{"id":"https://openalex.org/W2768569010","doi":"https://doi.org/10.1016/j.neuron.2017.10.023","title":"Endogenous G\u03b1q-Coupled Neuromodulator Receptors Activate Protein Kinase A","display_name":"Endogenous G\u03b1q-Coupled Neuromodulator Receptors Activate Protein Kinase A","publication_year":2017,"publication_date":"2017-11-16","ids":{"openalex":"https://openalex.org/W2768569010","doi":"https://doi.org/10.1016/j.neuron.2017.10.023","mag":"2768569010","pmid":"https://pubmed.ncbi.nlm.nih.gov/29154125","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5726796"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuron.2017.10.023","doi":"https://doi.org/10.1016/j.neuron.2017.10.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuron.2017.10.023","pdf_url":"http://www.cell.com/article/S0896627317309911/pdf","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0896627317309911/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018425994","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0003-1509-6634","observed_orcids":["https://orcid.org/0000-0003-1509-6634"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yao Chen","raw_affiliation_strings":["Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070261954","display_name":"Adam J. Granger","orcid":"https://orcid.org/0000-0002-3953-6764","observed_orcids":["https://orcid.org/0000-0002-3953-6764"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam J. Granger","raw_affiliation_strings":["Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110150148","display_name":"Trinh Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trinh Tran","raw_affiliation_strings":["Mind/Brain Institute, John Hopkins University, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mind/Brain Institute, John Hopkins University, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022541521","display_name":"Jessica L. Saulnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica L. Saulnier","raw_affiliation_strings":["Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017943286","display_name":"Alfredo Kirkwood","orcid":"https://orcid.org/0000-0001-9148-9742","observed_orcids":["https://orcid.org/0000-0001-9148-9742"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfredo Kirkwood","raw_affiliation_strings":["Mind/Brain Institute, John Hopkins University, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mind/Brain Institute, John Hopkins University, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043679513","display_name":"Bernardo\u00a0Luis Sabatini","orcid":"https://orcid.org/0000-0003-0095-9177","observed_orcids":["https://orcid.org/0000-0003-0095-9177"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bernardo L. Sabatini","raw_affiliation_strings":["Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address: bernardo_sabatini@hms.harvard.edu","Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address: bernardo_sabatini@hms.harvard.edu","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043679513"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":1.9483,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.86885474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"96","issue":"5","first_page":"1070","last_page":"1083.e5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.8659999966621399},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9369999766349792},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6460000276565552},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7225939035415649},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5927900075912476},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5754526257514954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5626428723335266},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.5372993350028992},{"id":"https://openalex.org/C66135807","wikidata":"https://www.wikidata.org/wiki/Q24726231","display_name":"Gq alpha subunit","level":4,"score":0.5340769290924072},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.5059561133384705},{"id":"https://openalex.org/C42221972","wikidata":"https://www.wikidata.org/wiki/Q7321217","display_name":"Rhodopsin-like receptors","level":5,"score":0.48116955161094666},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.45500585436820984},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4503055810928345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4343802332878113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4295768141746521},{"id":"https://openalex.org/C33235085","wikidata":"https://www.wikidata.org/wiki/Q4355943","display_name":"G protein-coupled receptor kinase","level":4,"score":0.410104364156723},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.38060224056243896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3414947986602783},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.139815092086792}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043802","descriptor_name":"GTP-Binding Protein alpha Subunits, Gq-G11","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuron.2017.10.023","doi":"https://doi.org/10.1016/j.neuron.2017.10.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuron.2017.10.023","pdf_url":"http://www.cell.com/article/S0896627317309911/pdf","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},{"id":"pmid:29154125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29154125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5244877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5726796","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5726796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5726796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuron","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neuron.2017.10.023","doi":"https://doi.org/10.1016/j.neuron.2017.10.