{"id":"https://openalex.org/W2770861237","doi":"https://doi.org/10.3727/096504017x15105708598531","title":"The Long Noncoding RNA HOTAIR Promotes Colorectal Cancer Progression by Sponging miR-197","display_name":"The Long Noncoding RNA HOTAIR Promotes Colorectal Cancer Progression by Sponging miR-197","publication_year":2017,"publication_date":"2017-11-14","ids":{"openalex":"https://openalex.org/W2770861237","doi":"https://doi.org/10.3727/096504017x15105708598531","mag":"2770861237","pmid":"https://pubmed.ncbi.nlm.nih.gov/29137688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7844719"},"language":"en","primary_location":{"id":"doi:10.3727/096504017x15105708598531","doi":"https://doi.org/10.3727/096504017x15105708598531","is_oa":true,"landing_page_url":"https://doi.org/10.3727/096504017x15105708598531","pdf_url":null,"source":{"id":"https://openalex.org/S146643948","display_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","issn_l":"0965-0407","issn":["0965-0407","1555-3906"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4360969325","host_organization_name":"Cognizant Communication Corporation","host_organization_lineage":["https://openalex.org/P4360969325"],"host_organization_lineage_names":["Cognizant Communication Corporation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3727/096504017x15105708598531","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110643368","display_name":"Xinyang Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162087","display_name":"Affiliated Hospital of Jining Medical University","ror":"https://ror.org/05e8kbn88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyang Lu","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China","institution_ids":["https://openalex.org/I4210162087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415103","display_name":"Zhiqiang Liu","orcid":"https://orcid.org/0000-0002-7579-6280","observed_orcids":["https://orcid.org/0000-0002-7579-6280"]},"institutions":[{"id":"https://openalex.org/I4210162087","display_name":"Affiliated Hospital of Jining Medical University","ror":"https://ror.org/05e8kbn88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Liu","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China","institution_ids":["https://openalex.org/I4210162087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018973067","display_name":"Xiaofei Ning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162087","display_name":"Affiliated Hospital of Jining Medical University","ror":"https://ror.org/05e8kbn88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofei Ning","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China","institution_ids":["https://openalex.org/I4210162087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043821261","display_name":"Lunhua Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162087","display_name":"Affiliated Hospital of Jining Medical University","ror":"https://ror.org/05e8kbn88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lunhua Huang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China","institution_ids":["https://openalex.org/I4210162087"]}]},{"author_position":"last","author":{"id":null,"display_name":"Biao Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162087","display_name":"Affiliated Hospital of Jining Medical University","ror":"https://ror.org/05e8kbn88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biao Jiang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical UniversityJiningP.R. China","institution_ids":["https://openalex.org/I4210162087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210162087"],"apc_list":null,"apc_paid":null,"fwci":2.2199,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.87967588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"26","issue":"3","first_page":"473","last_page":"481"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hotair","display_name":"HOTAIR","score":0.9980000257492065},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.984000027179718},{"id":"https://openalex.org/keywords/mir-197","display_name":"miR-197","score":0.9860000014305115},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7170000076293945},{"id":"https://openalex.org/keywords/microrna-sponging","display_name":"microRNA sponging","score":0.8259999752044678},{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"competing endogenous RNA","score":0.7770000100135803},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.921999990940094},{"id":"https://openalex.org/keywords/oncogenic-role","display_name":"oncogenic role","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2781128886","wikidata":"https://www.wikidata.org/wiki/Q18062498","display_name":"HOTAIR","level":5,"score":0.9900882840156555},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.7314699292182922},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7181093096733093},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7018465995788574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6149711012840271},{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.6145110130310059},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6115283370018005},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5349276065826416},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5209599733352661},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5142573714256287},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41601285338401794