{"id":"https://openalex.org/W2768044280","doi":"https://doi.org/10.1016/j.freeradbiomed.2017.11.007","title":"F2-isoprostanes can mediate bleomycin-induced lung fibrosis","display_name":"F2-isoprostanes can mediate bleomycin-induced lung fibrosis","publication_year":2017,"publication_date":"2017-11-09","ids":{"openalex":"https://openalex.org/W2768044280","doi":"https://doi.org/10.1016/j.freeradbiomed.2017.11.007","mag":"2768044280","pmid":"https://pubmed.ncbi.nlm.nih.gov/29129520"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2017.11.007","doi":"https://doi.org/10.1016/j.freeradbiomed.2017.11.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2017.11.007","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11365/1025707","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043482004","display_name":"Beatrice Arezzini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Arezzini","raw_affiliation_strings":["Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniela Vecchio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Vecchio","raw_affiliation_strings":["Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025566695","display_name":"Cinzia Signorini","orcid":"https://orcid.org/0000-0003-0006-9414","observed_orcids":["https://orcid.org/0000-0003-0006-9414"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Signorini","raw_affiliation_strings":["Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072099684","display_name":"Blerta Stringa","orcid":"https://orcid.org/0000-0002-2902-5979","observed_orcids":["https://orcid.org/0000-0002-2902-5979"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Blerta Stringa","raw_affiliation_strings":["Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy; Centre for Integrative Biology, University of Trento, Trento, Italy","Centre for Integrative Biology, University of Trento, Trento, Italy","Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy; Centre for Integrative Biology, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I102064193","https://openalex.org/I193223587"]},{"raw_affiliation_string":"Centre for Integrative Biology, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]},{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082741208","display_name":"Concetta Gardi","orcid":"https://orcid.org/0000-0003-3748-809X","observed_orcids":["https://orcid.org/0000-0003-3748-809X"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Concetta Gardi","raw_affiliation_strings":["Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. Electronic address: concetta.gardi@unisi.it","Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. Electronic address: concetta.gardi@unisi.it","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082741208"],"corresponding_institution_ids":["https://openalex.org/I102064193"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":1.6425,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.83364203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"115","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f2-isoprostanes","display_name":"F2-isoprostanes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bleomycin-induced-pulmonary-fibrosis","display_name":"bleomycin-induced lung fibrosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7820000052452087},{"id":"https://openalex.org/keywords/thromboxane-a2-receptor","display_name":"thromboxane A2 receptor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.824999988079071},{"id":"https://openalex.org/keywords/myofibroblast-activation","display_name":"myofibroblast activation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6370000243186951},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.8360986113548279},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.7909924983978271},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7100013494491577},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.6522094011306763},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6434028148651123},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5828502774238586},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5415264964103699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4455288350582123},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43870818614959717},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3836313784122467},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37621551752090454},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.360767662525177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30906665325164795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24763774871826172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12177586555480957},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028441","descriptor_name":"F2-Isoprostanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058628","descriptor_name":"Myofibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2017.11.007","doi":"https://doi.org/10.1016/j.freeradbiomed.2017.11.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2017.11.007","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:29129520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29129520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/1025707","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11365/1025707","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:usiena-air.unisi.it:11365/1025707","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11365/1025707","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313975","display_name":"Universit\u00e0 degli Studi di Siena","ror":"https://ror.org/01tevnk56"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W283535023","https://openalex.org/W289531125","https://openalex.org/W296319558","https://openalex.org/W1578101029","https://openalex.org/W1583483795","https://openalex.org/W1588127651","https://openalex.org/W1749356921","https://openalex.org/W1965689267","https://openalex.org/W1972038951","https://openalex.org/W1979685556","https://openalex.org/W1981324464","https://openalex.org/W1982179568","https://openalex.org/W1987014468","https://openalex.org/W1987547292","https://openalex.org/W1987899489","https://openalex.org/W1989698652","https://openalex.org/W1993559550","https://openalex.org/W1998398041","https://openalex.org/W2000932668","https://openalex.org/W2002165077","https://openalex.org/W2005142587","https://openalex.org/W2005143670","https://openalex.org/W2005958764","https://openalex.org/W2007012109","https://openalex.org/W2007102654","https://openalex.org/W2011327039","https://openalex.org/W2011434932","https://openalex.org/W2011912546","https://openalex.org/W2014187911","https://openalex.org/W2017279248","https://openalex.org/W2018809578","https://openalex.org/W2028164957","https://openalex.org/W2032905197","https://openalex.org/W2034726329","https://openalex.org/W2035255427","https://openalex.org/W2037495531","https://openalex.org/W2042022379","https://openalex.org/W2042306961","https://openalex.org/W2046501504","https://openalex.org/W2048087764","https://openalex.org/W2048575473","https://openalex.org/W2050189717","https://openalex.org/W2056667298","https://openalex.org/W2058339334","https://openalex.org/W2059867409","https://openalex.org/W2062510144","https://openalex.org/W2063560408","https://openalex.org/W2065977597","https://openalex.org/W2068007862","https://openalex.org/W2083026617","https://openalex.org/W2083341807","https://openalex.org/W2083756305","https://openalex.org/W2094114239","https://openalex.org/W2098459324","https://openalex.org/W2098642174","https://openalex.org/W2099780759","https://openalex.org/W2101303553","https://openalex.org/W2108633424","https://openalex.org/W2109076495","https://openalex.org/W2111779290","https://openalex.org/W2111791469","https://openalex.org/W2114330584","https://openalex.org/W2116971462","https://openalex.org/W2125241840","https://openalex.org/W2125310659","https://openalex.org/W2126656343","https://openalex.org/W2130289134","https://openalex.org/W2130336163","https://openalex.org/W2132345115","https://openalex.org/W2133782048","https://openalex.org/W2146260799","https://openalex.org/W2156668607","https://openalex.org/W2158949375","https://openalex.org/W2161995059","https://openalex.org/W2507833114","https://openalex.org/W2597686565","https://openalex.org/W2598265559","https://openalex.org/W6665451964"],"related_works":["https://openalex.org/W2794734238","https://openalex.org/W2917394274","https://openalex.org/W3121006023","https://openalex.org/W7064723544","https://openalex.org/W4283690204","https://openalex.org/W4283262510","https://openalex.org/W2009470034","https://openalex.org/W2318505111","https://openalex.org/W2007109726","https://openalex.org/W2154085274"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-11-17T00:00:00"}