{"id":"https://openalex.org/W2769554142","doi":"https://doi.org/10.1007/s13239-017-0334-x","title":"The Impact of Heat Treatment on Porcine Heart Valve Leaflets","display_name":"The Impact of Heat Treatment on Porcine Heart Valve Leaflets","publication_year":2017,"publication_date":"2017-11-13","ids":{"openalex":"https://openalex.org/W2769554142","doi":"https://doi.org/10.1007/s13239-017-0334-x","mag":"2769554142","pmid":"https://pubmed.ncbi.nlm.nih.gov/29134471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5797199"},"language":"en","primary_location":{"id":"doi:10.1007/s13239-017-0334-x","doi":"https://doi.org/10.1007/s13239-017-0334-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13239-017-0334-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13239-017-0334-x.pdf","source":{"id":"https://openalex.org/S72401558","display_name":"Cardiovascular Engineering and Technology","issn_l":"1869-408X","issn":["1869-408X","1869-4098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Engineering and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s13239-017-0334-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033819389","display_name":"R. Glenn Hepfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Glenn Hepfer","raw_affiliation_strings":["Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029336233","display_name":"Peng Chen","orcid":"https://orcid.org/0000-0001-9358-7813","observed_orcids":["https://orcid.org/0000-0001-9358-7813"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Chen","raw_affiliation_strings":["Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034594856","display_name":"Kelvin G.M. Brockbank","orcid":"https://orcid.org/0000-0002-2718-3455","observed_orcids":["https://orcid.org/0000-0002-2718-3455"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelvin G. M. Brockbank","raw_affiliation_strings":["Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA","Tissue Testing Technologies LLC, North Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"Tissue Testing Technologies LLC, North Charleston, SC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018878125","display_name":"Alyce Linthurst Jones","orcid":"https://orcid.org/0000-0003-3732-1089","observed_orcids":["https://orcid.org/0000-0003-3732-1089"]},"institutions":[{"id":"https://openalex.org/I4210126770","display_name":"Lifenet Health","ror":"https://ror.org/038st2x32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyce L. Jones","raw_affiliation_strings":["LifeNet Health, Virginia Beach, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeNet Health, Virginia Beach, VA, USA","institution_ids":["https://openalex.org/I4210126770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086324352","display_name":"Amanda K. Burnette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126770","display_name":"Lifenet Health","ror":"https://ror.org/038st2x32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda K. Burnette","raw_affiliation_strings":["LifeNet Health, Virginia Beach, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeNet Health, Virginia Beach, VA, USA","institution_ids":["https://openalex.org/I4210126770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100457659","display_name":"Zhen Chen","orcid":"https://orcid.org/0000-0001-9626-2061","observed_orcids":["https://orcid.org/0000-0001-9626-2061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhen Chen","raw_affiliation_strings":["Tissue Testing Technologies LLC, North Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Testing Technologies LLC, North Charleston, SC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003268538","display_name":"Elizabeth D. Greene","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth D. Greene","raw_affiliation_strings":["Tissue Testing Technologies LLC, North Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Testing Technologies LLC, North Charleston, SC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047924722","display_name":"Lia H. Campbell","orcid":"https://orcid.org/0000-0002-6501-9875","observed_orcids":["https://orcid.org/0000-0002-6501-9875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lia H. Campbell","raw_affiliation_strings":["Tissue Testing Technologies LLC, North Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Testing Technologies LLC, North Charleston, SC, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014195696","display_name":"Hai Yao","orcid":"https://orcid.org/0000-0001-5130-5128","observed_orcids":["https://orcid.org/0000-0001-5130-5128"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hai Yao","raw_affiliation_strings":["Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA. haiyao@clemson.edu","Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA. haiyao@clemson.edu","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University, 173 Ashley Avenue, MSC 508, Charleston, SC, 