{"id":"https://openalex.org/W2770197129","doi":"https://doi.org/10.1021/acsinfecdis.7b00129","title":"Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-\u03b2-Lactamases","display_name":"Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-\u03b2-Lactamases","publication_year":2017,"publication_date":"2017-11-26","ids":{"openalex":"https://openalex.org/W2770197129","doi":"https://doi.org/10.1021/acsinfecdis.7b00129","mag":"2770197129","pmid":"https://pubmed.ncbi.nlm.nih.gov/29172434"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.7b00129","doi":"https://doi.org/10.1021/acsinfecdis.7b00129","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.7b00129","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049043151","display_name":"Dominik B\u00fcttner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik B\u00fcttner","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006713342","display_name":"Jan S. Kramer","orcid":"https://orcid.org/0000-0002-1525-5896","observed_orcids":["https://orcid.org/0000-0002-1525-5896"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan S. Kramer","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029588773","display_name":"Franca\u2010Maria Klingler","orcid":"https://orcid.org/0000-0002-8295-374X","observed_orcids":["https://orcid.org/0000-0002-8295-374X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franca-M. Klingler","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037911252","display_name":"Sandra K. Wittmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandra K. Wittmann","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020121176","display_name":"M. Hartmann","orcid":"https://orcid.org/0000-0001-8734-302X","observed_orcids":["https://orcid.org/0000-0001-8734-302X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus R. Hartmann","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012218876","display_name":"Christian Georg Kurz","orcid":"https://orcid.org/0000-0001-8584-5827","observed_orcids":["https://orcid.org/0000-0001-8584-5827"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian G. Kurz","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033714680","display_name":"Daniel Kohnh\u00e4user","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Kohnh\u00e4user","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084334549","display_name":"Lilia Weizel","orcid":"https://orcid.org/0000-0002-0373-2114","observed_orcids":["https://orcid.org/0000-0002-0373-2114"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lilia Weizel","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045768797","display_name":"Astrid Br\u00fcggerhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Astrid Br\u00fcggerhoff","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103054411","display_name":"Denia Frank","orcid":"https://orcid.org/0000-0002-3433-504X","observed_orcids":["https://orcid.org/0000-0002-3433-504X"]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Denia Frank","raw_affiliation_strings":["Institute of Medical Microbiology and Infection Control, Goethe University Hospital, Paul-Ehrlich-Stra\u00dfe 40, 60596 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Infection Control, Goethe University Hospital, Paul-Ehrlich-Stra\u00dfe 40, 60596 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082078699","display_name":"Dieter Steinhilber","orcid":"https://orcid.org/0000-0001-8905-5208","observed_orcids":["https://orcid.org/0000-0001-8905-5208"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Steinhilber","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067364341","display_name":"Thomas A. Wichelhaus","orcid":"https://orcid.org/0000-0002-4029-2955","observed_orcids":["https://orcid.org/0000-0002-4029-2955"]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas A. Wichelhaus","raw_affiliation_strings":["Institute of Medical Microbiology and Infection Control, Goethe University Hospital, Paul-Ehrlich-Stra\u00dfe 40, 60596 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Infection Control, Goethe University Hospital, Paul-Ehrlich-Stra\u00dfe 40, 60596 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029075125","display_name":"Denys Pogoryelov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Denys Pogoryelov","raw_affiliation_strings":["Institute of Biochemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002124394","display_name":"Ewgenij Proschak","orcid":"https://orcid.org/0000-0003-1961-1859","observed_orcids":["https://orcid.org/0000-0003-1961-1859"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ewgenij Proschak","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1961-1859","affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Stra\u00dfe 9, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002124394","https://openalex.org/A5029075125"],"corresponding_institution_ids":["https://openalex.org/I114090438"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.5505,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.93094772,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"4","issue":"3","first_page":"360","last_page":"372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metallo-beta-lactamase","display_name":"metallo-beta-lactamase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.8119999766349792},{"id":"https://openalex.org/keywords/zinc-coordination","display_name":"zinc coordination","score":0.7710000276565552},{"id":"https://openalex.org/keywords/inhibitor-selectivity","display_name":"inhibitor