{"id":"https://openalex.org/W2768070062","doi":"https://doi.org/10.1161/circ.133.suppl_1.mp60","title":"Abstract MP60: Coronary Artery Calcium and Dementia Risk in the Multi-Ethnic Study of Atherosclerosis","display_name":"Abstract MP60: Coronary Artery Calcium and Dementia Risk in the Multi-Ethnic Study of Atherosclerosis","publication_year":2016,"publication_date":"2016-03-01","ids":{"openalex":"https://openalex.org/W2768070062","doi":"https://doi.org/10.1161/circ.133.suppl_1.mp60","mag":"2768070062"},"language":"en","primary_location":{"id":"doi:10.1161/circ.133.suppl_1.mp60","doi":"https://doi.org/10.1161/circ.133.suppl_1.mp60","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.133.suppl_1.mp60","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054947155","display_name":"Akira Fujiyoshi","orcid":"https://orcid.org/0000-0002-5790-7119","observed_orcids":["https://orcid.org/0000-0002-5790-7119"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Fujiyoshi","raw_affiliation_strings":["Shiga Univ of Med Science, Otsu, Shiga, Japan","Akira Fujiyoshi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiga Univ of Med Science, Otsu, Shiga, Japan","institution_ids":["https://openalex.org/I160046202"]},{"raw_affiliation_string":"Akira Fujiyoshi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051078160","display_name":"David R. Jacobs","orcid":"https://orcid.org/0000-0002-7232-0543","observed_orcids":["https://orcid.org/0000-0002-7232-0543"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R Jacobs","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","David R Jacobs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"David R Jacobs","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070515648","display_name":"Annette L. Fitzpatrick","orcid":"https://orcid.org/0000-0003-1941-6586","observed_orcids":["https://orcid.org/0000-0003-1941-6586"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annette L Fitzpatrick","raw_affiliation_strings":["Univ of Washington, Seattle, WA","Annette L Fitzpatrick"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Annette L Fitzpatrick","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004776448","display_name":"\u00c1lvaro Alonso","orcid":"https://orcid.org/0000-0002-2225-8323","observed_orcids":["https://orcid.org/0000-0002-2225-8323"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvaro Alonso","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","Alvaro Alonso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Alvaro Alonso","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075267063","display_name":"Daniel A. Duprez","orcid":"https://orcid.org/0000-0002-0993-6839","observed_orcids":["https://orcid.org/0000-0002-0993-6839"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A Duprez","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","Daniel A Duprez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Daniel A Duprez","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102903943","display_name":"A. Richey Sharrett","orcid":"https://orcid.org/0000-0002-8835-7770","observed_orcids":["https://orcid.org/0000-0002-8835-7770"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Richey Sharrett","raw_affiliation_strings":["Johns Hopkins Univ, Baltimore, MD","A. Richey Sharrett"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"A. Richey Sharrett","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008531984","display_name":"Michael Joseph Blaha","orcid":"https://orcid.org/0000-0001-5138-9683","observed_orcids":["https://orcid.org/0000-0001-5138-9683"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Blaha","raw_affiliation_strings":["The Johns Hopkins Ciccarone Cntr for the Prevention of Heart Disease, Baltimore, MD","Michael J Blaha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Ciccarone Cntr for the Prevention of Heart Disease, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Michael J Blaha","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014243827","display_name":"Jose Alejandro Luchsinger","orcid":"https://orcid.org/0000-0002-5886-3648","observed_orcids":["https://orcid.org/0000-0002-5886-3648"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A Luchsinger","raw_affiliation_strings":["Columbia Univ Med Cntr, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Univ Med Cntr, New York, NY","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062691878","display_name":"Stephen R. Rapp","orcid":"https://orcid.org/0000-0002-9766-3104","observed_orcids":["https://orcid.org/0000-0002-9766-3104"]},"institutions":[{"id":"https://openalex.org/I4210105302","display_name":"Rapp (Switzerland)","ror":"https://ror.org/01p5m8335","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210105302"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Stephen R Rapp","raw_affiliation_strings":["Wake Forest Univ, Winston-Salem, NC","Stephen R Rapp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Univ, Winston-Salem, NC","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Stephen R Rapp","institution_ids":["https://openalex.org/I4210105302"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091406579","display_name":"Teresa E. Seeman","orcid":"https://orcid.org/0000-0001-8583-4239","observed_orcids":["https://orcid.org/0000-0001-8583-4239"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa Seeman","raw_affiliation_strings":["Univ of California, Los Angeles, Los Angeles, CA","Teresa