{"id":"https://openalex.org/W2767934683","doi":null,"title":"Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthry)-L-cysteine (Phe-epoxide-NAC) in human urine: comparison with glutathione-S-transferase genotypes.","display_name":"Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthry)-L-cysteine (Phe-epoxide-NAC) in human urine: comparison with glutathione-S-transferase genotypes.","publication_year":2006,"publication_date":"2006-04-15","ids":{"openalex":"https://openalex.org/W2767934683","mag":"2767934683"},"language":"en","primary_location":{"id":"mag:2767934683","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/66/8_Supplement/1332.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033402104","display_name":"Stephen S. Hecht","orcid":"https://orcid.org/0000-0001-7228-1356","observed_orcids":["https://orcid.org/0000-0001-7228-1356"]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen S. Hecht","raw_affiliation_strings":["University of Minnesota Cancer Center, Minneapolis, MN"],"raw_orcid":"https://orcid.org/0000-0001-7228-1356","affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center, Minneapolis, MN","institution_ids":["https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Priyanka A. Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka A. Rao","raw_affiliation_strings":["University of Minnesota Cancer Center, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center, Minneapolis, MN","institution_ids":["https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001476935","display_name":"Pramod Upadhyaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pramod Upadhyaya","raw_affiliation_strings":["University of Minnesota Cancer Center, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center, Minneapolis, MN","institution_ids":["https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015278922","display_name":"Peter W. Villalta","orcid":"https://orcid.org/0000-0002-0067-3083","observed_orcids":["https://orcid.org/0000-0002-0067-3083"]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W. Villalta","raw_affiliation_strings":["University of Minnesota Cancer Center, Minneapolis, MN"],"raw_orcid":"https://orcid.org/0000-0002-0067-3083","affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center, Minneapolis, MN","institution_ids":["https://openalex.org/I4390039358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045941754","display_name":"J. Bradley Hochalter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bradley Hochalter","raw_affiliation_strings":["University of Minnesota Cancer Center, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center, Minneapolis, MN","institution_ids":["https://openalex.org/I4390039358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4390039358"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39668268,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":null,"first_page":"1332","last_page":"1332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.17980000376701355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gstm1","display_name":"GSTM1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gstt1","display_name":"GSTT1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9480000138282776},{"id":"https://openalex.org/keywords/glutathione-conjugation","display_name":"glutathione conjugation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/diastereomers","display_name":"diastereomers","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8581188917160034},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7647355198860168},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7040599584579468},{"id":"https://openalex.org/C2776920199","wikidata":"https://www.wikidata.org/wiki/Q408028","display_name":"Epoxide","level":3,"score":0.6416197419166565},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5759649276733398},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.562811553478241},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5420966148376465},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.41987839341163635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3661826252937317},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3058779239654541},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.2780199646949768},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2767934683","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/66/8_Supplement/1332.