29425, USA","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014195696"],"corresponding_institution_ids":["https://openalex.org/I8078737"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.27927588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"32","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-treatment-food-and-biological-processing","display_name":"heat treatment (food and biological processing)","score":0.972000002861023},{"id":"https://openalex.org/keywords/tissue-bank","display_name":"tissue banking","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pulmonary-valve","display_name":"pulmonary valve","score":0.5929999947547913},{"id":"https://openalex.org/keywords/tissue-viability","display_name":"tissue viability","score":0.6779999732971191},{"id":"https://openalex.org/keywords/collagen-content","display_name":"collagen content","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tissue-permeability","display_name":"tissue permeability","score":0.8709999918937683},{"id":"https://openalex.org/keywords/resazurin-assay","display_name":"resazurin assay","score":0.8619999885559082},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/collagen-fiber-organization","display_name":"collagen fiber organization","score":0.9330000281333923},{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/two-photon-microscopy","display_name":"two-photon microscopy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tissue-damage-assessment","display_name":"tissue damage assessment","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2778400546","wikidata":"https://www.wikidata.org/wiki/Q409628","display_name":"Resazurin","level":2,"score":0.8410764932632446},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.8127892017364502},{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.7590030431747437},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.6162240505218506},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.5546382069587708},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5323275327682495},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4285694658756256},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.40621840953826904},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38275593519210815},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3756765127182007},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35595548152923584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23469945788383484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.234361469745636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20011889934539795},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006350","descriptor_name":"Heart Valve Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006350","descriptor_name":"Heart Valve Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006350","descriptor_name":"Heart Valve Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D011664","descriptor_name":"Pulmonary Valve","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014022","descriptor_name":"Tissue Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014022","descriptor_name":"Tissue Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014022","descriptor_name":"Tissue Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019918","descriptor_name":"Heart Valve Prosthesis Implantation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019918","descriptor_name":"Heart Valve Prosthesis Implantation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019918","descriptor_name":"Heart Valve Prosthesis Implantation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024022","descriptor_name":"Fibrillar Collagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024022","descriptor_name":"Fibrillar Collagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024022","descriptor_name":"Fibrillar Collagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s13239-017-0334-x","doi":"https://doi.org/10.1007/s13239-017-0334-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13239-017-0334-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13239-017-0334-x.pdf","source":{"id":"https://openalex.org/S72401558","display_name":"Cardiovascular Engineering and Technology","issn_l":"1869-408X","issn":["1869-408X","1869-4098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Engineering and Technology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4713975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5797199","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5797199","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5797199","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Eng Technol","raw_type":"Text"},{"id":"pmid:29134471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29134471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular engineering and