{"id":"https://openalex.org/W2768166296","doi":"https://doi.org/10.1080/00498254.2017.1397811","title":"Metabonomics analysis of serum from rats given long-term and low-level cadmium by ultra-performance liquid chromatography\u2013mass spectrometry","display_name":"Metabonomics analysis of serum from rats given long-term and low-level cadmium by ultra-performance liquid chromatography\u2013mass spectrometry","publication_year":2017,"publication_date":"2017-11-16","ids":{"openalex":"https://openalex.org/W2768166296","doi":"https://doi.org/10.1080/00498254.2017.1397811","mag":"2768166296","pmid":"https://pubmed.ncbi.nlm.nih.gov/29143552"},"language":"en","primary_location":{"id":"doi:10.1080/00498254.2017.1397811","doi":"https://doi.org/10.1080/00498254.2017.1397811","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00498254.2017.1397811","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109593109","display_name":"Liyan Hu","orcid":"https://orcid.org/0000-0001-6197-419X","observed_orcids":["https://orcid.org/0000-0001-6197-419X"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyan Hu","raw_affiliation_strings":["Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769749","display_name":"Bo Lu","orcid":"https://orcid.org/0000-0001-7635-4452","observed_orcids":["https://orcid.org/0000-0001-7635-4452"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Bo","raw_affiliation_strings":["Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101644989","display_name":"Meiyan Zhang","orcid":"https://orcid.org/0000-0002-3968-8426","observed_orcids":["https://orcid.org/0000-0002-3968-8426","https://orcid.org/0000-0002-6045-3357"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiyan Zhang","raw_affiliation_strings":["Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336542","display_name":"Siqi Li","orcid":"https://orcid.org/0000-0001-6460-6886","observed_orcids":["https://orcid.org/0000-0001-6460-6886"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Li","raw_affiliation_strings":["Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082664685","display_name":"Xiujuan Zhao","orcid":"https://orcid.org/0000-0001-6953-4148","observed_orcids":["https://orcid.org/0000-0001-6953-4148"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiujuan Zhao","raw_affiliation_strings":["Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030009823","display_name":"Changhao Sun","orcid":"https://orcid.org/0000-0001-9416-7044","observed_orcids":["https://orcid.org/0000-0001-9416-7044","https://orcid.org/0000-0002-7651-2083"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changhao Sun","raw_affiliation_strings":["Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030009823","https://openalex.org/A5082664685"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":null,"apc_paid":null,"fwci":0.5554,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.59309309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"48","issue":"11","first_page":"1079","last_page":"1088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadmium-toxicity","display_name":"cadmium toxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/serum-metabolites","display_name":"serum metabolites","score":0.7870000004768372},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.8029999732971191},{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bile-acid-metabolites","display_name":"bile acid metabolites","score":0.6629999876022339},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.7089999914169312},{"id":"https://openalex.org/keywords/lysophosphatidylethanolamine","display_name":"lysophosphatidylethanolamine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/lysophosphatidylcholine","display_name":"lysophosphatidylcholine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/3-indolepropionic-acid","display_name":"3-indolepropionic acid","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9300000071525574},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.9649999737739563},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.7630000114440918},{"id":"https://openalex.org/keywords/liver-and-kidney-function","display_name":"liver and kidney function","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C544657597","wikidata":"https://www.wikidata.org/wiki/Q1091","display_name":"Cadmium","level":2,"score":0.748810887336731},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7344708442687988},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6896079778671265},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.6101701855659485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6026433706283569},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.49598774313926697},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019256","descriptor_name":"Cadmium Chloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019256","descriptor_name":"Cadmium Chloride","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D036401","descriptor_name":"Toxicity Tests, Chronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/00498254.2017.1397811","doi":"https://doi.org/10.1080/00498254.2017.1397811","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00498254.2017.1397811","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},{"id":"pmid:29143552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29143552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica; the