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991977220","https://openalex.org/W2103228625","https://openalex.org/W2732478374","https://openalex.org/W2527262596","https://openalex.org/W2187805565","https://openalex.org/W2165955839","https://openalex.org/W2141726469","https://openalex.org/W2119084381","https://openalex.org/W1967603262","https://openalex.org/W2095779678"],"abstract_inverted_index":{"5666":[0],"Polycyclic":[3],"aromatic":[4],"hydrocarbons":[5],"(PAH)":[6],"are":[7],"likely":[8],"to":[9,30,42,74,96,101,126,145,231],"play":[10],"a":[11,71,124,339,348],"major":[12],"role":[13],"in":[14,17,27,54,78,91,147,193,238,246,262,281,294,343],"cancer":[15,43,66],"induction":[16],"smokers":[18],"and":[19,36,65,110,139,171,179,288,301,313],"certain":[20],"occupationally":[21],"exposed":[22],"groups.":[23],"Humans":[24],"vary":[25],"widely":[26],"their":[28],"abilities":[29],"metabolically":[31],"activate":[32],"or":[33,318],"detoxify":[34],"PAH,":[35],"these":[37],"variations":[38],"may":[39,69],"be":[40,70],"related":[41],"risk.":[44,67],"Many":[45],"studies":[46],"have":[47,115],"examined":[48],"the":[49,106,129,194,327,333],"possible":[50],"relationship":[51],"between":[52],"variants":[53,146],"genotypes":[55],"of":[56,88,134,137,142,234,250,275,323,336,338],"carcinogen":[57,354],"metabolizing":[58],"enzymes":[59],"such":[60],"as":[61,93,157],"glutathione-":[62,148],"S":[63,149],"-transferases":[64],"Phenotyping":[68],"better":[72],"way":[73],"determine":[75],"inter-individual":[76],"differences":[77],"PAH":[79,97,324,340],"metabolism.":[80],"Our":[81],"laboratory":[82],"has":[83],"developed":[84,123],"methods":[85],"for":[86,351],"analysis":[87],"phenanthrene":[89],"metabolites":[90],"urine,":[92],"an":[94],"approach":[95],"metabolite":[98,144,252,277],"phenotyping.":[99],"Methods":[100],"measure":[102],"metabolic":[103],"activation":[104],"by":[105,112,164],"diol":[107],"epoxide":[108],"pathway":[109],"detoxification":[111,325,355],"phenol":[113],"formation":[114],"already":[116],"been":[117],"published.":[118],"In":[119],"this":[120,143,251,276,352],"study,":[121],"we":[122],"method":[125],"quantify":[127],"Phe-epoxide-NAC,":[128],"urinary":[130],"meracapturic":[131],"acid":[132,329,342],"end-product":[133],"glutathione":[135],"conjugation":[136],"phenanthrene-9,10-epoxide,":[138],"compared":[140],"levels":[141,322],"-transferase":[150],"genotypes.":[151],"[D":[152],"10":[153],"]Phe-epoxide-NAC":[154],"was":[155,181,226],"used":[156],"internal":[158],"standard.":[159],"Urine":[160],"samples":[161,241],"were":[162,236,244,278],"purified":[163],"passage":[165],"through":[166,326],"cation":[167],"exchange,":[168,170],"anion":[169],"reverse":[172],"phase":[173,175],"solid":[174],"extraction":[176],"cartridges.":[177],"Analysis":[178],"quantitation":[180,337],"achieved":[182],"using":[183],"liquid":[184],"chromatography-electrospray":[185],"ionization-tandem":[186],"mass":[187],"spectrometry":[188],"with":[189,283,296],"selected":[190],"reaction":[191],"monitoring,":[192],"negative":[195],"ion":[196],"chemical":[197],"ionization":[198],"mode.":[199],"The":[200],"transition":[201],"m/z":[203,213],"356":[205],"(M":[206],"\u2212":[207,209,217],"1)":[208],"\u2192":[211],"209":[215],"[M":[216],"(H":[218],"2":[219,222],"O+":[220],"CH":[221],"CH(COOH)NHCOCH":[223],"3":[224],")]":[225],"monitored.":[227],"Clean":[228],"peaks":[229],"corresponding":[230],"two":[232],"diastereomers":[233],"Phe-epoxide-NAC":[235],"observed":[237],"15":[239],"urine":[240,345],"while":[242],"none":[243],"detected":[245,256],"another":[247],"17.":[248],"Levels":[249,274],"varied":[253],"from":[254],"not":[255],"(":[257],"GSTM1":[258,264,286,299,311],"present":[260,292],"than":[261,293],"null":[266],"individuals":[267,282],"(15.8":[268],"\u00b1":[269],"30.1,":[270],"N":[271],"=":[272],"22).":[273],"also":[279],"higher":[280],"both":[284,297],"GSTT1":[290,303,315],"those":[295],"null.":[305],"These":[306],"results":[307],"suggest":[308],"that":[309],"presence":[317],"absence":[319],"do":[320],"affect":[321],"mercapturic":[328,341],"pathway.":[330,356],"This":[331],"is":[332],"first":[334],"report":[335],"human":[344],"thus":[346],"allowing":[347],"phenotype-genotype":[349],"comparison":[350],"important":[353]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-11-17T00:00:00"}