane","score":0.5960000157356262},{"id":"https://openalex.org/keywords/interferon-inducible-proteins","display_name":"interferon-induced proteins","score":0.7450000047683716},{"id":"https://openalex.org/keywords/antiviral-mechanism","display_name":"antiviral mechanism","score":0.734000027179718},{"id":"https://openalex.org/keywords/alanine-scanning","display_name":"alanine scanning","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6764015555381775},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.5828558206558228},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5791475176811218},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5609703063964844},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5368175506591797},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5063923597335815},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4802320599555969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4727626442909241},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4650273323059082},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46272483468055725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4547027051448822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.449546754360199},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4250966012477875},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.366113543510437},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.22421181201934814},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1775597631931305},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08945801854133606},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07217618823051453},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.196.supp.63.8","doi":"https://doi.org/10.4049/jimmunol.196.supp.63.8","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.196.supp.63.8","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2745504864","https://openalex.org/W4319918996","https://openalex.org/W4307248095","https://openalex.org/W3130913383","https://openalex.org/W4391657840","https://openalex.org/W3130763788","https://openalex.org/W4286515857","https://openalex.org/W2028170369","https://openalex.org/W4230077171","https://openalex.org/W3135661508"],"abstract_inverted_index":{"Abstract":[0],"Interferon-induced":[1],"transmembrane":[2],"protein":[3],"3":[4],"(IFITM3)":[5],"inhibits":[6],"influenza":[7,94],"virus":[8,95],"fusion":[9],"with":[10,70,93,184],"endosomes":[11],"by":[12],"altering":[13,78],"cellular":[14],"membrane":[15,79],"properties":[16],"through":[17],"mechanisms":[18],"that":[19,33,61,83,107,158,166,193],"are":[20],"largely":[21],"uncharacterized.":[22],"In":[23],"order":[24],"to":[25,36,114,188],"identify":[26],"regions":[27],"of":[28,39,58,66,74,89,110,123,132,139,150,201],"secondary":[29],"structure":[30],"within":[31],"IFITM3":[32,90,194],"may":[34],"contribute":[35],"its":[37],"mechanism":[38,198],"action,":[40],"we":[41,52,81,179],"performed":[42],"structural":[43],"predictions":[44],"using":[45],"the":[46,71,108,124,129,133,147,151,190],"I-TASSER":[47],"and":[48,119],"PSSpred":[49],"algorithms.":[50],"Insterestingly,":[51],"identified":[53],"a":[54,86,97],"10-amino":[55],"acid":[56,156,162],"region":[57,170],"likely":[59],"helicity":[60],"possesses":[62],"an":[63,196],"amphipathic":[64,75],"distribution":[65],"amino":[67,155],"acids.":[68],"Consistent":[69],"known":[72],"role":[73],"helices":[76],"in":[77,146,168,174],"properties,":[80],"observed":[82],"cells":[84,102],"expressing":[85,103],"helix-deleted":[87],"mutant":[88],"were":[91],"infected":[92],"at":[96],"4-fold":[98],"higher":[99],"rate":[100],"than":[101],"WT":[104],"IFITM3.":[105],"Confirming":[106],"amphipathicity":[109,167],"this":[111,169],"helix":[112,134],"contributes":[113],"antiviral":[115,137],"activity,":[116],"single,":[117],"double":[118],"triple":[120],"alanine":[121],"mutations":[122,145],"three":[125],"residues":[126],"making":[127],"up":[128],"hydrophilic":[130],"face":[131,149],"progressively":[135],"decreased":[136],"activity":[138],"IFITM3,":[140],"as":[141],"did":[142],"single":[143,154],"polar":[144],"hydrophobic":[148],"helix,":[152],"or":[153],"insertions":[157],"disrupted":[159],"amphipathicity.":[160],"Amino":[161],"sequence":[163],"alignments":[164],"suggest":[165],"is":[171],"highly":[172],"conserved":[173],"IFITMs":[175],"throughout":[176],"evolution.":[177],"Overall,":[178],"utilized":[180],"bioinformatics":[181],"methods":[182],"coupled":[183],"functional":[185],"infectivity":[186],"assays":[187],"provide":[189],"first":[191],"evidence":[192],"utilizes":[195],"amphipathicity-based":[197],"for":[199],"inhibition":[200],"viruses.":[202]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-12-22T00:00:00"}