{"id":"https://openalex.org/W2769739641","doi":"https://doi.org/10.18632/oncotarget.22660","title":"Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers","display_name":"Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers","publication_year":2017,"publication_date":"2017-11-26","ids":{"openalex":"https://openalex.org/W2769739641","doi":"https://doi.org/10.18632/oncotarget.22660","mag":"2769739641","pmid":"https://pubmed.ncbi.nlm.nih.gov/29312532","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5752445"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.22660","doi":"https://doi.org/10.18632/oncotarget.22660","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.22660","pdf_url":"https://www.oncotarget.com/article/22660/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.oncotarget.com/article/22660/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074922944","display_name":"Sergey V. Kozin","orcid":"https://orcid.org/0000-0002-4722-8315","observed_orcids":["https://orcid.org/0000-0002-4722-8315"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sergey V. Kozin","raw_affiliation_strings":["Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000617175","display_name":"Nir Maimon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nir Maimon","raw_affiliation_strings":["Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005778507","display_name":"Rong Wang","orcid":"https://orcid.org/0000-0001-5706-7650","observed_orcids":["https://orcid.org/0000-0001-5706-7650"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rong Wang","raw_affiliation_strings":["Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041352432","display_name":"Nisha Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nisha Gupta","raw_affiliation_strings":["Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001539646","display_name":"Lance L. Munn","orcid":"https://orcid.org/0000-0003-0698-7232","observed_orcids":["https://orcid.org/0000-0003-0698-7232"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance Munn","raw_affiliation_strings":["Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rakesh K. Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh K. Jain","raw_affiliation_strings":["Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080632209","display_name":"Igor Garkavtsev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Garkavtsev","raw_affiliation_strings":["Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000617175","https://openalex.org/A5005778507","https://openalex.org/A5074922944"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":0.7473,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.64769509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"65","first_page":"108292","last_page":"108302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.31520000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-leukocyte-protease-inhibitor","display_name":"secretory leukocyte protease inhibitor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9639999866485596},{"id":"https://openalex.org/keywords/4t1-cells","display_name":"4T1 cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.4909999966621399},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2777090344","wikidata":"https://www.wikidata.org/wiki/Q18031590","display_name":"SLPI","level":3,"score":0.954310417175293},{"id":"https://openalex.org/C170240278","wikidata":"https://www.wikidata.org/wiki/Q17928773","display_name":"FOXM1","level":4,"score":0.7927255630493164},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7507082223892212},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.663396418094635},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.638446569442749},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6187379360198975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5379340052604675},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5019958019256592},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35424739122390747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35230904817581177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33670774102211},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3276151716709137},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.11117333173751831},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.09317225217819214}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18632/oncotarget.22660","doi":"https://doi.org/10.18632/oncotarget.22660","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.22660","pdf_url":"https://www.oncotarget.com/article/22660/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5752445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5752445","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:29312532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29312532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.22660","doi":"https://doi.org/10.18632/oncotarget.22660","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.22660","pdf_url":"https://www.oncotarget.com/article/22660/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G228964210","display_name":"Evaluation of TNBC treatment strategy utilizing novel signaling pathways","funder_award_id":"R21CA169616","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2769739641.pdf","grobid_xml":"https://content.openalex.org/works/W2769739641.