Seeman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Teresa Seeman","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"133","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-calcium","display_name":"coronary artery calcium","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.8610000014305115},{"id":"https://openalex.org/keywords/vascular-risk-factors","display_name":"vascular risk factors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8050000071525574},{"id":"https://openalex.org/keywords/agatston-score","display_name":"Agatston score","score":0.8740000128746033},{"id":"https://openalex.org/keywords/incident-dementia","display_name":"incident dementia","score":0.7129999995231628},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.8080000281333923},{"id":"https://openalex.org/keywords/multi-ethnic-study-of-atherosclerosis","display_name":"Multi-Ethnic Study of Atherosclerosis","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9281350374221802},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7779456377029419},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6391302943229675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6134663224220276},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5325305461883545},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5127750039100647},{"id":"https://openalex.org/C2780906993","wikidata":"https://www.wikidata.org/wiki/Q5133756","display_name":"Clinical Dementia Rating","level":4,"score":0.42819395661354065},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.4273771047592163},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.42118629813194275},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.278166800737381},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.23818853497505188},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.133.suppl_1.mp60","doi":"https://doi.org/10.1161/circ.133.suppl_1.mp60","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.133.suppl_1.mp60","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2610760505","https://openalex.org/W4221097349","https://openalex.org/W4400556562","https://openalex.org/W4394909545","https://openalex.org/W2895913543","https://openalex.org/W7160184535","https://openalex.org/W3188516054","https://openalex.org/W7201845509","https://openalex.org/W2042826767","https://openalex.org/W4392813085"],"abstract_inverted_index":{"Introduction:":[0],"Vascular":[1],"risk":[2,220,241],"factors":[3],"(VRFs)":[4],"predict":[5,17],"incident":[6,31,67,145,205],"dementia.":[7,243,258],"Coronary":[8],"artery":[9],"calcium":[10],"(CAC),":[11],"capturing":[12],"cumulative":[13],"VRFs":[14,35],"exposure,":[15],"may":[16],"dementia":[18,32,69,105,149,174,185,225],"beyond":[19],"VRFs.":[20],"Hypothesis:":[21],"In":[22],"a":[23,162,214],"community-based":[24],"sample,":[25],"baseline":[26,38,59,179,233],"CAC":[27,108,180,189,229],"is":[28,246],"associated":[29,238],"with":[30,161,177,223,239,248],"independent":[33],"of":[34,48,52,165,173,184,221,242,257],"assessed":[36],"at":[37,58,232],"and":[39,72,102,126,144,236],"APOE":[40,141],"-\u03b5":[41,142],"4":[42],"genotype.":[43],"Methods:":[44],"Among":[45],"6,814":[46],"participants":[47],"the":[49,78],"Multi-Ethnic":[50],"Study":[51],"Atherosclerosis":[53],"(MESA),":[54],"aged":[55],"45-84":[56],"years":[57,167],"(2000-2002),":[60],"we":[61,80],"first":[62],"identified":[63],"candidate":[64],"cases":[65,83],"for":[66,138,159,218,252],"all-cause":[68],"using":[70,88,213],"hospital":[71],"death":[73,222],"certificate":[74],"ICD":[75],"codes.":[76],"For":[77],"analyses,":[79],"limited":[81],"to":[82,112,118,121,124,132,148],"whose":[84],"diagnosis":[85,99],"was":[86,109,191,234],"validated":[87,169],"following":[89],"criteria:":[90],"1)":[91],"verifiable":[92],"medical":[93],"records":[94],"available,":[95],"2)":[96],"unlikely":[97],"alternative":[98],"(e.g.":[100],"delirium),":[101],"3)":[103],"written":[104],"diagnosis.":[106,150,226],"Baseline":[107],"categorized":[110],"according":[111],"Agatston":[113],"score":[114,230],"(0,":[115],">":[116],"0":[117],"<50,":[119],"50":[120],"<100,":[122],"100":[123],"<400,":[125],"\u2265400).":[127],"Cox":[128],"models":[129],"were":[130,175,200],"used":[131],"obtain":[133],"hazard":[134],"ratios":[135],"(HRs)":[136],"adjusted":[137],"demographics,":[139],"VRFs,":[140],"4,":[143],"stroke":[146],"prior":[147],"Results:":[151],"We":[152],"had":[153],"complete":[154],"data":[155],"on":[156],"6,295":[157],"individuals":[158],"analysis":[160],"mean":[163],"follow-up":[164],"11.1":[166],"(208":[168],"cases).":[170],"Crude":[171],"rates":[172],"greater":[176],"higher":[178,188],"categories.":[181],"Adjusted":[182],"HR":[183],"per":[186],"one":[187],"category":[190],"1.14":[192],"(95%CI":[193],"1.03,":[194],"1.26)":[195],"(see":[196],"Table).":[197],"The":[198],"associations":[199],"similar":[201],"when":[202],"excluding":[203],"interim":[204],"coronary":[206],"heart":[207],"disease,":[208],"or":[209,212],"cardiovascular":[210],"diseases,":[211],"model":[215],"that":[216],"accounted":[217],"competing":[219],"no":[224],"Conclusion:":[227],"Higher":[228],"measured":[231],"independently":[235],"significantly":[237],"increased":[240],"This":[244],"finding":[245],"consistent":[247],"an":[249],"important":[250],"role":[251],"vascular":[253],"injury":[254],"in":[255],"development":[256]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-11-17T00:00:00"}