{"id":"https://openalex.org/W2769019593","doi":"https://doi.org/10.5530/pj.2017.6s.169","title":"Aristolochia bracteolata Enhances Wound Healing in vitro through Anti-inflammatory and Proliferative Effect on Human Dermal Fibroblasts and Keratinocytes","display_name":"Aristolochia bracteolata Enhances Wound Healing in vitro through Anti-inflammatory and Proliferative Effect on Human Dermal Fibroblasts and Keratinocytes","publication_year":2017,"publication_date":"2017-11-25","ids":{"openalex":"https://openalex.org/W2769019593","doi":"https://doi.org/10.5530/pj.2017.6s.169","mag":"2769019593"},"language":"en","primary_location":{"id":"doi:10.5530/pj.2017.6s.169","doi":"https://doi.org/10.5530/pj.2017.6s.169","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2017.6s.169","pdf_url":"http://phcogj.com/sites/default/files/PharmacognJ-9s-S129.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://phcogj.com/sites/default/files/PharmacognJ-9s-S129.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Dinesh Murugan Girija","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dinesh Murugan Girija","raw_affiliation_strings":["Centre for Indian Systems of Medicine Quality Assurance and Standardization Sri Ramachandra University, Chennai, Tamil Nadu, INDIA","Department of Pharmacognosy , Faculty of Pharmacy , Sri Ramachandra University , Porur , Chennai -116 , Tamil Nadu , INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Indian Systems of Medicine Quality Assurance and Standardization Sri Ramachandra University, Chennai, Tamil Nadu, INDIA","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacognosy , Faculty of Pharmacy , Sri Ramachandra University , Porur , Chennai -116 , Tamil Nadu , INDIA","institution_ids":["https://openalex.org/I20107917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041798513","display_name":"Mangathayaru Kalachaveedu","orcid":"https://orcid.org/0000-0002-1002-8088","observed_orcids":["https://orcid.org/0000-0002-1002-8088"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mangathayaru Kalachaveedu","raw_affiliation_strings":["Faculty of Pharmacy, Sri Ramachandra University, Chennai, Tamil Nadu, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Sri Ramachandra University, Chennai, Tamil Nadu, INDIA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104321598","display_name":"Rajasekaran Subbarayan","orcid":"https://orcid.org/0000-0001-5890-5273","observed_orcids":["https://orcid.org/0000-0001-5890-5273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajasekaran Subbarayan","raw_affiliation_strings":["Centre for Regenerative Medicine and Stem Cell Research, Sri Ramachandra University, Chennai, Tamil Nadu, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Regenerative Medicine and Stem Cell Research, Sri Ramachandra University, Chennai, Tamil Nadu, INDIA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007303559","display_name":"Preethi Jenifer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Preethi Jenifer","raw_affiliation_strings":["Faculty of Pharmacy, Sri Ramachandra University, Chennai, Tamil Nadu, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Sri Ramachandra University, Chennai, Tamil Nadu, INDIA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101415850","display_name":"Suresh Ranga Rao","orcid":"https://orcid.org/0000-0001-9247-6695","observed_orcids":["https://orcid.org/0000-0001-9247-6695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh Ranga Rao","raw_affiliation_strings":["Department of Periodontology, Sri Ramachandra University, Chennai, Tamil Nadu, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Sri Ramachandra University, Chennai, Tamil Nadu, INDIA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041798513"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3885,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78901101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"9","issue":"6s","first_page":"s129","last_page":"s136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aristolochia-bracteolata","display_name":"Aristolochia bracteolata","score":1.0},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9179999828338623},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9049999713897705},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/collagen-expression","display_name":"collagen expression","score":0.6079999804496765},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.9378933906555176},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6296800374984741},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6267222762107849},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.6087716817855835},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5616579055786133},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.5368839502334595},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5110033750534058},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5028843283653259},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4906858205795288},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4877784848213196},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4790964424610138},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47617262601852417},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.46981173753738403},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.44978439807891846},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44835126399993896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28706252574920654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2348947525024414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1800692081451416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5530/pj.2017.6s.169","doi":"https://doi.org/10.5530/pj.2017.6s.169","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2017.6s.169","pdf_url":"http://phcogj.com/sites/default/files/PharmacognJ-9s-S129.