{"id":"https://openalex.org/W2767560205","doi":"https://doi.org/10.1093/gerona/glx182","title":"Understanding How Dogs Age: Longitudinal Analysis of Markers of Inflammation, Immune Function, and Oxidative Stress","display_name":"Understanding How Dogs Age: Longitudinal Analysis of Markers of Inflammation, Immune Function, and Oxidative Stress","publication_year":2017,"publication_date":"2017-11-06","ids":{"openalex":"https://openalex.org/W2767560205","doi":"https://doi.org/10.1093/gerona/glx182","mag":"2767560205","pmid":"https://pubmed.ncbi.nlm.nih.gov/29126143"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/glx182","doi":"https://doi.org/10.1093/gerona/glx182","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/glx182","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042082669","display_name":"Janet E. Alexander","orcid":"https://orcid.org/0000-0002-1028-4022","observed_orcids":["https://orcid.org/0000-0002-1028-4022"]},"institutions":[{"id":"https://openalex.org/I4392738287","display_name":"Waltham Centre for Pet Nutrition","ror":"https://ror.org/00p7f7z86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210113968","https://openalex.org/I4392738287"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Janet E Alexander","raw_affiliation_strings":["WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, UK","institution_ids":["https://openalex.org/I4392738287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061436482","display_name":"Alison Colyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738287","display_name":"Waltham Centre for Pet Nutrition","ror":"https://ror.org/00p7f7z86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210113968","https://openalex.org/I4392738287"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alison Colyer","raw_affiliation_strings":["WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, UK","institution_ids":["https://openalex.org/I4392738287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043395132","display_name":"Richard Haydock","orcid":"https://orcid.org/0009-0004-9281-856X","observed_orcids":["https://orcid.org/0009-0004-9281-856X"]},"institutions":[{"id":"https://openalex.org/I4392738287","display_name":"Waltham Centre for Pet Nutrition","ror":"https://ror.org/00p7f7z86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210113968","https://openalex.org/I4392738287"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard M Haydock","raw_affiliation_strings":["WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, UK","institution_ids":["https://openalex.org/I4392738287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112405114","display_name":"Michael G. Hayek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael G Hayek","raw_affiliation_strings":["Mars Petcare, Thompsons Station, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mars Petcare, Thompsons Station, Tennessee","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048540354","display_name":"JeanSoon Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JeanSoon Park","raw_affiliation_strings":["Royal Canin Pet Health and Nutrition Centre, Lewisburg, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Canin Pet Health and Nutrition Centre, Lewisburg, Ohio","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042082669"],"corresponding_institution_ids":["https://openalex.org/I4392738287"],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":1.6646,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.81279398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"73","issue":"6","first_page":"720","last_page":"728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-aging","display_name":"canine aging","score":0.9210000038146973},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immunoglobulin-m","display_name":"immunoglobulin M","score":0.7609999775886536},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8980000019073486},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.9089999794960022},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9259999990463257},{"id":"https://openalex.org/keywords/labrador-retriever","display_name":"Labrador Retriever","score":0.6480000019073486},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.5180000066757202},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7575917840003967},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7189776301383972},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.6446132063865662},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6101157069206238},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.547644317150116},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5011489391326904},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.48348814249038696},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47873350977897644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47537341713905334},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.47432419657707214},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.4453224539756775},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.4405423700809479},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.41212227940559387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3151000738143921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30066877603530884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08799701929092407},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068884","descriptor_name":"Immunosenescence","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000068884","descriptor_name":"Immunosenescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000080242","descriptor_name":"8-Hydroxy-2'-Deoxyguanosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/gerona/glx182","doi":"https://doi.org/10.1093/gerona/glx182","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/glx182","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},{"id":"pmid:29126143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29126143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Clinical