{"id":"https://openalex.org/W2767730103","doi":null,"title":"MiRNA-135a regulates the expression of small conductance calcium-activated potassium (SK3) channels in epilepsy-like conditions","display_name":"MiRNA-135a regulates the expression of small conductance calcium-activated potassium (SK3) channels in epilepsy-like conditions","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2767730103","mag":"2767730103"},"language":"en","primary_location":{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/9991f96f-1495-4768-b7b6-e7950254d005","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/9991f96f-1495-4768-b7b6-e7950254d005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honrath, B, Norwood, B, Tanrioever, G, Kuter, K, Henshall, D C, Aksel-Aksoy, A, Schratt, G, Pasterkamp, J, Dencher, N A, Nieweg, K, Culmsee, C & Dolga, A M 2017, 'MiRNA-135a regulates the expression of small conductance calcium-activated potassium (SK3) channels in epilepsy-like conditions', 8th Annual Alliance for Healthy Aging Conference, Groningen, Netherlands, 09/11/2017 - 11/11/2017.","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056069757","display_name":"Birgit Honrath","orcid":"https://orcid.org/0000-0003-4964-9874","observed_orcids":["https://orcid.org/0000-0003-4964-9874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birgit Honrath","raw_affiliation_strings":["Molecular Pharmacology"],"raw_orcid":"https://orcid.org/0000-0003-4964-9874","affiliations":[{"raw_affiliation_string":"Molecular Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108503749","display_name":"Braxton A. Norwood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Braxton A. Norwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014324648","display_name":"Gaye Tanri\u00f6ver","orcid":"https://orcid.org/0000-0002-5252-8443","observed_orcids":["https://orcid.org/0000-0002-5252-8443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaye Tanrioever","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043279454","display_name":"Katarzyna Z. Kuter","orcid":"https://orcid.org/0000-0001-8210-6447","observed_orcids":["https://orcid.org/0000-0001-8210-6447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarzyna Kuter","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8210-6447","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002978004","display_name":"David Clifford Henshall","orcid":"https://orcid.org/0000-0001-6237-9632","observed_orcids":["https://orcid.org/0000-0001-6237-9632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Henshall","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6237-9632","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035177159","display_name":"Ayla Aksoy\u2010Aksel","orcid":"https://orcid.org/0000-0002-5987-2829","observed_orcids":["https://orcid.org/0000-0002-5987-2829","https://orcid.org/0000-0003-0418-6466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayla Aksel-Aksoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013488851","display_name":"Gerhard M. Schratt","orcid":"https://orcid.org/0000-0001-7527-2025","observed_orcids":["https://orcid.org/0000-0001-7527-2025"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerhard Schratt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7527-2025","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064421447","display_name":"R. Jeroen Pasterkamp","orcid":"https://orcid.org/0000-0003-1631-6440","observed_orcids":["https://orcid.org/0000-0003-1631-6440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Jeroen Pasterkamp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1631-6440","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082961606","display_name":"Norbert A. Dencher","orcid":"https://orcid.org/0000-0002-1745-8670","observed_orcids":["https://orcid.org/0000-0002-1745-8670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert A. Dencher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042728362","display_name":"Katja Nieweg","orcid":"https://orcid.org/0000-0002-0495-7470","observed_orcids":["https://orcid.org/0000-0002-0495-7470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katja Nieweg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0495-7470","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053579288","display_name":"Carsten Culmsee","orcid":"https://orcid.org/0000-0002-5121-5015","observed_orcids":["https://orcid.org/0000-0002-5121-5015"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten Culmsee","raw_affiliation_strings":["Univ Marburg, Philipps University Marburg, Inst Pharmacol & Clin Pharm"],"raw_orcid":"https://orcid.org/0000-0002-5121-5015","affiliations":[{"raw_affiliation_string":"Univ Marburg, Philipps University Marburg, Inst Pharmacol & Clin Pharm","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064422858","display_name":"Amalia M. Dolga","orcid":"https://orcid.org/0000-0001-5400-5614","observed_orcids":["https://orcid.org/0000-0001-5400-5614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amalia M. Dolga","raw_affiliation_strings":["Molecular Pharmacology"],"raw_orcid":"https://orcid.org/0000-0001-5400-5614","affiliations":[{"raw_affiliation_string":"Molecular Pharmacology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1827957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.45730000734329224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sk3-channel","display_name":"SK3 channel","score":0.7300000190734863},{"id":"https://openalex.org/keywords/small-conductance-calcium-activated-potassium-channels","display_name":"small conductance calcium-activated potassium channels","score":0.996999979019165},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.722000002861023},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.6420000195503235},{"id":"https://openalex.org/keywords/magnesium-deprivation","display_name":"magnesium deprivation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hippocampal-seizures","display_name":"hippocampal