{"id":"https://openalex.org/W2767488985","doi":"https://doi.org/10.1021/acs.jmedchem.7b00736","title":"Pyrrolobenzodiazepine Dimer Antibody\u2013Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers","display_name":"Pyrrolobenzodiazepine Dimer Antibody\u2013Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers","publication_year":2017,"publication_date":"2017-11-07","ids":{"openalex":"https://openalex.org/W2767488985","doi":"https://doi.org/10.1021/acs.jmedchem.7b00736","mag":"2767488985","pmid":"https://pubmed.ncbi.nlm.nih.gov/29112410"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.7b00736","doi":"https://doi.org/10.1021/acs.jmedchem.7b00736","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.7b00736","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2767488985"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070013000","display_name":"Stephen J. Gregson","orcid":"https://orcid.org/0000-0002-6859-9772","observed_orcids":["https://orcid.org/0000-0002-6859-9772"]},"institutions":[{"id":"https://openalex.org/I4210146545","display_name":"Spirogen (United Kingdom)","ror":"https://ror.org/04mqss956","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146545"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephen J. Gregson","raw_affiliation_strings":["Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6859-9772","affiliations":[{"raw_affiliation_string":"Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom","institution_ids":["https://openalex.org/I4210146545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044830291","display_name":"Luke A. Masterson","orcid":"https://orcid.org/0000-0002-5366-4025","observed_orcids":["https://orcid.org/0000-0002-5366-4025"]},"institutions":[{"id":"https://openalex.org/I4210146545","display_name":"Spirogen (United Kingdom)","ror":"https://ror.org/04mqss956","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146545"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Luke A. Masterson","raw_affiliation_strings":["Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom","institution_ids":["https://openalex.org/I4210146545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066818395","display_name":"Binqing Q. Wei","orcid":"https://orcid.org/0000-0002-3654-3459","observed_orcids":["https://orcid.org/0000-0002-3654-3459"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Binqing Wei","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075200671","display_name":"Thomas H. Pillow","orcid":"https://orcid.org/0000-0001-7300-1002","observed_orcids":["https://orcid.org/0000-0001-7300-1002"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas H. Pillow","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032111440","display_name":"Susan D. Spencer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan D. Spencer","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042410729","display_name":"Gyoung\u2010Dong Kang","orcid":"https://orcid.org/0000-0002-7465-9276","observed_orcids":["https://orcid.org/0000-0002-7465-9276"]},"institutions":[{"id":"https://openalex.org/I4210146545","display_name":"Spirogen (United Kingdom)","ror":"https://ror.org/04mqss956","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146545"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gyoung-Dong Kang","raw_affiliation_strings":["Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom","institution_ids":["https://openalex.org/I4210146545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012042690","display_name":"Shang\u2010Fan Yu","orcid":"https://orcid.org/0009-0002-2625-663X","observed_orcids":["https://orcid.org/0009-0002-2625-663X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shang-Fan Yu","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007239062","display_name":"Helga E. Raab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helga Raab","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089112550","display_name":"Jeffrey Lau","orcid":"https://orcid.org/0009-0006-6526-2222","observed_orcids":["https://orcid.org/0009-0006-6526-2222"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Lau","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038648623","display_name":"Guangmin Li","orcid":"https://orcid.org/0000-0001-7045-572X","observed_orcids":["https://orcid.org/0000-0001-7045-572X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangmin Li","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089444669","display_name":"Gail D. Lewis Phillips","orcid":"https://orcid.org/0000-0001-7051-016X","observed_orcids":["https://orcid.org/0000-0001-7051-016X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail D. Lewis Phillips","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091025965","display_name":"Janet L. Gunzner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Gunzner-Toste","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048892054","display_name":"Brian S. Safina","orcid":"https://orcid.org/0000-0001-8134-9949","observed_orcids":["https://orcid.org/0000-0001-8134-9949"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian S. Safina","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062587644","display_name":"Rachana V. Ohri","orcid":"https://orcid.org/0000-0002-8862-6854","observed_orcids":["https://orcid.org/0000-0002-8862-6854"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachana Ohri","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029982556","display_name":"Martine Darwish","orcid":"https://orcid.org/0000-0003-4490-2164","observed_orcids":["https://orcid.org/0000-0003-4490-2164"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martine Darwish","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055879067","display_name":"Katherine R. Kozak","orcid":"https://orcid.org/0000-0003-3751-7225","observed_orcids":["https://orcid.org/0000-0003-3751-7225"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine R. Kozak","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040565950","display_name":"Josefa dela Cruz-Chuh","orcid":"https://orcid.org/0000-0001-5417-8750","observed_orcids":["https://orcid.org/0000-0001-5417-8750"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josefa dela Cruz-Chuh","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022150086","display_name":"Andrew G. Polson","orcid":"https://orcid.org/0000-0003-3289-6502","observed_orcids":["https://orcid.org/0000-0003-3289-6502"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Polson","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073714235","display_name":"John A. Flygare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Flygare","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051368970","display_name":"Philip