{"id":"https://openalex.org/W2767607752","doi":"https://doi.org/10.1111/febs.14293","title":"In vitro modeling of HIV proviral activity in microglia","display_name":"In vitro modeling of HIV proviral activity in microglia","publication_year":2017,"publication_date":"2017-11-08","ids":{"openalex":"https://openalex.org/W2767607752","doi":"https://doi.org/10.1111/febs.14293","mag":"2767607752","pmid":"https://pubmed.ncbi.nlm.nih.gov/29114997","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835391"},"language":"en","primary_location":{"id":"doi:10.1111/febs.14293","doi":"https://doi.org/10.1111/febs.14293","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.14293","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5835391","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040308280","display_name":"Lee Ann Campbell","orcid":"https://orcid.org/0000-0003-4724-1824","observed_orcids":["https://orcid.org/0000-0003-4724-1824"]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee A. Campbell","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086681709","display_name":"Christopher T. Richie","orcid":"https://orcid.org/0000-0002-7944-4928","observed_orcids":["https://orcid.org/0000-0002-7944-4928"]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher T. Richie","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443321","display_name":"Yajun Zhang","orcid":"https://orcid.org/0000-0002-0689-475X","observed_orcids":["https://orcid.org/0000-0002-0689-475X"]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yajun Zhang","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089031017","display_name":"Emily J. Heathward","orcid":"https://orcid.org/0000-0003-4196-1118","observed_orcids":["https://orcid.org/0000-0003-4196-1118"]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily J. Heathward","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068092697","display_name":"Lamarque M. Coke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lamarque M. Coke","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017421070","display_name":"Emily Y. Park","orcid":"https://orcid.org/0000-0002-5696-5034","observed_orcids":["https://orcid.org/0000-0002-5696-5034"]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Y. Park","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108880617","display_name":"Brandon K. Harvey","orcid":"https://orcid.org/0000-0002-4036-1383","observed_orcids":["https://orcid.org/0000-0002-4036-1383","https://orcid.org/0000-0002-7471-9937"]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brandon K. Harvey","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-4036-1383","affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1327069482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108880617"],"corresponding_institution_ids":["https://openalex.org/I1327069482"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.0418,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.73422752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"284","issue":"23","first_page":"4096","last_page":"4114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hiv-long-terminal-repeat","display_name":"HIV long terminal repeat","score":0.5669999718666077},{"id":"https://openalex.org/keywords/hiv-nef","display_name":"HIV Nef","score":0.4429999887943268},{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.843999981880188},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9309999942779541},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8709999918937683},{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hiv-neuropathology","display_name":"HIV neuropathology","score":0.6069999933242798},{"id":"https://openalex.org/keywords/in-vitro-infection-model","display_name":"in vitro infection model","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.9364597797393799},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8433021903038025},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5386054515838623},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.5134154558181763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5002641677856445},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.4576011002063751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3219952881336212},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.321633517742157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25817054510116577},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20039182901382446},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14418190717697144},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/febs.14293","doi":"https://doi.org/10.1111/febs.14293","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.14293","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:29114997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29114997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5235138","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5835391","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5835391","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835391","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEBS J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5235138","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5835391","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000906489","display_name":"Microglia, HIV and drugs of