{"id":"https://openalex.org/W2767464985","doi":"https://doi.org/10.1093/neuonc/nox168.353","title":"EXTH-61. TARGETED NANOPARTICLE DELIVERY OF THERAPEUTIC ANTIMIR-21 AND ANTIMIR-10B PRESENSITIZES GLIOBLASTOMA TO LOWER EFFECTIVE DOSES OF TEMOZOLOMIDE IN CELLS AND XENOGRAFTS","display_name":"EXTH-61. TARGETED NANOPARTICLE DELIVERY OF THERAPEUTIC ANTIMIR-21 AND ANTIMIR-10B PRESENSITIZES GLIOBLASTOMA TO LOWER EFFECTIVE DOSES OF TEMOZOLOMIDE IN CELLS AND XENOGRAFTS","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2767464985","doi":"https://doi.org/10.1093/neuonc/nox168.353","mag":"2767464985"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/nox168.353","doi":"https://doi.org/10.1093/neuonc/nox168.353","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nox168.353","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5692759","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039402697","display_name":"Meenakshi Malhotra","orcid":"https://orcid.org/0000-0002-9731-5628","observed_orcids":["https://orcid.org/0000-0002-9731-5628"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenakshi Malhotra","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036552090","display_name":"Thillai V. Sekar","orcid":"https://orcid.org/0000-0002-2919-8802","observed_orcids":["https://orcid.org/0000-0002-2919-8802"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thillai Sekar","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084733765","display_name":"Rammohan Devulapally","orcid":"https://orcid.org/0000-0002-8721-3716","observed_orcids":["https://orcid.org/0000-0002-8721-3716"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rammohan Devulapally","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074133989","display_name":"Rayhaneh Afjei","orcid":"https://orcid.org/0000-0002-3762-3549","observed_orcids":["https://orcid.org/0000-0002-3762-3549"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rayhaneh Afjei","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018880989","display_name":"Ramasamy Paulmurugan","orcid":"https://orcid.org/0000-0001-7155-4738","observed_orcids":["https://orcid.org/0000-0001-7155-4738"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramasamy Paulmurugan","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037257563","display_name":"Tarik F. Massoud","orcid":"https://orcid.org/0000-0002-9694-1408","observed_orcids":["https://orcid.org/0000-0002-9694-1408"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarik Massoud","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"suppl_6","first_page":"vi86","last_page":"vi86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3434999883174896,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.8500000238418579},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.8550000190734863},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.8270000219345093},{"id":"https://openalex.org/keywords/oncogenic-microrna","display_name":"oncogenic microRNA","score":0.7639999985694885},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8489999771118164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.916942298412323},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6246848702430725},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5844905376434326},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5817681550979614},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4872349798679352},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4381866753101349},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42602938413619995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20129001140594482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14953646063804626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07310152053833008},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/nox168.353","doi":"https://doi.org/10.1093/neuonc/nox168.353","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nox168.353","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5154485","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5692759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5692759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5692759","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5154485","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5692759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2802627587","https://openalex.org/W2423792871","https://openalex.org/W2498596498","https://openalex.org/W4404656070","https://openalex.org/W4319458883","https://openalex.org/W2986269383","https://openalex.org/W4411961654","https://openalex.org/W4380997794","https://openalex.org/W2912791198","https://openalex.org/W4313837508"],"abstract_inverted_index":{"MiR-21":[0],"and":[1,23,47,56,59,66,72,84,88,97,124,167,274],"miR-10b":[2,275],"are":[3],"oncomiRs":[4],"overexpressed":[5],"in":[6,43,108,154,180,198,215,233,241,262],"glioblastoma":[7],"(GBM).":[8],"Therapeutic":[9],"antisense":[10],"microRNAs":[11],"(antimiRs)":[12],"can":[13],"effectively":[14],"initiate":[15],"cellular":[16,80,117],"apoptosis.":[17],"We":[18,54,62,99,150],"hypothesized":[19],"that":[20,286],"encapsulating":[21],"antimiR-21":[22],"antimiR-10b":[24],"into":[25],"c-RGD":[26,226],"peptide":[27],"surface":[28,195],"tagged":[29],"PLGA":[30],"nanoparticles":[31],"(NPs)":[32],"would":[33],"lead":[34,288],"to":[35,50,78,105,230,259,277,289],"enhanced":[36],"GBM":[37,231],"cell":[38,138,156],"uptake":[39,118],"of":[40,76,95,119,158,186,194,203,207,239,253,272],"NPs,":[41,70,123,209],"efficient":[42],"vivo":[44,242],"antimiR":[45],"delivery,":[46],"greater":[48],"chemosensitization":[49,252],"concurrent":[51],"temozolomide":[52],"(TMZ).":[53],"developed":[55],"characterized":[57],"c-RGD-targeted":[58],"non-targeted":[60,122],"NPs.":[61,172],"first":[63],"treated":[64,101,170],"U-87MG":[65,103,155],"Ln229":[67],"cells":[68,232,255],"with":[69,71,171,225,256],"without":[73],"different":[74],"doses":[75],"TMZ":[77,129,187,204,267,278],"determine":[79],"uptake,":[81],"toxicity,":[82],"anti-proliferation,":[83],"apoptosis":[85],"by":[86],"qRT-PCR":[87],"an":[89,152,281],"immunoassay":[90],"for":[91,145,191,248,293],"key":[92,160,246],"target":[93,161],"genes":[94],"miR-21":[96,159,273],"miR-10b.":[98],"then":[100],"mouse":[102],"xenografts":[104],"measure":[106],"changes":[107],"tumor":[109,181,216,237,250,263],"volumes.":[110],"In":[111,173],"culture,":[112],"we":[113,210],"found":[114,211],"higher":[115],"(p<0.001)":[116],"targeted":[120,146,208],"versus":[121],"increased":[125,137],"chemosensitivity":[126],"(p<0.01)":[127,178,214],"towards":[128],"at":[130,141,219,265],"lower":[131,266],"concentrations":[132],"(62.75":[133],"\u00b5M).":[134],"There":[135],"was":[136,176],"cycle":[139],"arrest":[140],"G2/M":[142],"phase,":[143],"especially":[144],"NPs":[147,192,224,240],"plus":[148],"TMZ.":[149,222],"observed":[151],"increase":[153],"expression":[157],"genes:":[162],"PTEN,":[163],"PDCD4,":[164],"Caspase":[165],"3,":[166],"p53,":[168],"when":[169],"mice":[174],"there":[175],"significant":[177],"reduction":[179,213,261],"volumes":[182,217,264],"after":[183],"Day":[184],"6":[185],"treatment":[188,279,291],"(25":[189],"mg/kg)":[190],"irrespective":[193],"modifications.":[196],"However,":[197],"a":[199,212,245,260],"dose":[200],"escalation":[201],"study":[202],"following":[205],"delivery":[206],"starting":[218],"6.25":[220],"mg/kg":[221],"Tagging":[223],"enhances":[227],"their":[228],"targeting":[229,238],"culture.":[234],"Although":[235],"passive":[236],"may":[243,287],"be":[244],"mechanism":[247],"NP":[249],"localization,":[251],"cancer":[254],"antimiRs":[257],"leads":[258],"dosages.":[268],"Thus,":[269],"NP-assisted":[270],"silencing":[271],"prior":[276],"is":[280],"effective":[282],"molecular":[283],"theranostic":[284],"strategy":[285],"improved":[290],"options":[292],"GBM.":[294]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-11-17T00:00:00"}