selectivity","score":0.5989999771118164},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.7649999856948853},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.3930000066757202},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.7566721439361572},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5511783361434937},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.5336516499519348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4591898024082184},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.416747510433197},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.415093332529068},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36548542976379395},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.34421974420547485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31893348693847656}],"mesh":[{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acsinfecdis.7b00129","doi":"https://doi.org/10.1021/acsinfecdis.7b00129","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.7b00129","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:29172434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29172434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:fraunhofer.de:N-541021","doi":null,"is_oa":false,"landing_page_url":"http://publica.fraunhofer.de/documents/N-541021.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer IME","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/257327","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/257327","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2013436488","display_name":null,"funder_award_id":"SFB-1039","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2620064217","display_name":null,"funder_award_id":"PR1405/4\u20131","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2880403063","display_name":null,"funder_award_id":"PR 1405/2-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1527793640","https://openalex.org/W1970368423","https://openalex.org/W1976669318","https://openalex.org/W1978484656","https://openalex.org/W1979054003","https://openalex.org/W1981202673","https://openalex.org/W1983774126","https://openalex.org/W1994144563","https://openalex.org/W1995725336","https://openalex.org/W2025902627","https://openalex.org/W2045076361","https://openalex.org/W2054585308","https://openalex.org/W2063467721","https://openalex.org/W2067395148","https://openalex.org/W2082991379","https://openalex.org/W2087857771","https://openalex.org/W2096489042","https://openalex.org/W2127999800","https://openalex.org/W2130239585","https://openalex.org/W2138559853","https://openalex.org/W2144081223","https://openalex.org/W2148621428","https://openalex.org/W2154714625","https://openalex.org/W2163003023","https://openalex.org/W2180229411","https://openalex.org/W2208804807","https://openalex.org/W2308144791","https://openalex.org/W2333126666","https://openalex.org/W2407151623","https://openalex.org/W2415189273","https://openalex.org/W2444191930","https://openalex.org/W2463871935","https://openalex.org/W2486711554","https://openalex.org/W2512927387","https://openalex.org/W2538487396","https://openalex.org/W2585093856","https://openalex.org/W2606685996","https://openalex.org/W2607607338","https://openalex.org/W2617364164","https://openalex.org/W2785436589","https://openalex.org/W2952357829","https://openalex.org/W2990798082","https://openalex.org/W2996646896","https://openalex.org/W4248872320","https://openalex.org/W4300720636"],"related_works":["https://openalex.org/W4385587895","https://openalex.org/W1995725336","https://openalex.org/W3151927712","https://openalex.org/W2308144791","https://openalex.org/W2082991379","https://openalex.org/W4321375474","https://openalex.org/W2601276799","https://openalex.org/W627401517","https://openalex.org/W3008657815","https://openalex.org/W3204133185"],"abstract_inverted_index":{"Pathogens,":[0],"expressing":[1],"metallo-\u03b2-lactamases":[2],"(MBLs),":[3],"become":[4],"resistant":[5,27],"against":[6,26,131,137],"most":[7],"\u03b2-lactam":[8],"antibiotics.":[9],"Besides":[10],"the":[11,36,50,64,99,110,113],"dragging":[12],"search":[13],"for":[14],"new":[15],"antibiotics,":[16],"development":[17,79,114],"of":[18,31,39,53,67,80,104,115,128],"MBL":[19,44,70,83,106],"inhibitors":[20,45,84,107],"would":[21],"be":[22],"an":[23],"alternative":[24],"weapon":[25],"bacterial":[28],"pathogens.":[29],"Inhibition":[30],"resistance":[32],"enzymes":[33],"could":[34],"restore":[35],"antibacterial":[37],"activity":[38,123,136],"\u03b2-lactams.":[40],"Various":[41],"approaches":[42],"to":[43],"are":[46],"described;":[47],"among":[48],"others,":[49],"promising":[51],"motif":[52],"a":[54,68,125],"zinc":[55],"coordinating":[56],"thiol":[57,81],"moiety":[58],"is":[59],"very":[60],"popular.":[61],"Nevertheless,":[62],"since":[63],"first":[65],"report":[66,97],"thiol-based":[69,105,116],"inhibitor":[71],"(thiomandelic":[72],"acid)":[73],"in":[74,78,121],"2001,":[75],"no":[76],"steps":[77],"based":[82],"were":[85],"reported":[86],"that":[87],"go":[88],"beyond":[89],"clinical":[90,138],"isolate":[91],"testing.":[92],"In":[93],"this":[94],"study,":[95],"we":[96],"on":[98],"synthesis":[100],"and":[101,108,134],"biochemical":[102],"characterization":[103],"highlight":[109],"challenges":[111],"behind":[112],"compounds,":[117],"which":[118],"exhibit":[119],"good":[120],"vitro":[122],"toward":[124],"broad":[126],"spectrum":[127],"MBLs,":[129],"selectivity":[130],"human":[132],"off-targets,":[133],"reasonable":[135],"isolates.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-12-04T00:00:00"}