{"id":"https://openalex.org/W2767535966","doi":"https://doi.org/10.1016/j.jviromet.2017.11.003","title":"Hepatitis B core antigen based novel vaccine against porcine epidemic diarrhea virus","display_name":"Hepatitis B core antigen based novel vaccine against porcine epidemic diarrhea virus","publication_year":2017,"publication_date":"2017-11-09","ids":{"openalex":"https://openalex.org/W2767535966","doi":"https://doi.org/10.1016/j.jviromet.2017.11.003","mag":"2767535966","pmid":"https://pubmed.ncbi.nlm.nih.gov/29129402"},"language":"en","primary_location":{"id":"doi:10.1016/j.jviromet.2017.11.003","doi":"https://doi.org/10.1016/j.jviromet.2017.11.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jviromet.2017.11.003","pdf_url":null,"source":{"id":"https://openalex.org/S7140881","display_name":"Journal of Virological Methods","issn_l":"0166-0934","issn":["0166-0934","1879-0984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virological Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077287917","display_name":"Frank Gillam","orcid":"https://orcid.org/0000-0002-4927-2280","observed_orcids":["https://orcid.org/0000-0002-4927-2280"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Gillam","raw_affiliation_strings":["Department of Biological Systems Engineering, Virginia Tech, 1230 Washington St. SW, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Systems Engineering, Virginia Tech, 1230 Washington St. SW, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100718724","display_name":"Jianqiang Zhang","orcid":"https://orcid.org/0000-0001-7228-6202","observed_orcids":["https://orcid.org/0000-0001-7228-6202"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianqiang Zhang","raw_affiliation_strings":["Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101480352","display_name":"Chenming Zhang","orcid":"https://orcid.org/0000-0002-6770-5334","observed_orcids":["https://orcid.org/0000-0002-6770-5334"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chenming Zhang","raw_affiliation_strings":["Department of Biological Systems Engineering, Virginia Tech, 1230 Washington St. SW, Blacksburg, VA 24061, USA. Electronic address: chzhang2@vt.edu","Department of Biological Systems Engineering, Virginia Tech, 1230 Washington St. SW, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Systems Engineering, Virginia Tech, 1230 Washington St. SW, Blacksburg, VA 24061, USA. Electronic address: chzhang2@vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Biological Systems Engineering, Virginia Tech, 1230 Washington St. SW, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100718724","https://openalex.org/A5101480352"],"corresponding_institution_ids":["https://openalex.org/I173911158","https://openalex.org/I859038795"],"apc_list":{"value":3210,"currency":"USD","value_usd":3210},"apc_paid":null,"fwci":3.3469,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91306937,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"253","issue":null,"first_page":"61","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-epidemic-diarrhea-virus","display_name":"porcine epidemic diarrhea virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hbcag","display_name":"HBcAg","score":0.9229999780654907},{"id":"https://openalex.org/keywords/recombinant-vaccine","display_name":"recombinant vaccine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/multivalent-vaccine","display_name":"multivalent vaccine","score":0.6919999718666077},{"id":"https://openalex.org/keywords/peptide-insertion","display_name":"peptide insertion","score":0.550000011920929},{"id":"https://openalex.org/keywords/immunodominant-region","display_name":"immunodominant region","score":0.871999979019165},{"id":"https://openalex.org/keywords/escherichia-coli-expression","display_name":"Escherichia coli expression","score":0.8360000252723694},{"id":"https://openalex.org/keywords/virus-neutralization","display_name":"virus neutralization","score":0.6380000114440918},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.4970000088214874},{"id":"https://openalex.org/keywords/intraperitoneal-administration","display_name":"intraperitoneal administration","score":0.7049999833106995},{"id":"https://openalex.org/keywords/intranasal-administration","display_name":"intranasal administration","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2779729466","wikidata":"https://www.wikidata.org/wiki/Q24723361","display_name":"HBcAg","level":5,"score":0.9377268552780151},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.9017086029052734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6845902800559998},{"id":"https://openalex.org/C2775862345","wikidata":"https://www.wikidata.org/wiki/Q16023751","display_name":"Porcine epidemic diarrhea virus","level":3,"score":0.6529361009597778},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5500879287719727},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5435308218002319},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.41834717988967896},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.4042462706565857},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3662928342819214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2790233790874481},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.16867470741271973}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006512","descriptor_name":"Hepatitis B Core Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006512","descriptor_name":"Hepatitis B Core Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053485","descriptor_name":"Porcine epidemic diarrhea virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058425","descriptor_name":"Vaccines, Virus-Like Particle","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jviromet.2017.11.003","doi":"https://doi.org/10.1016/j.jviromet.2017.11.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jviromet.2017.11.003","pdf_url":null,"source":{"id":"https://openalex.org/S7140881","display_name":"Journal of Virological Methods","issn_l":"0166-0934","issn":["0166-0934","1879-0984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virological Methods","raw_type":"journal-article"},{"id":"pmid:29129402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29129402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virological methods","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318728","display_name":"Smithfield Foods","ror":"https://ror.org/05fsmwf85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1603446342","https://openalex.org/W1604813814","https://openalex.org/W1823361762","https://openalex.org/W1840872076","https://openalex.org/W1894591641","https://openalex.org/W1896058554","https://openalex.org/W1928945856","https://openalex.org/W1966561205","https://openalex.org/W1971212505","https://openalex.org/W1992851412","https://openalex.org/W1996095557","https://openalex.org/W1999106655","https://openalex.org/W1999441390","https://openalex.org/W2012688036","https://openalex.org/W2014899539","https://openalex.org/W2024431338","https://openalex.org/W2033389023","https://openalex.org/W2034253067","https://openalex.org/W2038080369","https://openalex.org/W2038738042","https://openalex.org/W2042157784","https://openalex.org/W2046190332","https://openalex.org/W2048385123","https://openalex.org/W2049816729","https://openalex.org/W2052950580","https://openalex.org/W2060800255","https://openalex.org/W2065729511","https://openalex.org/W2067704944","https://openalex.org/W2070315095","https://openalex.org/W2094023848","https://openalex.org/W2094869942","https://openalex.org/W2097957152","https://openalex.org/W2106713698","https://openalex.org/W2107376609","https://openalex.org/W2108654152","https://openalex.org/W2132869815","https://openalex.org/W2134846739","https://openalex.org/W2138541522","https://openalex.org/W2139250720","https://openalex.org/W2150070509","https://openalex.org/W2156307441","https://openalex.org/W2165836333","https://openalex.org/W2166880388","https://openalex.org/W2167183296","https://openalex.org/W2168036974","https://openalex.org/W2169267616","https://openalex.org/W2220565019","https://openalex.org/W2320311613","https://openalex.org/W2347305151","https://openalex.org/W2401872796","https://openalex.org/W2413479284","https://openalex.org/W2609048818","https://openalex.org/W2655519188","https://openalex.org/W2733818964","https://openalex.org/W2743526398","https://openalex.org/W6705199420","https://openalex.org/W6715552713"],"related_works":["https://openalex.org/W2807866389","https://openalex.org/W2955948705","https://openalex.org/W3035798728","https://openalex.org/W7119783591","https://openalex.org/W7130728025","https://openalex.org/W3198164698","https://openalex.org/W4411895459","https://openalex.org/W7171528381","https://openalex.org/W2982030334","https://openalex.org/W2811123069"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-11-17T00:00:00"}