W. Howard","orcid":"https://orcid.org/0000-0001-6392-2289","observed_orcids":["https://orcid.org/0000-0001-6392-2289","https://orcid.org/0000-0001-7828-1154"]},"institutions":[{"id":"https://openalex.org/I4210146545","display_name":"Spirogen (United Kingdom)","ror":"https://ror.org/04mqss956","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146545"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip W. Howard","raw_affiliation_strings":["Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom","institution_ids":["https://openalex.org/I4210146545"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070013000","https://openalex.org/A5075200671"],"corresponding_institution_ids":["https://openalex.org/I183934855","https://openalex.org/I4210146545"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9074,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.8507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"60","issue":"23","first_page":"9490","last_page":"9507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrrolobenzodiazepine","display_name":"pyrrolobenzodiazepine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9760000109672546},{"id":"https://openalex.org/keywords/maleimide-linker","display_name":"maleimide linker","score":0.6299999952316284},{"id":"https://openalex.org/keywords/triazole-linkers","display_name":"triazole linkers","score":0.746999979019165},{"id":"https://openalex.org/keywords/piperazine-linker","display_name":"piperazine linker","score":0.9520000219345093},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.7599999904632568},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.7170000076293945},{"id":"https://openalex.org/keywords/skbr3","display_name":"SKBR3","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9173142910003662},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7585132122039795},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7401292324066162},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5517579317092896},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.5078399777412415},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.47221261262893677},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.397489994764328},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3896148204803467},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37543541193008423},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.15905287861824036},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12728115916252136},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051918","descriptor_name":"Sialic Acid Binding Ig-like Lectin 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jmedchem.7b00736","doi":"https://doi.org/10.1021/acs.jmedchem.7b00736","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.7b00736","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:29112410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29112410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1692977678","https://openalex.org/W1822869875","https://openalex.org/W1953598751","https://openalex.org/W1974375788","https://openalex.org/W1984007340","https://openalex.org/W1992175481","https://openalex.org/W1993966288","https://openalex.org/W1996520089","https://openalex.org/W2003282396","https://openalex.org/W2010727342","https://openalex.org/W2020619239","https://openalex.org/W2030249962","https://openalex.org/W2031774809","https://openalex.org/W2042106494","https://openalex.org/W2052768531","https://openalex.org/W2058111745","https://openalex.org/W2068506054","https://openalex.org/W2081260096","https://openalex.org/W2082412374","https://openalex.org/W2084513035","https://openalex.org/W2089197481","https://openalex.org/W2112796828","https://openalex.org/W2116150122","https://openalex.org/W2136101268","https://openalex.org/W2141199885","https://openalex.org/W2157765555","https://openalex.org/W2164231501","https://openalex.org/W2179836657","https://openalex.org/W2233888390","https://openalex.org/W2288867196","https://openalex.org/W2314772071","https://openalex.org/W2395592928","https://openalex.org/W2403458189","https://openalex.org/W2417431203","https://openalex.org/W2419639370","https://openalex.org/W2507318226","https://openalex.org/W2513682949","https://openalex.org/W2539720888","https://openalex.org/W2549780925","https://openalex.org/W2559908363","https://openalex.org/W2560431464","https://openalex.org/W2560829310","https://openalex.org/W2596753223","https://openalex.org/W2597045666","https://openalex.org/W2603088210","https://openalex.org/W2610971372","https://openalex.org/W2699328289","https://openalex.org/W2936528150"],"related_works":["https://openalex.org/W2315176717","https://openalex.org/W2002329021","https://openalex.org/W4283791096","https://openalex.org/W2052768531","https://openalex.org/W2080228517","https://openalex.org/W2961257847","https://openalex.org/W2884679026","https://openalex.org/W2604196310","https://openalex.org/W4388021259","https://openalex.org/W4292393355"],"abstract_inverted_index":{"Three":[0],"rationally":[1],"designed":[2],"pyrrolobenzodiazepine":[3],"(PBD)":[4],"drug-linkers":[5],"have":[6],"been":[7],"synthesized":[8],"via":[9],"intermediate":[10],"19":[11],"for":[12,31,75,96,111,131,144],"use":[13],"in":[14,23,66,90,115,147,157],"antibody\u2013drug":[15],"conjugates":[16],"(ADCs).":[17],"They":[18],"lack":[19],"a":[20,29,35],"cleavable":[21],"trigger":[22],"the":[24,56,76,112],"linker":[25],"and":[26,38,70,84,94,128,134],"consist":[27],"of":[28],"maleimide":[30],"cysteine":[32],"antibody":[33],"conjugation,":[34],"hydrophilic":[36],"spacer,":[37],"either":[39],"an":[40],"alkyne":[41],"(":[42,46,51,72,87],"6":[43,146],"),":[44,48],"triazole":[45],"7":[47,73,88],"or":[49],"piperazine":[50],"8":[52],")":[53],"link":[54],"to":[55],"PBD.":[57],"In":[58,107,149],"vitro":[59],"IC":[60],"50":[61],"values":[62],"were":[63],"11\u201348":[64],"ng/mL":[65],"HER2":[67,158],"3+":[68,92],"SK-BR-3":[69],"KPL-4":[71],"inactive)":[74,83,89],"anti-HER2":[77,113],"ADCs":[78,98,114],"(HER2":[79],"0":[80,100],"MCF7,":[81],"all":[82,102],"0.10\u20131.73":[85],"\u03bcg/mL":[86],"CD22":[91],"BJAB":[93],"WSU-DLCL2":[95],"anti-CD22":[97,145],"(CD22":[99],"Jurkat,":[101],"inactive":[103],"at":[104,123,139],"low":[105],"doses).":[106],"vivo":[108],"antitumor":[109],"efficacy":[110],"Founder":[116],"5":[117],"was":[118,142],"observed":[119,143],"with":[120],"tumor":[121],"stasis":[122,138],"0.5\u20131":[124],"mg/kg,":[125,127],"1":[126],"3\u20136":[129],"mg/kg":[130,141],"6,":[132],"8,":[133],"7,":[135],"respectively.":[136],"Tumor":[137],"2":[140],"WSU-DLCL2.":[148],"summary,":[150],"noncleavable":[151],"PBD-ADCs":[152],"exhibit":[153],"potent":[154],"activity,":[155],"particularly":[156],"models.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-11-17T00:00:00"}