{"id":"https://openalex.org/W2770527020","doi":"https://doi.org/10.1002/jgm.2999","title":"MMP\u20103 (\u20131171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)\u20103 and correlate with severity of COPD: A study of MMP\u20103, MMP\u20107 and MMP\u201012 in a Tunisian population","display_name":"MMP\u20103 (\u20131171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)\u20103 and correlate with severity of COPD: A study of MMP\u20103, MMP\u20107 and MMP\u201012 in a Tunisian population","publication_year":2017,"publication_date":"2017-11-22","ids":{"openalex":"https://openalex.org/W2770527020","doi":"https://doi.org/10.1002/jgm.2999","mag":"2770527020","pmid":"https://pubmed.ncbi.nlm.nih.gov/29165854"},"language":"en","primary_location":{"id":"doi:10.1002/jgm.2999","doi":"https://doi.org/10.1002/jgm.2999","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jgm.2999","pdf_url":null,"source":{"id":"https://openalex.org/S91057606","display_name":"The Journal of Gene Medicine","issn_l":"1099-498X","issn":["1099-498X","1521-2254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Gene Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040318599","display_name":"Sarra Bchir","orcid":"https://orcid.org/0000-0001-6861-2191","observed_orcids":["https://orcid.org/0000-0001-6861-2191"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I8636806","display_name":"University of Sousse","ror":"https://ror.org/00dmpgj58","country_code":"TN","type":"education","lineage":["https://openalex.org/I8636806"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Sarra Bchir","raw_affiliation_strings":["Department of Biology Institut Sup\u00e9rieur de Biotechnologie de Monastir, Universit\u00e9 de Monastir  Tunisia","Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology Institut Sup\u00e9rieur de Biotechnologie de Monastir, Universit\u00e9 de Monastir  Tunisia","institution_ids":["https://openalex.org/I166928557"]},{"raw_affiliation_string":"Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia","institution_ids":["https://openalex.org/I8636806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030340473","display_name":"Hela Ben Nasr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8636806","display_name":"University of Sousse","ror":"https://ror.org/00dmpgj58","country_code":"TN","type":"education","lineage":["https://openalex.org/I8636806"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hela ben Nasr","raw_affiliation_strings":["Department of Biology Institut des Sciences Infirmi\u00e8res  Sousse Tunisia","Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology Institut des Sciences Infirmi\u00e8res  Sousse Tunisia","institution_ids":["https://openalex.org/I8636806"]},{"raw_affiliation_string":"Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia","institution_ids":["https://openalex.org/I8636806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041570831","display_name":"A. Garrouch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Abdelhamid Garrouch","raw_affiliation_strings":["Service de Pneumo-Allergologie, CHU Farhat Hached, Sousse, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Pneumo-Allergologie, CHU Farhat Hached, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026252870","display_name":"Amel ben Anes","orcid":"https://orcid.org/0000-0003-0030-3442","observed_orcids":["https://orcid.org/0000-0003-0030-3442"]},"institutions":[{"id":"https://openalex.org/I8636806","display_name":"University of Sousse","ror":"https://ror.org/00dmpgj58","country_code":"TN","type":"education","lineage":["https://openalex.org/I8636806"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Amel ben Anes","raw_affiliation_strings":["Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia","institution_ids":["https://openalex.org/I8636806"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ammar Abbassi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8636806","display_name":"University of Sousse","ror":"https://ror.org/00dmpgj58","country_code":"TN","type":"education","lineage":["https://openalex.org/I8636806"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ammar Abbassi","raw_affiliation_strings":["District Medical du Centre CNAM  Sousse Tunisia","Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"District Medical du Centre CNAM  Sousse Tunisia","institution_ids":[]},{"raw_affiliation_string":"Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse Tunisia","institution_ids":["https://openalex.org/I8636806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066950083","display_name":"Zouha\u00efr Tabka","orcid":"https://orcid.org/0000-0002-8854-8286","observed_orcids":["https://orcid.org/0000-0002-8854-8286"]},"institutions":[{"id":"https://openalex.org/I8636806","display_name":"University of