{"id":"https://openalex.org/W2770676136","doi":"https://doi.org/10.1128/cmr.00060-17","title":"New Approaches and Therapeutic Options for Mycobacterium tuberculosis in a Dormant State","display_name":"New Approaches and Therapeutic Options for Mycobacterium tuberculosis in a Dormant State","publication_year":2017,"publication_date":"2017-11-29","ids":{"openalex":"https://openalex.org/W2770676136","doi":"https://doi.org/10.1128/cmr.00060-17","mag":"2770676136","pmid":"https://pubmed.ncbi.nlm.nih.gov/29187395","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5740979"},"language":"en","primary_location":{"id":"doi:10.1128/cmr.00060-17","doi":"https://doi.org/10.1128/cmr.00060-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cmr.00060-17","pdf_url":"https://cmr.asm.org/content/cmr/31/1/e00060-17.full.pdf","source":{"id":"https://openalex.org/S112662651","display_name":"Clinical Microbiology Reviews","issn_l":"0893-8512","issn":["0893-8512","1070-6305","1098-6618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://cmr.asm.org/content/cmr/31/1/e00060-17.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5097766838","display_name":"Santiago E. Ca\u00f1o Mu\u00f1iz","orcid":"https://orcid.org/0000-0002-9808-7030","observed_orcids":["https://orcid.org/0000-0002-9808-7030"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Santiago Ca\u00f1o-Mu\u00f1iz","raw_affiliation_strings":["University of Cambridge, Department of Genetics, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Department of Genetics, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040431176","display_name":"Richard M. Anthony","orcid":"https://orcid.org/0000-0002-0550-5273","observed_orcids":["https://orcid.org/0000-0002-0550-5273"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Richard Anthony","raw_affiliation_strings":["National Institute for Public Health and the Environment, National Mycobateria Reference Laboratory, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Public Health and the Environment, National Mycobateria Reference Laboratory, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063438724","display_name":"Stefan Niemann","orcid":"https://orcid.org/0000-0002-6604-0684","observed_orcids":["https://orcid.org/0000-0002-6604-0684"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Niemann","raw_affiliation_strings":["German Center for Infection Research (DZIF), Partner Site Borstel, Borstel, Germany","Molecular and Experimental Mycobacteriology, Forschungszentrum Borstel, Leibniz-Zentrum f\u00fcr Medizin und Biowissenschaften, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner Site Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Forschungszentrum Borstel, Leibniz-Zentrum f\u00fcr Medizin und Biowissenschaften, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000820066","display_name":"Jan\u2010Willem C. Alffenaar","orcid":"https://orcid.org/0000-0001-6703-0288","observed_orcids":["https://orcid.org/0000-0001-6703-0288"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan-Willem C. Alffenaar","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2901,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.79133065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"31","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.6840000152587891},{"id":"https://openalex.org/keywords/bacterial-dormancy","display_name":"bacterial dormancy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dormancy-regulation","display_name":"dormancy regulation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/dormancy-genes","display_name":"dormancy genes","score":0.44699999690055847},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6940000057220459},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6539999842643738},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.6579999923706055},{"id":"https://openalex.org/keywords/metabolic-activity","display_name":"metabolic activity","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.8136810064315796},{"id":"https://openalex.org/C3527866","wikidata":"https://www.wikidata.org/wiki/Q162267","display_name":"Dormancy","level":3,"score":0.8108057975769043},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7251170873641968},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6194368600845337},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5234396457672119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48874449729919434},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47420933842658997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4425734579563141},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3878336548805237},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35206711292266846},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3260805010795593},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13209357857704163},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.13113710284233093},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055985","descriptor_name":"Latent Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D055985","descriptor_name":"Latent Tuberculosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1128/cmr.00060-17","doi":"https://doi.org/10.1128/cmr.00060-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cmr.00060-17","pdf_url":"https://cmr.asm.org/content/cmr/31/1/e00060-17.full.pdf","source":{"id":"https://openalex.org/S112662651","display_name":"Clinical Microbiology Reviews","issn_l":"0893-8512","issn":["0893-8512","1070-6305","1098-6618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology Reviews","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5221358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5740979","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5740979","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5740979","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Microbiol Rev","raw_type":"Text"},{"id":"pmid:29187395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29187395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical microbiology reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/b3cba59e-75fe-484c-ab48-7b6e907ccacb","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/b3cba59e-75fe-484c-ab48-7b6e907ccacb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cano-Muniz, S, Anthony, R, Niemann, S & Alffenaar, J-W C 2018, 'New Approaches and Therapeutic Options for Mycobacterium tuberculosis in a Dormant State', Clinical microbiology reviews, vol. 31, no. 