{"id":"https://openalex.org/W2769496969","doi":"https://doi.org/10.1038/protex.2017.134","title":"A Protocol for the Implantation of a Permanent Window for High-Resolution Imaging of the Murine Lung","display_name":"A Protocol for the Implantation of a Permanent Window for High-Resolution Imaging of the Murine Lung","publication_year":2017,"publication_date":"2017-11-27","ids":{"openalex":"https://openalex.org/W2769496969","doi":"https://doi.org/10.1038/protex.2017.134","mag":"2769496969"},"language":"en","primary_location":{"id":"doi:10.1038/protex.2017.134","doi":"https://doi.org/10.1038/protex.2017.134","is_oa":true,"landing_page_url":"https://doi.org/10.1038/protex.2017.134","pdf_url":"https://protocolexchange.researchsquare.com/article/nprot-6351/v1.pdf","source":{"id":"https://openalex.org/S2764931282","display_name":"Protocol Exchange","issn_l":"2043-0116","issn":["2043-0116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protocol Exchange","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://protocolexchange.researchsquare.com/article/nprot-6351/v1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086159127","display_name":"David R. Entenberg","orcid":"https://orcid.org/0000-0003-0422-7264","observed_orcids":["https://orcid.org/0000-0003-0422-7264"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Entenberg","raw_affiliation_strings":["Einstein College of Medicine / Monte ore Medical Center","Einstein College of Medicine / Monte ore Medical Center John Condeelis","Einstein College of Medicine / Monte ore Medical Center Lucia Borriello Einstein College of Medicine / Monte ore Medical Center Anouchka Coste-Abramson Einstein College of Medicine / Monte ore Medical Center Francis Baccay Einstein College of Medicine / Monte ore Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center John Condeelis","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center Lucia Borriello Einstein College of Medicine / Monte ore Medical Center Anouchka Coste-Abramson Einstein College of Medicine / Monte ore Medical Center Francis Baccay Einstein College of Medicine / Monte ore Medical Center","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086159127","display_name":"David R. Entenberg","orcid":"https://orcid.org/0000-0003-0422-7264","observed_orcids":["https://orcid.org/0000-0003-0422-7264"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Entenberg","raw_affiliation_strings":["Einstein College of Medicine / Monte ore Medical Center","Einstein College of Medicine / Monte ore Medical Center John Condeelis","Einstein College of Medicine / Monte ore Medical Center Lucia Borriello Einstein College of Medicine / Monte ore Medical Center Anouchka Coste-Abramson Einstein College of Medicine / Monte ore Medical Center Francis Baccay Einstein College of Medicine / Monte ore Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center John Condeelis","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center Lucia Borriello Einstein College of Medicine / Monte ore Medical Center Anouchka Coste-Abramson Einstein College of Medicine / Monte ore Medical Center Francis Baccay Einstein College of Medicine / Monte ore Medical Center","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015810435","display_name":"Sonia E. Voiculescu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia Voiculescu","raw_affiliation_strings":["Einstein College of Medicine / Monte ore Medical Center Lucia Borriello Einstein College of Medicine / Monte ore Medical Center Anouchka Coste-Abramson Einstein College of Medicine / Monte ore Medical Center Francis Baccay Einstein College of Medicine / Monte ore Medical Center","Einstein College of Medicine / Monte ore Medical Center","Einstein College of Medicine / Monte ore Medical Center John Condeelis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center Lucia Borriello Einstein College of Medicine / Monte ore Medical Center Anouchka Coste-Abramson Einstein College of Medicine / Monte ore Medical Center Francis Baccay Einstein College of Medicine / Monte ore Medical Center","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center John Condeelis","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090829224","display_name":"Lucia Borriello","orcid":"https://orcid.org/0000-0002-8730-4079","observed_orcids":["https://orcid.org/0000-0002-8730-4079","https://orcid.org/0000-0002-3164-8374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucia Borriello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103914594","display_name":"Anouchka Coste","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anouchka Coste-Abramson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057634846","display_name":"Francis Baccay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis Baccay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014100567","display_name":"John S. Condeelis","orcid":"https://orcid.org/0000-0001-8826-2336","observed_orcids":["https://orcid.org/0000-0001-8826-2336"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Condeelis","raw_affiliation_strings":["Einstein College of Medicine / Monte ore Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein College of Medicine / Monte ore Medical Center","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086159127"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":0.1603,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5419728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.3582000136375427,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravital-imaging","display_name":"intravital imaging","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lung-imaging","display_name":"lung