Sousse","ror":"https://ror.org/00dmpgj58","country_code":"TN","type":"education","lineage":["https://openalex.org/I8636806"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Zouhair Tabka","raw_affiliation_strings":["Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia","institution_ids":["https://openalex.org/I8636806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005650196","display_name":"Karim Chahed","orcid":"https://orcid.org/0000-0003-3814-8695","observed_orcids":["https://orcid.org/0000-0003-3814-8695"]},"institutions":[{"id":"https://openalex.org/I142899784","display_name":"University of Sfax","ror":"https://ror.org/04d4sd432","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784"]},{"id":"https://openalex.org/I4405252705","display_name":"Faculty of Sciences of Sfax","ror":"https://ror.org/01thp0k37","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784","https://openalex.org/I4405252705"]},{"id":"https://openalex.org/I8636806","display_name":"University of Sousse","ror":"https://ror.org/00dmpgj58","country_code":"TN","type":"education","lineage":["https://openalex.org/I8636806"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Karim Chahed","raw_affiliation_strings":["Department of Biochemistry Universit\u00e9 de Sfax, Facult\u00e9 des Sciences de Sfax  Tunisia","Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry Universit\u00e9 de Sfax, Facult\u00e9 des Sciences de Sfax  Tunisia","institution_ids":["https://openalex.org/I142899784","https://openalex.org/I4405252705"]},{"raw_affiliation_string":"Unit\u00e9 de recherche UR12ES06, Physiologie de l'Exercice et Physiopathologie: de l'Int\u00e9gr\u00e9 au Mol\u00e9culaire \u2018Biologie, M\u00e9decine et Sant\u00e9\u2019 Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse  Tunisia","institution_ids":["https://openalex.org/I8636806"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5040318599"],"corresponding_institution_ids":["https://openalex.org/I166928557","https://openalex.org/I8636806"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":1.2319,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79272605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"20","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.902999997138977},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-3","display_name":"matrix metalloproteinase-3","score":0.953000009059906},{"id":"https://openalex.org/keywords/mmp-7","display_name":"MMP-7","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mmp-12","display_name":"MMP-12","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6110000014305115},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.722000002861023},{"id":"https://openalex.org/keywords/airflow-obstruction","display_name":"airflow obstruction","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5640000104904175},{"id":"https://openalex.org/keywords/tunisian-population","display_name":"Tunisian population","score":0.7649999856948853},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.9685884714126587},{"id":"https://openalex.org/C2991819120","wikidata":"https://www.wikidata.org/wiki/Q13033749","display_name":"Matrix metalloproteinase 9","level":3,"score":0.5682244300842285},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.5650423169136047},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5505155920982361},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.5072557330131531},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3680766820907593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32595348358154297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28610944747924805},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26605528593063354},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.098949134349823}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020783","descriptor_name":"Matrix Metalloproteinase 7","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020783","descriptor_name":"Matrix Metalloproteinase 7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D053508","descriptor_name":"Matrix Metalloproteinase 12","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D053508","descriptor_name":"Matrix Metalloproteinase 12","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jgm.2999","doi":"https://doi.org/10.1002/jgm.2999","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jgm.2999","pdf_url":null,"source":{"id":"https://openalex.org/S91057606","display_name":"The Journal of Gene Medicine","issn_l":"1099-498X","issn":["1099-498X","1521-2254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Gene Medicine","raw_type":"journal-article"},{"id":"pmid:29165854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29165854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of gene medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321147","display_name":"Ministry of Higher