{"id":"https://openalex.org/W2767975686","doi":"https://doi.org/10.1016/s0092-8674(04)00163-1","title":"DNA Deamination Mediates Innate Immunity to Retroviral Infection","display_name":"DNA Deamination Mediates Innate Immunity to Retroviral Infection","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W2767975686","doi":"https://doi.org/10.1016/s0092-8674(04)00163-1","mag":"2767975686"},"language":"en","primary_location":{"id":"doi:10.1016/s0092-8674(04)00163-1","doi":"https://doi.org/10.1016/s0092-8674(04)00163-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(04)00163-1","pdf_url":"http://www.cell.com/article/S0092867404001631/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867404001631/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035901749","display_name":"Reuben S. Harris","orcid":"https://orcid.org/0000-0002-9034-9112","observed_orcids":["https://orcid.org/0000-0002-9034-9112"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Reuben S Harris","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031690071","display_name":"Kate N. Bishop","orcid":"https://orcid.org/0000-0003-3991-614X","observed_orcids":["https://orcid.org/0000-0003-3991-614X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kate N Bishop","raw_affiliation_strings":["Department of Infectious Diseases, Guy's, King's and St Thomas' School of Medicine, King's College London, London, SE1 9RT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Guy's, King's and St Thomas' School of Medicine, King's College London, London, SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102882846","display_name":"Ann M. Sheehy","orcid":"https://orcid.org/0000-0001-5622-8176","observed_orcids":["https://orcid.org/0000-0001-5622-8176"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ann M Sheehy","raw_affiliation_strings":["Department of Infectious Diseases, Guy's, King's and St Thomas' School of Medicine, King's College London, London, SE1 9RT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Guy's, King's and St Thomas' School of Medicine, King's College London, London, SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071858225","display_name":"Heather M. Craig","orcid":"https://orcid.org/0000-0002-4715-415X","observed_orcids":["https://orcid.org/0000-0002-4715-415X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heather M Craig","raw_affiliation_strings":["Department of Infectious Diseases, Guy's, King's and St Thomas' School of Medicine, King's College London, London, SE1 9RT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Guy's, King's and St Thomas' School of Medicine, King's College London, London, SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012391915","display_name":"Svend K. Petersen\u2010Mahrt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Svend K Petersen-Mahrt","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054053300","display_name":"Ian N. Watt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian N Watt","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018578853","display_name":"Michael S. Neuberger","orcid":"https://orcid.org/0000-0001-8453-5325","observed_orcids":["https://orcid.org/0000-0001-8453-5325"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael S Neuberger","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091639782","display_name":"Michael H. Malim","orcid":"https://orcid.org/0000-0002-7699-2064","observed_orcids":["https://orcid.org/0000-0002-7699-2064"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael H Malim","raw_affiliation_strings":["Department of Infectious Diseases, Guy's, King's and St Thomas' School of Medicine, King's College London, London, SE1 9RT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Guy's, King's and St Thomas' School of Medicine, King's College London, London, SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035901749"],"corresponding_institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":2.4562,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.90182186,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"116","issue":"4","first_page":"629","last_page":"629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-deamination","display_name":"DNA deamination","score":0.9559999704360962},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/retrovirus-infection","display_name":"retroviral infection","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.6449999809265137},{"id":"https://openalex.org/keywords/vif","display_name":"Vif","score":0.6579999923706055},{"id":"https://openalex.org/keywords/virion-incorporation","display_name":"virion incorporation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/retroviral-restriction-factors","display_name":"retroviral restriction factors","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9614375829696655},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7746674418449402},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5985720753669739},{"id":"https://openalex.org/C137993225","wikidata":"https://www.wikidata.org/wiki/Q6058723","display_name":"Intrinsic immunity","level":4,"score":0.5822616219520569},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5698853731155396},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5336516499519348},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41490787267684937},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19756191968917847}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0092-8674(04)00163-1","doi":"https://doi.org/10.1016/s0092-8674(04)00163-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(04)00163-1","pdf_url":"http://www.cell.com/article/S0092867404001631/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0092-8674(04)00163-1","doi":"https://doi.org/10.1016/s0092-8674(04)00163-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(04)00163-1","pdf_url":"http://www.cell.com/article/S0092867404001631/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2767975686.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W24381101","https://openalex.org/W1991069890","https://openalex.org/W2600378181","https://openalex.org/W2000620255","https://openalex.org/W1430138787","https://openalex.org/W2050613958","https://openalex.org/W1604102076","https://openalex.org/W1649851242","https://openalex.org/W2347695229","https://openalex.org/W2073406070"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-11-17T00:00:00"}