Trial, Veterinary"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333669","display_name":"Waltham Centre for Pet Nutrition","ror":"https://ror.org/00p7f7z86"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W25586695","https://openalex.org/W67192295","https://openalex.org/W1422666500","https://openalex.org/W1537633288","https://openalex.org/W1560729591","https://openalex.org/W1593875304","https://openalex.org/W1758915839","https://openalex.org/W1873062108","https://openalex.org/W1896970469","https://openalex.org/W1902060129","https://openalex.org/W1918323552","https://openalex.org/W1966174633","https://openalex.org/W1968329980","https://openalex.org/W1970979615","https://openalex.org/W1990410488","https://openalex.org/W1995672598","https://openalex.org/W2011092724","https://openalex.org/W2015347505","https://openalex.org/W2017699847","https://openalex.org/W2020383780","https://openalex.org/W2030135352","https://openalex.org/W2030772730","https://openalex.org/W2031324624","https://openalex.org/W2039538740","https://openalex.org/W2041813741","https://openalex.org/W2046202110","https://openalex.org/W2046203903","https://openalex.org/W2048764708","https://openalex.org/W2055857680","https://openalex.org/W2059096846","https://openalex.org/W2062447017","https://openalex.org/W2066699333","https://openalex.org/W2077239322","https://openalex.org/W2083383950","https://openalex.org/W2084695787","https://openalex.org/W2091273397","https://openalex.org/W2092845362","https://openalex.org/W2101076939","https://openalex.org/W2104334082","https://openalex.org/W2104755183","https://openalex.org/W2117738774","https://openalex.org/W2143333241","https://openalex.org/W2146883798","https://openalex.org/W2153127464","https://openalex.org/W2156514757","https://openalex.org/W2159234781","https://openalex.org/W2168823729","https://openalex.org/W2322584079","https://openalex.org/W2383398344","https://openalex.org/W2397177102","https://openalex.org/W2484443960","https://openalex.org/W2512943105","https://openalex.org/W2661056469"],"related_works":["https://openalex.org/W4399268428","https://openalex.org/W4376873039","https://openalex.org/W1593214503","https://openalex.org/W7111706856","https://openalex.org/W4412392321","https://openalex.org/W2920854522","https://openalex.org/W2066699333","https://openalex.org/W4401012053","https://openalex.org/W4392357816","https://openalex.org/W4410918477"],"abstract_inverted_index":{"As":[0],"in":[1,5,15,26,55,59,71,76,85,133,174],"human":[2,45,199],"populations,":[3],"advances":[4],"nutrition":[6],"and":[7,53,80,104,201],"veterinary":[8],"care":[9],"have":[10],"led":[11],"to":[12,36,62,91,156,198,210],"an":[13],"increase":[14,54],"the":[16,50,72,92,126,134,175,203],"lifespan":[17],"of":[18,44,49,78,94,98,115,129,141,169,205],"companion":[19],"animals.":[20],"Detrimental":[21],"physiological":[22],"changes":[23,75,196],"occurring":[24],"later":[25],"life":[27,130,170],"must":[28],"be":[29,34],"understood":[30],"before":[31],"interventions":[32],"can":[33],"made":[35],"slow":[37],"or":[38,122,207,212],"reduce":[39,213],"them.":[40],"One":[41],"important":[42],"aspect":[43],"aging":[46,73,193],"is":[47],"upregulation":[48],"inflammatory":[51],"response":[52,180],"oxidative":[56,81],"damage":[57],"resulting":[58],"pathologies":[60],"linked":[61],"chronic":[63],"inflammation.":[64],"To":[65],"determine":[66],"whether":[67],"similar":[68,197],"processes":[69],"occur":[70],"dog,":[74],"markers":[77],"inflammation":[79],"stress":[82,158,183],"were":[83,159],"investigated":[84],"80":[86],"Labrador":[87],"retrievers":[88],"from":[89],"adulthood":[90],"end":[93],"life.":[95],"Serum":[96],"levels":[97,140],"immunoglobulin":[99,120],"M":[100],"(p":[101,106,136,149,161,186],"<":[102,107,150],".001)":[103,108,151],"8-hydroxy-2-deoxyguanosine":[105],"increased":[109],"with":[110,147],"age,":[111],"whereas":[112],"no":[113],"effect":[114],"age":[116,148],"was":[117,131,184],"detected":[118],"for":[119],"G":[121],"C-reactive":[123],"protein":[124,144,178],"unless":[125],"last":[127],"year":[128,168],"included":[132],"analysis":[135],"=":[137,162,187],".002).":[138],"Baseline":[139],"heat":[142,157,176,182],"shock":[143,177],"70":[145,179],"decreased":[146],"while":[152],"those":[153],"after":[154,181],"exposure":[155],"maintained":[160],".018).":[163],"However,":[164],"when":[165],"excluding":[166],"final":[167],"data,":[171],"a":[172],"decline":[173],"observed":[185],".004).":[188],"These":[189],"findings":[190],"indicate":[191],"that":[192],"dogs":[194],"undergo":[195],"inflammaging":[200],"offer":[202],"possibility":[204],"nutritional":[206],"pharmacological":[208],"intervention":[209],"delay":[211],"these":[214],"effects.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-11-17T00:00:00"}