seizures","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.5950000286102295},{"id":"https://openalex.org/keywords/neuronal-firing","display_name":"neuronal firing","score":0.4909999966621399},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.7163474559783936},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6386317014694214},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6261100769042969},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.571664571762085},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.5494255423545837},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4951252043247223},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4869872033596039},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.4119589328765869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34225931763648987},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3410990238189697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32422372698783875},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.14905932545661926},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10858625173568726},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1037757396697998}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/9991f96f-1495-4768-b7b6-e7950254d005","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/9991f96f-1495-4768-b7b6-e7950254d005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honrath, B, Norwood, B, Tanrioever, G, Kuter, K, Henshall, D C, Aksel-Aksoy, A, Schratt, G, Pasterkamp, J, Dencher, N A, Nieweg, K, Culmsee, C & Dolga, A M 2017, 'MiRNA-135a regulates the expression of small conductance calcium-activated potassium (SK3) channels in epilepsy-like conditions', 8th Annual Alliance for Healthy Aging Conference, Groningen, Netherlands, 09/11/2017 - 11/11/2017.","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:rug:oai:pure.rug.nl:publications/9991f96f-1495-4768-b7b6-e7950254d005","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/9991f96f-1495-4768-b7b6-e7950254d005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TITLE=8th Annual Alliance for Healthy Aging Conference","raw_type":"info:eu-repo/semantics/conferenceitemnotinproceedings"},{"id":"mag:2767730103","doi":null,"is_oa":false,"landing_page_url":"https://www.narcis.nl/publication/RecordID/oai%3Apure.rug.nl%3Apublications%2F9991f96f-1495-4768-b7b6-e7950254d005","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1998450146","https://openalex.org/W2125556242","https://openalex.org/W2901106311","https://openalex.org/W4384664908","https://openalex.org/W2122932525","https://openalex.org/W2100068597","https://openalex.org/W2047523290","https://openalex.org/W126753634","https://openalex.org/W2043767728","https://openalex.org/W7097272409"],"abstract_inverted_index":{"Background":[0],"Excessive":[1],"and":[2,41,55,65,76,136,157,183,198,253,259],"hypersynchronous":[3,85],"neuronal":[4,24,78,86,105,123,163,169,181,251],"discharges":[5],"are":[6,241,247],"key":[7,224],"characteristics":[8],"in":[9,35,46,71,88,119,165,180,196,201,205,209,230,243],"the":[10,39,63,178,202,212,260],"pathophysiology":[11],"of":[12,22,38,49,67,74,101,162,214,226,256,263],"neurological":[13],"disorders":[14],"such":[15],"as":[16,222,269],"epilepsy.":[17],"Owing":[18],"to":[19,103,115],"their":[20,42],"ability":[21],"regulating":[23],"excitability,":[25],"small":[26],"conductance":[27],"calcium-activated":[28],"potassium":[29],"(SK)":[30],"channels":[31,149,240],"have":[32],"been":[33],"implicated":[34],"several":[36],"diseases":[37],"brain,":[40],"activation":[43,175],"provided":[44],"neuroprotection":[45],"different":[47,72],"paradigms":[48],"cell":[50],"death,":[51],"including":[52],"oxidative":[53],"stress":[54],"excitotoxicity.":[56],"Objectives":[57],"In":[58,107,159],"our":[59],"study,":[60],"we":[61,90,109,219,234],"investigated":[62,122,151],"function":[64],"regulation":[66,262],"SK":[68,130,173],"channel":[69,131,174,191,228,265],"expression":[70,132,192,229,266],"models":[73],"epilepsy":[75],"excessive":[77],"firing.":[79,106],"Methods":[80],"As":[81],"a":[82,153,223,270],"model":[83],"for":[84],"firing":[87,124,164,252],"vitro,":[89,160,197],"used":[91,110],"primary":[92,168,231],"cortical":[93],"neurons":[94],"either":[95],"challenged":[96],"with":[97],"glutamate":[98],"or":[99],"deprived":[100,167],"magnesium":[102,166],"increase":[104,179],"addition,":[108],"perforant":[111],"pathway":[112],"stimulation":[113],"(PPS)":[114],"induce":[116],"hippocampal":[117],"seizures":[118],"vivo.":[120,206],"We":[121,187],"using":[125,152],"multielectrode":[126],"array":[127],"recordings,":[128],"analyze":[129],"by":[133,140,249],"Western":[134],"blot,":[135],"assess":[137],"mitochondrial":[138,142,215,257],"performance":[139,213],"evaluating":[141],"complex":[143,216],"activity.":[144],"MicroRNA135a-dependent":[145],"effects":[146],"on":[147],"SK3":[148,190,227,239,264],"were":[150],"dual-luciferase":[154],"assay.":[155],"Results":[156],"Conclusions":[158],"analysis":[161],"cultures":[170],"revealed":[171],"that":[172,238],"fully":[176],"blocked":[177],"activity,":[182],"restored":[184],"homeostatic":[185],"signaling.":[186],"found":[188],"reduced":[189],"following":[193,199],"glutamate-induced":[194],"excitotoxicity":[195],"PPS":[200,208],"rat":[203],"hippocampus":[204],"Further,":[207],"vivo":[210],"impaired":[211],"I.":[217],"Interestingly,":[218],"identified":[220],"miRNA-135a":[221],"regulator":[225],"neurons.":[232],"Thus,":[233],"provide":[235],"strong":[236],"evidence":[237],"involved":[242],"epilepsy(-like)":[244],"conditions":[245],"which":[246],"characterized":[248],"enhanced":[250],"an":[254],"impairment":[255],"function,":[258],"miRNA135a-dependent":[261],"was":[267],"unraveled":[268],"new":[271],"regulatory":[272],"mechanism.":[273]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-11-17T00:00:00"}