abuse","funder_award_id":"ZIADA000586","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W137643597","https://openalex.org/W811863687","https://openalex.org/W1554513767","https://openalex.org/W1753490518","https://openalex.org/W1903112902","https://openalex.org/W1942667573","https://openalex.org/W1966452674","https://openalex.org/W1974682327","https://openalex.org/W1977709885","https://openalex.org/W1978917197","https://openalex.org/W1980135039","https://openalex.org/W1980280932","https://openalex.org/W1980818815","https://openalex.org/W1985445237","https://openalex.org/W1998055329","https://openalex.org/W1998892759","https://openalex.org/W2001153111","https://openalex.org/W2009482935","https://openalex.org/W2015266566","https://openalex.org/W2022978872","https://openalex.org/W2023803162","https://openalex.org/W2032026535","https://openalex.org/W2050075454","https://openalex.org/W2052543965","https://openalex.org/W2062268073","https://openalex.org/W2071545649","https://openalex.org/W2071620927","https://openalex.org/W2087423729","https://openalex.org/W2088493593","https://openalex.org/W2100859269","https://openalex.org/W2102367553","https://openalex.org/W2108117437","https://openalex.org/W2110536925","https://openalex.org/W2116053253","https://openalex.org/W2122483069","https://openalex.org/W2122660117","https://openalex.org/W2123711662","https://openalex.org/W2125524975","https://openalex.org/W2126259097","https://openalex.org/W2130599091","https://openalex.org/W2131395804","https://openalex.org/W2142102457","https://openalex.org/W2142529927","https://openalex.org/W2142677020","https://openalex.org/W2151197540","https://openalex.org/W2163445749","https://openalex.org/W2164309162","https://openalex.org/W2165311084","https://openalex.org/W2167380395","https://openalex.org/W2319061195","https://openalex.org/W2466192218","https://openalex.org/W2469238969","https://openalex.org/W2511019440","https://openalex.org/W2514020573","https://openalex.org/W2516111383","https://openalex.org/W2552908886"],"related_works":["https://openalex.org/W2174420693","https://openalex.org/W4407590186","https://openalex.org/W3213515053","https://openalex.org/W4410030133","https://openalex.org/W2110308923","https://openalex.org/W2737612875","https://openalex.org/W2042252087","https://openalex.org/W3100305783","https://openalex.org/W2998586063","https://openalex.org/W3112884593"],"abstract_inverted_index":{"Microglia,":[0],"the":[1,5,12,29,41,52,105,108,114,123,139,163,180,183,191,206,215,249],"resident":[2],"macrophages":[3],"of":[4,14,31,43,48,71,75,126,176,182,214,228,251],"brain,":[6],"play":[7],"a":[8,60,92,133,174,245],"key":[9],"role":[10],"in":[11,28,248],"pathogenesis":[13],"HIV-associated":[15],"neurocognitive":[16],"disorders":[17],"(HAND)":[18],"due":[19],"to":[20,58,100,143,173,178],"their":[21],"productive":[22],"infection":[23,50],"by":[24,189,204,219],"HIV.":[25],"This":[26],"results":[27],"release":[30],"neurotoxic":[32,146],"viral":[33,147,165,207],"proteins":[34,148],"and":[35,90,198,203,225,254],"pro-inflammatory":[36,194],"compounds":[37],"which":[38,120],"negatively":[39],"affect":[40],"functionality":[42],"surrounding":[44],"neurons.":[45],"Because":[46],"models":[47],"HIV":[49,68,76,94,127,164],"within":[51],"brain":[53],"are":[54],"limited,":[55],"we":[56],"aimed":[57],"create":[59,101],"novel":[61],"microglia":[62,99,158],"cell":[63],"line":[64],"with":[65,113,162,193],"an":[66],"integrated":[67,91],"provirus":[69,95],"capable":[70],"recreating":[72],"several":[73],"hallmarks":[74],"infection.":[77],"We":[78,153,168],"utilized":[79],"clustered":[80],"regularly":[81],"interspaced":[82],"short":[83],"palindromic":[84],"repeats":[85],"(CRISPR)/Cas9":[86],"gene":[87,218],"editing":[88],"technology":[89],"modified":[93,106],"into":[96],"CHME-5":[97,157,242],"immortalized":[98],"HIV-NanoLuc":[102,156,241],"CHME-5.":[103],"In":[104],"provirus,":[107],"Gag-Pol":[109],"region":[110,116],"is":[111],"replaced":[112],"coding":[115],"for":[117,122],"NanoLuciferase":[118],"(NanoLuc),":[119],"allows":[121],"rapid":[124],"assay":[125],"long":[128],"terminal":[129],"repeat":[130],"activity":[131,181,186],"using":[132],"luminescent":[134],"substrate,":[135],"while":[136],"still":[137],"containing":[138],"necessary":[140],"genetic":[141,212],"material":[142],"produce":[144],"established":[145],"(e.g.":[149],"tat,":[150],"nef,":[151],"gp120).":[152],"confirmed":[154],"that":[155,240],"express":[159],"NanoLuc,":[160],"along":[161],"protein":[166,209],"Nef.":[167],"subsequently":[169],"exposed":[170],"these":[171,237],"cells":[172,192],"battery":[175],"experiments":[177],"modulate":[179],"provirus.":[184],"Proviral":[185],"was":[187],"enhanced":[188],"treating":[190],"factors":[195],"lipopolysaccharide":[196],"(LPS)":[197],"tumor":[199],"necrosis":[200],"factor":[201],"alpha":[202],"overexpressing":[205],"regulatory":[208],"Tat.":[210],"Conversely,":[211],"modification":[213],"toll-like":[216],"receptor-4":[217],"CRISPR/Cas9":[220],"reduced":[221],"LPS-mediated":[222],"proviral":[223,234,255],"activation,":[224],"pharmacological":[226],"application":[227],"NF-\u03baB":[229],"inhibitor":[230],"sulfasalazine":[231],"similarly":[232],"diminished":[233],"activity.":[235],"Overall,":[236],"data":[238],"suggest":[239],"may":[243],"be":[244],"useful":[246],"tool":[247],"study":[250],"HIV-mediated":[252],"neuropathology":[253],"regulation.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-11-17T00:00:00"}
