{"id":"https://openalex.org/W2769735587","doi":"https://doi.org/10.1016/j.jpeds.2017.08.076","title":"The Clinical Utility and Safety of a New Strategy for the Treatment of Refractory Kawasaki Disease","display_name":"The Clinical Utility and Safety of a New Strategy for the Treatment of Refractory Kawasaki Disease","publication_year":2017,"publication_date":"2017-11-21","ids":{"openalex":"https://openalex.org/W2769735587","doi":"https://doi.org/10.1016/j.jpeds.2017.08.076","mag":"2769735587","pmid":"https://pubmed.ncbi.nlm.nih.gov/29173297"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpeds.2017.08.076","doi":"https://doi.org/10.1016/j.jpeds.2017.08.076","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpeds.2017.08.076","pdf_url":null,"source":{"id":"https://openalex.org/S3774022","display_name":"The Journal of Pediatrics","issn_l":"0022-3476","issn":["0022-3476","1085-8695","1097-6833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072796946","display_name":"Takasuke Ebato","orcid":"https://orcid.org/0000-0002-4952-533X","observed_orcids":["https://orcid.org/0000-0002-4952-533X"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takasuke Ebato","raw_affiliation_strings":["Department of Pediatrics, Kitasato University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056584442","display_name":"Shohei Ogata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shohei Ogata","raw_affiliation_strings":["Department of Pediatrics, Kitasato University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103142953","display_name":"Yoshihito Ogihara","orcid":"https://orcid.org/0000-0003-4161-5987","observed_orcids":["https://orcid.org/0000-0003-4161-5987"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihito Ogihara","raw_affiliation_strings":["Department of Pediatrics, Kitasato University, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4161-5987","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057008386","display_name":"Mayu Fujimoto","orcid":"https://orcid.org/0000-0002-8214-5144","observed_orcids":["https://orcid.org/0000-0002-8214-5144"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayu Fujimoto","raw_affiliation_strings":["Department of Pediatrics, Kitasato University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056324339","display_name":"Atsushi KITAGAWA","orcid":"https://orcid.org/0000-0002-1032-4557","observed_orcids":["https://orcid.org/0000-0002-1032-4557"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kitagawa","raw_affiliation_strings":["Department of Pediatrics, Kitasato University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005880320","display_name":"Manabu Takanashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Takanashi","raw_affiliation_strings":["Department of Pediatrics, Kitasato University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100617640","display_name":"Masahiro Ishii","orcid":"https://orcid.org/0000-0001-5523-2341","observed_orcids":["https://orcid.org/0000-0001-5523-2341"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahiro Ishii","raw_affiliation_strings":["Department of Pediatrics, Kitasato University, Kanagawa, Japan. Electronic address: Ishiim@med.kitasato-u.ac.jp","Department of Pediatrics, Kitasato University, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5523-2341","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kitasato University, Kanagawa, Japan. Electronic address: Ishiim@med.kitasato-u.ac.jp","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"Department of Pediatrics, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100617640"],"corresponding_institution_ids":["https://openalex.org/I64189623"],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":4.7601,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.95601974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"191","issue":null,"first_page":"140","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/refractory-kawasaki-disease","display_name":"refractory Kawasaki disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9570000171661377},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.953000009059906},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bcg-vaccination","display_name":"BCG vaccination","score":0.7870000004768372},{"id":"https://openalex.org/keywords/coronary-artery-anomalies","display_name":"coronary artery anomalies","score":0.7940000295639038},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5989999771118164},{"id":"https://openalex.org/keywords/pediatric-vasculitis","display_name":"pediatric vasculitis","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9661388993263245},{"id":"https://openalex.org/C2781423770","wikidata":"https://www.wikidata.org/wiki/Q265936","display_name":"Kawasaki disease","level":3,"score":0.7886677384376526},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6916316151618958},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6903367042541504},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5178406834602356},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.4272244870662689},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.20188406109809875},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19737675786018372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1852407157421112},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003323","descriptor_name":"Coronary Aneurysm","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003323","descriptor_name":"Coronary Aneurysm","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010951","descriptor_name":"Plasma Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jpeds.2017.08.076","doi":"https://doi.org/10.1016/j.jpeds.2017.08.076","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpeds.2017.08.076","pdf_url":null,"source":{"id":"https://openalex.org/S3774022","display_name":"The Journal of Pediatrics","issn_l":"0022-3476","issn":["0022-3476","1085-8695","1097-6833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:29173297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29173297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pediatrics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1487425572","https://openalex.org/W1963598954","https://openalex.org/W1973811181","https://openalex.org/W1976754613","https://openalex.org/W1993310310","https://openalex.org/W2010666563","https://openalex.org/W2020009342","https://openalex.org/W2020577123","https://openalex.org/W2023857457","https://openalex.org/W2032887536","https://openalex.org/W2034173888","https://openalex.org/W2041755747","https://openalex.org/W2050966310","https://openalex.org/W2063642853","https://openalex.org/W2071347890","https://openalex.org/W2073873228","https://openalex.org/W2107116109","https://openalex.org/W2109450728","https://openalex.org/W2172847217","https://openalex.org/W2315160100","https://openalex.org/W2604027935","https://openalex.org/W4244865467","https://openalex.org/W4255017270"],"related_works":["https://openalex.org/W2516319461","https://openalex.org/W1991290828","https://openalex.org/W2107116109","https://openalex.org/W4385335522","https://openalex.org/W2319381636","https://openalex.org/W4410334958","https://openalex.org/W2020299922","https://openalex.org/W4386260334","https://openalex.org/W2013892856","https://openalex.org/W2086392178"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-12-04T00:00:00"}