{"id":"https://openalex.org/W2769972663","doi":"https://doi.org/10.3390/ijms18122525","title":"Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage","display_name":"Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage","publication_year":2017,"publication_date":"2017-11-25","ids":{"openalex":"https://openalex.org/W2769972663","doi":"https://doi.org/10.3390/ijms18122525","mag":"2769972663","pmid":"https://pubmed.ncbi.nlm.nih.gov/29186841","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5751128"},"language":"en","primary_location":{"id":"doi:10.3390/ijms18122525","doi":"https://doi.org/10.3390/ijms18122525","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18122525","pdf_url":"https://www.mdpi.com/1422-0067/18/12/2525/pdf?version=1512528314","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/18/12/2525/pdf?version=1512528314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060059045","display_name":"Anastasia P. Velalopoulou","orcid":"https://orcid.org/0000-0002-1166-6102","observed_orcids":["https://orcid.org/0000-0002-1166-6102"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasia Velalopoulou","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041484624","display_name":"Shampa Chatterjee","orcid":"https://orcid.org/0000-0003-3351-5580","observed_orcids":["https://orcid.org/0000-0003-3351-5580"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shampa Chatterjee","raw_affiliation_strings":["Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076092861","display_name":"Ralph A. Pietrofesa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Pietrofesa","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069662146","display_name":"Cynthia J. Koziol\u2010White","orcid":"https://orcid.org/0000-0003-1101-2747","observed_orcids":["https://orcid.org/0000-0003-1101-2747"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Koziol-White","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082888399","display_name":"Reynold A. Panettieri","orcid":"https://orcid.org/0000-0003-0834-4636","observed_orcids":["https://orcid.org/0000-0003-0834-4636"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reynold Panettieri","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005298316","display_name":"Liyong Lin","orcid":"https://orcid.org/0000-0002-0820-8063","observed_orcids":["https://orcid.org/0000-0002-0820-8063"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liyong Lin","raw_affiliation_strings":["Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108370573","display_name":"Stephen W. Tuttle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Tuttle","raw_affiliation_strings":["Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082385497","display_name":"Abigail T. Berman","orcid":"https://orcid.org/0000-0002-9969-3462","observed_orcids":["https://orcid.org/0000-0002-9969-3462"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail Berman","raw_affiliation_strings":["Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082801249","display_name":"Constantinos Koumenis","orcid":"https://orcid.org/0000-0001-5945-4726","observed_orcids":["https://orcid.org/0000-0001-5945-4726"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constantinos Koumenis","raw_affiliation_strings":["Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017021744","display_name":"Melpo Christofidou\u2010Solomidou","orcid":"https://orcid.org/0000-0002-5945-6569","observed_orcids":["https://orcid.org/0000-0002-5945-6569"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melpo Christofidou-Solomidou","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017021744"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.3047,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.78718295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"12","first_page":"2525","last_page":"2525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secoisolariciresinol-diglucoside","display_name":"secoisolariciresinol diglucoside","score":0.9480000138282776},{"id":"https://openalex.org/keywords/proton-radiation","display_name":"proton radiation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/radiation-induced-lung-injury","display_name":"radiation-induced lung injury","score":0.8659999966621399},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.9750000238418579},{"id":"https://openalex.org/keywords/precision-cut-lung-slices","display_name":"precision-cut lung slices","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8629999756813049},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.847000002861023},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.968999981880188},{"id":"https://openalex.org/keywords/space-radiation","display_name":"space radiation","score":0.4749999940395355},{"id":"https://openalex.org/keywords/thoracic-radiotherapy","display_name":"thoracic radiotherapy","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.643216609954834},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6252432465553284},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5902388691902161},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49898838996887207},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4836646020412445},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4811097979545593},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.44137224555015564},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44093069434165955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4198186695575714},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.386071115732193},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37372249364852905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26485827565193176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24153149127960205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20218372344970703},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.07762980461120605}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002072","descriptor_name":"Butylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002072","descriptor_name":"Butylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017564","descriptor_name":"Radiation Pneumonitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017564","descriptor_name":"Radiation Pneumonitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D017564","descriptor_name":"Radiation Pneumonitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms18122525","doi":"https://doi.org/10.3390/ijms18122525","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18122525","pdf_url":"https://www.mdpi.com/1422-0067/18/12/2525/pdf?version=1512528314","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5751128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5751128","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:29186841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29186841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:087e33b0af93462c949cd8956f661cbf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/087e33b0af93462c949cd8956f661cbf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 18, Iss 12, p 2525 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms18122525","doi":"https://doi.org/10.3390/ijms18122525","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18122525","pdf_url":"https://www.mdpi.com/1422-0067/18/12/2525/pdf?version=1512528314","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2886405977","display_name":null,"funder_award_id":"NIH-1R21NS087406-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6279591387","display_name":"Asbestos fate, exposure, remediation, and adverse health effects","funder_award_id":"P42ES023720","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7735752605","display_name":"Piperlongumine as a Novel Radiosensitizer for Lung Cancer","funder_award_id":"R21CA178654","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8567267918","display_name":"NOVEL SYNTHETIC SDG TO TREAT TRAUMA-INDUCED INFLAMMATION","funder_award_id":"R21AT008291","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G8618995187","display_name":"Mesothelioma inhibition by secoisolariciresinol diglucoside (SDG)","funder_award_id":"R03CA180548","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000872793","display_name":"Center of Excellence in Environmental Toxicology","funder_award_id":"P30ES013508","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G936267877","display_name":"Secoisolariciresinol Diglucoside (SDB) Protection in Radiation Pheumonopathy","funder_award_id":"R01CA133470","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2769972663.pdf","grobid_xml":"https://content.openalex.org/works/W2769972663.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W138993849","https://openalex.org/W1964598557","https://openalex.org/W1966163762","https://openalex.org/W1980879738","https://openalex.org/W1984032738","https://openalex.org/W1987364842","https://openalex.org/W1991251712","https://openalex.org/W1998051584","https://openalex.org/W2003790902","https://openalex.org/W2003889048","https://openalex.org/W2009788005","https://openalex.org/W2011573190","https://openalex.org/W2017290871","https://openalex.org/W2018165119","https://openalex.org/W2028855764","https://openalex.org/W2059999514","https://openalex.org/W2064168997","https://openalex.org/W2066192654","https://openalex.org/W2066485136","https://openalex.org/W2094292688","https://openalex.org/W2094625414","https://openalex.org/W2104872963","https://openalex.org/W2155918577","https://openalex.org/W2167298849","https://openalex.org/W2199386068","https://openalex.org/W2211952525","https://openalex.org/W2292886889","https://openalex.org/W2435274812","https://openalex.org/W2463833592","https://openalex.org/W2506452942","https://openalex.org/W2549271198","https://openalex.org/W2568843865","https://openalex.org/W2605641002","https://openalex.org/W2733328118","https://openalex.org/W2735491497"],"related_works":["https://openalex.org/W2906796461","https://openalex.org/W2132964456","https://openalex.org/W3174782243","https://openalex.org/W6939961873","https://openalex.org/W2786809822","https://openalex.org/W1990303455","https://openalex.org/W1982540632","https://openalex.org/W2111505704","https://openalex.org/W3155313602","https://openalex.org/W7167060632"],"abstract_inverted_index":{"Radiation":[0],"therapy":[1],"for":[2,163],"the":[3,14,21,28,86,91,215,222],"treatment":[4],"of":[5,13,36,59,94,117,123,190,217,221,225],"thoracic":[6],"malignancies":[7],"has":[8],"improved":[9],"significantly":[10],"by":[11,53,103],"directing":[12],"proton":[15,63,96,135,152,191,218],"beam":[16],"in":[17,48,56,85,101,108,130],"higher":[18],"doses":[19],"on":[20,214,227],"targeted":[22],"tumor":[23,29],"while":[24],"normal":[25,37],"tissues":[26,38],"around":[27],"receive":[30],"much":[31],"lower":[32],"doses.":[33],"Nevertheless,":[34],"exposure":[35],"to":[39,43,62,89,134,149,168],"protons":[40],"is":[41,75,210],"known":[42],"pose":[44],"a":[45,76,211],"substantial":[46],"risk":[47],"long-term":[49],"survivors,":[50],"as":[51],"confirmed":[52],"our":[54],"work":[55],"space-relevant":[57],"exposures":[58],"murine":[60],"lungs":[61],"radiation.":[64,136],"Thus,":[65],"radioprotective":[66,223],"strategies":[67],"are":[68],"being":[69],"sought.":[70],"We":[71,111,137,185],"established":[72],"that":[73],"LGM2605":[74,226],"potent":[77],"protector":[78],"from":[79],"radiation-induced":[80,178,192],"lung":[81,99,127,141,143],"toxicity":[82],"and":[83,132,154,159,172,176,181,195,204,220],"aimed":[84],"current":[87],"study":[88],"extend":[90],"initial":[92],"findings":[93],"space-relevant,":[95],"radiation-associated":[97],"late":[98],"damage":[100],"mice":[102],"looking":[104],"at":[105],"acute":[106],"changes":[107,166],"human":[109,126,140,228],"lung.":[110,229],"used":[112],"an":[113,187,200],"ex":[114],"vivo":[115],"model":[116],"organ":[118],"culture":[119,131],"where":[120],"tissue":[121,183,207],"slices":[122],"donor":[124,139],"living":[125],"were":[128],"kept":[129],"exposed":[133,138],"precision-cut":[142],"sections":[144],"(huPCLS),":[145],"pretreated":[146],"with":[147],"LGM2605,":[148],"4":[150],"Gy":[151],"radiation":[153,219],"evaluated":[155],"them":[156],"30":[157],"min":[158],"24":[160],"h":[161],"later":[162],"gene":[164],"expression":[165],"relevant":[167],"inflammation,":[169,180],"oxidative":[170,182,206],"stress,":[171],"cell":[173,197],"cycle":[174,198],"arrest,":[175],"determined":[177],"senescence,":[179],"damage.":[184,208],"identified":[186],"LGM2605-mediated":[188],"reduction":[189],"cellular":[193],"senescence":[194],"associated":[196,201,205],"changes,":[199],"proinflammatory":[202],"phenotype,":[203],"This":[209],"first":[212],"report":[213],"effects":[216],"properties":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-04T00:00:00"}