{"id":"https://openalex.org/W2768304491","doi":null,"title":"Intravenous anesthetic propofol binds to 5-lipoxygenase (5-LOX) and attenuates leukotriene B4 production","display_name":"Intravenous anesthetic propofol binds to 5-lipoxygenase (5-LOX) and attenuates leukotriene B4 production","publication_year":2017,"publication_date":"2017-10-23","ids":{"openalex":"https://openalex.org/W2768304491","mag":"2768304491"},"language":"en","primary_location":{"id":"mag:2768304491","doi":null,"is_oa":false,"landing_page_url":"https://confit.atlas.jp/guide/event/conbio2017/author/3P-0072/confit_3P-0072_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306532260","display_name":"The Japanese Biochemical Society/The Molecular Biology Society of Japan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Japanese Biochemical Society/The Molecular Biology Society of Japan","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004821325","display_name":"Toshiaki Okuno","orcid":"https://orcid.org/0000-0003-0270-5744","observed_orcids":["https://orcid.org/0000-0003-0270-5744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiaki Okuno","raw_affiliation_strings":["Dept of Biochem"],"raw_orcid":"https://orcid.org/0000-0003-0270-5744","affiliations":[{"raw_affiliation_string":"Dept of Biochem","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031855645","display_name":"Sophia Koutsogiannaki","orcid":"https://orcid.org/0000-0003-3555-1681","observed_orcids":["https://orcid.org/0000-0003-3555-1681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophia Koutsogiannaki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3555-1681","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112633668","display_name":"Mai Ohba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mai Ohba","raw_affiliation_strings":["Dept of Biochem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Biochem","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013562952","display_name":"Matthew Chamberlain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Chamberlain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108215128","display_name":"Weiming Bu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiming Bu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072845533","display_name":"Fu-Yan Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fu-Yan Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007410972","display_name":"Roderic G. Eckenhoff","orcid":"https://orcid.org/0000-0002-5581-746X","observed_orcids":["https://orcid.org/0000-0002-5581-746X","https://orcid.org/0009-0007-1761-9765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roderic G. Eckenhoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076042354","display_name":"Takehiko Yokomizo","orcid":"https://orcid.org/0000-0002-5219-1553","observed_orcids":["https://orcid.org/0000-0002-5219-1553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takehiko Yokomizo","raw_affiliation_strings":["Dept of Biochem"],"raw_orcid":"https://orcid.org/0000-0002-5219-1553","affiliations":[{"raw_affiliation_string":"Dept of Biochem","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015363564","display_name":"Koichi Yuki","orcid":"https://orcid.org/0000-0003-1312-585X","observed_orcids":["https://orcid.org/0000-0003-1312-585X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koichi Yuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18887523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.11079999804496765,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":1.0},{"id":"https://openalex.org/keywords/5-lipoxygenase","display_name":"5-lipoxygenase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9879999756813049},{"id":"https://openalex.org/keywords/leukotriene-biosynthesis","display_name":"leukotriene biosynthesis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/anesthetic-binding","display_name":"anesthetic binding","score":0.45899999141693115},{"id":"https://openalex.org/keywords/leukotriene-receptor-antagonism","display_name":"leukotriene receptor antagonism","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.6557533740997314},{"id":"https://openalex.org/C2776685179","wikidata":"https://www.wikidata.org/wiki/Q2704449","display_name":"Leukotriene B4","level":3,"score":0.5937532782554626},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.5153235793113708},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.4889003336429596},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4749976396560669},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44128406047821045},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.4287121593952179},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.326019287109375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20688766241073608},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13870713114738464},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12172621488571167},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.11212277412414551},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2768304491","doi":null,"is_oa":false,"landing_page_url":"https://confit.atlas.jp/guide/event/conbio2017/author/3P-0072/confit_3P-0072_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306532260","display_name":"The Japanese Biochemical Society/The Molecular Biology Society of Japan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Japanese Biochemical Society/The Molecular Biology Society of Japan","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2569463693","https://openalex.org/W4313383840","https://openalex.org/W3012485831","https://openalex.org/W2150006152","https://openalex.org/W3105850413","https://openalex.org/W2409171387","https://openalex.org/W2809930570","https://openalex.org/W1994214516","https://openalex.org/W6315285","https://openalex.org/W1970767043"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2017-12-04T00:00:00"}
