{"id":"https://openalex.org/W2769737211","doi":"https://doi.org/10.2147/ijn.s143824","title":"Oligosaccharide nanomedicine of alginate sodium improves therapeutic results of posterior lumbar interbody fusion with cages for degenerative lumbar disease in osteoporosis patients by downregulating serum miR-155","display_name":"Oligosaccharide nanomedicine of alginate sodium improves therapeutic results of posterior lumbar interbody fusion with cages for degenerative lumbar disease in osteoporosis patients by downregulating serum miR-155","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2769737211","doi":"https://doi.org/10.2147/ijn.s143824","mag":"2769737211","pmid":"https://pubmed.ncbi.nlm.nih.gov/29200854","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703176"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s143824","doi":"https://doi.org/10.2147/ijn.s143824","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s143824","pdf_url":"https://www.dovepress.com/getfile.php?fileID=39434","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=39434","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100773498","display_name":"Yang Qu","orcid":"https://orcid.org/0000-0002-3714-1814","observed_orcids":["https://orcid.org/0000-0002-3714-1814"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Qu","raw_affiliation_strings":["Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713139","display_name":"Zhengming Wang","orcid":"https://orcid.org/0000-0002-8385-6343","observed_orcids":["https://orcid.org/0000-0002-8385-6343"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengming Wang","raw_affiliation_strings":["Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101456115","display_name":"Haohan Zhou","orcid":"https://orcid.org/0000-0001-5916-0402","observed_orcids":["https://orcid.org/0000-0001-5916-0402"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haohan Zhou","raw_affiliation_strings":["Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110538430","display_name":"Mingyang Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyang Kang","raw_affiliation_strings":["Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101136030","display_name":"Rongpeng Dong","orcid":"https://orcid.org/0000-0001-8585-4344","observed_orcids":["https://orcid.org/0000-0001-8585-4344"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongpeng Dong","raw_affiliation_strings":["Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008358099","display_name":"Jianwu Zhao","orcid":"https://orcid.org/0000-0003-0574-9742","observed_orcids":["https://orcid.org/0000-0003-0574-9742","https://orcid.org/0000-0002-1424-0473"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianwu Zhao","raw_affiliation_strings":["Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China","Department of Orthopedics, The second hospital of Jilin University, 218 Ziqiang street, changchun 130041, People's republic of china"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]},{"raw_affiliation_string":"Department of Orthopedics, The second hospital of Jilin University, 218 Ziqiang street, changchun 130041, People's republic of china","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008358099"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":4.4239,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.94230511,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"Volume 12","issue":null,"first_page":"8459","last_page":"8469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posterior-lumbar-interbody-fusion","display_name":"posterior lumbar interbody fusion","score":0.859000027179718},{"id":"https://openalex.org/keywords/lumbar-degenerative-disease","display_name":"lumbar degenerative disease","score":0.8849999904632568},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/mir-155","display_name":"miR-155","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":0.847000002861023},{"id":"https://openalex.org/keywords/postoperative-infection","display_name":"postoperative infection","score":0.753000020980835},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5699999928474426},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/fusion-rate","display_name":"fusion rate","score":0.5320000052452087},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6359999775886536},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.7504554390907288},{"id":"https://openalex.org/C44575665","wikidata":"https://www.wikidata.org/wiki/Q1293405","display_name":"Lumbar","level":2,"score":0.7295331358909607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7208294868469238},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6779081225395203},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.5320585370063782},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4748283326625824},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33713918924331665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33002758026123047},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2671593725681305},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19422075152397156},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.16880449652671814},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.07188385725021362}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008159","descriptor_name":"Lumbar Vertebrae","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011785","descriptor_name":"Quality Assurance, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013123","descriptor_name":"Spinal Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.2147/ijn.s143824","doi":"https://doi.org/10.2147/ijn.s143824","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s143824","pdf_url":"https://www.dovepress.com/getfile.php?fileID=39434","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4623284","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29200854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29200854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:5703176","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5703176/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4d30bd9c9a0a43b89496216a52ccb512","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4d30bd9c9a0a43b89496216a52ccb512","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 12, Pp 8459-8469 (2017)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/35719","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/oligosaccharide-nanomedicine-of-alginate-sodium-improves-therapeutic-r-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s143824","doi":"https://doi.org/10.2147/ijn.s143824","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s143824","pdf_url":"https://www.dovepress.com/getfile.php?fileID=39434","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2769737211.pdf","grobid_xml":"https://content.openalex.org/works/W2769737211.