technology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s13239-017-0334-x","doi":"https://doi.org/10.1007/s13239-017-0334-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13239-017-0334-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13239-017-0334-x.pdf","source":{"id":"https://openalex.org/S72401558","display_name":"Cardiovascular Engineering and Technology","issn_l":"1869-408X","issn":["1869-408X","1869-4098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Engineering and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3542080705","display_name":"Biophysical Modeling of Fluid and Solute Transport in the TMJ Disc","funder_award_id":"R03DE018741","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000281755","display_name":null,"funder_award_id":"AR055775","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000886197","display_name":"Integrating craniofacial morphology, oral function, temporomandibular biomechanics and mechanobiology to determine sex-specific TMJ pathophysiology in humans","funder_award_id":"R01DE021134","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320309383","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2769554142.pdf","grobid_xml":"https://content.openalex.org/works/W2769554142.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W204382757","https://openalex.org/W294328494","https://openalex.org/W1978113197","https://openalex.org/W1979968811","https://openalex.org/W1982298638","https://openalex.org/W1987534533","https://openalex.org/W1996841581","https://openalex.org/W2002422344","https://openalex.org/W2007924064","https://openalex.org/W2017262454","https://openalex.org/W2021186660","https://openalex.org/W2026639406","https://openalex.org/W2027316020","https://openalex.org/W2049024822","https://openalex.org/W2052121896","https://openalex.org/W2053963626","https://openalex.org/W2074983647","https://openalex.org/W2090242943","https://openalex.org/W2099327671","https://openalex.org/W2105624703","https://openalex.org/W2116167491","https://openalex.org/W2130368723","https://openalex.org/W2131442097","https://openalex.org/W2154385453","https://openalex.org/W2344487845","https://openalex.org/W2405312697","https://openalex.org/W2587643481","https://openalex.org/W2748725547","https://openalex.org/W4205490020","https://openalex.org/W4300905470"],"related_works":["https://openalex.org/W2344487845","https://openalex.org/W2246447406","https://openalex.org/W2017701297","https://openalex.org/W958309651","https://openalex.org/W2400733250","https://openalex.org/W2235948684","https://openalex.org/W2085945137","https://openalex.org/W2416359835","https://openalex.org/W2064047462","https://openalex.org/W4281782497"],"abstract_inverted_index":{"The":[0,67],"purpose":[1],"of":[2,10,29,71,106,123,181],"this":[3],"study":[4],"was":[5,23,133],"to":[6,24,32,39,48,103,128],"determine":[7,25],"the":[8,26,76,83,191],"impact":[9],"elevated":[11],"temperature":[12,40],"exposure":[13],"in":[14,35,166,173],"tissue":[15,109],"banking":[16],"on":[17],"soft":[18,36],"tissues.":[19],"A":[20],"secondary":[21],"objective":[22],"relative":[27],"ability":[28],"various":[30],"assays":[31],"detect":[33],"changes":[34],"tissues":[37,189],"due":[38],"deviations.":[41],"Porcine":[42],"pulmonary":[43],"heart":[44],"valve":[45],"leaflets":[46],"exposed":[47],"37":[49],"\u00b0C":[50,60],"were":[51,101],"compared":[52],"with":[53,126],"those":[54],"incubated":[55],"at":[56],"52":[57],"and":[58,64,86,97,108,114,145,159,170,195],"67":[59],"for":[61,187],"10,":[62],"30":[63],"100":[65],"min.":[66],"analytical":[68],"methods":[69],"consisted":[70],"(1)":[72],"viability":[73,132,183,203],"assessment":[74,89],"using":[75,82,90],"resazurin":[77],"assay,":[78,85],"(2)":[79],"collagen":[80,112,147,167],"content":[81,148],"Sircol":[84],"(3)":[87],"permeability":[88,115,141,197],"an":[91,171],"electrical":[92],"conductivity":[93],"assay.":[94],"Additionally,":[95],"histology":[96,155],"two":[98,160],"photon":[99,161],"microscopy":[100,162],"used":[102],"reveal":[104],"mechanisms":[105],"cell":[107,131,182,202],"damage.":[110],"Viability,":[111],"content,":[113],"all":[116],"decreased":[117],"following":[118],"heat":[119,153],"treatment.":[120],"In":[121],"terms":[122],"statistical":[124],"significance":[125],"respect":[127],"treatment":[129],"temperature,":[130],"most":[134],"affected":[135],"(p":[136,142,149],"<":[137,143],"0.0001),":[138,144],"followed":[139],"by":[140],"then":[146],"=":[150],"0.13).":[151],"After":[152],"treatment,":[154],"indicated":[156],"increased":[157],"apoptosis":[158],"revealed":[163],"a":[164],"decrease":[165],"fiber":[168],"organization":[169],"increase":[172],"elastin":[174],"density.":[175],"These":[176],"results":[177],"suggest":[178],"that":[179,196],"measures":[180],"would":[184],"be":[185,199],"best":[186,200],"assessing":[188],"where":[190,201],"cells":[192],"are":[193],"alive":[194],"may":[198],"is":[204],"not":[205],"intentionally":[206],"maintained.":[207]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2017-12-04T00:00:00"}