1, e00060-17. https://doi.org/10.1128/CMR.00060-17","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:rivm.openrepository.com:10029/621541","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10029/621541","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:rivm.openrepository.com:10029/651113","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/651113","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:rivm:oai:rivm.openrepository.com:10029/621541","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10029/621541","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/b3cba59e-75fe-484c-ab48-7b6e907ccacb","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/b3cba59e-75fe-484c-ab48-7b6e907ccacb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical microbiology reviews, 31(1):e00060-17. AMER SOC MICROBIOLOGY","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.1128/cmr.00060-17","doi":"https://doi.org/10.1128/cmr.00060-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cmr.00060-17","pdf_url":"https://cmr.asm.org/content/cmr/31/1/e00060-17.full.pdf","source":{"id":"https://openalex.org/S112662651","display_name":"Clinical Microbiology Reviews","issn_l":"0893-8512","issn":["0893-8512","1070-6305","1098-6618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308275","display_name":"American Educational Research Association","ror":"https://ror.org/00pmt4r91"},{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2770676136.pdf","grobid_xml":"https://content.openalex.org/works/W2770676136.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1487815846","https://openalex.org/W1533844751","https://openalex.org/W1593580245","https://openalex.org/W1607802369","https://openalex.org/W1771315794","https://openalex.org/W1850649151","https://openalex.org/W1963912923","https://openalex.org/W1964951600","https://openalex.org/W1975610050","https://openalex.org/W1975853762","https://openalex.org/W1984213404","https://openalex.org/W1984523365","https://openalex.org/W1986106712","https://openalex.org/W1987146215","https://openalex.org/W1992572387","https://openalex.org/W2001133402","https://openalex.org/W2008186432","https://openalex.org/W2012251902","https://openalex.org/W2017145164","https://openalex.org/W2017173637","https://openalex.org/W2018348121","https://openalex.org/W2019835759","https://openalex.org/W2020201637","https://openalex.org/W2023304660","https://openalex.org/W2023750004","https://openalex.org/W2033377386","https://openalex.org/W2039050297","https://openalex.org/W2040694642","https://openalex.org/W2041350348","https://openalex.org/W2043487490","https://openalex.org/W2049085776","https://openalex.org/W2051584259","https://openalex.org/W2054962812","https://openalex.org/W2061043632","https://openalex.org/W2062827094","https://openalex.org/W2064744296","https://openalex.org/W2068320778","https://openalex.org/W2078663039","https://openalex.org/W2081589091","https://openalex.org/W2083487129","https://openalex.org/W2090486365","https://openalex.org/W2094095960","https://openalex.org/W2098793988","https://openalex.org/W2107618364","https://openalex.org/W2108888559","https://openalex.org/W2110463078","https://openalex.org/W2110926912","https://openalex.org/W2111350904","https://openalex.org/W2119473325","https://openalex.org/W2125112523","https://openalex.org/W2127240867","https://openalex.org/W2130710889","https://openalex.org/W2130825211","https://openalex.org/W2131178604","https://openalex.org/W2133378792","https://openalex.org/W2135131748","https://openalex.org/W2138751689","https://openalex.org/W2139018622","https://openalex.org/W2139101379","https://openalex.org/W2143853155","https://openalex.org/W2144353673","https://openalex.org/W2145085703","https://openalex.org/W2147425587","https://openalex.org/W2148111565","https://openalex.org/W2148323109","https://openalex.org/W2159174433","https://openalex.org/W2160677022","https://openalex.org/W2160839923","https://openalex.org/W2164282552","https://openalex.org/W2167315117","https://openalex.org/W2182861476","https://openalex.org/W2188306988","https://openalex.org/W2302275788","https://openalex.org/W2303117993","https://openalex.org/W2413022520","https://openalex.org/W2413419174","https://openalex.org/W2493613850","https://openalex.org/W2509241255","https://openalex.org/W2518271586","https://openalex.org/W3009705041","https://openalex.org/W4213353716"],"related_works":["https://openalex.org/W4310214313","https://openalex.org/W2759416435","https://openalex.org/W4399579657","https://openalex.org/W4312187668","https://openalex.org/W2152206032","https://openalex.org/W2587971454","https://openalex.org/W1984213404","https://openalex.org/W2163026732","https://openalex.org/W2130004041","https://openalex.org/W3002402303"],"abstract_inverted_index":{"complex":[0],"(MTBC)":[1],"strains":[2,90],"are":[3],"still":[4],"the":[5,28,34,43,52,64,86,98,122,140,144,148],"leading":[6],"cause":[7,110],"of":[8,27,54,63,88,103,118,125,150],"morbidity":[9],"and":[10,21,109,152],"mortality":[11],"by":[12,33],"a":[13,67,115],"single":[14],"infectious":[15],"disease,":[16],"with":[17,39],"9.6":[18],"million":[19,23],"cases":[20],"1.5":[22],"deaths":[24],"reported.":[25],"One-third":[26],"world's":[29],"population":[30],"is":[31,82],"estimated":[32],"WHO":[35],"to":[36,50,66,84,91,156],"be":[37],"infected":[38],"latent":[40,59],"TB.":[41],"During":[42],"last":[44],"decade,":[45],"several":[46,71],"studies":[47],"have":[48],"aimed":[49],"define":[51],"characteristics":[53],"dormant":[55,68,105,131],"bacteria":[56],"in":[57,147],"these":[58],"infections.":[60],"General":[61],"features":[62],"shift":[65],"state":[69,81],"encompass":[70],"phenotypic":[72],"changes":[73],"that":[74,129],"reduce":[75],"metabolic":[76,80],"activity.":[77],"This":[78],"low":[79],"thought":[83],"increase":[85],"resistance":[87],"MTBC":[89],"host/environmental":[92],"stresses,":[93],"including":[94],"antibiotic":[95],"action.":[96],"Once":[97],"stress":[99],"ceases":[100],"(e.g.,":[101],"interruption":[102],"treatment),":[104],"cells":[106],"can":[107],"reactivate":[108],"symptomatic":[111],"disease":[112],"again.":[113],"Therefore,":[114],"proper":[116],"understanding":[117],"dormancy":[119,151],"could":[120],"guide":[121],"rational":[123],"development":[124],"new":[126,154],"treatment":[127],"regimens":[128],"target":[130],"cells,":[132],"reducing":[133],"later":[134],"relapse.":[135],"Here,":[136],"we":[137],"briefly":[138],"summarize":[139],"latest":[141],"data":[142],"on":[143],"genetics":[145],"involved":[146],"regulation":[149],"discuss":[153],"approaches":[155],"TB":[157],"treatment.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-12-04T00:00:00"}