Education","ror":"https://ror.org/0512bh102"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W114845050","https://openalex.org/W225952425","https://openalex.org/W1545271627","https://openalex.org/W1965414352","https://openalex.org/W1972316102","https://openalex.org/W1979567907","https://openalex.org/W1980978565","https://openalex.org/W1987825791","https://openalex.org/W1988456342","https://openalex.org/W1990584310","https://openalex.org/W2001071020","https://openalex.org/W2005521257","https://openalex.org/W2005764942","https://openalex.org/W2018775727","https://openalex.org/W2020830960","https://openalex.org/W2020863153","https://openalex.org/W2022799351","https://openalex.org/W2027438719","https://openalex.org/W2033640275","https://openalex.org/W2033836926","https://openalex.org/W2072760945","https://openalex.org/W2073016379","https://openalex.org/W2077523026","https://openalex.org/W2096759470","https://openalex.org/W2107272258","https://openalex.org/W2107834294","https://openalex.org/W2108228497","https://openalex.org/W2110287460","https://openalex.org/W2112008499","https://openalex.org/W2112334970","https://openalex.org/W2116728322","https://openalex.org/W2116875982","https://openalex.org/W2121044578","https://openalex.org/W2122495122","https://openalex.org/W2124920819","https://openalex.org/W2134311523","https://openalex.org/W2137828665","https://openalex.org/W2143604872","https://openalex.org/W2149832507","https://openalex.org/W2151830472","https://openalex.org/W2152652790","https://openalex.org/W2156013958","https://openalex.org/W2179490665","https://openalex.org/W2401537340","https://openalex.org/W2562671504","https://openalex.org/W2721575552","https://openalex.org/W2746421487"],"related_works":["https://openalex.org/W2460767744","https://openalex.org/W2152652790","https://openalex.org/W7140042412","https://openalex.org/W1912913555","https://openalex.org/W1999939988","https://openalex.org/W1979567907","https://openalex.org/W2904680290","https://openalex.org/W114845050","https://openalex.org/W2134311523","https://openalex.org/W2912516029"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"present":[2,212],"study":[3],"aimed":[4],"to":[5,47,242],"examine":[6],"the":[7,28,122,145,153,185,193,206,229,243,253],"role":[8],"of":[9,32,64,92,124,126,131,152,175,192,205,231,245],"matrix":[10],"metalloproteinase":[11],"(MMP)-3":[12],"[(-1171)":[13],"5A/6A;":[14],"Lys45Glu":[15,161,223],"(A/G)],":[16],"MMP-7":[17,66,118,132],"[(-181)":[18],"A/G]":[19],"and":[20,30,60,67,78,94,119,121,135,149,160,188,196,208,222,256],"MMP-12":[21,68,120,136],"[(-82)":[22,137],"A/G;":[23,138],"Asn357Ser":[24,139],"(A/G)]":[25,140],"variants":[26,163],"in":[27,38,44,52,73,116,177,247],"development":[29,125],"severity":[31],"chronic":[33],"obstructive":[34],"pulmonary":[35],"disease":[36],"(COPD)":[37],"Tunisians.":[39],"METHODS:":[40],"Plethysmography":[41],"was":[42,70,142,182],"performed":[43],"all":[45],"participants":[46],"measure":[48],"forced":[49,56],"expiratory":[50],"volume":[51],"1":[53],"s":[54],"(FEV1),":[55],"vital":[57],"capacity":[58],"(FVC)":[59],"FEV1/FVC":[61],"parameters.":[62],"Genotyping":[63],"MMP-3,":[65,117],"polymorphisms":[69,141,225],"carried":[71],"out":[72],"138":[74],"patients":[75,251],"with":[76,166,172,228],"COPD":[77,178,201,235,250],"216":[79],"healthy":[80],"controls":[81],"using":[82],"a":[83],"polymerase":[84],"chain":[85],"reaction-restriction":[86],"fragment":[87],"length":[88],"polymorphism.":[89],"Serum":[90],"levels":[91,148,174,215],"MMPs":[93],"cytokines":[95],"(interleukin-6,":[96],"tumor":[97],"necrosis":[98],"factor-\u03b1)":[99],"were":[100,111,164,226],"determined":[101],"by":[102],"an":[103],"enzyme-linked":[104],"immunosorbent":[105],"assay.":[106],"RESULTS:":[107],"No":[108],"significant":[109],"correlations":[110],"observed":[112,143],"between":[113,184],"genetic":[114],"variations":[115],"risk":[123],"COPD.":[127],"Additionally,":[128,203],"no":[129],"impact":[130],"(-181)":[133],"A/G":[134],"on":[144],"respective":[146],"protein":[147],"clinical":[150],"parameters":[151],"disease.":[154],"Interestingly,":[155],"both":[156],"MMP-3":[157,176,194,214,219,246],"(-1171)":[158,186,220,254],"5A/6A":[159,221],"(A/G)":[162,224],"associated":[165,227],"respiratory":[167],"function,":[168],"as":[169,171],"well":[170],"serum":[173,248],"patients.":[179,202,236],"A":[180],"relationship":[181],"found":[183],"6A":[187,255],"45Glu":[189],"(G)":[190],"alleles":[191],"gene":[195],"enhanced":[197],"airflow":[198],"limitation":[199],"among":[200,234],"carriers":[204],"6A6A":[207],"45":[209,257],"GG":[210],"genotypes":[211],"higher":[213],"than":[216],"noncarriers.":[217],"CONCLUSIONS:":[218],"decline":[230],"lung":[232],"function":[233],"These":[237],"results":[238],"could":[239],"be":[240],"linked":[241],"upregulation":[244],"from":[249],"carrying":[252],"G":[258],"homozygous":[259],"genotypes.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-04T00:00:00"}