{"id":"https://openalex.org/W2770020522","doi":"https://doi.org/10.3390/ijms18122511","title":"The Evaluation of Pro-Cognitive and Antiamnestic Properties of Berberine and Magnoflorine Isolated from Barberry Species by Centrifugal Partition Chromatography (CPC), in Relation to QSAR Modelling","display_name":"The Evaluation of Pro-Cognitive and Antiamnestic Properties of Berberine and Magnoflorine Isolated from Barberry Species by Centrifugal Partition Chromatography (CPC), in Relation to QSAR Modelling","publication_year":2017,"publication_date":"2017-11-24","ids":{"openalex":"https://openalex.org/W2770020522","doi":"https://doi.org/10.3390/ijms18122511","mag":"2770020522","pmid":"https://pubmed.ncbi.nlm.nih.gov/29186770","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5751114"},"language":"en","primary_location":{"id":"doi:10.3390/ijms18122511","doi":"https://doi.org/10.3390/ijms18122511","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18122511","pdf_url":"https://www.mdpi.com/1422-0067/18/12/2511/pdf?version=1511523122","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/18/12/2511/pdf?version=1511523122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006299106","display_name":"Wirginia Kuku\u0142a\u2010Koch","orcid":"https://orcid.org/0000-0001-7076-600X","observed_orcids":["https://orcid.org/0000-0001-7076-600X"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Wirginia Kukula-Koch","raw_affiliation_strings":["Chair and Department of Pharmacognosy with Medicinal Plant Unit, Medical University in Lublin, 20-093 Lublin, Poland"],"raw_orcid":"https://orcid.org/0000-0001-7076-600X","affiliations":[{"raw_affiliation_string":"Chair and Department of Pharmacognosy with Medicinal Plant Unit, Medical University in Lublin, 20-093 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044230377","display_name":"Marta Kruk-S\u0142omka","orcid":"https://orcid.org/0000-0001-9201-7181","observed_orcids":["https://orcid.org/0000-0001-9201-7181"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta Kruk-S\u0142omka","raw_affiliation_strings":["Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 20-093 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 20-093 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078279653","display_name":"Katarzyna E. St\u0119pnik","orcid":"https://orcid.org/0000-0002-9812-9114","observed_orcids":["https://orcid.org/0000-0002-9812-9114"]},"institutions":[{"id":"https://openalex.org/I174183983","display_name":"Maria Curie-Sk\u0142odowska University","ror":"https://ror.org/015h0qg34","country_code":"PL","type":"education","lineage":["https://openalex.org/I174183983"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna St\u0119pnik","raw_affiliation_strings":["Faculty of Chemistry, Chair of Physical Chemistry, Department of Planar Chromatography, Maria Curie-Sk\u0142odowska University, 20-031 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Chair of Physical Chemistry, Department of Planar Chromatography, Maria Curie-Sk\u0142odowska University, 20-031 Lublin, Poland","institution_ids":["https://openalex.org/I174183983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077675150","display_name":"Rados\u0142aw Szalak","orcid":"https://orcid.org/0000-0001-9501-7806","observed_orcids":["https://orcid.org/0000-0001-9501-7806"]},"institutions":[{"id":"https://openalex.org/I158552681","display_name":"University of Life Sciences in Lublin","ror":"https://ror.org/03hq67y94","country_code":"PL","type":"education","lineage":["https://openalex.org/I158552681"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rados\u0142aw Szalak","raw_affiliation_strings":["Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Science, 20-950 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Science, 20-950 Lublin, Poland","institution_ids":["https://openalex.org/I158552681"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008872103","display_name":"Gra\u017cyna Bia\u0142a","orcid":"https://orcid.org/0000-0001-8270-9635","observed_orcids":["https://orcid.org/0000-0001-8270-9635"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Gra\u017cyna Bia\u0142a","raw_affiliation_strings":["Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 20-093 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 20-093 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006299106"],"corresponding_institution_ids":["https://openalex.org/I121032520"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.7613,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.80799317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"12","first_page":"2511","last_page":"2511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/magnoflorine","display_name":"magnoflorine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/berberis","display_name":"Berberis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/memory-enhancement","display_name":"memory enhancement","score":0.7429999709129333},{"id":"https://openalex.org/keywords/scopolamine-induced-amnesia","display_name":"scopolamine-induced amnesia","score":0.7829999923706055},{"id":"https://openalex.org/keywords/passive-avoidance-test","display_name":"passive avoidance test","score":0.9290000200271606},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.8109999895095825},{"id":"https://openalex.org/keywords/centrifugal-partition-chromatography","display_name":"centrifugal partition chromatography","score":0.8619999885559082},{"id":"https://openalex.org/keywords/isoquinoline-alkaloids","display_name":"isoquinoline alkaloids","score":0.7620000243186951},{"id":"https://openalex.org/keywords/qsar-modeling","display_name":"QSAR models","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cognitive-enhancement","display_name":"cognitive enhancement","score":0.4320000112056732},{"id":"https://openalex.org/keywords/plant-extract-purification","display_name":"plant extract