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuron.2017.10.023","pdf_url":"http://www.cell.com/article/S0896627317309911/pdf","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2179045227","display_name":null,"funder_award_id":"6193253-02","funder_id":"https://openalex.org/F4320309786","funder_display_name":"Nancy Lurie Marks Family Foundation"},{"id":"https://openalex.org/G2538009882","display_name":"Action and interaction of ionotropic and metabotropic neurotransmission","funder_award_id":"R01NS046579","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4267291720","display_name":"HMS/BCH Center for Neuroscience Research","funder_award_id":"P30NS072030","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4508064520","display_name":"Integration and Dynamics of Neuromodulator Action in the Striatum","funder_award_id":"F32DA035543","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6623860787","display_name":"Action and interaction of ionotropic and metabotropic neurotransmission","funder_award_id":"R37NS046579","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6755751552","display_name":"Regulation of Synaptic Plasticity in Visual Cortex","funder_award_id":"R01EY012124","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320309786","display_name":"Nancy Lurie Marks Family Foundation","ror":"https://ror.org/05r023w67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2768569010.pdf"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1491958169","https://openalex.org/W1494623690","https://openalex.org/W1521158172","https://openalex.org/W1538989554","https://openalex.org/W1634923911","https://openalex.org/W1802980406","https://openalex.org/W1810053083","https://openalex.org/W1908814407","https://openalex.org/W1928783644","https://openalex.org/W1963705823","https://openalex.org/W1966403223","https://openalex.org/W1971999279","https://openalex.org/W1973163678","https://openalex.org/W1974018894","https://openalex.org/W1977348373","https://openalex.org/W1977984619","https://openalex.org/W1979460067","https://openalex.org/W1979707864","https://openalex.org/W1979994346","https://openalex.org/W1980624722","https://openalex.org/W1980803846","https://openalex.org/W1981327350","https://openalex.org/W1989470236","https://openalex.org/W1990107671","https://openalex.org/W1990499518","https://openalex.org/W1993135690","https://openalex.org/W1994041040","https://openalex.org/W2002494433","https://openalex.org/W2003981789","https://openalex.org/W2005253053","https://openalex.org/W2008245136","https://openalex.org/W2010980507","https://openalex.org/W2012286072","https://openalex.org/W2013542246","https://openalex.org/W2015144766","https://openalex.org/W2015634638","https://openalex.org/W2017316435","https://openalex.org/W2018894220","https://openalex.org/W2019257559","https://openalex.org/W2019435757","https://openalex.org/W2023455262","https://openalex.org/W2028851705","https://openalex.org/W2037104507","https://openalex.org/W2040750669","https://openalex.org/W2043212816","https://openalex.org/W2044405962","https://openalex.org/W2044851240","https://openalex.org/W2046929321","https://openalex.org/W2053696585","https://openalex.org/W2055408934","https://openalex.org/W2056811959","https://openalex.org/W2061214285","https://openalex.org/W2062499314","https://openalex.org/W2068719237","https://openalex.org/W2069072617","https://openalex.org/W2072154257","https://openalex.org/W2073769248","https://openalex.org/W2074521340","https://openalex.org/W2074844667","https://openalex.org/W2075988095","https://openalex.org/W2077306952","https://openalex.org/W2079054696","https://openalex.org/W2082350440","https://openalex.org/W2086181854","https://openalex.org/W2086543171","https://openalex.org/W2094013515","https://openalex.org/W2098466209","https://openalex.org/W2101491694","https://openalex.org/W2109234881","https://openalex.org/W2110741783","https://openalex.org/W2113630547","https://openalex.org/W2117400459","https://openalex.org/W2118536789","https://openalex.org/W2121071682","https://openalex.org/W2141449078","https://openalex.org/W2149561999","https://openalex.org/W2150107846","https://openalex.org/W2154684077","https://openalex.org/W2156635287","https://openalex.org/W2157673954","https://openalex.org/W2160991890","https://openalex.org/W2168821750","https://openalex.org/W2172734677","https://openalex.org/W2175316650","https://openalex.org/W2178106250","https://openalex.org/W2184364461","https://openalex.org/W2238525991","https://openalex.org/W2255155372","https://openalex.org/W2266737276","https://openalex.org/W2304029455","https://openalex.org/W2331959327","https://openalex.org/W2340117956","https://openalex.org/W2341631145","https://openalex.org/W2549192463"],"related_works":["https://openalex.org/W2154684077","https://openalex.org/W2800673567","https://openalex.org/W2073831388","https://openalex.org/W2170136226","https://openalex.org/W2035504473","https://openalex.org/W1672480124","https://openalex.org/W1532214820","https://openalex.org/W2088895310","https://openalex.org/W2010144291","https://openalex.org/W2055059211"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-12-04T00:00:00"}