imaging","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4569999873638153},{"id":"https://openalex.org/keywords/minimally-invasive-surgery","display_name":"minimally invasive surgery","score":0.8399999737739563},{"id":"https://openalex.org/keywords/longitudinal-imaging","display_name":"longitudinal imaging","score":0.4659999907016754},{"id":"https://openalex.org/keywords/high-resolution-imaging","display_name":"high-resolution imaging","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2778751112","wikidata":"https://www.wikidata.org/wiki/Q835016","display_name":"Window (computing)","level":2,"score":0.7838958501815796},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.5360318422317505},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.511372983455658},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.5071661472320557},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.42272478342056274},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36305302381515503},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3406860828399658},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3145598769187927},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19935551285743713},{"id":"https://openalex.org/C62649853","wikidata":"https://www.wikidata.org/wiki/Q199687","display_name":"Remote sensing","level":1,"score":0.1738784909248352},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13386982679367065},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.1295839548110962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10690364241600037},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.08266359567642212},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/protex.2017.134","doi":"https://doi.org/10.1038/protex.2017.134","is_oa":true,"landing_page_url":"https://doi.org/10.1038/protex.2017.134","pdf_url":"https://protocolexchange.researchsquare.com/article/nprot-6351/v1.pdf","source":{"id":"https://openalex.org/S2764931282","display_name":"Protocol Exchange","issn_l":"2043-0116","issn":["2043-0116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protocol Exchange","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/protex.2017.134","doi":"https://doi.org/10.1038/protex.2017.134","is_oa":true,"landing_page_url":"https://doi.org/10.1038/protex.2017.134","pdf_url":"https://protocolexchange.researchsquare.com/article/nprot-6351/v1.pdf","source":{"id":"https://openalex.org/S2764931282","display_name":"Protocol Exchange","issn_l":"2043-0116","issn":["2043-0116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protocol Exchange","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2202362502","display_name":"(7) Novel imaging devices for measurement and control of tumor microenvironments","funder_award_id":"R01CA216248","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4212357415","display_name":"Training of Surgeon Scientists in Basic and Translational Cancer Research","funder_award_id":"T32CA200561","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7829110550","display_name":"High-speed/resolution whole slide scanner supported by two core facilities","funder_award_id":"1s10od019961-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000210086","display_name":null,"funder_award_id":"CA100324","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2769496969.pdf","grobid_xml":"https://content.openalex.org/works/W2769496969.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1972081326","https://openalex.org/W1979200687","https://openalex.org/W2002054283","https://openalex.org/W2027146979","https://openalex.org/W2037546616","https://openalex.org/W2152464567","https://openalex.org/W2154693268","https://openalex.org/W2270196325","https://openalex.org/W2285479374","https://openalex.org/W2527956919"],"related_works":["https://openalex.org/W2479778541","https://openalex.org/W2047027201","https://openalex.org/W3174911935","https://openalex.org/W2527956919","https://openalex.org/W2179218972","https://openalex.org/W3167163470","https://openalex.org/W4360823188","https://openalex.org/W4205761492","https://openalex.org/W1989718007","https://openalex.org/W1608130001"],"abstract_inverted_index":{"High":[0],"resolution":[1,96],"optical":[2,83],"imaging":[3,60,67,84,97,118],"of":[4,35,59,79,90,98,119],"living":[5],"tissues,":[6],"a":[7,15,71,80,91],"process":[8],"known":[9],"as":[10,41],"intravital":[11],"imaging,":[12],"has":[13],"become":[14],"powerful":[16],"tool":[17],"for":[18,76],"understanding":[19],"biological":[20],"processes":[21],"in":[22],"the":[23,42,45,57,77,87,99,103,107,111,120],"most":[24],"physiologically":[25],"relevant":[26],"manner":[27],"possible.Recent":[28],"advances":[29],"have":[30],"even":[31],"enabled":[32],"direct":[33],"visualization":[34],"delicate":[36],"internal":[37],"vital":[38],"organs":[39],"such":[40],"lung":[43,121],"and":[44,61,113,116],"heart.Unfortunately":[46],"however,":[47],"these":[48],"protocols":[49],"involve":[50],"extremely":[51],"invasive,":[52],"terminal":[53],"surgeries":[54],"that":[55],"limit":[56],"duration":[58],"allow":[62,94],"no":[63],"more":[64],"than":[65],"one":[66],"session.We":[68],"present":[69],"here":[70],"minimally":[72],"invasive":[73],"surgical":[74],"protocol":[75],"implantation":[78],"permanent,":[81],"indwelling,":[82],"window":[85,101],"into":[86],"chest":[88],"wall":[89],"mouse":[92,108],"to":[93,109,125],"high":[95],"lung.The":[100],"reseals":[102],"thoracic":[104],"cavity,":[105],"enabling":[106],"survive":[110],"surgery":[112],"breathe":[114],"independently,":[115],"makes":[117],"tissue":[122],"over":[123],"days":[124],"weeks":[126],"possible.":[127]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2017-12-04T00:00:00"}