},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.35420355200767517},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.26778069138526917},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26218271255493164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14141568541526794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09713634848594666}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3727/096504017x15105708598531","doi":"https://doi.org/10.3727/096504017x15105708598531","is_oa":true,"landing_page_url":"https://doi.org/10.3727/096504017x15105708598531","pdf_url":null,"source":{"id":"https://openalex.org/S146643948","display_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","issn_l":"0965-0407","issn":["0965-0407","1555-3906"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4360969325","host_organization_name":"Cognizant Communication Corporation","host_organization_lineage":["https://openalex.org/P4360969325"],"host_organization_lineage_names":["Cognizant Communication Corporation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7844719","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7844719","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Res","raw_type":"Text"},{"id":"pmid:29137688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29137688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3727/096504017x15105708598531","doi":"https://doi.org/10.3727/096504017x15105708598531","is_oa":true,"landing_page_url":"https://doi.org/10.3727/096504017x15105708598531","pdf_url":null,"source":{"id":"https://openalex.org/S146643948","display_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","issn_l":"0965-0407","issn":["0965-0407","1555-3906"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4360969325","host_organization_name":"Cognizant Communication Corporation","host_organization_lineage":["https://openalex.org/P4360969325"],"host_organization_lineage_names":["Cognizant Communication Corporation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W190590421","https://openalex.org/W644811534","https://openalex.org/W1723027875","https://openalex.org/W1963853602","https://openalex.org/W1969328947","https://openalex.org/W1975167804","https://openalex.org/W1990139919","https://openalex.org/W1994846342","https://openalex.org/W1998477030","https://openalex.org/W2003723466","https://openalex.org/W2066800750","https://openalex.org/W2067533524","https://openalex.org/W2070777085","https://openalex.org/W2078590818","https://openalex.org/W2087377443","https://openalex.org/W2090957074","https://openalex.org/W2105512929","https://openalex.org/W2106787323","https://openalex.org/W2112087504","https://openalex.org/W2116186603","https://openalex.org/W2116236561","https://openalex.org/W2127744901","https://openalex.org/W2130720854","https://openalex.org/W2136222002","https://openalex.org/W2136943892","https://openalex.org/W2146573461","https://openalex.org/W2148050145","https://openalex.org/W2148629421","https://openalex.org/W2153268494","https://openalex.org/W2155044281","https://openalex.org/W2171598473","https://openalex.org/W2190984842","https://openalex.org/W2334588356","https://openalex.org/W2594271137","https://openalex.org/W2612346955","https://openalex.org/W2619301319"],"related_works":["https://openalex.org/W3027730324","https://openalex.org/W2806686587","https://openalex.org/W2003599023","https://openalex.org/W3029925662","https://openalex.org/W2096858457","https://openalex.org/W2366917385","https://openalex.org/W2767775057","https://openalex.org/W2985160043","https://openalex.org/W3010540654","https://openalex.org/W2519906560"],"abstract_inverted_index":{"The":[0],"long":[1],"noncoding":[2],"RNA":[3,7],"HOX":[4],"transcript":[5],"antisense":[6],"(HOTAIR)":[8],"has":[9,133],"been":[10],"found":[11,75],"to":[12],"be":[13,46],"overexpressed":[14],"in":[15,21,48,61,69,72,82,112,115,155],"many":[16],"human":[17],"malignancies":[18],"and":[19,24,59,71,86,105,110,114,145,158],"involved":[20,47],"tumor":[22,34],"progression":[23,63,121],"metastasis.":[25],"Although":[26],"the":[27,52,55,62,90,120,156],"downstream":[28],"target":[29],"through":[30,138],"which":[31,139],"HOTAIR":[32,58,77,101,118,140,154],"modulates":[33],"metastasis":[35],"is":[36],"not":[37],"well":[38],"known,":[39],"evidence":[40],"suggests":[41],"that":[42,76,100],"microRNA-197":[43],"(miR-197)":[44],"might":[45],"this":[49],"event.":[50],"In":[51,88],"present":[53],"study,":[54],"significance":[56],"of":[57,64,92,122,153,160],"miR-197":[60,93],"colorectal":[65,83,123,161],"cancer":[66,84,124],"was":[67,79,94],"detected":[68],"vitro":[70,113],"vivo.":[73,116],"We":[74,97],"expression":[78,91],"significantly":[80],"increased":[81],"cells":[85],"tissues.":[87],"contrast,":[89],"obviously":[95],"decreased.":[96],"further":[98],"demonstrated":[99],"knockdown":[102],"promoted":[103],"apoptosis":[104],"inhibited":[106],"cell":[107],"proliferation,":[108],"migration,":[109],"invasion":[111],"Moreover,":[117],"modulated":[119],"by":[125],"competitively":[126],"binding":[127],"miR-197.":[128],"Taken":[129],"together,":[130],"our":[131],"study":[132],"identified":[134],"a":[135,147],"novel":[136],"pathway":[137],"exerts":[141],"its":[142],"oncogenic":[143],"role":[144],"provided":[146],"molecular":[148],"basis":[149],"for":[150],"potential":[151],"applications":[152],"prognosis":[157],"treatment":[159],"cancer.":[162]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-12-04T00:00:00"}