{"id":"https://openalex.org/W2767598535","doi":"https://doi.org/10.4314/ovj.v7i4.2","title":"Multiple myeloma in an Amur tiger (Panthera tigris altaica)","display_name":"Multiple myeloma in an Amur tiger (Panthera tigris altaica)","publication_year":2017,"publication_date":"2017-11-08","ids":{"openalex":"https://openalex.org/W2767598535","doi":"https://doi.org/10.4314/ovj.v7i4.2","mag":"2767598535","pmid":"https://pubmed.ncbi.nlm.nih.gov/29138744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5681727"},"language":"en","primary_location":{"id":"doi:10.4314/ovj.v7i4.2","doi":"https://doi.org/10.4314/ovj.v7i4.2","is_oa":true,"landing_page_url":"https://doi.org/10.4314/ovj.v7i4.2","pdf_url":"https://www.ajol.info/index.php/ovj/article/download/162611/152111","source":{"id":"https://openalex.org/S2764524492","display_name":"Open Veterinary Journal","issn_l":"2218-6050","issn":["2218-6050","2226-4485"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310998","host_organization_name":"University of Tripoli","host_organization_lineage":["https://openalex.org/P4310310998"],"host_organization_lineage_names":["University of Tripoli"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Veterinary Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ajol.info/index.php/ovj/article/download/162611/152111","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086207187","display_name":"Alison M. Lee","orcid":"https://orcid.org/0000-0003-4452-1935","observed_orcids":["https://orcid.org/0000-0003-4452-1935","https://orcid.org/0000-0002-2224-5549"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Alison M. Lee","raw_affiliation_strings":["Pathobiology Section, UCD School of Veterinary Medicine, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology Section, UCD School of Veterinary Medicine, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015673151","display_name":"Naomi Guppy","orcid":"https://orcid.org/0000-0003-1004-3605","observed_orcids":["https://orcid.org/0000-0003-1004-3605"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Naomi Guppy","raw_affiliation_strings":["UCL Advanced Diagnostics, Rockefeller Building, Bloomsbury, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Advanced Diagnostics, Rockefeller Building, Bloomsbury, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Bainbridge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Bainbridge","raw_affiliation_strings":["Dublin Zoo, Phoenix Park, Dublin 8, Ireland","Dublin Zoo, Phoenix Park, Dublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dublin Zoo, Phoenix Park, Dublin 8, Ireland","institution_ids":[]},{"raw_affiliation_string":"Dublin Zoo, Phoenix Park, Dublin","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028101086","display_name":"Hanne Jahns","orcid":"https://orcid.org/0000-0001-6944-154X","observed_orcids":["https://orcid.org/0000-0001-6944-154X"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Hanne Jahns","raw_affiliation_strings":["Pathobiology Section, UCD School of Veterinary Medicine, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology Section, UCD School of Veterinary Medicine, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086207187"],"corresponding_institution_ids":["https://openalex.org/I100930933"],"apc_list":{"value":350,"currency":"USD","value_usd":350},"apc_paid":{"value":350,"currency":"USD","value_usd":350},"fwci":0.2065,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58416406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"7","issue":"4","first_page":"300","last_page":"300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.3984000086784363,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/amur-tiger","display_name":"Amur tiger","score":0.996999979019165},{"id":"https://openalex.org/keywords/panthera-tigris-altaica","display_name":"Panthera tigris altaica","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hemoabdomen","display_name":"hemoabdomen","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bone-marrow-lesions","display_name":"bone marrow lesions","score":0.6430000066757202},{"id":"https://openalex.org/keywords/monoclonal-gammopathy","display_name":"monoclonal gammopathy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/irf4","display_name":"IRF4","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cd20","display_name":"CD20","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lambda-light-chain","display_name":"lambda light chain","score":0.5239999890327454},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hepatic-hemorrhage","display_name":"hepatic hemorrhage","score":0.671999990940094},{"id":"https://openalex.org/keywords/threatened-species","display_name":"threatened species","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7498646974563599},{"id":"https://openalex.org/C2778611284","wikidata":"https://www.wikidata.org/wiki/Q127960","display_name":"Panthera","level":3,"score":0.7100631594657898},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6569095849990845},{"id":"https://openalex.org/C2779382419","wikidata":"https://www.wikidata.org/wiki/Q1757427","display_name":"Pancytopenia","level":3,"score":0.4868554472923279},{"id":"https://openalex.org/C2776855637","wikidata":"https://www.wikidata.org/wiki/Q10633013","display_name":"Serum protein