{"id":"https://openalex.org/W2768898332","doi":"https://doi.org/10.1101/220988","title":"Reorientation of the primary body axis by ectopic embryonic cWnt signaling","display_name":"Reorientation of the primary body axis by ectopic embryonic cWnt signaling","publication_year":2017,"publication_date":"2017-11-17","ids":{"openalex":"https://openalex.org/W2768898332","doi":"https://doi.org/10.1101/220988","mag":"2768898332"},"language":"en","primary_location":{"id":"doi:10.1101/220988","doi":"https://doi.org/10.1101/220988","is_oa":true,"landing_page_url":"https://doi.org/10.1101/220988","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/17/220988.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/17/220988.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041420819","display_name":"Naveen M. Wijesena","orcid":"https://orcid.org/0000-0002-1277-5714","observed_orcids":["https://orcid.org/0000-0002-1277-5714"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74648663","display_name":"Rajarata University of Sri Lanka","ror":"https://ror.org/04dd86x86","country_code":"LK","type":"education","lineage":["https://openalex.org/I74648663"]}],"countries":["LK","US"],"is_corresponding":false,"raw_author_name":"Naveen Wijesena","raw_affiliation_strings":["Present Address: Faculty of Technology, Rajarata University of Sri Lanka, Mihintale 50300, Sri Lanka","Whitney Laboratory for Marine Bioscience, University of Florida, Saint Augustine, FL 32080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present Address: Faculty of Technology, Rajarata University of Sri Lanka, Mihintale 50300, Sri Lanka","institution_ids":["https://openalex.org/I74648663"]},{"raw_affiliation_string":"Whitney Laboratory for Marine Bioscience, University of Florida, Saint Augustine, FL 32080","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086568453","display_name":"Mark Q. Martindale","orcid":"https://orcid.org/0000-0002-5805-5640","observed_orcids":["https://orcid.org/0000-0002-5805-5640"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Q. Martindale","raw_affiliation_strings":["Whitney Laboratory for Marine Bioscience, University of Florida, Saint Augustine, FL 32080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitney Laboratory for Marine Bioscience, University of Florida, Saint Augustine, FL 32080","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086568453"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.2583000063896179,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-aboral-axis","display_name":"oral-aboral axis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.7720000147819519},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.7639999985694885},{"id":"https://openalex.org/keywords/nematostella-vectensis","display_name":"Nematostella vectensis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/blastomere-injection","display_name":"blastomere injection","score":0.8180000185966492},{"id":"https://openalex.org/keywords/endomesoderm-specification","display_name":"endomesoderm specification","score":0.9079999923706055},{"id":"https://openalex.org/keywords/animal-pole","display_name":"animal pole","score":0.7329999804496765},{"id":"https://openalex.org/keywords/vegetal-pole","display_name":"vegetal pole","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bilaterian-evolution","display_name":"bilaterian evolution","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cephalization","display_name":"cephalization","score":0.8140000104904175},{"id":"https://openalex.org/keywords/developmental-constraints","display_name":"developmental constraints","score":0.5659999847412109},{"id":"https://openalex.org/keywords/neural-fate-specification","display_name":"neural fate specification","score":0.375}],"concepts":[{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.8794094920158386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.818021297454834},{"id":"https://openalex.org/C194058213","wikidata":"https://www.wikidata.org/wiki/Q7209147","display_name":"Polarity in embryogenesis","level":5,"score":0.816340446472168},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6899591684341431},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5556233525276184},{"id":"https://openalex.org/C197583594","wikidata":"https://www.wikidata.org/wiki/Q1052390","display_name":"Most recent common ancestor","level":4,"score":0.5098744630813599},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4931161105632782},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4871539771556854},{"id":"https://openalex.org/C68760520","wikidata":"https://www.wikidata.org/wiki/Q882097","display_name":"Blastomere","level":4,"score":0.44858455657958984},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.423177033662796},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4162978529930115},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.37128889560699463},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32713761925697327},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29500874876976013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23891538381576538},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1763155162334442},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.10757660865783691}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/220988","doi":"https://doi.org/10.1101/220988","is_oa":true,"landing_page_url":"https://doi.org/10.1101/220988","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/17/220988.