purification","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.8932429552078247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7828118801116943},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.49087363481521606},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.4695107638835907},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4404330849647522},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4383026361465454},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42328527569770813},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.33281293511390686},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.22813451290130615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22714188694953918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08718010783195496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06956717371940613},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000647","descriptor_name":"Amnesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001060","descriptor_name":"Aporphines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001060","descriptor_name":"Aporphines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001060","descriptor_name":"Aporphines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001060","descriptor_name":"Aporphines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028142","descriptor_name":"Berberis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms18122511","doi":"https://doi.org/10.3390/ijms18122511","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18122511","pdf_url":"https://www.mdpi.com/1422-0067/18/12/2511/pdf?version=1511523122","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:29186770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29186770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5751114","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5751114/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d7b824a8691e4a7aa55958916228b371","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d7b824a8691e4a7aa55958916228b371","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 18, Iss 12, p 2511 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms18122511","doi":"https://doi.org/10.3390/ijms18122511","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18122511","pdf_url":"https://www.mdpi.com/1422-0067/18/12/2511/pdf?version=1511523122","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4531761562","display_name":null,"funder_award_id":"4/POLTUR-1/2016","funder_id":"https://openalex.org/F4320335039","funder_display_name":"Narodowe Centrum Bada\u0144 i Rozwoju"}],"funders":[{"id":"https://openalex.org/F4320335039","display_name":"Narodowe Centrum Bada\u0144 i Rozwoju","ror":"https://ror.org/05pwfyy15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2770020522.pdf","grobid_xml":"https://content.openalex.org/works/W2770020522.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W45411166","https://openalex.org/W283993550","https://openalex.org/W587377093","https://openalex.org/W1501358501","https://openalex.org/W1964892539","https://openalex.org/W1971768346","https://openalex.org/W1976406451","https://openalex.org/W1981432419","https://openalex.org/W1995592726","https://openalex.org/W1997306366","https://openalex.org/W2005020926","https://openalex.org/W2017398555","https://openalex.org/W2017930992","https://openalex.org/W2024164727","https://openalex.org/W2024211635","https://openalex.org/W2033592766","https://openalex.org/W2037083212","https://openalex.org/W2040972896","https://openalex.org/W2052008210","https://openalex.org/W2052226480","https://openalex.org/W2058051835","https://openalex.org/W2059178696","https://openalex.org/W2080576711","https://openalex.org/W2083025840","https://openalex.org/W2085865547","https://openalex.org/W2130919666","https://openalex.org/W2133295219","https://openalex.org/W2135732933","https://openalex.org/W2166592632","https://openalex.org/W2284162826","https://openalex.org/W2335863657","https://openalex.org/W2464240089","https://openalex.org/W2591443617","https://openalex.org/W2604636580","https://openalex.org/W6645803424"],"related_works":["https://openalex.org/W3157048023","https://openalex.org/W2000167518","https://openalex.org/W2342394460","https://openalex.org/W7096159589","https://openalex.org/W4403416960","https://openalex.org/W2760521477","https://openalex.org/W2066828327","https://openalex.org/W4405920566","https://openalex.org/W4388248602","https://openalex.org/W4365454136"],"abstract_inverted_index":{"Civilization":[0],"diseases":[1],"associated":[2],"with":[3,34,150],"memory":[4,103,162],"disorders":[5],"are":[6],"important":[7],"health":[8],"problems":[9],"occurring":[10],"due":[11],"to":[12,53,156,189],"a":[13,79,179],"prolonged":[14],"life":[15],"span.":[16],"The":[17,37,176],"manuscript":[18],"shows":[19],"the":[20,28,47,55,60,97,130,147,151,167,173,187,191],"results":[21,177],"of":[22,30,49,62,73,183,193],"an":[23,110],"in":[24,109,111],"vivo":[25,112],"study":[26],"targeting":[27],"emergence":[29],"two":[31],"drug":[32],"candidates":[33],"anti-amnestic":[35],"properties.":[36],"preceding":[38],"quantitative":[39],"structure\u2013activity":[40],"relationship":[41],"(QSAR)":[42],"studies":[43],"provided":[44],"information":[45],"on":[46,117,166],"ability":[48],"berberine":[50,137],"and":[51,83,105,121,138,185],"magnoflorine":[52,184],"cross":[54],"blood\u2013brain":[56],"barrier":[57],"(BBB).":[58],"In":[59,144],"light":[61],"these":[63],"findings,":[64],"both":[65,146],"compounds":[66,98],"were":[67,99,127,154],"purified":[68],"from":[69],"crude":[70],"plant":[71],"extracts":[72],"barberries:":[74],"berberine\u2014from":[75],"Berberis":[76,85],"siberica":[77],"using":[78],"method":[80],"published":[81],"earlier,":[82],"magnoflorine\u2014from":[84],"cretica":[86],"by":[87],"centrifugal":[88],"partition":[89],"chromatography":[90],"(solvent":[91],"system:":[92],"ethyl":[93],"acetate:butanol:water-0.6:1.5:3":[94],"v/v/v).":[95],"Both":[96],"evaluated":[100],"for":[101,136,142,172,201],"their":[102],"enhancing":[104,125],"scopolamine":[106,153],"inhibitory":[107],"properties":[108,126],"passive":[113],"avoidance":[114],"(PA)":[115],"test":[116],"mice":[118],"towards":[119],"short-term":[120,161],"long-term":[122,158],"memory.":[123],"Cognition":[124],"observed":[128,171],"at":[129],"following":[131],"doses:":[132],"5":[133],"mg/kg":[134,140],"(i.p.)":[135,141],"20":[139],"magnoflorine.":[143,202],"addition,":[145],"tested":[148,174],"isoquinolines":[149],"co-administered":[152],"found":[155],"block":[157],"but":[159],"not":[160],"impairment.":[163],"No":[164],"influence":[165],"locomotor":[168],"activity":[169,182],"was":[170],"doses.":[175],"confirmed":[178],"marked":[180],"central":[181],"showed":[186],"necessity":[188],"lower":[190],"dosage":[192],"berberine.":[194],"Optimized":[195],"purification":[196],"conditions":[197],"have":[198],"been":[199],"elaborated":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-12-04T00:00:00"}