electrophoresis","level":5,"score":0.4746977686882019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4548996686935425},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4399661123752594},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4225865602493286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.413720965385437},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.20343941450119019},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15947750210762024},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13239890336990356},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.12636405229568481},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C188382862","wikidata":"https://www.wikidata.org/wiki/Q170430","display_name":"Predation","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.4314/ovj.v7i4.2","doi":"https://doi.org/10.4314/ovj.v7i4.2","is_oa":true,"landing_page_url":"https://doi.org/10.4314/ovj.v7i4.2","pdf_url":"https://www.ajol.info/index.php/ovj/article/download/162611/152111","source":{"id":"https://openalex.org/S2764524492","display_name":"Open Veterinary Journal","issn_l":"2218-6050","issn":["2218-6050","2226-4485"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310998","host_organization_name":"University of Tripoli","host_organization_lineage":["https://openalex.org/P4310310998"],"host_organization_lineage_names":["University of Tripoli"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Veterinary Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4598486","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5681727","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5681727","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5681727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Vet J","raw_type":"Text"},{"id":"pmid:29138744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29138744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open veterinary journal","raw_type":"Case Reports"},{"id":"pmh:http://www.rian.ie/191765/","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10197/11674","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:7e0e15936d1c45b7adb79aad388e5111","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7e0e15936d1c45b7adb79aad388e5111","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Veterinary Journal, Vol 7, Iss 4, Pp 300-305 (2017)","raw_type":"article"},{"id":"pmh:oai:researchrepository.ucd.ie:10197/11674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10197/11674","pdf_url":null,"source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4314/ovj.v7i4.2","doi":"https://doi.org/10.4314/ovj.v7i4.2","is_oa":true,"landing_page_url":"https://doi.org/10.4314/ovj.v7i4.2","pdf_url":"https://www.ajol.info/index.php/ovj/article/download/162611/152111","source":{"id":"https://openalex.org/S2764524492","display_name":"Open Veterinary Journal","issn_l":"2218-6050","issn":["2218-6050","2226-4485"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310998","host_organization_name":"University of Tripoli","host_organization_lineage":["https://openalex.org/P4310310998"],"host_organization_lineage_names":["University of Tripoli"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Veterinary Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2767598535.pdf","grobid_xml":"https://content.openalex.org/works/W2767598535.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1985208713","https://openalex.org/W2065395965","https://openalex.org/W2125312453","https://openalex.org/W2131345344","https://openalex.org/W2132600682","https://openalex.org/W2138166627","https://openalex.org/W2142582254","https://openalex.org/W2149291446","https://openalex.org/W2155328952","https://openalex.org/W2160261302","https://openalex.org/W2161771249","https://openalex.org/W2161829335","https://openalex.org/W2162388744","https://openalex.org/W4211018560","https://openalex.org/W4235960991","https://openalex.org/W4407218052","https://openalex.org/W6646508775"],"related_works":["https://openalex.org/W2942635965","https://openalex.org/W2008983777","https://openalex.org/W3110395523","https://openalex.org/W2433044139","https://openalex.org/W2167973836","https://openalex.org/W7002231400","https://openalex.org/W172709819","https://openalex.org/W2103880402","https://openalex.org/W2744878564","https://openalex.org/W3210229920"],"abstract_inverted_index":{")":[0],"is":[1,128],"an":[2],"endangered":[3],"tiger":[4],"subspecies.":[5],"An":[6],"adult":[7],"zoo-bred":[8],"female":[9],"was":[10],"found":[11],"collapsed,":[12],"and":[13,19,23,25,46,64,76,78,104,107],"died":[14,120],"despite":[15],"supportive":[16],"treatment.":[17],"Hematology":[18],"biochemistry":[20],"showed":[21],"pancytopenia":[22],"hyperglobulinemia,":[24],"serum":[26],"protein":[27],"electrophoresis":[28],"revealed":[29],"a":[30,138],"monoclonal":[31],"band":[32],"in":[33,59,137],"the":[34,60,72,88,129],"\u03b2-globulin":[35],"region.":[36],"Necropsy":[37],"demonstrated":[38,68],"hemoabdomen,":[39],"multifocal":[40],"lytic":[41],"bone":[42,73,97,105],"marrow":[43,98,106],"lesions,":[44],"splenomegaly,":[45],"hemorrhagic":[47],"hepatic":[48],"nodules,":[49],"with":[50],"left":[51],"medial":[52],"lobe":[53],"rupture.":[54],"There":[55],"were":[56,91,100,110],"mutifocal":[57],"hemorrhages":[58],"subcutis,":[61],"lung,":[62],"epicardium,":[63],"intestinal":[65],"mucosa.":[66],"Histopathology":[67],"plasmacytoid":[69],"cells":[70],"infiltrating":[71],"marrow,":[74],"liver":[75],"spleen,":[77],"circulating":[79],"within":[80],"blood":[81],"vessels.":[82],"On":[83],"immunohistochemistry,":[84],"cell":[85],"infiltrates":[86,99,109],"of":[87,121],"three":[89],"tissues":[90],"positive":[92,101,111],"for":[93,102,112],"\u03bb":[94],"light":[95],"chains,":[96],"MUM-1":[103],"spleen":[108],"CD20.":[113],"These":[114],"findings":[115],"indicate":[116],"that":[117],"this":[118,132],"animal":[119],"hemoabdomen":[122],"subsequent":[123],"to":[124],"multiple":[125],"myeloma.":[126],"This":[127],"first":[130],"time":[131],"disease":[133],"has":[134],"been":[135],"reported":[136],"tiger.":[139]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2017-11-17T00:00:00"}