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/220988","doi":"https://doi.org/10.1101/220988","is_oa":true,"landing_page_url":"https://doi.org/10.1101/220988","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/17/220988.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.8899999856948853,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2768898332.pdf","grobid_xml":"https://content.openalex.org/works/W2768898332.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1975001515","https://openalex.org/W1978732075","https://openalex.org/W1989889624","https://openalex.org/W1990916591","https://openalex.org/W1992150639","https://openalex.org/W2009379859","https://openalex.org/W2009785574","https://openalex.org/W2015243499","https://openalex.org/W2029609524","https://openalex.org/W2064584559","https://openalex.org/W2073514647","https://openalex.org/W2075585528","https://openalex.org/W2078058386","https://openalex.org/W2087503970","https://openalex.org/W2095869247","https://openalex.org/W2096641211","https://openalex.org/W2115744210","https://openalex.org/W2117799366","https://openalex.org/W2124819017","https://openalex.org/W2140233004","https://openalex.org/W2159606671","https://openalex.org/W2542324871","https://openalex.org/W4241001892"],"related_works":["https://openalex.org/W2789593061","https://openalex.org/W2088221562","https://openalex.org/W2009379859","https://openalex.org/W4402334005","https://openalex.org/W4224307368","https://openalex.org/W1967931013","https://openalex.org/W2082689616","https://openalex.org/W2944434557","https://openalex.org/W4408351504","https://openalex.org/W3213579719"],"abstract_inverted_index":{"The":[0],"major":[1],"longitudinal":[2],"body":[3,267],"axis":[4,16,25,108],"of":[5,35,41,78,113,145,167,175,179,193,207,248,264],"cnidarians":[6],"(e.g.":[7,259],"sea":[8],"anemones,":[9],"corals,":[10],"hydroids)":[11],"is":[12,26,172,228],"called":[13],"the":[14,19,29,36,42,51,58,63,69,76,82,96,105,111,117,134,162,165,173,180,185,189,202,205,210,216,224,230,249,253,256,265],"oral-aboral":[15,107,156],"and":[17,32,119,169,242,251,261],"in":[18,47,95,116,148,153,164,188,204,213,219,223,234],"anthozoan":[20],"cnidarian":[21,98],"Nematostella":[22],"vectensis,":[23],"this":[24],"established":[27],"by":[28,102,109,126],"selective":[30],"stabilization":[31],"nuclear":[33],"localization":[34],"protein":[37],"Beta-catenin":[38],"(a":[39],"component":[40],"canonical":[43],"Wnt":[44,181],"signaling":[45,94,115,124,147,182],"pathway)":[46],"cells":[48,56],"derived":[49],"from":[50,209],"animal":[52,70,135,211,235],"pole.":[53,71,84,136],"These":[55],"form":[57],"endomesoderm":[59,170],"during":[60],"gastrulation":[61,79,168,208],"with":[62],"oral":[64],"(anterior)":[65],"pole":[66,187,212,218],"forming":[67],"at":[68,81,125,129],"In":[73],"bilaterian":[74,266],"embryos":[75,101,151],"site":[77,131,166,206],"occurs":[80],"vegetal":[83,186,217],"We":[85],"used":[86],"a":[87,130,154,198],"two-step":[88],"experimental":[89],"approach":[90],"to":[91,184,215,245],"mis-activate":[92],"cWnt":[93,114,123,146],"developing":[97],"N.":[99,149],"vectensis":[100,150],"first":[103],"erasing":[104],"endogenous":[106],"inhibiting":[110],"activation":[112],"embryo":[118,250],"then,":[120],"ectopically":[121],"activating":[122],"blastomere":[127],"injection":[128],"other":[132],"than":[133],"Using":[137],"marker":[138],"gene":[139],"expression,":[140],"we":[141],"show":[142,160],"that":[143,161],"mis-activation":[144],"result":[152,174],"new":[155],"axis.":[157],"Our":[158],"data":[159],"change":[163,203,222],"specification":[171],"moving":[176],"localized":[177],"components":[178],"pathways":[183],"last":[190],"common":[191],"ancestor":[192],"all":[194],"bilaterians,":[195],"thus,":[196],"providing":[197],"plausible":[199],"mechanism":[200],"for":[201,255],"non-bilaterians":[214],"bilaterians.":[220],"This":[221],"metazoan":[225],"developmental":[226,232],"program":[227],"arguably":[229],"largest":[231],"constraint":[233],"evolution":[236],"as":[237],"it":[238],"restricts":[239],"endomesodermal":[240],"fates":[241,244],"neural":[243],"opposite":[246],"poles":[247],"paved":[252],"way":[254],"rapid":[257],"diversification":[258],"cephalization":[260],"mesoderm":[262],"formation)":[263],"plans.":[268]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-12-04T00:00:00"}