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1849942152","https://openalex.org/W1965345750","https://openalex.org/W1995214179","https://openalex.org/W2016509828","https://openalex.org/W2030149941","https://openalex.org/W2036459378","https://openalex.org/W2046310455","https://openalex.org/W2055441487","https://openalex.org/W2059716370","https://openalex.org/W2070196288","https://openalex.org/W2091065368","https://openalex.org/W2104771964","https://openalex.org/W2106138558","https://openalex.org/W2168781925","https://openalex.org/W2297376695","https://openalex.org/W2320344854","https://openalex.org/W2398353212","https://openalex.org/W2467014757","https://openalex.org/W2522550174","https://openalex.org/W2528872795","https://openalex.org/W2568751801","https://openalex.org/W2589358108","https://openalex.org/W2597520942","https://openalex.org/W2616401560","https://openalex.org/W2618320771","https://openalex.org/W2692836451"],"related_works":["https://openalex.org/W4221057090","https://openalex.org/W3092963844","https://openalex.org/W2912351185","https://openalex.org/W1728174319","https://openalex.org/W2900785204","https://openalex.org/W3197383120","https://openalex.org/W3029992516","https://openalex.org/W4390295869","https://openalex.org/W4401538475","https://openalex.org/W4386041839"],"abstract_inverted_index":{"Abstract:":[0],"Degenerative":[1],"lumbar":[2,13],"disease":[3],"(DLD)":[4],"is":[5,51],"a":[6,52],"significant":[7,235],"issue":[8],"for":[9,47,239],"public":[10],"health.":[11],"Posterior":[12],"intervertebral":[14],"fusion":[15,21,157,198,317],"with":[16,55,79],"cages":[17],"(PLIFC)":[18],"has":[19,298],"high-level":[20],"rate":[22],"and":[23,40,43,57,70,91,106,139,159,176,233,244,254,261,278,280,287,303],"realignment":[24],"on":[25,306],"DLD.":[26],"However,":[27],"there":[28],"are":[29],"some":[30],"complications":[31,302],"following":[32],"the":[33,240,273,282],"surgery.":[34],"Alginate":[35],"oligosaccharides":[36],"(AOS)":[37],"have":[38],"antioxidant":[39],"anti-inflammatory":[41],"activities":[42],"may":[44,61],"be":[45],"suitable":[46],"infection":[48,155,174,319],"therapy.":[49],"MiR-155":[50,270],"biomarker":[53],"associated":[54],"inflammatory":[56],"oxidative":[58],"stress.":[59],"AOS":[60],"promote":[62],"PLIFC":[63,90],"therapy":[64],"by":[65,119,308],"regulating":[66,309],"miR-155.":[67,311],"Pluronic":[68],"nanoparticles":[69],"oligosaccharide":[71],"nanomedicine":[72],"of":[73,101,125,250,275,284],"alginate":[74,313],"sodium":[75],"(ONAS)":[76],"were":[77,92,144,165,179,200,218,256,263],"prepared":[78],"ampicillin":[80],"at":[81],"size":[82],"<200":[83],"nm.":[84],"Ninety-six":[85],"DLD":[86,307],"osteoporosis":[87],"patients":[88],"received":[89],"evenly":[93],"assigned":[94],"into":[95],"ONAS":[96,104,297],"group":[97,108],"(OG,":[98],"oral":[99],"administration":[100],"100":[102,110],"mg":[103,111],"daily)":[105],"control":[107],"(PG,":[109],"pluronic":[112],"nanoparticles).":[113],"Serum":[114,248],"miR-155":[115,291],"level":[116],"was":[117,237],"measured":[118],"real-time":[120],"quantitative":[121],"PCR.":[122],"The":[123,197,215],"levels":[124,249,274,283],"superoxide":[126],"dismutase":[127],"(SOD),":[128],"glutathione":[129],"(GSH),":[130],"aspartate":[131],"aminotransaminase":[132],"(AST),":[133],"alanine":[134],"aminotransferase":[135],"(ALT),":[136],"interleukin-1\u03b2":[137],"(IL-1\u03b2),":[138],"interleukin-1":[140],"receptor":[141],"antagonist":[142],"(IL-1ra)":[143],"measured.":[145],"Weighted":[146],"mean":[147],"difference":[148,236],"(WMD),":[149],"relative":[150],"risk":[151],"(RR),":[152],"complications,":[153],"surgery":[154],"rate,":[156,158,318,320],"Japanese":[160,321],"Orthopaedic":[161,322],"Association":[162],"(JOA)":[163],"scores":[164,217],"used":[166],"to":[167],"evaluate":[168],"therapeutic":[169,304],"efficacy.":[170],"After":[171],"1-month":[172],"therapy,":[173],"rates":[175,199],"side":[177],"effects":[178,305],"lower":[180,257],"in":[181,185,202,205,220,223,265,268,301],"OG":[182,203,221,266],"than":[183,204,222,267],"those":[184],"PG":[186,206,224],"(RR":[187,225],"=0.64,":[188],"95%":[189,209,227],"confidence":[190],"interval":[191],"[CI]":[192],"[0.48,":[193],"0.84],":[194,230],"P":[195,213,231],"=0.001).":[196],"higher":[201,219,264],"(WMD":[207],"=21.96,":[208],"CI":[210,228],"[\u20130.24,":[211],"37.62],":[212],"=0.021).":[214],"JOA":[216],"=0.52,":[226],"[0.33,":[229],"=0.007),":[232],"no":[234],"found":[238],"visual":[241],"analog":[242],"scale":[243],"Oswestry":[245,324],"Disability":[246,325],"Index.":[247],"miR-155,":[251],"ALT,":[252,276],"AST,":[253,277],"IL-1\u03b2":[255,279],"while":[258],"SOD,":[259,285],"GSH,":[260,286],"IL-1ra":[262],"PG.":[269],"mimic":[271],"increased":[272],"reduced":[281],"IL-1ra.":[288],"In":[289],"contrast,":[290],"inhibitor":[292],"had":[293],"reverse":[294],"results.":[295],"Therefore,":[296],"better":[299],"improvement":[300],"serum":[310],"Keywords:":[312],"oligosaccharide,":[314],"antioxidant,":[315],"anti-inflammatory,":[316],"Association,":[323],"Index":[326]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-12-04T00:00:00"}