fate of foreign compounds in biological systems","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312270","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583"},{"id":"https://openalex.org/F4320317553","display_name":"China National Center for Food Safety Risk Assessment","ror":"https://ror.org/03kcjz738"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W36003463","https://openalex.org/W1491753771","https://openalex.org/W1560536306","https://openalex.org/W1858871280","https://openalex.org/W1968813633","https://openalex.org/W1977492878","https://openalex.org/W1989755866","https://openalex.org/W1990588824","https://openalex.org/W1991495331","https://openalex.org/W1992471965","https://openalex.org/W2003101395","https://openalex.org/W2004652176","https://openalex.org/W2007064374","https://openalex.org/W2008650611","https://openalex.org/W2011105081","https://openalex.org/W2015680388","https://openalex.org/W2016228066","https://openalex.org/W2019591402","https://openalex.org/W2021756392","https://openalex.org/W2027187941","https://openalex.org/W2029727413","https://openalex.org/W2037687294","https://openalex.org/W2037779780","https://openalex.org/W2037999466","https://openalex.org/W2041898089","https://openalex.org/W2057048811","https://openalex.org/W2063845760","https://openalex.org/W2068043591","https://openalex.org/W2074110517","https://openalex.org/W2089077776","https://openalex.org/W2092873672","https://openalex.org/W2094791697","https://openalex.org/W2095189712","https://openalex.org/W2105270157","https://openalex.org/W2106316475","https://openalex.org/W2106415248","https://openalex.org/W2140903090","https://openalex.org/W2147145238","https://openalex.org/W2157472805","https://openalex.org/W2161723467","https://openalex.org/W2181859739","https://openalex.org/W2275637818","https://openalex.org/W2289409849","https://openalex.org/W2315994057","https://openalex.org/W2319671198","https://openalex.org/W2324559253","https://openalex.org/W2417615270","https://openalex.org/W2533731321","https://openalex.org/W2586804188","https://openalex.org/W2589319755","https://openalex.org/W2605431828","https://openalex.org/W2614874662"],"related_works":["https://openalex.org/W2770714411","https://openalex.org/W2897035981","https://openalex.org/W3001612101","https://openalex.org/W1990666027","https://openalex.org/W4381470037","https://openalex.org/W2089234771","https://openalex.org/W1977030545","https://openalex.org/W2048499297","https://openalex.org/W2126512951","https://openalex.org/W3000463229"],"abstract_inverted_index":{"1.":[0],"This":[1],"study":[2],"evaluated":[3],"the":[4,32,70,97,101,105,122,180],"toxicity":[5],"of":[6,95,139,159],"chronic":[7],"exposure":[8,173],"to":[9,28,133,174],"low-level":[10],"cadmium":[11],"(Cd)":[12],"in":[13,114,121,136,167,179],"rats":[14,24,49],"using":[15,74],"ultra-performance":[16],"liquid":[17],"chromatography\u2013mass":[18],"spectrometry":[19],"(UPLC\u2013MS).":[20],"Forty":[21],"male":[22],"Sprague\u2013Dawley":[23],"were":[25,61,108],"randomly":[26],"assigned":[27],"four":[29],"groups,":[30],"namely,":[31],"control":[33,102,123],"group,":[34],"low-dose":[35],"group":[36,40,45,124],"(0.13":[37],"mg/kg\u00b7bw),":[38],"middle-dose":[39],"(0.8":[41],"mg/kg\u00b7bw)":[42],"and":[43,79,90,110,151,164,192],"high-dose":[44],"(4.89":[46],"mg/kg\u00b7bw).":[47],"The":[48,66],"continuously":[50],"received":[51],"CdCl2":[52],"via":[53],"drinking":[54],"water":[55],"for":[56,63],"24":[57],"weeks.":[58],"Serum":[59],"samples":[60],"collected":[62],"metabonomics":[64],"analysis.":[65],"data":[67],"generated":[68],"from":[69,100],"UPLC\u2013MS":[71],"was":[72],"analysed":[73],"principal":[75],"components":[76],"analysis":[77,83],"(PCA)":[78],"partial":[80],"least-squares":[81],"discriminant":[82],"(PLS-DA).":[84],"PLS-DA":[85],"model":[86],"with":[87,119],"satisfactory":[88],"explanatory":[89],"predictive":[91],"ability":[92],"is":[93],"capable":[94],"discriminating":[96],"treatment":[98,116],"groups":[99,117],"group.2.":[103],"Finally,":[104],"10":[106],"metabolites":[107],"identified":[109],"showed":[111],"significant":[112],"changes":[113],"some":[115],"compared":[118],"that":[120,172],"(p":[125],"<":[126,130],"0.0167":[127],"or":[128],"p":[129],"0.003).":[131],"Exposure":[132],"Cd":[134,175],"resulted":[135],"increased":[137],"intensities":[138,158],"lysophosphatidic":[140],"acid":[141,166,184],"(P-16:0e/0:0),":[142],"glycocholic":[143],"acid,":[144,161],"bicyclo-prostaglandin":[145],"E2,":[146],"lithocholyltaurine,":[147],"sulfolithocholylglycine,":[148],"lysophosphatidylethanolamine":[149],"(20:5/0:0)":[150],"lysophosphatidylcholine":[152],"(20:0),":[153],"as":[154,156],"well":[155],"decreased":[157],"3-indolepropionic":[160],"phosphatidylcholine":[162],"(18:4/18:0)":[163],"15S-hydroxyeicosatrienoic":[165],"rat":[168],"serum.3.":[169],"Results":[170],"suggest":[171],"can":[176],"cause":[177],"disturbances":[178],"lipid":[181],"metabolism,":[182,185],"amino":[183],"nervous":[186],"system,":[187,190],"antioxidant":[188],"defence":[189],"liver":[191],"kidney":[193],"function.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-12-04T00:00:00"}