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5530/pj.2017.6s.169","doi":"https://doi.org/10.5530/pj.2017.6s.169","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2017.6s.169","pdf_url":"http://phcogj.com/sites/default/files/PharmacognJ-9s-S129.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2769019593.pdf","grobid_xml":"https://content.openalex.org/works/W2769019593.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1560533935","https://openalex.org/W1561328894","https://openalex.org/W1929105682","https://openalex.org/W1966355489","https://openalex.org/W1980343965","https://openalex.org/W2004886833","https://openalex.org/W2018561546","https://openalex.org/W2035266890","https://openalex.org/W2048604783","https://openalex.org/W2058616412","https://openalex.org/W2062550861","https://openalex.org/W2080417621","https://openalex.org/W2082062885","https://openalex.org/W2095521867","https://openalex.org/W2114918609","https://openalex.org/W2133632488","https://openalex.org/W2142605112","https://openalex.org/W2148054347","https://openalex.org/W2159504105","https://openalex.org/W2161146123","https://openalex.org/W2165892104","https://openalex.org/W2277188841","https://openalex.org/W2323005614"],"related_works":["https://openalex.org/W2062550861","https://openalex.org/W4380898289","https://openalex.org/W2623353350","https://openalex.org/W2945754617","https://openalex.org/W861983588","https://openalex.org/W6968182589","https://openalex.org/W2754863051","https://openalex.org/W2161146123","https://openalex.org/W2043577682","https://openalex.org/W1564781664"],"abstract_inverted_index":{"Objective:":[0],"In":[1],"the":[2,7,61,90,181,207,211,228,240,259,271,276],"present":[3,272],"study,":[4],"we":[5],"examined":[6],"effect":[8,44,62,179],"of":[9,45,63,68,82,88,132,137,155,183,192,213,230,247,262,278],"Aristolochia":[10],"bracteolata":[11,37,84,174,194,223,280],"extract":[12,47,81,147,191,242],"on":[13,66,158,180],"Human":[14,19],"dermal":[15],"fibroblast":[16],"(HDF)":[17],"and":[18,25,32,40,55,70,97,106,117,143,185,252,267],"keratinocyte":[20],"cell":[21,108,169],"line":[22],"(HaCaT)":[23],"proliferation":[24,87],"migration":[26,67],"during":[27],"in":[28,53,166,227,234,244,255,281],"vitro":[29,57,124],"wound":[30,126,130,282],"healing":[31,127],"its":[33,71],"underlying":[34,72],"mechanism.Method:":[35],"A.":[36,83,173,193,222,279],"was":[38,48,74,112,148,217],"collected":[39],"extracted":[41],"using":[42],"methanol.Cytotoxiciy":[43],"plant":[46,64,80,190,241],"determined":[49,60,75],"by":[50,76,153,203,219,257],"MTT":[51],"assay":[52,59],"HDF":[54,116],"HaCaT.In":[56],"Scratch":[58],"extracts":[65],"cells":[69,91],"mechanism":[73,208],"RT-PCR":[77],"analysis.Result:":[78],"The":[79],"selectively":[85],"inhibited":[86,195],"both":[89],"at":[92,98],"higher":[93],"concentration":[94,136],"(>100":[95],"\u03bcg/mL)":[96],"lower":[99],"concentrations":[100],"(<25":[101],"\u03bcg/mL),":[102],"it":[103],"exhibited":[104],"linear":[105],"dose-dependent":[107],"proliferation.IC":[109],"50":[110],"value":[111],"87.60\u00b11.67":[113],"\u03bcg/mL":[114,119,139],"for":[115,150,210],"85.50\u00b11.65":[118],"after":[120,140],"24":[121,141],"h":[122,142],"treatment.In":[123],"scratch":[125],"studies":[128],"showed":[129,224],"closure":[131],"50.38%\u00b11.39and":[133],"69.81%\u00b11.89at":[134],"a":[135,176,225,235,250],"25":[138],"48":[144],"h,":[145],"respectively.The":[146],"tested":[149],"anti-inflammatory":[151],"activity":[152,157],"determination":[154],"inhibitory":[156,178],"lipopolysaccharide":[159,204],"(LPS)":[160],"induced":[161],"nitric":[162,197],"oxide":[163,198],"(NO)":[164],"production":[165,182],"RAW":[167],"264.7":[168],"lines.We":[170],"found":[171],"that":[172],"has":[175],"strong":[177],"NO":[184],"tumor":[186],"necrosis":[187],"factor-\u03b1":[188],"(TNF-\u03b1).The":[189],"inducible":[196],"synthase":[199],"(iNOS)":[200],"gene":[201,215],"expression":[202,216,229,246],"(LPS).To":[205],"explore":[206],"responsible":[209],"inhibition":[212],"iNOS,":[214],"analyzed":[218],"Real-Time":[220],"PCR.":[221],"decrease":[226],"pro-inflammatory":[231],"cytokine":[232],"mRNA":[233,260],"concentration-dependent":[236],"manner.Treat":[237],"ment":[238],"with":[239],"resulted":[243],"enhanced":[245],"Collagen":[248,253],"1":[249],"(I)":[251],"IV":[254],"HDFs":[256],"regulating":[258],"levels":[261],"extracellular":[263],"matrix":[264],"(ECM)":[265],"proteins":[266],"Matrix":[268],"metalloproteinase-2.Conclusion:":[269],"Thus,":[270],"investigation":[273],"scientifically":[274],"validates":[275],"use":[277],"healing.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-12-04T00:00:00"}
