{"id":"https://openalex.org/W2770698352","doi":"https://doi.org/10.1158/2326-6066.cir-17-0201","title":"Impact of Tumor Purity on Immune Gene Expression and Clustering Analyses across Multiple Cancer Types","display_name":"Impact of Tumor Purity on Immune Gene Expression and Clustering Analyses across Multiple Cancer Types","publication_year":2017,"publication_date":"2017-11-15","ids":{"openalex":"https://openalex.org/W2770698352","doi":"https://doi.org/10.1158/2326-6066.cir-17-0201","mag":"2770698352","pmid":"https://pubmed.ncbi.nlm.nih.gov/29141981"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.cir-17-0201","doi":"https://doi.org/10.1158/2326-6066.cir-17-0201","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-17-0201","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/167162","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012207088","display_name":"Je\u2010Keun Rhee","orcid":"https://orcid.org/0000-0003-4811-8895","observed_orcids":["https://orcid.org/0000-0003-4811-8895"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Je-Keun Rhee","raw_affiliation_strings":["1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017031673","display_name":"Yu Chae Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31766871","display_name":"Sookmyung Women's University","ror":"https://ror.org/00vvvt117","country_code":"KR","type":"education","lineage":["https://openalex.org/I31766871"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu Chae Jung","raw_affiliation_strings":["3Department of IT Engineering, Sookmyung Women's University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of IT Engineering, Sookmyung Women's University, Seoul, Korea","institution_ids":["https://openalex.org/I31766871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110968210","display_name":"Kyu Ryung Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyu Ryung Kim","raw_affiliation_strings":["1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090860121","display_name":"Jinseon Yoo","orcid":"https://orcid.org/0000-0002-3210-6374","observed_orcids":["https://orcid.org/0000-0002-3210-6374"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinseon Yoo","raw_affiliation_strings":["1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033477135","display_name":"Jeeyoon Kim","orcid":"https://orcid.org/0000-0003-3279-9286","observed_orcids":["https://orcid.org/0000-0003-3279-9286"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeeyoon Kim","raw_affiliation_strings":["1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104273229","display_name":"Yongjae Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Jae Lee","raw_affiliation_strings":["1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076585994","display_name":"Yoon Ho Ko","orcid":"https://orcid.org/0000-0002-2506-3740","observed_orcids":["https://orcid.org/0000-0002-2506-3740"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon Ho Ko","raw_affiliation_strings":["4Division of Medical Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Medical Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080937552","display_name":"Han Hong Lee","orcid":"https://orcid.org/0000-0002-7541-8490","observed_orcids":["https://orcid.org/0000-0002-7541-8490"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Han Hong Lee","raw_affiliation_strings":["5Division of Gastrointestinal Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Division of Gastrointestinal Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064697305","display_name":"Byoung Chul Cho","orcid":"https://orcid.org/0000-0002-5562-270X","observed_orcids":["https://orcid.org/0000-0002-5562-270X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung Chul Cho","raw_affiliation_strings":["6Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100719073","display_name":"Tae\u2010Min Kim","orcid":"https://orcid.org/0000-0002-7993-9701","observed_orcids":["https://orcid.org/0000-0002-7993-9701"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae-Min Kim","raw_affiliation_strings":["1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2406,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.89087495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"87","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.11959999799728394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-purity","display_name":"tumor purity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-related-gene-expression","display_name":"immune gene expression","score":0.8149999976158142},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.6740000247955322},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mutation-burden","display_name":"mutational burden","score":0.6460000276565552},{"id":"https://openalex.org/keywords/gene-clustering","display_name":"gene clustering","score":0.6769999861717224},{"id":"https://openalex.org/keywords/molecular-taxonomy","display_name":"molecular taxonomy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/mesenchymal-subtype","display_name":"mesenchymal subtype","score":0.7680000066757202},{"id":"https://openalex.org/keywords/classical-subtype","display_name":"classical subtype","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6566382646560669},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5636652708053589},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5184288024902344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47483474016189575},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4652486741542816},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4569743871688843},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4236065745353699},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.41531726717948914},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4004560112953186},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39203697443008423},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3826400935649872},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2724211513996124},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12539958953857422},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09523546695709229}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/2326-6066.cir-17-0201","doi":"https://doi.org/10.1158/2326-6066.cir-17-0201","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-17-0201","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},{"id":"pmid:29141981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29141981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology research","raw_type":"Journal Article"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/167162","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/167162","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/167162","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/167162","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/167162","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/167162","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3926276534","display_name":null,"funder_award_id":"HI15C3224","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G4579939637","display_name":null,"funder_award_id":"HI15C1578, HI15C1592, and HI15C3224","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G6628724354","display_name":null,"funder_award_id":"HI15C1578","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"}],"funders":[{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2770698352.pdf","grobid_xml":"https://content.openalex.org/works/W2770698352.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1497915798","https://openalex.org/W1940241680","https://openalex.org/W1984236815","https://openalex.org/W1985987855","https://openalex.org/W2004630197","https://openalex.org/W2028433016","https://openalex.org/W2033751993","https://openalex.org/W2035252444","https://openalex.org/W2049553585","https://openalex.org/W2062265555","https://openalex.org/W2076948707","https://openalex.org/W2077059059","https://openalex.org/W2081319583","https://openalex.org/W2104347254","https://openalex.org/W2104885590","https://openalex.org/W2107429737","https://openalex.org/W2109485845","https://openalex.org/W2115462905","https://openalex.org/W2122863289","https://openalex.org/W2124427232","https://openalex.org/W2128035403","https://openalex.org/W2129463704","https://openalex.org/W2130410032","https://openalex.org/W2130430382","https://openalex.org/W2137085845","https://openalex.org/W2150633526","https://openalex.org/W2161289668","https://openalex.org/W2185207072","https://openalex.org/W2254576822","https://openalex.org/W2288153033","https://openalex.org/W2332016763","https://openalex.org/W2461410982","https://openalex.org/W2507880739","https://openalex.org/W2550990550","https://openalex.org/W2582414407","https://openalex.org/W2610509384"],"related_works":["https://openalex.org/W2185207072","https://openalex.org/W4364359655","https://openalex.org/W4281656296","https://openalex.org/W2998649814","https://openalex.org/W4282964991","https://openalex.org/W3157660871","https://openalex.org/W3044054981","https://openalex.org/W4244357696","https://openalex.org/W6958469691","https://openalex.org/W2887311561"],"abstract_inverted_index":{"Abstract":[0],"Surgical":[1],"archives":[2],"of":[3,11,26,35,87,101,136,147,150],"tumor":[4,36,43,49,53,82,110,131,142,158,162,173,186,191,207,214],"specimens":[5,50],"are":[6],"often":[7],"impure.":[8],"The":[9,57,85],"presence":[10],"RNA":[12],"transcripts":[13],"from":[14,140],"nontumor":[15],"cells,":[16,22],"such":[17,230],"as":[18,231,234,236],"immune":[19,94,102,119],"and":[20,42,71,78,92,122,188,198,204,227,239],"stromal":[21],"can":[23],"impede":[24],"analyses":[25],"cancer":[27],"expression":[28,40,86,121,137,226],"profiles.":[29],"To":[30],"systematically":[31],"analyze":[32],"the":[33,38,81,99,116,126,134,196,222],"impact":[34,168],"purity,":[37,83,159,187,208],"gene":[39,120,151,170,225,237],"profiles":[41],"purities":[44],"were":[45,74,181,201],"obtained":[46,139],"for":[47,130,157,178,183,189],"7,794":[48],"across":[51,172],"21":[52],"types":[54],"(available":[55],"in":[56,69,90,133,220],"Cancer":[58,242],"Genome":[59],"Atlas":[60],"consortium).":[61],"First,":[62],"we":[63],"observed":[64],"that":[65,161,213],"genes":[66,88,177,194],"with":[67,80,98,109,153,185,206],"roles":[68],"immunity":[70],"oxidative":[72],"phosphorylation":[73],"significantly":[75],"inversely":[76,107,202],"correlated":[77,79,108,203,205],"respectively.":[84,209],"implicated":[89],"immunotherapy":[91],"specific":[93],"cell":[95,103],"genes,":[96],"along":[97],"abundance":[100],"infiltrates,":[104],"was":[105],"substantially":[106],"purity.":[111],"This":[112],"relationship":[113],"may":[114,164],"explain":[115],"correlation":[117,184,223],"between":[118,224],"mutation":[123,232],"burden,":[124,233],"highlighting":[125],"need":[127],"to":[128],"account":[129],"purity":[132,163,215],"evaluation":[135],"markers":[138],"bulk":[141],"transcriptome":[143],"data.":[144],"Second,":[145],"examination":[146],"cluster":[148],"membership":[149],"pairs,":[152],"or":[154],"without":[155],"controlling":[156],"revealed":[160],"have":[165],"a":[166],"substantial":[167],"on":[169],"clustering":[171,238],"types.":[174],"Third,":[175],"feature":[176,193],"molecular":[179,240],"taxonomy":[180],"analyzed":[182],"some":[190],"types,":[192],"representing":[195],"mesenchymal":[197],"classical":[199],"subtypes":[200],"Our":[210],"findings":[211],"indicate":[212],"is":[216],"an":[217],"important":[218],"confounder":[219],"evaluating":[221],"clinicopathologic":[228],"features":[229],"well":[235],"taxonomy.":[241],"Immunol":[243],"Res;":[244],"6(1);":[245],"87\u201397.":[246],"\u00a92017":[247],"AACR.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-12-04T00:00:00"}