{"id":"https://openalex.org/W2769939740","doi":"https://doi.org/10.1016/j.jgar.2017.11.012","title":"New chalcone compound as a promising antileishmanial drug for an old neglected disease: Biological evaluation using radiolabelled biodistribution","display_name":"New chalcone compound as a promising antileishmanial drug for an old neglected disease: Biological evaluation using radiolabelled biodistribution","publication_year":2017,"publication_date":"2017-11-28","ids":{"openalex":"https://openalex.org/W2769939740","doi":"https://doi.org/10.1016/j.jgar.2017.11.012","mag":"2769939740","pmid":"https://pubmed.ncbi.nlm.nih.gov/29196220"},"language":"en","primary_location":{"id":"doi:10.1016/j.jgar.2017.11.012","doi":"https://doi.org/10.1016/j.jgar.2017.11.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jgar.2017.11.012","pdf_url":null,"source":{"id":"https://openalex.org/S2764745279","display_name":"Journal of Global Antimicrobial Resistance","issn_l":"2213-7165","issn":["2213-7165","2213-7173"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Global Antimicrobial Resistance","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090591470","display_name":"Ariane J. Sousa-Batista","orcid":"https://orcid.org/0000-0002-1642-6669","observed_orcids":["https://orcid.org/0000-0002-1642-6669"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ariane de J. Sousa-Batista","raw_affiliation_strings":["Carlos Chagas Filho Biophysics Institute, Rio de Janeiro Federal University, 21941-901 Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Chagas Filho Biophysics Institute, Rio de Janeiro Federal University, 21941-901 Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060562645","display_name":"C\u00edntia I.M. Silva Philipon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C\u00edntia I.M. Silva Philipon","raw_affiliation_strings":["Carlos Chagas Filho Biophysics Institute, Rio de Janeiro Federal University, 21941-901 Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Chagas Filho Biophysics Institute, Rio de Janeiro Federal University, 21941-901 Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108622978","display_name":"Marta de Souza Albernaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4210138087","display_name":"Hospital Universit\u00e1rio Clementino Fraga Filho","ror":"https://ror.org/04pznag94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210138087"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marta de Souza Albernaz","raw_affiliation_strings":["University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4210138087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054689273","display_name":"Suyene Rocha Pinto","orcid":"https://orcid.org/0000-0002-3523-6617","observed_orcids":["https://orcid.org/0000-0002-3523-6617"]},"institutions":[{"id":"https://openalex.org/I4210142725","display_name":"Nuclear Engineering Institute","ror":"https://ror.org/040bdaa45","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210142725","https://openalex.org/I4210151455","https://openalex.org/I76248293"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Suyene Rocha Pinto","raw_affiliation_strings":["Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, 21941906 Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, 21941906 Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4210142725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012030356","display_name":"Bartira Rossi\u2010Bergmann","orcid":"https://orcid.org/0000-0002-3791-8996","observed_orcids":["https://orcid.org/0000-0002-3791-8996"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bartira Rossi-Bergmann","raw_affiliation_strings":["Carlos Chagas Filho Biophysics Institute, Rio de Janeiro Federal University, 21941-901 Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Chagas Filho Biophysics Institute, Rio de Janeiro Federal University, 21941-901 Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075467933","display_name":"Ralph Santos\u2010Oliveira","orcid":"https://orcid.org/0000-0002-0905-481X","observed_orcids":["https://orcid.org/0000-0002-0905-481X"]},"institutions":[{"id":"https://openalex.org/I4210142725","display_name":"Nuclear Engineering Institute","ror":"https://ror.org/040bdaa45","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210142725","https://openalex.org/I4210151455","https://openalex.org/I76248293"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ralph Santos-Oliveira","raw_affiliation_strings":["Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, 21941906 Rio de Janeiro, RJ, Brazil. Electronic address: roliveira@ien.gov.br","Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, 21941906 Rio de Janeiro, RJ, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0905-481X","affiliations":[{"raw_affiliation_string":"Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, 21941906 Rio de Janeiro, RJ, Brazil. Electronic address: roliveira@ien.gov.br","institution_ids":["https://openalex.org/I4210142725"]},{"raw_affiliation_string":"Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, 21941906 Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4210142725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075467933"],"corresponding_institution_ids":["https://openalex.org/I4210142725"],"apc_list":{"value":1890,"currency":"USD","value_usd":1890},"apc_paid":null,"fwci":0.5123,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69319844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":null,"first_page":"139","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chalcones","display_name":"chalcones","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cutaneous-leishmaniasis","display_name":"cutaneous leishmaniasis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/visceral-leishmaniasis","display_name":"visceral leishmaniasis","score":1.0},{"id":"https://openalex.org/keywords/leishmania-infantum","display_name":"Leishmania infantum","score":0.8519999980926514},{"id":"https://openalex.org/keywords/leishmania-amazonensis","display_name":"Leishmania amazonensis","score":1.0},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8610000014305115},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6869999766349792},{"id":"https://openalex.org/keywords/intralesional-administration","display_name":"intralesional administration","score":0.7919999957084656},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.44999998807907104},{"id":"https://openalex.org/keywords/neglected-tropical-diseases","display_name":"neglected tropical diseases","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.897010326385498},{"id":"https://openalex.org/C2780764945","wikidata":"https://www.wikidata.org/wiki/Q899416","display_name":"Chalcone","level":2,"score":0.8834871649742126},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5813618302345276},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49257785081863403},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4390026926994324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33980923891067505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31152114272117615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13625848293304443},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.10957074165344238},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09922337532043457},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.04929032921791077}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007898","descriptor_name":"Leishmaniasis, Visceral","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016284","descriptor_name":"Technetium Tc 99m Pentetate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018314","descriptor_name":"Leishmania infantum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jgar.2017.11.012","doi":"https://doi.org/10.1016/j.jgar.2017.11.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jgar.2017.11.012","pdf_url":null,"source":{"id":"https://openalex.org/S2764745279","display_name":"Journal of Global Antimicrobial Resistance","issn_l":"2213-7165","issn":["2213-7165","2213-7173"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Global Antimicrobial Resistance","raw_type":"journal-article"},{"id":"pmid:29196220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29196220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of global antimicrobial resistance","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W770563939","https://openalex.org/W1953777455","https://openalex.org/W1976793229","https://openalex.org/W1981756460","https://openalex.org/W2022298723","https://openalex.org/W2022631389","https://openalex.org/W2028703802","https://openalex.org/W2086272987","https://openalex.org/W2091379146","https://openalex.org/W2100041796","https://openalex.org/W2104158217","https://openalex.org/W2108118767","https://openalex.org/W2162470238","https://openalex.org/W2281172785","https://openalex.org/W2287543165","https://openalex.org/W2335356348","https://openalex.org/W2385321340","https://openalex.org/W2416090016","https://openalex.org/W2545375234","https://openalex.org/W2592913394","https://openalex.org/W2606795663","https://openalex.org/W2617692334"],"related_works":["https://openalex.org/W3021865675","https://openalex.org/W2791604611","https://openalex.org/W2883692625","https://openalex.org/W2092546329","https://openalex.org/W4313244765","https://openalex.org/W2982289972","https://openalex.org/W2083623816","https://openalex.org/W797907886","https://openalex.org/W2909810699","https://openalex.org/W2033112004"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-04T00:00:00"}