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1978521623","https://openalex.org/W1979486580","https://openalex.org/W1981827621","https://openalex.org/W1983425558","https://openalex.org/W1984708567","https://openalex.org/W1985921109","https://openalex.org/W1992510946","https://openalex.org/W1997782804","https://openalex.org/W2022130479","https://openalex.org/W2024882709","https://openalex.org/W2034019461","https://openalex.org/W2046558969","https://openalex.org/W2046700952","https://openalex.org/W2049145125","https://openalex.org/W2059204916","https://openalex.org/W2064553360","https://openalex.org/W2066841492","https://openalex.org/W2071074097","https://openalex.org/W2080232352","https://openalex.org/W2088197775","https://openalex.org/W2092068698","https://openalex.org/W2094088886","https://openalex.org/W2098021159","https://openalex.org/W2118413367","https://openalex.org/W2126496132","https://openalex.org/W2132036647","https://openalex.org/W2134975919","https://openalex.org/W2136088948","https://openalex.org/W2149886576","https://openalex.org/W2158770026","https://openalex.org/W2158838322","https://openalex.org/W2167505689","https://openalex.org/W2292378658","https://openalex.org/W2402636472","https://openalex.org/W2623745775"],"related_works":["https://openalex.org/W2066841492","https://openalex.org/W7099059877","https://openalex.org/W2046558969","https://openalex.org/W2955028868","https://openalex.org/W4408176701","https://openalex.org/W2019478450","https://openalex.org/W2094088886","https://openalex.org/W3039056092","https://openalex.org/W1983425558","https://openalex.org/W4378906251"],"abstract_inverted_index":{"//":[0,62],"Sergey":[1],"V.":[2],"Kozin":[3],"1,*":[4,8,12],",":[5,9,13,17,21],"Nir":[6],"Maimon":[7],"Rong":[10],"Wang":[11],"Nisha":[14],"Gupta":[15],"1":[16,20,25,29,30],"Lance":[18],"Munn":[19],"Rakesh":[22],"K.":[23],"Jain":[24],"and":[26,95,109,199,220],"Igor":[27,59],"Garkavtsev":[28],"Department":[31],"of":[32,97,103,195],"Radiation":[33],"Oncology,":[34],"Edwin":[35],"L.":[36],"Steele":[37],"Laboratory":[38],"for":[39],"Tumor":[40],"Biology,":[41],"Massachusetts":[42],"General":[43],"Hospital,":[44],"Boston,":[45],"MA,":[46],"USA":[47],"*":[48],"These":[49],"authors":[50],"have":[51],"contributed":[52],"equally":[53],"to":[54,106,131,203],"this":[55],"paper":[56],"Correspondence":[57],"to:":[58],"Garkavtsev,":[60],"email:":[61],"Keywords":[63],":":[64,73,78,83],"SLPI;":[65],"triple-negative":[66,121],"breast":[67,122,235],"cancer;":[68],"FoxM1;":[69],"anti-metastatic":[70],"compound":[71],"Received":[72],"September":[74],"15,":[75],"2017":[76,81,86],"Accepted":[77],"October":[79],"30,":[80],"Published":[82],"November":[84],"26,":[85],"Abstract":[87],"SLPI":[88,104,129,136,161,184,210],"has":[89],"been":[90],"implicated":[91],"in":[92,149,169,188,234],"the":[93,101,110,193,204,214,224],"progression":[94],"metastasis":[96,143],"certain":[98],"cancers.":[99],"However,":[100],"effects":[102],"seem":[105],"be":[107],"tumor-specific":[108],"mechanisms":[111],"remain":[112],"poorly":[113],"defined.":[114],"Here,":[115],"we":[116,156,175],"demonstrate":[117],"that":[118,159,209],"highly":[119],"metastatic,":[120],"cancer":[123,236],"(TNBC)":[124],"4T1":[125,145,197],"cells":[126],"secreted":[127],"more":[128],"compared":[130],"their":[132,201],"non-metastatic":[133],"counterparts.":[134],"Furthermore,":[135],"secretion":[137],"directly":[138],"correlated":[139],"with":[140,152,165,213],"spontaneous":[141],"lung":[142],"from":[144,223],"tumors":[146,198],"orthotopically":[147],"implanted":[148],"mice.":[150],"Consistent":[151],"our":[153,189],"experimental":[154],"results,":[155],"also":[157,207],"found":[158],"higher":[160],"expression":[162],"levels":[163],"correlate":[164],"worse":[166],"clinical":[167],"outcome":[168],"basal/TNBC":[170],"patients.":[171],"Using":[172],"high-throughput":[173],"screening":[174],"identified":[176],"a":[177],"novel":[178],"compound,":[179],"C74,":[180],"which":[181,227],"significantly":[182],"inhibits":[183,200],"secretion.":[185],"C74":[186],"administration":[187],"mouse":[190],"model":[191],"slows":[192],"growth":[194],"primary":[196],"dissemination":[202],"lung.":[205],"We":[206],"discovered":[208],"physically":[211],"interacts":[212],"retinoblastoma":[215],"tumor":[216],"suppressor":[217],"protein":[218],"(Rb)":[219],"releases":[221],"FoxM1":[222,230],"Rb-FoxM1":[225],"complex,":[226],"may":[228],"activate":[229],"target":[231],"genes":[232],"involved":[233],"metastasis.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-12-04T00:00:00"}
