{"id":"https://openalex.org/W2767534113","doi":null,"title":"Effects of SIRT1 mutation or over-expression in astrocytes on metabolism and reproduction /","display_name":"Effects of SIRT1 mutation or over-expression in astrocytes on metabolism and reproduction /","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2767534113","mag":"2767534113"},"language":"en","primary_location":{"id":"pmh:qt2kp9f999","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/2kp9f999","pdf_url":"http://www.escholarship.org/uc/item/2kp9f999","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Choi, Irene Su Jeen. (2014). Effects of SIRT1 mutation or over-expression in astrocytes on metabolism and reproduction /. UC San Diego: Biology. Retrieved from: http://www.escholarship.org/uc/item/2kp9f999","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.escholarship.org/uc/item/2kp9f999","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072197947","display_name":"Irene Choi","orcid":"https://orcid.org/0000-0002-9146-8324","observed_orcids":["https://orcid.org/0000-0002-9146-8324"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Irene Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072197947"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/reproductive-function","display_name":"reproductive function","score":0.628000020980835},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.6769999861717224},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.675000011920929},{"id":"https://openalex.org/keywords/insulin-tolerance","display_name":"insulin tolerance","score":0.9610000252723694},{"id":"https://openalex.org/keywords/estrous-cyclicity","display_name":"estrous cyclicity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.7390000224113464},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9850000143051147},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7739999890327454},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.8130000233650208},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4429999887943268},{"id":"https://openalex.org/keywords/nad-dependent-histone-deacetylase","display_name":"NAD+-dependent histone deacetylase","score":0.7689999938011169},{"id":"https://openalex.org/keywords/steroid-hormones","display_name":"steroid hormones","score":0.5989999771118164},{"id":"https://openalex.org/keywords/gonadal-histology","display_name":"gonad histology","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7916131615638733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7619822025299072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7534850835800171},{"id":"https://openalex.org/C125929170","wikidata":"https://www.wikidata.org/wiki/Q908966","display_name":"Cre recombinase","level":5,"score":0.5891807079315186},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.5433093309402466},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.48009636998176575},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4190016984939575},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.35529568791389465},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.31124675273895264},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11898332834243774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10017955303192139},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.08352896571159363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:qt2kp9f999","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/2kp9f999","pdf_url":"http://www.escholarship.org/uc/item/2kp9f999","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Choi, Irene Su Jeen. (2014). Effects of SIRT1 mutation or over-expression in astrocytes on metabolism and reproduction /. UC San Diego: Biology. Retrieved from: http://www.escholarship.org/uc/item/2kp9f999","raw_type":"dissertation"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt2kp9f999","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2kp9f999","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:2767534113","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt2kp9f999/qt2kp9f999.pdf?t=o949q2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:qt2kp9f999","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/2kp9f999","pdf_url":"http://www.escholarship.org/uc/item/2kp9f999","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Choi, Irene Su Jeen. (2014). Effects of SIRT1 mutation or over-expression in astrocytes on metabolism and reproduction /. UC San Diego: Biology. Retrieved from: http://www.escholarship.org/uc/item/2kp9f999","raw_type":"dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2767534113.pdf","grobid_xml":"https://content.openalex.org/works/W2767534113.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1512733937","https://openalex.org/W1555023540","https://openalex.org/W1969408132","https://openalex.org/W1976868184","https://openalex.org/W2006173437","https://openalex.org/W2008054955","https://openalex.org/W2022267544","https://openalex.org/W2038253875","https://openalex.org/W2039017765","https://openalex.org/W2059193930","https://openalex.org/W2059267070","https://openalex.org/W2090225971","https://openalex.org/W2109061188","https://openalex.org/W2110271190","https://openalex.org/W2113252743","https://openalex.org/W2118204731","https://openalex.org/W2118713503","https://openalex.org/W2135387645","https://openalex.org/W2135711139","https://openalex.org/W2136969651","https://openalex.org/W2140530719","https://openalex.org/W2143687302","https://openalex.org/W2158124286","https://openalex.org/W2158153532","https://openalex.org/W2165398964"],"related_works":["https://openalex.org/W2942053059","https://openalex.org/W3175961289","https://openalex.org/W2906661487","https://openalex.org/W3174225797","https://openalex.org/W3150425881","https://openalex.org/W2005027604","https://openalex.org/W2594519135","https://openalex.org/W1969480537","https://openalex.org/W2158124286","https://openalex.org/W2897918777"],"abstract_inverted_index":{"Sirtuin":[0],"1":[1],"(SIRT1)":[2],"is":[3,45],"an":[4],"NAD+-dependent":[5],"histone":[6],"deacetylase,":[7],"activating":[8],"and":[9,23,41,69,82,95,111,118,130,203,224,229,235,256],"inhibiting":[10],"gene-expression":[11],"in":[12,30,39,55,102,116,151,219],"several":[13],"organs,":[14],"such":[15,85],"as":[16,86,260,262],"the":[17,26,139,142,184,211,242],"liver,":[18],"pancreas,":[19],"adipose":[20],"tissue,":[21],"intestine,":[22],"brain.":[24],"Whereas":[25],"impact":[27],"of":[28,63,76,141,163,170,197,213,244],"SIRT1":[29,48,79,101,133,164,174],"these":[31],"tissues":[32],"has":[33,125],"been":[34],"extensively":[35],"studied,":[36],"its":[37],"role":[38,115],"astrocytes":[40,103],"effect":[42,243],"on":[43,180],"reproduction":[44],"still":[46],"elusive.":[47],"over-expressing":[49,128],"mice":[50,54],"show":[51],"phenotypes":[52],"resembling":[53],"caloric":[56,77],"restriction":[57],"-":[58],"inhibited":[59],"adipogenesis,":[60],"lowered":[61],"levels":[62,80,228],"blood":[64],"cholesterol,":[65],"improved":[66],"glucose":[67,223],"tolerance,":[68,226],"increased":[70],"metabolic":[71],"activity.":[72],"Furthermore,":[73],"during":[74],"times":[75],"restriction,":[78],"increase":[81],"reproductive":[83,109,182,230],"events":[84],"gonadotropin-releasing":[87],"hormone":[88,92,227,258],"(GnRH)":[89],"pulses,":[90,94],"luteinizing":[91],"(LH)":[93],"ovulation":[96],"cease.":[97],"I":[98],"hypothesize":[99],"that":[100],"may":[104],"contribute":[105],"to":[106,240],"this":[107],"altered":[108],"function":[110],"also":[112],"play":[113],"a":[114,135,159,166,173,204],"metabolism":[117],"inflammation.":[119],"To":[120,176],"evaluate":[121,241],"this,":[122],"our":[123],"laboratory":[124],"developed":[126],"conditional":[127],"(OX)":[129],"mutant":[131],"(MUT)":[132],"using":[134],"tamoxifen-inducible":[136],"cre-recombinase":[137],"under":[138],"control":[140],"glial":[143],"fibrillary":[144],"acidic":[145],"protein":[146],"(GFAP)":[147],"promoter,":[148],"which":[149],"expresses":[150],"astrocytes.":[152],"The":[153],"two":[154],"transgenic":[155],"lines":[156],"include":[157],"either":[158],"floxed":[160,167],"stop":[161],"over-expression":[162],"or":[165],"exon":[168],"4":[169],"SIRT1,":[171],"mimicking":[172],"knockout.":[175],"prevent":[177],"any":[178],"affects":[179],"mouse":[181],"development,":[183],"normal":[185],"chow":[186],"(NC)":[187],"infused":[188],"tamoxifen":[189],"diet":[190,233],"was":[191],"not":[192],"started":[193],"until":[194],"10":[195],"weeks":[196,209],"age,":[198],"maintained":[199],"for":[200,207],"2":[201,208],"weeks,":[202],"recovery":[205],"period":[206],"before":[210],"start":[212],"all":[214],"studies.":[215],"Differences":[216],"were":[217,238,249],"seen":[218],"weights,":[220],"food":[221],"intakes,":[222],"insulin":[225],"cyclicity.":[231],"High-fat":[232],"(HFD)":[234],"24hr":[236],"fast":[237],"performed":[239],"stress-induced":[245],"diets.":[246],"Reproductive":[247],"changes":[248],"evaluated":[250],"by":[251],"monitoring":[252],"estrous":[253],"cyclicity,":[254],"endocrine":[255],"steroid":[257],"levels,":[259],"well":[261],"gonadal":[263],"histology":[264]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-11-17T00:00:00"}